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Last Updated: December 7, 2021

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Patent: 10,041,044

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Summary for Patent: 10,041,044
Title:Age-associated clonal hematopoiesis accelerates cardio-metabolic disease development
Abstract: As demonstrated herein, a preferential and progressive expansion of a subset of hematopoietic cells bearing somatic mutations in TET2 leads to pro-inflammatory IL-1.beta. signaling at multiple levels, including increased IL-1.beta. transcription, increased NLRP3 inflammasome-mediated IL-1.beta. secretion, and increased IL-1-Receptor 1-mediated IL-1.beta. signaling. Accordingly, provided herein are compositions, methods, and assays for modulating TET2 mutation-mediated IL-1.beta. (interleukin-1.beta.) proinflammatory activity, particularly when caused by somatic mutations in TET2.
Inventor(s): Walsh; Kenneth (Carlisle, MA), Fuster; Jose (Brighton, MA)
Application Number:15/662,546
Patent Claims:see list of patent claims

Details for Patent 10,041,044

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Novartis Pharmaceuticals Corporation ILARIS canakinumab For Injection 125319 2009-06-17 ⤷  Try it Free 2036-07-29
Novartis Pharmaceuticals Corporation ILARIS canakinumab Injection 125319 2016-12-22 ⤷  Try it Free 2036-07-29
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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