Claims for Patent: 9,782,448

Summary for Patent: 9,782,448

Title:	Methods and compositions for treating skin
Abstract:	A method for treating intact irritated or inflamed skin with a composition comprising at least one Histamine Receptor pathway inhibitor; at least one Lipoxygenase pathway inhibitor; at least one Cyclooxygenase pathway inhibitor and at least one Chemotaxis pathway inhibitor.
Inventor(s):	Collins; Donald F. (Plainview, NY), Maes; Daniel H. (Huntington, NY), Muizzuddin; Neelam (Bethpage, NY)
Assignee:	ELC Management LLC (New York, NY)
Application Number:	13/957,647
Patent Claims:	1. A method for reducing redness, pain or heat in intact skin in need of such treatment by topically applying to the skin a composition free of hydrocortisone in the form of anhydrous, emulsion, or gel composition comprising: at least one botanic extract that inhibits the Histamine pathway when topically applied; at least one botanic extract that inhibits the Phospholipase A2 pathway when topically applied, at least one botanic extract that inhibits the Cyclooxygenase 2 pathway when topically applied, at least one botanic extract that inhibits the Vascular Endothelial Growth Factor pathway inhibitor when topically applied, at least one botanic extract that inhibits the Histamine Receptor pathway when topically applied, at least one botanic extract that inhibits the Lipoxygenase pathway-when topically applied; and at least one botanic extract that inhibits the Chemotaxis pathway when topically applied, wherein the composition containing the combined pathway inhibitors has an effectiveness in reducing the redness, pain, or heat that is equal to or greater than the identical composition containing 1% hydrocortisone and being free of the combined pathway inhibitors. 2. The method of claim 1 wherein the inhibitor of the Histamine pathway is in the form of a botanical extract having a component selected from the group consisting of flavones, apigenins, flavonoids, luteolins, phloretins, chalcones and mixtures thereof. 3. The method of claim 1 wherein the inhibitor of the Phospholipase A2 pathway is selected from the group consisting of Lyngbya extract; grapeseed extract; licochalcone; Viapure poria extract; Polyporus umbellatus; avocado extract; Camellia sinensis; Chrysanthellum indicum; Tridentata marginata extract; Pomegranate extract; Gorgonian extract; and mixtures thereof. 4. The method of claim 1 wherein the inhibitor of the Cyclooxygenase 2 pathway is selected from the group consisting of Acacia genus; Calluna Vulgaris; Rosa Canina fruit extract; nettle leaf extract; Polyporus Umbellatus; Chamomilla Recutita (Matricaria) flower oil; a mixture of Butcher's Broom extract and heperidin methyl chalcone; resveratrol; HOP's beta acids; and mixtures thereof. 5. The method of claim 1 wherein the inhibitor of the Vascular Endothelial Growth Factor pathway is selected from the group consisting of the Saussurea genus such as Saussurea Costus extract, Saussurea Lappa; Sesquiterpene lactones; magnolia extract; a mixture of butylene glycol, water, and Cynara Scolymus (Artichoke) Leaf Extract); hypoestoxide (HE); Magnolia Officianalis Bark extract; Echineacea Pallida extract; and mixtures thereof. 6. The method of claim 1 wherein the inhibitor of the Lipooxygenase pathway is selected from the group consisting of Haplophyllum hispanicum Spach; Scutellaria Rivularis extract; alpha ketoboswellic acid; Zileuton.RTM. (1-(1-benzothiophen-2-ylethyl)-1-hydroxy-urea); Centaurium extract; nordihydroguaiaretic acid; ginger oil; resveratrol; Polygonum Cuspidatum extract; cedar himalaya extract; tetrahydrocurcuminoids; Nigella Sativa essential oil; copaiba balsam; Australian sandalwood; Rhodiola Rosea; frankincense; blue cypress oil; blue chamomile oil; vetiver mada; bulgarian rose oil; Helichrysum oil; rosmarinic acid; resveratrol triphosphate; noni leaf extract; and mixtures thereof. 7. The method of claim 1 wherein the inhibitor of the Chemotaxis pathway is selected from the group consisting of licorice extract; genestein; extracts from the genus Scutellaria; extracts from the Boswellia genus; extract from the Commiphora genus; Bursera Microphylla; Nidularium Procerum; sequoia extract; hypoestoxide; Curcuma Longa (turmeric) extract; butyloctyl salicylate; abyssine; plai oil; geranium bourbon oil; jiagolun EX; fucoidan YSK; caffeine; galactoarabinan; lion's mane mushroom extract; clerilys; extracts from Macrycystis Pyrifera; reishi mushroom extract; Pleurotus Ostreatus extract; Hypsizygus Ulmarius extract; Cladosiphon Okamuranus Extract; Acalypha Wilkesiana extract; Acanthopanax Gracilistylus extract; Allium Sativum extract; Ananus Comosus extract; Cissampelos Sympodialis extract; Coriolus Versicolor extract; Echinacea Purpurea extract; Grifola Frondosa extract; Harpagophytum Procumbens extract; Panax Ginseng extract; Polygala Tenuifolia extract; Poria Cocos extract; Silybum Marianum extract; Smilax Glabra extract; Tinospora Cordifolia extract; Uncaria Tomentosa extract; Withania Somnifera extract; slime mold; Echinancea extract; Viscum Album extract; coffee robusta seed extract; capsaicin; a hexapeptide having the amino acid sequence (SEQ ID NO: 1) Val-Gly-Val-Ala-Pro-Gly (VGVAPG); ubiquitin; nicotinalides; cytochalasin B; and mixtures thereof. 8. The method of claim 1 additionally comprising at least one botanic extract that inhibits the Adhesion pathway when topically applied. 9. The method of claim 1 additionally comprising at least one botanic extract that inhibits the Collagenase pathway when topically applied. 10. A method for reducing redness, pain or heat in intact skin in need of such treatment by topically applying to the skin a composition free of hydrocortisone in the form of anhydrous, or emulsion, or gel composition comprising: at least one Histamine pathway inhibitor in the form of a botanical extract having a component selected from the group consisting of flavones, apigenins, flavonoids, luteolins, phloretins, chalcones, and mixtures thereof; at least one Phospholipase A2 pathway inhibitor in the form of a botanical extract having a component selected from the group consisting of amentoflavone, licochalcone, ellagic acid, hesperitin, polyphenol, and mixtures thereof; at least one Cyclooxygenase-2 pathway inhibitor in the form of a botanical extract from the Acacia genus, Calluna genus, Rosa genus, Polyporus genus, Chamomilla genus, nettle leaf, Butcher's broom; hesperidin, methyl chalcone, resveratrol, HOPS beta acids, and mixtures thereof; at least one Vascular Endothelial Growth Factor pathway inhibitor in the form of a botanical extract selected from the group consisting of Saussurea genus, Magnolia genus, Cynara genus, Echineacea genus, Pallida genus; sesquiterpene lactones, hypoestoxide, and mixtures thereof; at least one Histamine receptor pathway inhibitor in the form of a botanical extract selected from the group consisting of Japanese Butterbur, Garcinia genus, and mixtures thereof; at least one Lipoxygenase pathway inhibitor selected from the group consisting of Haplophyllum hispanicum Spach; Scutellaria Rivularis extract; alpha ketoboswellic acid; Zileuton.RTM. (1-(1-benzothiophen-2-ylethyl)-1-hydroxy-urea); Centaurium extract; nordihydroguaiaretic acid; ginger oil; resveratrol; Polygonum Cuspidatum extract; cedar himalaya extract; tetrahydrocurcuminoids; Nigella Sativa essential oil; copaiba balsam; Australian sandalwood; Rhodiola Rosea; frankincense; blue cypress oil; blue chamomile oil; vetiver mada; bulgarian rose oil; Helichrysum oil; rosmarinic acid; resveratrol triphosphate; noni leaf extract; and mixtures thereof; and at least one Chemotaxis pathway inhibitor selected from the group consisting of licorice extract; genestein; extracts from the genus Scutellaria; extracts from the Boswellia genus; extract from the Commiphora genus; Bursera Microphylla extract; Nidularium Proceru extract; sequoia extract; hypoestoxide; Curcuma Longa (turmeric) extract; butyloctyl salicylate; abyssine; plai oil; geranium bourbon oil; jiagolun EX; fucoidan YSK; caffeine; galactoarabinan; lion's mane mushroom extract; clerilys extract; extracts from Macrycystis Pyrifera; reishi mushroom extract; Pleurotus Ostreatus extract; Hypsizygus Ulmarius extract; Cladosiphon Okamuranus Extract; Acalypha Wilkesiana extract; Acanthopanax Gracilistylus extract; Allium Sativum extract; Ananus Comosus extract; Cissampelos Sympodialis extract; Coriolus Versicolor extract; Echinacea Purpurea extract; Grifola Frondosa extract; Harpagophytum Procumbens extract; Panax Ginseng extract; Polygala Tenuifolia extract; Poria Cocos extract; Silybum Marianum extract; Smilax Glabra extract; Tinospora Cordifolia extract; Uncaria Tomentosa extract; Withania Somnifera extract; slime mold; Echinancea extract; Viscum Album extract; coffee robusta seed extract; capsaicin; a hexapeptide having the amino acid sequence (SEQ ID NO: 1) Val-Gly-Val-Ala-Pro-Gly (VGVAPG); ubiquitin; nicotinalides; cytochalasin B; and mixtures thereof; wherein the composition containing the combined pathway inhibitors has an effectiveness in reducing the redness, pain, or heat that is equal to or greater than the identical composition containing 1% hydrocortisone and being free of the combined pathway inhibitors.

Details for Patent 9,782,448

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995	06/04/1965		2027-12-20
Jubilant Hollisterstier Llc	N/A	positive skin test control-histamine	Injection	103891	03/13/1924		2027-12-20