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Last Updated: July 27, 2021

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Patent: 10,023,894

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Summary for Patent: 10,023,894
Title:Galactose-alpha-1, 3-galactose-containing n-glycans in glycoprotein products derived from CHO cells
Abstract: Methods of producing recombinant therapeutic fusion proteins described herein can include culturing Chinese hamster ovary (CHO) cells under conditions suitable for expression of a recombinant therapeutic fusion protein including one or more glycans, where the CHO cells have not been genetically engineered to produce terminal alpha-galactosyl residues on glycans; treating the one or more glycans of the recombinant glycoprotein with one or more exoglycosidases; measuring glycans containing terminal galactose-alpha-1-3-galactose residues on the fusion protein by nuclear magnetic resonance (NMR); and producing a recombinant therapeutic fusion protein in the CHO cells if a target level of terminal galactose-alpha-1-3-galactose residues is measured.
Inventor(s): Bosques; Carlos J. (Arlington, MA), Murphy; Jennifer (Marshfield, MA), Sarvaiya; Hetal (Quincy, MA), Washburn; Nathaniel (Littleton, MA), Liu; Cuihua (Belmont, MA), Xu; Xiao-Jin (Southborough, MA)
Assignee: Momenta Pharmaceuticals, Inc. (Cambridge, MA)
Application Number:14/832,784
Patent Claims:see list of patent claims

Details for Patent 10,023,894

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Bristol Myers Squibb ORENCIA abatacept INJECTABLE; IV (INFUSION) 125118 001 2005-12-23 ⤷  Try it Free Momenta Pharmaceuticals, Inc. (Cambridge, MA) 2029-01-22 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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