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Generated: July 23, 2019

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Patent: 10,041,044

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Summary for Patent: 10,041,044
Title:Age-associated clonal hematopoiesis accelerates cardio-metabolic disease development
Abstract: As demonstrated herein, a preferential and progressive expansion of a subset of hematopoietic cells bearing somatic mutations in TET2 leads to pro-inflammatory IL-1.beta. signaling at multiple levels, including increased IL-1.beta. transcription, increased NLRP3 inflammasome-mediated IL-1.beta. secretion, and increased IL-1-Receptor 1-mediated IL-1.beta. signaling. Accordingly, provided herein are compositions, methods, and assays for modulating TET2 mutation-mediated IL-1.beta. (interleukin-1.beta.) proinflammatory activity, particularly when caused by somatic mutations in TET2.
Inventor(s): Walsh; Kenneth (Carlisle, MA), Fuster; Jose (Brighton, MA)
Assignee: TRUSTEES OF BOSTON UNIVERSITY (Boston, MA)
Application Number:15/662,546
Patent Claims:see list of patent claims

Details for Patent 10,041,044

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source
Novartis Pharms ILARIS canakinumab INJECTABLE; SUBCUTANEOUS 125319 001 2009-06-17 ➤ Sign Up TRUSTEES OF BOSTON UNIVERSITY (Boston, MA) ➤ Sign Up RX search
Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source

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