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Generated: August 21, 2019

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Patent: 10,072,246

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Summary for Patent: 10,072,246
Title:Enhanced generation of cytotoxic T lymphocytes by IL-21 mediated FoxP3 suppression
Abstract: A method of carrying out adoptive immunotherapy by administering a subject an antigen-specific cytotoxic T lymphocytes (CTL) preparation in a treatment-effective amount is described. In the method, the CTL preparation is preferably administered as a preparation of an in vitro antigen-stimulated and expanded primate CTL population, the CTL population: (i) depleted of FoxP3+ T lymphocytes prior to antigen stimulation; (ii) antigen-stimulated in vitro in the presence of interleukin-21; or (iii) both depleted of FoxP3+ T lymphocytes prior to antigen stimulation and then antigen-stimulated in vitro in the presence of interleukin-21. Methods of preparing such compositions, and compositions useful for carrying out the adoptive immunotherapy, are also described.
Inventor(s): Yee; Cassian (Seattle, WA), Li; Yongqing (Shoreline, WA)
Assignee: The Fred Hutchinson Cancer Research Center (Seattle, WA)
Application Number:15/188,096
Patent Claims:see list of patent claims

Details for Patent 10,072,246

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Eisai Inc ONTAK denileukin diftitox VIAL 103767 001 1999-02-05   Try a Free Trial The Fred Hutchinson Cancer Research Center (Seattle, WA) 2027-10-03 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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