Claims for Patent: 9,999,225

Summary for Patent: 9,999,225

Title:	Silver nanoparticle-enhanced photosensitizers
Abstract:	The present invention relates generally to compositions and methods of killing bacteria using a surface plasmon coupled to a photosensitizer. A nanostructure (10) may include a silver nanoparticle core (12), a mesoporous silica shell (14), and a photosensitizer (16). A method of killing bacteria may include contacting bacteria with a nanostructure (10) including a silver nanoparticle core (12), a mesoporous silica shell (14), and a photosensitizer (16) to form a blend and exposing the blend to light.
Inventor(s):	Zhang; Peng (Cincinnati, OH), Hu; Bo (Cincinnati, OH), Tang; Hong (Cincinnati, OH)
Assignee:	University Of Cincinnati (Cincinnati, OH)
Application Number:	15/123,549
Patent Claims:	1. A nanostructure comprising: a silver nanoparticle core; a mesoporous silica shell that contacts the silver nanoparticle core; and a photosensitizer adsorbed onto said mesoporous silica shell without being covalently bonded to said mesoporous silica shell. 2. The nanostructure claimed in claim 1, wherein said photosensitizer is selected from the group consisting of hematoporphyrin IX dihydrochloride, meso-porphyrin IX, meso-tetra(4-carboxyphenyl) porphine, protoporphyrin IX, rose Bengal, erythrosin B, tris(2,2'-bipyridyl)dichlororuthenium(II) hexahydrate, Riboflavin, and Hemin. 3. The nanostructure clamed in claim 1, wherein said silver nanoparticle core consists of silver. 4. The nanostructure clamed in claim 1, wherein said mesoporous silica shell includes a plurality of pores having a diameter in a range of about 2 to 50nm. 5. The nanostructure clamed in claim 1, wherein said mesoporous silica shell has a thickness in a range of about 10 to 100 nm.

Details for Patent 9,999,225

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Recordati Rare Diseases, Inc.	PANHEMATIN	hemin for injection	For Injection	101246	07/20/1983		2040-01-28