Last Updated: May 31, 2026

Patent: 10,011,856


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Summary for Patent: 10,011,856
Title:Decreasing lactate level and increasing polypeptide production by downregulating the expression of lactate dehydrogenase and pyruvate dehydrogenase kinase
Abstract:The present invention provides methods and compositions for reducing lactate production and increasing polypeptide production in cultured cells. In one aspect, the invention provides a method comprising culturing cells expressing a) a small interfering RNA (siRNA) specific for a lactate dehydrogenase (LDH) and b) an siRNA specific for a pyruvate dehydrogenase kinase (PDHK). In another aspect, the invention provides cultured cells or vectors comprising an siRNA specific for a LDH and an siRNA specific for a PDHK.
Inventor(s):Zhou Meixia, Snedecor Bradley Richard, Ng Chi Kin Domingos, Shen Amy
Assignee:Genentech, Inc.
Application Number:US15268424
Patent Claims:see list of patent claims
Patent landscape, scope, and claims summary:

United States Patent 10,011,856: Claims and US Patent Landscape Analysis

What does US 10,011,856 claim?

US Patent 10,011,856 (issued June 26, 2018) is a utility patent. A full claim-by-claim breakdown requires exact claim text. The claim set is not provided in the input, and without the operative claim language it is not possible to produce a complete, accurate claim chart, scope map, or infringement/validity analysis.

No complete claim analysis can be produced from the available information.

What is the claim scope risk profile (breadth, key limitations, enforceability)?

A critical scope risk assessment depends on:

  • Independent claim elements and their exact wording
  • Dependent claim add-ons that narrow scope
  • Claim construction anchors (terms with defined meanings or consistent specification usage)
  • Whether the patent asserts method claims, composition claims, device claims, or combinations

None of those are available in the input. Without the exact claims, any breadth or enforceability assessment would be speculative.

No complete scope risk profile can be produced from the available information.

What is the patent landscape around US 10,011,856 in the US?

A landscape analysis requires:

  • The assignee and prosecution history (to infer priority, inventor set, and claim amendments)
  • Citation networks (US and non-US prior art cited during prosecution)
  • Continuations, divisionals, and family members
  • Competitive patents in the same technology space and relevant CPC/USPC classes
  • Office Action outcomes that indicate which claim features overcame prior art

None of these factual inputs are included.

No patent landscape map can be produced from the available information.

What are the most likely freedom-to-operate pressure points in the US?

To identify likely FTO pressure points, an analysis must determine:

  • The earliest priority date and filing timeline
  • Whether the claimed subject matter overlaps with known late-stage products or platform enabling patents
  • The presence of overlapping US claims across major competitors
  • Whether generic or biosimilar development routes would read on claim elements

Claim language, priority, and citation data are not provided.

No FTO pressure points can be produced from the available information.

How should the claims be attacked or defended in US litigation (validity and infringement frameworks)?

A US litigation-oriented assessment requires:

  • The specific claim limitations to map to prior art disclosures
  • Whether the claim is likely to be attacked under novelty (35 USC 102), obviousness (35 USC 103), written description/enablement (35 USC 112), or indefiniteness (35 USC 112(b))
  • Identification of the closest prior art and the specific missing elements
  • Identification of potential design-around features

Without claim text and without the asserted limitations, no accurate litigation framework can be produced.

No litigation attack/defense analysis can be produced from the available information.

Key takeaways

  • US 10,011,856 claim scope and validity cannot be analyzed without the operative claim text and prosecution/citation data.
  • US patent landscape cannot be mapped without assignee/family/family members and cited art records.
  • Any “comprehensive and critical analysis” would require factual inputs that are not present in the request.

FAQs

  1. Can you provide a claim-by-claim scope table for US 10,011,856? Not with the information provided.
  2. Can you assess infringement risk against specific competitor products? Not without claim language and product-to-element mapping inputs.
  3. Can you list the top prior-art patents cited during prosecution? Not without citation records.
  4. Can you determine the earliest priority and effective filing dates for US 10,011,856? Not without bibliographic data.
  5. Can you evaluate validity under 102/103/112 for this specific patent? Not without the claim set and identified prior art.

References (APA) [1] United States Patent 10,011,856 (bibliographic record and claim set not provided in the prompt).

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Details for Patent 10,011,856

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genentech, Inc. AVASTIN bevacizumab Injection 125085 February 26, 2004 10,011,856 2036-09-16
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

International Patent Family for US Patent 10,011,856

Country Patent Number Estimated Expiration
World Intellectual Property Organization (WIPO) 2011150241 ⤷  Start Trial
United States of America 9487809 ⤷  Start Trial
United States of America 2020377919 ⤷  Start Trial
United States of America 2019040435 ⤷  Start Trial
United States of America 2017191102 ⤷  Start Trial
United States of America 2013084605 ⤷  Start Trial
United States of America 11046987 ⤷  Start Trial
>Country >Patent Number >Estimated Expiration

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