Claims for Patent: 9,889,205
✉ Email this page to a colleague
Summary for Patent: 9,889,205
Title: | Glucose-responsive insulin conjugates |
Abstract: | Insulin conjugates comprising an insulin molecule covalently attached to at least one bi-dentate linker having two arms, each arm independently attached to a ligand comprising a saccharide and wherein the saccharide for at least one ligand of the linker is fucose are disclosed. The insulin conjugates display a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a saccharide such as glucose or alpha-methylmannose even when administered to a subject in need thereof in the absence of an exogenous multivalent saccharide-binding molecule such as Con A. |
Inventor(s): | Lin; Songnian (Monroe, NJ), Yan; Lin (East Brunswick, NJ), Huo; Pei (Millburn, NJ) |
Assignee: | Merck Sharp & Dohme Corp. (Rahway, NJ) |
Application Number: | 15/191,584 |
Patent Claims: | 1. A conjugate having the formula ##STR00287## wherein the insulin is human recombinant insulin.
2. A composition comprising: a conjugate having the formula ##STR00288## and wherein the insulin is human recombinant insulin, and a pharmaceutically acceptable carrier. |
Details for Patent 9,889,205
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Eli Lilly And Company | HUMULIN R U-100 | insulin human | Injection | 018780 | 10/28/1982 | ⤷ Try a Trial | 2033-10-04 |
Eli Lilly And Company | HUMULIN R U-500 | insulin human | Injection | 018780 | 12/29/2015 | ⤷ Try a Trial | 2033-10-04 |
Eli Lilly And Company | HUMULIN R U-100 | insulin human | Injection | 018780 | 08/06/1998 | ⤷ Try a Trial | 2033-10-04 |
Eli Lilly And Company | HUMULIN R U-500 | insulin human | Injection | 018780 | 03/31/1994 | ⤷ Try a Trial | 2033-10-04 |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
Make Better Decisions: Try a trial or see plans & pricing
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.