Claims for Patent: 9,707,281

Summary for Patent: 9,707,281

Title:	Pharmaceutical compositions and methods for digesting atherosclerotic plaques
Abstract:	Disclosed are pharmaceutical compositions and methods for digesting atherosclerotic plaques in a patient in need thereof. The compositions include and the methods utilize a mixture of collagenases for digesting plaques and optionally may include or utilize additional agents such as cyclodextrins, chelating agents, and tissue plasminogen activator.
Inventor(s):	Kibbe; Melina R. (Chicago, IL), Ameer; Guillermo A. (Chicago, IL), Varu; Vinit N. (Chicago, IL)
Assignee:	Northwestern University (Evanston, IL)
Application Number:	14/326,904
Patent Claims:	1. A method for digesting a human arterial plaque within an artery of a patient the method comprising: (a) contacting the arterial plaque with a pharmaceutical composition comprising a collagenase mixture consisting of collagenase type I collagenase type III, collagenase type IV, and collagenase type V by administering the composition to the patient via a double-balloon catheter, wherein each of the collagenase type I, collagenase type III, collagenase type IV, and collagenase type V is present in the composition at a concentration of at least 0.5 mg/ml: and (b) applying ultrasonic energy at a frequency of 10-100 kHz to the arterial plaque during contacting the arterial plaque with the composition, wherein the ultrasonic energy is applied for u period of time sufficient to reduce mass of the arterial plaque by at least 30%. 2. The method of claim 1, wherein the composition further comprises a cyclodextrin at a concentration of 5-25 mM. 3. The method of claim 1, wherein the composition further comprises a chelating agent at a concentration of 0.75-1.25 mg/ml. 4. The method of claim 1, wherein the composition further comprises tissue plasminogen activator at a concentration of 0.75-1.25 mg/ml. 5. The method of claim 1, wherein the composition further comprises cholesterol esterase at a concentration of 0.1-10 units/ml. 6. The method of claim 1, wherein the composition further comprises lipoprotein lipase at a concentration of 30-10,000 units/ml. 7. The method of claim 1, wherein the composition further comprises apolipoprotein CII at a concentration of 1-20 units/ml. 8. The method of claim 1, wherein the composition further comprises phospholipase A2. 9. The method of claim 1, wherein the composition further comprises pepsin at a concentration of 1-50 mg/ml. 10. The method of claim 1, wherein the composition has a pH of about 7.2-7.6. 11. The method of claim 1, wherein the composition further comprises calcium chloride.

Details for Patent 9,707,281

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995	06/04/1965		2030-04-14