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Last Updated: September 19, 2020

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Patent: 10,005,847

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Summary for Patent: 10,005,847

Title:	Anti-HER2 glycoantibodies and uses thereof
Abstract:	The present disclosure relates to a novel class of anti-HER2 monoclonal antibodies comprising a homogeneous population of anti-HER2 IgG molecules having the same N-glycan on each of Fc. The antibodies of the invention can be produced from anti-HER2 monoclonal antibodies by Fc glycoengineering. Importantly, the antibodies of the invention have improved therapeutic values with increased ADCC activity and increased Fc receptor binding affinity compared to the corresponding monoclonal antibodies that have not been glycoengineered.
Inventor(s):	Wong; Chi-Huey (Rancho Santa Fe, CA), Wu; Chung-Yi (New Taipei, TW)
Assignee:	ACADEMIA SINICA (Taipei, TW)
Application Number:	14/723,181
Patent Claims:	see list of patent claims

Details for Patent 10,005,847

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Number	Approval Date	Patent No.	Assignee	Estimated Patent Expiration	Status	Orphan	Source
Genentech	HERCEPTIN	trastuzumab	VIAL; INTRAVENOUS	103792	001	1998-09-25	Start Trial	ACADEMIA SINICA (Taipei, TW)	2034-05-27	RX	Orphan	search
Genentech Inc	HERCEPTIN HYLECTA	trastuzumab; hyaluronidase-oysk	INJECTABLE;SUBCUTANEOUS	761106	001	2019-02-28	Start Trial	ACADEMIA SINICA (Taipei, TW)	2034-05-27	RX		search
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Number	>Approval Date	>Patent No.	>Assignee	>Estimated Patent Expiration	>Status	>Orphan	>Source

International Patent Family for US Patent 10,005,847

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Country	Patent Number	Estimated Expiration
Australia	2015206370	Start Trial
Australia	2015267044	Start Trial
Australia	2015267045	Start Trial
Australia	2015267047	Start Trial
>Country	>Patent Number	>Estimated Expiration

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