Claims for Patent: 9,867,820
✉ Email this page to a colleague
Summary for Patent: 9,867,820
Title: | Role of N-2-hydroxy-ethyl-piperazine-N\'-2-ethane sulfonic acid (HEPES) in pain control and reversal of demyelinization injury |
Abstract: | Compositions and therapeutic uses of HEPES and derivatives in the treatment of pain associated with cancers and side-effects including post-chemotherapy cognitive impairment are disclosed herein. HEPES is also used to treat neurodegenerative and neurological diseases, demyelinization injuries, and side-effects and withdrawal symptoms associated with benzodiazepines, anti-depressants, and other neurological agents. |
Inventor(s): | Danhof; Ivan E. (Grand Prairie, TX) |
Assignee: | Bespoke Bioscience, LLC (Dallas, TX) |
Application Number: | 14/481,582 |
Patent Claims: | 1. A method of treating neurological impairment caused by diseases that cause demyelination in a human subject comprising the steps of: identifying a human subject in need
for treatment against the neurological impairment caused by the disease that causes demyelination selected from the group consisting of transverse myelitis, Devic's disease, progressive multifocal leukoencephalopathy, optic neuritis, leukodystrophy,
Guillain-Barre syndrome Charcot-Marie-Tooth disease, and Krabbe's disease; and administering a pharmaceutical composition comprising N-2-hydroxy-ethyl-piperazine-N'-2-ethane sulfonic acid (HEPES) and derivatives thereof dissolved in sterile water,
buffer, saline or other pharmaceutically acceptable carriers in an amount sufficient to treat the demyelination, wherein the pharmaceutical composition is administered orally, subcutaneously, parenterally, intravenously, peritoneally, or intramuscularly.
2. The method of claim 1, wherein the HEPES is dissolved in sterile water for injection for oral, subcutaneous, parenteral, intravenous, peritoneal, or intramuscular administration. 3. The method of claim 1, wherein the composition is administered once daily on a body weight basis at 10-100 mg/kg. 4. The method of claim 1, wherein the composition treats the one or more demyelination diseases by restoring, repairing, and/or regenerating a myelin sheath. |
Details for Patent 9,867,820
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Merck Sharp & Dohme Corp. | ZOSTAVAX | zoster vaccine live | For Injection | 125123 | 05/25/2006 | ⤷ Try a Trial | 2029-09-17 |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
Make Better Decisions: Try a trial or see plans & pricing
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.