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Last Updated: February 7, 2023

Patent: 10,023,917

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Summary for Patent: 10,023,917
Title:High resolution melting analysis as a prescreening tool
Abstract: Compositions and methods for determining an increased likelihood of a response to a targeted treatment of a cancer disease including isolating genomic DNA from a patient sample, amplifying a fragment of DNA by means of PCR with a specific pair of amplification primers, determining if the amplified fragment comprises a wildtype sequence or a mutation by means of a High Resolution Melting Analysis (HRM), and correlating the presence or absence of a mutation with an increased likelihood of success of said targeted treatment. Respective primer pairs, compositions and kits are also claimed.
Inventor(s): Buettner; Reinhard (Villiprott, DE), Froehner; Stefanie (Penzberg, DE), Merkelbach-Bruse; Sabine (Aachen, DE), Ney; Jasmin (Wallerfangen, DE), Roesler; Angelika (Sindelsdorf, DE)
Assignee: Roche Molecular Systems, Inc. (Pleasanton, CA)
Application Number:14/958,567
Patent Claims:see list of patent claims

Details for Patent 10,023,917

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Eli Lilly And Company ERBITUX cetuximab Injection 125084 02/12/2004 See Plans and Pricing 2031-01-11
Eli Lilly And Company ERBITUX cetuximab Injection 125084 03/28/2007 See Plans and Pricing 2031-01-11
Amgen, Inc. VECTIBIX panitumumab Injection 125147 09/27/2006 See Plans and Pricing 2031-01-11
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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