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Last Updated: May 4, 2024

Claims for Patent: 9,688,965

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Summary for Patent: 9,688,965

Title:	Recombinant neuraminidase and uses thereof
Abstract:	A recombinant neuraminidase based on amino acid sequence (SEQ ID NO: 1) of wild-type pH1N1-NA (A/Texas/05/2009) influenza virus is provided. The recombinant neuraminidase of the present invention has an ectodomain with an amino acid sequence identical to SEQ ID NO: 1 and replaced at specific positions 149, 344, 365 and 366 residue(s) with corresponding amino acids of other influenza viruses. The recombinant neuraminidase may incur cross-protective immunity and be used as universal influenza vaccine.
Inventor(s):	Wu; Suh-Chin (Hsinchu, TW), Liu; Wen-Chun (Hsinchu, TW), Lin; Chia-Ying (Hsinchu, TW)
Assignee:	National Tsing Hua University (Hsinchu, TW)
Application Number:	14/685,286
Patent Claims:	1. A recombinant neuraminidase, comprising an ectodomain provided with an amino acid sequence at least 95% identical to SEQ ID NO: 1, wherein the amino acids at positions 365 and 366 are replaced from IS to TN. 2. The recombinant neuraminidase as claimed in claim 1, wherein the amino acid sequence is at least 97% identical to SEQ ID NO: 1. 3. The recombinant neuraminidase as claimed in claim 1, wherein the amino acid sequence is at least 99% identical to SEQ ID NO: 1. 4. The recombinant neuraminidase as claimed in claim 1, wherein the amino acid sequence is selected from Seq ID NO: 4. 5. A recombinant influenza virus, comprising: a recombinant neuraminidase, comprising an ectodomain provided with an amino acid sequence at least 95% identical to SEQ ID NO: 1, wherein the amino acids at positions 365 and 366 is replaced from IS to TN. 6. The recombinant influenza virus as claimed in claim 5, wherein the amino acid sequence is at least 97% identical to SEQ ID NO: 1. 7. The recombinant influenza virus as claimed in claim 5, wherein the amino acid sequence is at least 99% identical to SEQ ID NO: 1. 8. The recombinant influenza virus as claimed in claim 5, wherein the amino acid sequence is selected from Seq ID NO: 4. 9. An influenza virus vaccine, comprising: a recombinant neuraminidase, comprising an ectodomain provided with an amino acid sequence at least 95% identical to SEQ ID NO: 1, wherein the amino acids at positions 365 and 366 is replaced from IS to TN. 10. The influenza virus vaccine, as claimed in claim 9, wherein the amino acid sequence is at least 97% identical to SEQ ID NO: 1. 11. The influenza virus vaccine as claimed in claim 9, wherein the amino acid sequence is at least 99% identical to SEQ ID NO: 1. 12. The influenza virus vaccine as claimed in claim 9, wherein the amino acid sequence is selected from Seq ID NO: 4. 13. The influenza virus vaccine as claimed in claim 9, wherein the influenza virus vaccine is an inactivated vaccine, an attenuated influenza, a virus-like particle vaccine or a subunit vaccine.

Details for Patent 9,688,965

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Seqirus Vaccines Limited	FLUVIRIN	influenza virus vaccine	Injection	103837	11/03/1998	⤷ Try a Trial	2034-09-04
Sanofi Pasteur Inc.	FLUZONE, FLUZONE HD QUADRIVALENT, FLUZONE HIGH DOSE, FLUZONE INTRADERMAL, FLUZONE QUADRIVALENT	influenza virus vaccine	Injection	103914	12/09/1999	⤷ Try a Trial	2034-09-04
Sanofi Pasteur Inc.	FLUZONE, FLUZONE HD QUADRIVALENT, FLUZONE HIGH DOSE, FLUZONE INTRADERMAL, FLUZONE QUADRIVALENT	influenza virus vaccine	Injection	103914	12/23/1909	⤷ Try a Trial	2034-09-04
Sanofi Pasteur Inc.	FLUZONE, FLUZONE HD QUADRIVALENT, FLUZONE HIGH DOSE, FLUZONE INTRADERMAL, FLUZONE QUADRIVALENT	influenza virus vaccine	Injection	103914	05/09/2011	⤷ Try a Trial	2034-09-04
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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