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Last Updated: September 30, 2020

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Patent: 10,011,660

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Summary for Patent: 10,011,660
Title:Molecules with reduced effector function and extended half-lives, compositions, and uses thereof
Abstract: Provided are polypeptides comprising a variant IgG Fc domain, wherein the polypeptides exhibit reduced or ablated effector functions (e.g., ADCC and/or CDC) and increased stability and plasma half-life compared to a parent polypeptide. Also provided are compositions, methods of treatment, and methods to diminish Fc-induced effector function in a parent polypeptide.
Inventor(s): Tsui; Ping (Gaithersburg, MD), Borrok, II; Martin (Gaithersburg, MD), Dall\'Acqua; William (Gaithersburg, MD)
Assignee: MedImmune, LLC (Gaithersburg, MD)
Application Number:14/397,958
Patent Claims:see list of patent claims

Details for Patent 10,011,660

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Csl Behring Ag CARIMUNE human immunoglobulin g INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 102367 1 2009-02-10   Start Trial MedImmune, LLC (Gaithersburg, MD) 2032-04-30 search
Csl Behring Ag PRIVIGEN human immunoglobulin g LIQUID 125201 1 2009-01-20   Start Trial MedImmune, LLC (Gaithersburg, MD) 2032-04-30 search
Bio Products Laboratory Limited GAMMAPLEX human immunoglobulin g SOLUTION 125329 1 2017-04-07   Start Trial MedImmune, LLC (Gaithersburg, MD) 2032-04-30 search
Csl Behring Ag HIZENTRA human immunoglobulin g LIQUID 125350 1 2020-01-01   Start Trial MedImmune, LLC (Gaithersburg, MD) 2032-04-30 search
Adma Biologics, Inc. ASCENIV human immunoglobulin g LIQUID 125590 1 2019-04-01   Start Trial MedImmune, LLC (Gaithersburg, MD) 2032-04-30 search
Octapharma Usa Inc CUTAQUIG immunoglobulin g SOLUTION 125668 1 2019-05-03   Start Trial MedImmune, LLC (Gaithersburg, MD) 2032-04-30 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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