Claims for Patent: 9,662,450

Summary for Patent: 9,662,450

Title:	Plasma or CVD pre-treatment for lubricated pharmaceutical package, coating process and apparatus
Abstract:	An article is described including an article surface, a primer coating or layer of SiOx, SiO.sub.xC.sub.y or SiN.sub.xC.sub.y applied to the article surface, and a deposit of lubricant applied to the primer coating or layer. The primer coating or layer of SiO.sub.x, SiO.sub.xC.sub.y or SiN.sub.xC.sub.y is applied by chemical vapor deposition of a polysiloxane or polysilazane precursor in the presence of oxygen. A first deposit of lubricant is applied to the primer coating or layer. The primer coating or layer improves the adhesion or wetting of the lubricant on the surface to be lubricated. Examples of such an article are a prefilled syringe having a barrel with a lubricated interior portion and a plunger tip that slides along it. Another example of such an article is a vial having a lubricated opening to receive a septum. Another aspect of the invention is a method of making such an article.
Inventor(s):	Jones; Joseph A. (Birmingham, AL), Weikart; Christopher (Auburn, AL), Martin; Steven J. (Midland, MI)
Assignee:	SIO2 MEDICAL PRODUCTS, INC. (Auburn, AL)
Application Number:	14/194,221
Patent Claims:	1. A syringe barrel comprising: a wall having a generally cylindrical interior surface defining an inner sliding surface and a lumen; a plasma enhanced chemical vapor deposition (PECVD) primer coating or layer on the wall defining a PECVD treated surface, in which the primer coating or layer consists essentially of SiO.sub.xC.sub.y, in which x is from about 0.5 to about 2.4 and y is from about 0.6 to about 3; and a deposit of fluid lubricant on the PECVD treated surface wherein the fluid lubricant comprises polydimethylsiloxane; in which the deposit of fluid lubricant and primer coating or layer is effective to provide a lower frictional resistance between the inner sliding surface and a relatively sliding part than the deposit of fluid lubricant without the primer coating or layer at least one year after the syringe barrel is assembled with a plunger. 2. The syringe barrel of claim 1, further comprising a plunger. 3. The syringe barrel of claim 2, in which at least a portion of the plunger comprises chlorobutyl rubber, bromobutyl rubber, silicone rubber, or a combination of any two or more of these. 4. A prefilled syringe comprising the syringe barrel of claim 2 containing a fluid to be dispensed and closed with the plunger, in which the fluid comprises a member selected from the group consisting of: INHALATION ANESTHETICS Aliflurane Chloroform Cyclopropane Desflurane (Suprane) Diethyl Ether Enflurane (Ethrane) Ethyl Chloride Ethylene Halothane (Fluothane) Isoflurane (Forane, Isoflo) Isopropenyl vinyl ether Methoxyflurane methoxyflurane, Methoxypropane Nitrous Oxide Roflurane Sevoflurane (Sevorane, Ultane, Sevoflo) Teflurane Trichloroethylene Vinyl Ether Xenon INJECTABLE DRUGS Ablavar (Gadofosveset Trisodium Injection) Abarelix Depot Abobotulinumtoxin A Injection (Dysport) ABT-263 ABT-869 ABX-EFG Accretropin (Somatropin Injection) Acetadote (Acetylcysteine Injection) Acetazolamide Injection (Acetazolamide Injection) Acetylcysteine Injection (Acetadote) Actemra (Tocilizumab Injection) Acthrel (Corticorelin Ovine Triflutate for Injection) Actummune Activase Acyclovir for Injection (Zovirax Injection) Adacel Adalimumab Adenoscan (Adenosine Injection) Adenosine Injection (Adenoscan) Adrenaclick AdreView (lobenguane I 123 Injection for Intravenous Use) Afluria Ak-Fluor (Fluorescein Injection) Aldurazyme (Laronidase) Alglucerase Injection (Ceredase) Alkeran Injection (Melphalan Hcl Injection) Allopurinol Sodium for Injection (Aloprim) Aloprim (Allopurinol Sodium for Injection) Alprostadil Alsuma (Sumatriptan Injection) ALTU-238 Amino Acid Injections Aminosyn Apidra Apremilast Alprostadil Dual Chamber System for Injection (Caverject Impulse) AMG 009 AMG 076 AMG 102 AMG 108 AMG 114 AMG 162 AMG 220 AMG 221 AMG 222 AMG 223 AMG 317 AMG 379 AMG 386 AMG 403 AMG 477 AMG 479 AMG 517 AMG 531 AMG 557 AMG 623 AMG 655 AMG 706 AMG 714 AMG 745 AMG 785 AMG 811 AMG 827 AMG 837 AMG 853 AMG 951 Amiodarone HCl Injection (Amiodarone HCl Injection) Amobarbital Sodium Injection (Amytal Sodium) Amytal Sodium (Amobarbital Sodium Injection) Anakinra Anti-Abeta Anti-Beta7 Anti-Beta20 Anti-CD4 Anti-CD20 Anti-CD40 Anti-IFNalpha Anti-IL13 Anti-OX40L Anti-oxLDS Anti-NGF Anti-NRP1 Arixtra Amphadase (Hyaluronidase Inj) Ammonul (Sodium Phenylacetate and Sodium Benzoate Injection) Anaprox Anzemet Injection (Dolasetron Mesylate Injection) Apidra (Insulin Glulisine [rDNA origin] Inj) Apomab Aranesp (darbepoetin alfa) Argatroban (Argatroban Injection) Arginine Hydrochloride Injection (R-Gene 10) Aristocort Aristospan Arsenic Trioxide Injection (Trisenox) Articane HCl and Epinephrine Injection (Septocaine) Arzerra (Ofatumumab Injection) Asclera (Polidocanol Injection) Ataluren Ataluren-DMD Atenolol Inj (Tenormin I.V. Injection) Atracurium Besylate Injection (Atracurium Besylate Injection) Avastin Azactam Injection (Aztreonam Injection) Azithromycin (Zithromax Injection) Aztreonam Injection (Azactam Injection) Baclofen Injection (Lioresal Intrathecal) Bacteriostatic Water (Bacteriostatic Water for Injection) Baclofen Injection (Lioresal Intrathecal) Bal in Oil Ampules (Dimercarprol Injection) BayHepB BayTet Benadryl Bendamustine Hydrochloride Injection (Treanda) Benztropine Mesylate Injection (Cogentin) Betamethasone Injectable Suspension (Celestone Soluspan) Bexxar Bicillin C-R 900/300 (Penicillin G Benzathine and Penicillin G Procaine Injection) Blenoxane (Bleomycin Sulfate Injection) Bleomycin Sulfate Injection (Blenoxane) Boniva Injection (Ibandronate Sodium Injection) Botox Cosmetic (OnabotulinumtoxinA for Injection) BR3-FC Bravelle (Urofollitropin Injection) Bretylium (Bretylium Tosylate Injection) Brevital Sodium (Methohexital Sodium for Injection) Brethine Briobacept BTT-1023 Bupivacaine HCl Byetta Ca-DTPA (Pentetate Calcium Trisodium Inj) Cabazitaxel Injection (Jevtana) Caffeine Alkaloid (Caffeine and Sodium Benzoate Injection) Calcijex Injection (Calcitrol) Calcitrol (Calcijex Injection) Calcium Chloride (Calcium Chloride Injection 10%) Calcium Disodium Versenate (Edetate Calcium Disodium Injection) Campath (Altemtuzumab) Camptosar Injection (Irinotecan Hydrochloride) Canakinumab Injection (Ilaris) Capastat Sulfate (Capreomycin for Injection) Capreomycin for Injection (Capastat Sulfate) Cardiolite (Prep kit for Technetium Tc99 Sestamibi for Injection) Carticel Cathflo Cefazolin and Dextrose for Injection (Cefazolin Injection) Cefepime Hydrochloride Cefotaxime Ceftriaxone Cerezyme Carnitor Injection Caverject Celestone Soluspan Celsior Cerebyx (Fosphenytoin Sodium Injection) Ceredase (Alglucerase Injection) Ceretec (Technetium Tc99m Exametazime Injection) Certolizumab CF-101 Chloramphenicol Sodium Succinate (Chloramphenicol Sodium Succinate Injection) Chloramphenicol Sodium Succinate Injection (Chloramphenicol Sodium Succinate) Cholestagel (Colesevelam HCL) Choriogonadotropin Alfa Injection (Ovidrel) Cimzia Cisplatin (Cisplatin Injection) Clolar (Clofarabine Injection) Clomiphine Citrate Clonidine Injection (Duraclon) Cogentin (Benztropine Mesylate Injection) Colistimethate Injection (Coly-Mycin M) Coly-Mycin M (Colistimethate Injection) Compath Conivaptan Hcl Injection (Vaprisol) Conjugated Estrogens for Injection (Premarin Injection) Copaxone Corticorelin Ovine Triflutate for Injection (Acthrel) Corvert (Ibutilide Fumarate Injection) Cubicin (Daptomycin Injection) CF-101 Cyanokit (Hydroxocobalamin for Injection) Cytarabine Liposome Injection (DepoCyt) Cyanocobalamin Cytovene (ganciclovir) D.H.E. 45 Dacetuzumab Dacogen (Decitabine Injection) Dalteparin Dantrium IV (Dantrolene Sodium for Injection) Dantrolene Sodium for Injection (Dantrium IV) Daptomycin Injection (Cubicin) Darbepoietin Alfa DDAVP Injection (Desmopressin Acetate Injection) Decavax Decitabine Injection (Dacogen) Dehydrated Alcohol (Dehydrated Alcohol Injection) Denosumab Injection (Prolia) Delatestryl Delestrogen Delteparin Sodium Depacon (Valproate Sodium Injection) Depo Medrol (Methylprednisolone Acetate Injectable Suspension) DepoCyt (Cytarabine Liposome Injection) DepoDur (Morphine Sulfate XR Liposome Injection) Desmopressin Acetate Injection (DDAVP Injection) Depo-Estradiol Depo-Provera 104 mg/ml Depo-Provera 150 mg/ml Depo-Testosterone Dexrazoxane for Injection, Intravenous Infusion Only (Totect) Dextrose/Electrolytes Dextrose and Sodium Chloride Inj (Dextrose 5% in 0.9% Sodium Chloride) Dextrose Diazepam Injection (Diazepam Injection) Digoxin Injection (Lanoxin Injection) Dilaudid-HP (Hydromorphone Hydrochloride Injection) Dimercarprol Injection (Bal in Oil Ampules) Diphenhydramine Injection (Benadryl Injection) Dipyridamole Injection (Dipyridamole Injection) DMOAD Docetaxel for Injection (Taxotere) Dolasetron Mesylate Injection (Anzemet Injection) Doribax (Doripenem for Injection) Doripenem for Injection (Doribax) Doxercalciferol Injection (Hectorol Injection) Doxil (Doxorubicin Hcl Liposome Injection) Doxorubicin Hcl Liposome Injection (Doxil) Duraclon (Clonidine Injection) Duramorph (Morphine Injection) Dysport (Abobotulinumtoxin A Injection) Ecallantide Injection (Kalbitor) EC-Naprosyn (naproxen) Edetate Calcium Disodium Injection (Calcium Disodium Versenate) Edex (Alprostadil for Injection) Engerix Edrophonium Injection (Enlon) Eliglustat Tartate Eloxatin (Oxaliplatin Injection) Emend Injection (Fosaprepitant Dimeglumine Injection) Enalaprilat Injection (Enalaprilat Injection) Enlon (Edrophonium Injection) Enoxaparin Sodium Injection (Lovenox) Eovist (Gadoxetate Disodium Injection) Enbrel (etanercept) Enoxaparin Epicel Epinepherine Epipen Epipen Jr. Epratuzumab Erbitux Ertapenem Injection (Invanz) Erythropoieten Essential Amino Acid Injection (Nephramine) Estradiol Cypionate Estradiol Valerate Etanercept Exenatide Injection (Byetta) Evlotra Fabrazyme (Adalsidase beta) Famotidine Injection FDG (Fludeoxyglucose F 18 Injection) Feraheme (Ferumoxytol Injection) Feridex I.V. (Ferumoxides Injectable Solution) Fertinex Ferumoxides Injectable Solution (Feridex I.V.) Ferumoxytol Injection (Feraheme) Flagyl Injection (Metronidazole Injection) Fluarix Fludara (Fludarabine Phosphate) Fludeoxyglucose F 18 Injection (FDG) Fluorescein Injection (Ak-Fluor) Follistim AQ Cartridge (Follitropin Beta Injection) Follitropin Alfa Injection (Gonal-f RFF) Follitropin Beta Injection (Follistim AQ Cartridge) Folotyn (Pralatrexate Solution for Intravenous Injection) Fondaparinux Forteo (Teriparatide (rDNA origin) Injection) Fostamatinib Fosaprepitant Dimeglumine Injection (Emend Injection) Foscarnet Sodium Injection (Foscavir) Foscavir (Foscarnet Sodium Injection) Fosphenytoin Sodium Injection (Cerebyx) Fospropofol Disodium Injection (Lusedra) Fragmin Fuzeon (enfuvirtide) GA101 Gadobenate Dimeglumine Injection (Multihance) Gadofosveset Trisodium Injection (Ablavar) Gadoteridol Injection Solution (ProHance) Gadoversetamide Injection (OptiMARK) Gadoxetate Disodium Injection (Eovist) Ganirelix (Ganirelix Acetate Injection) Gardasil GC1008 GDFD Gemtuzumab Ozogamicin for Injection (Mylotarg) Genotropin Gentamicin Injection GENZ-112638 Golimumab Injection (Simponi Injection) Gonal-f RFF (Follitropin Alfa Injection) Granisetron Hydrochloride (Kytril Injection) Gentamicin Sulfate Glatiramer Acetate Glucagen Glucagon HAE1 Haldol (Haloperidol Injection) Havrix Hectorol Injection (Doxercalciferol Injection) Hedgehog Pathway Inhibitor Heparin Herceptin hG-CSF Humalog Human Growth Hormone Humatrope HuMax Humegon Humira Humulin Ibandronate Sodium Injection (Boniva Injection) Ibuprofen Lysine Injection (NeoProfen) Ibutilide Fumarate Injection (Corvert) Idamycin PFS (Idarubicin Hydrochloride Injection) Idarubicin Hydrochloride Injection (Idamycin PFS) Ilaris (Canakinumab Injection) Imipenem and Cilastatin for Injection (Primaxin I.V.) Imitrex Incobotulinumtoxin A for Injection (Xeomin) Increlex (Mecasermin [rDNA origin] Injection) Indocin IV (Indomethacin Inj) Indomethacin Inj (Indocin IV) Infanrix Innohep Insulin Insulin Aspart [rDNA origin] Inj (NovoLog) Insulin Glargine [rDNA origin] Injection (Lantus) Insulin Glulisine [rDNA origin] Inj (Apidra) Interferon alfa-2b, Recombinant for Injection (Intron A) Intron A (Interferon alfa-2b, Recombinant for Injection) Invanz (Ertapenem Injection) Invega Sustenna (Paliperidone Palmitate Extended-Release Injectable Suspension) Invirase (saquinavir mesylate) Iobenguane I 123 Injection for Intravenous Use (AdreView) Iopromide Injection (Ultravist) Ioversol Injection (Optiray Injection) Iplex (Mecasermin Rinfabate [rDNA origin] Injection) Iprivask Irinotecan Hydrochloride (Camptosar Injection) Iron Sucrose Injection (Venofer) Istodax (Romidepsin for Injection) Itraconazole Injection (Sporanox Injection) Jevtana (Cabazitaxel Injection) Jonexa Kalbitor (Ecallantide Injection) KCL in D5NS (Potassium Chloride in 5% Dextrose and Sodium Chloride Injection) KCL in D5W KCL in NS Kenalog 10 Injection (Triamcinolone Acetonide Injectable Suspension) Kepivance (Palifermin) Keppra Injection (Levetiracetam) Keratinocyte KFG Kinase Inhibitor Kineret (Anakinra) Kinlytic (Urokinase Injection) Kinrix Klonopin (clonazepam) Kytril Injection (Granisetron Hydrochloride) lacosamide Tablet and Injection (Vimpat) Lactated Ringer's Lanoxin Injection (Digoxin Injection) Lansoprazole for Injection (Prevacid I.V.) Lantus Leucovorin Calcium (Leucovorin Calcium Injection) Lente (L) Leptin Levemir Leukine Sargramostim Leuprolide Acetate Levothyroxine Levetiracetam (Keppra Injection) Lovenox Levocarnitine Injection (Carnitor Injection) Lexiscan (Regadenoson Injection) Lioresal Intrathecal (Baclofen Injection) Liraglutide [rDNA] Injection (Victoza) Lovenox (Enoxaparin Sodium Injection) Lucentis (Ranibizumab Injection) Lumizyme Lupron (Leuprolide Acetate Injection) Lusedra (Fospropofol Disodium Injection) Maci Magnesium Sulfate (Magnesium Sulfate Injection) Mannitol Injection (Mannitol IV) Marcaine (Bupivacaine Hydrochloride and Epinephrine Injection) Maxipime (Cefepime Hydrochloride for Injection) MDP Multidose Kit of Technetium Injection (Technetium Tc99m Medronate Injection) Mecasermin [rDNA origin] Injection (Increlex) Mecasermin Rinfabate [rDNA origin] Injection (Iplex) Melphalan Hcl Injection (Alkeran Injection) Methotrexate Menactra Menopur (Menotropins Injection) Menotropins for Injection (Repronex) Methohexital Sodium for Injection (Brevital Sodium) Methyldopate Hydrochloride Injection, Solution (Methyldopate Hcl) Methylene Blue (Methylene Blue Injection) Methylprednisolone Acetate Injectable Suspension (Depo Medrol) MetMab Metoclopramide Injection (Reglan Injection) Metrodin (Urofollitropin for Injection) Metronidazole Injection (Flagyl Injection) Miacalcin Midazolam (Midazolam Injection) Mimpara (Cinacalet) Minocin Injection (Minocycline Inj) Minocycline Inj (Minocin Injection) Mipomersen Mitoxantrone for Injection Concentrate (Novantrone) Morphine Injection (Duramorph) Morphine Sulfate XR Liposome Injection (DepoDur) Morrhuate Sodium (Morrhuate Sodium Injection) Motesanib Mozobil (Plerixafor Injection) Multihance (Gadobenate Dimeglumine Injection) Multiple Electrolytes and Dextrose Injection Multiple Electrolytes Injection Mylotarg (Gemtuzumab Ozogamicin for Injection) Myozyme (Alglucosidase alfa) Nafcillin Injection (Nafcillin Sodium) Nafcillin Sodium (Nafcillin Injection) Naltrexone XR Inj (Vivitrol) Naprosyn (naproxen) NeoProfen (Ibuprofen Lysine Injection) Nandrol Decanoate Neostigmine Methylsulfate (Neostigmine Methylsulfate Injection) NEO-GAA NeoTect (Technetium Tc 99m Depreotide Injection) Nephramine (Essential Amino Acid Injection) Neulasta (pegfilgrastim) Neupogen (Filgrastim) Novolin Novolog NeoRecormon Neutrexin (Trimetrexate Glucuronate Inj) NPH (N) Nexterone (Amiodarone HCl Injection) Norditropin (Somatropin Injection) Normal Saline (Sodium Chloride Injection) Novantrone (Mitoxantrone for Injection Concentrate) Novolin 70/30 Innolet (70% NPH, Human Insulin Isophane Suspension and 30% Regular, Human Insulin Injection) NovoLog (Insulin Aspart [rDNA origin] Inj) Nplate (romiplostim) Nutropin (Somatropin (rDNA origin) for Inj) Nutropin AQ Nutropin Depot (Somatropin (rDNA origin) for Inj) Octreotide Acetate Injection (Sandostatin LAR) Ocrelizumab Ofatumumab Injection (Arzerra) Olanzapine Extended Release Injectable Suspension (Zyprexa Relprevv) Omnitarg Omnitrope (Somatropin [rDNA origin] Injection) Ondansetron Hydrochloride Injection (Zofran Injection) OptiMARK (Gadoversetamide Injection) Optiray Injection (Ioversol Injection) Orencia Osmitrol Injection in Aviva (Mannitol Injection in Aviva Plastic Vessel) Osmitrol Injection in Viaflex (Mannitol Injection in Viaflex Plastic Vessel) Osteoprotegrin Ovidrel (Choriogonadotropin Alfa Injection) Oxacillin (Oxacillin for Injection) Oxaliplatin Injection (Eloxatin) Oxytocin Injection (Pitocin) Paliperidone Palmitate Extended-Release Injectable Suspension (Invega Sustenna) Pamidronate Disodium Injection (Pamidronate Disodium Injection) Panitumumab Injection for Intravenous Use (Vectibix) Papaverine Hydrochloride Injection (Papaverine Injection) Papaverine Injection (Papaverine Hydrochloride Injection) Parathyroid Hormone Paricalcitol Injection Fliptop Vial (Zemplar Injection) PARP Inhibitor Pediarix PEGIntron Peginterferon Pegfilgrastim Penicillin G Benzathine and Penicillin G Procaine Pentetate Calcium Trisodium Inj (Ca-DTPA) Pentetate Zinc Trisodium Injection (Zn-DTPA) Pepcid Injection (Famotidine Injection) Pergonal Pertuzumab Phentolamine Mesylate (Phentolamine Mesylate for Injection) Physostigmine Salicylate (Physostigmine Salicylate (injection)) Physostigmine Salicylate (injection) (Physostigmine Salicylate) Piperacillin and Tazobactam Injection (Zosyn) Pitocin (Oxytocin Injection) Plasma-Lyte 148 (Multiple Electrolytes Inj) Plasma-Lyte 56 and Dextrose (Multiple Electrolytes and Dextrose Injection in Viaflex Plastic Vessel) PlasmaLyte Plerixafor Injection (Mozobil) Polidocanol Injection (Asclera) Potassium Chloride Pralatrexate Solution for Intravenous Injection (Folotyn) Pramlintide Acetate Injection (Symlin) Premarin Injection (Conjugated Estrogens for Injection) Prep kit for Technetium Tc99 Sestamibi for Injection (Cardiolite) Prevacid I.V. (Lansoprazole for Injection) Primaxin I.V. (Imipenem and Cilastatin for Injection) Prochymal Procrit Progesterone ProHance (Gadoteridol Injection Solution) Prolia (Denosumab Injection) Promethazine HCl Injection (Promethazine Hydrochloride Injection) Propranolol Hydrochloride Injection (Propranolol Hydrochloride Injection) Quinidine Gluconate Injection (Quinidine Injection) Quinidine Injection (Quinidine Gluconate Injection) R-Gene 10 (Arginine Hydrochloride Injection) Ranibizumab Injection (Lucentis) Ranitidine Hydrochloride Injection (Zantac Injection) Raptiva Reclast (Zoledronic Acid Injection) Recombivarix HB Regadenoson Injection (Lexiscan) Reglan Injection (Metoclopramide Injection) Remicade Renagel Renvela (Sevelamer Carbonate) Repronex (Menotropins for Injection) Retrovir IV (Zidovudine Injection) rhApo2L/TRAIL Ringer's and 5% Dextrose Injection (Ringers in Dextrose) Ringer's Injection (Ringers Injection) Rituxan Rituximab Rocephin (ceftriaxone) Rocuronium Bromide Injection (Zemuron) Roferon-A (interferon alfa-2a) Romazicon (flumazenil) Romidepsin for Injection (Istodax) Saizen (Somatropin Injection) Sandostatin LAR (Octreotide Acetate Injection) Sclerostin Ab Sensipar (cinacalcet) Sensorcaine (Bupivacaine HCl Injections) Septocaine (Articane HCl and Epinephrine Injection) Serostim LQ (Somatropin (rDNA origin) Injection) Simponi Injection (Golimumab Injection) Sodium Acetate (Sodium Acetate Injection) Sodium Bicarbonate (Sodium Bicarbonate 5% Injection) Sodium Lactate (Sodium Lactate Injection in AVIVA) Sodium Phenylacetate and Sodium Benzoate Injection (Ammonul) Somatropin (rDNA origin) for Inj (Nutropin) Sporanox Injection (Itraconazole Injection) Stelara Injection (Ustekinumab) Stemgen Sufenta (Sufentanil Citrate Injection) Sufentanil Citrate Injection (Sufenta) Sumavel Sumatriptan Injection (Alsuma) Symlin Symlin Pen Systemic Hedgehog Antagonist Synvisc-One (Hylan G-F 20 Single Intra-articular Injection) Tarceva Taxotere (Docetaxel for Injection) Technetium Tc 99m Telavancin for Injection (Vibativ) Temsirolimus Injection (Torisel) Tenormin I.V. Injection (Atenolol Inj) Teriparatide (rDNA origin) Injection (Forteo) Testosterone Cypionate Testosterone Enanthate Testosterone Propionate Tev-Tropin (Somatropin, rDNA Origin, for Injection) tgAAC94 Thallous Chloride Theophylline Thiotepa (Thiotepa Injection) Thymoglobulin (Anti-Thymocyte Globulin (Rabbit) Thyrogen (Thyrotropin Alfa for Injection) Ticarcillin Disodium and Clavulanate Potassium Galaxy (Timentin Injection) Tigan Injection (Trimethobenzamide Hydrochloride Injectable) Timentin Injection (Ticarcillin Disodium and Clavulanate Potassium Galaxy) TNKase Tobramycin Injection (Tobramycin Injection) Tocilizumab Injection (Actemra) Torisel (Temsirolimus Injection) Totect (Dexrazoxane for Injection, Intravenous Infusion Only) Trastuzumab-DM1 Travasol (Amino Acids (Injection)) Treanda (Bendamustine Hydrochloride Injection) Trelstar (Triptorelin Pamoate for Injectable Suspension) Triamcinolone Acetonide Triamcinolone Diacetate Triamcinolone Hexacetonide Injectable Suspension (Aristospan Injection 20 mg) Triesence (Triamcinolone Acetonide Injectable Suspension) Trimethobenzamide Hydrochloride Injectable (Tigan Injection) Trimetrexate Glucuronate Inj (Neutrexin) Triptorelin Pamoate for Injectable Suspension (Trelstar) Twinject Trivaris (Triamcinolone Acetonide Injectable Suspension) Trisenox (Arsenic Trioxide Injection) Twinrix Typhoid Vi Ultravist (Iopromide Injection) Urofollitropin for Injection (Metrodin) Urokinase Injection (Kinlytic) Ustekinumab (Stelara Injection) Ultralente (U) Valium (diazepam) Valproate Sodium Injection (Depacon) Valtropin (Somatropin Injection) Vancomycin Hydrochloride (Vancomycin Hydrochloride Injection) Vancomycin Hydrochloride Injection (Vancomycin Hydrochloride) Vaprisol (Conivaptan Hcl Injection) VAQTA Vasovist (Gadofosveset Trisodium Injection for Intravenous Use) Vectibix (Panitumumab Injection for Intravenous Use) Venofer (Iron Sucrose Injection) Verteporfin Inj (Visudyne) Vibativ (Telavancin for Injection) Victoza (Liraglutide [rDNA] Injection) Vimpat (lacosamide Tablet and Injection) Vinblastine Sulfate (Vinblastine Sulfate Injection) Vincasar PFS (Vincristine Sulfate Injection) Victoza Vincristine Sulfate (Vincristine Sulfate Injection) Visudyne (Verteporfin Inj) Vitamin B-12 Vivitrol (Naltrexone XR Inj) Voluven (Hydroxyethyl Starch in Sodium Chloride Injection) Xeloda Xenical (orlistat) Xeomin (Incobotulinumtoxin A for Injection) Xolair Zantac Injection (Ranitidine Hydrochloride Injection) Zemplar Injection (Paricalcitol Injection Fliptop Vial) Zemuron (Rocuronium Bromide Injection) Zenapax (daclizumab) Zevalin Zidovudine Injection (Retrovir IV) Zithromax Injection (Azithromycin) Zn-DTPA (Pentetate Zinc Trisodium Injection) Zofran Injection (Ondansetron Hydrochloride Injection) Zingo Zoledronic Acid for Inj (Zometa) Zoledronic Acid Injection (Reclast) Zometa (Zoledronic Acid for Inj) Zosyn (Piperacillin and Tazobactam Injection) Zyprexa Relprevv (Olanzapine Extended Release Injectable Suspension) LIQUID DRUGS (NON-INJECTABLE) Abilify AccuNeb (Albuterol Sulfate Inhalation Solution) Actidose Aqua (Activated Charcoal Suspension) Activated Charcoal Suspension (Actidose Aqua) Advair Agenerase Oral Solution (Amprenavir Oral Solution) Akten (Lidocaine Hydrochloride Ophthalmic Gel) Alamast (Pemirolast Potassium Ophthalmic Solution) Albumin (Human) 5% Solution (Buminate 5%) Albuterol Sulfate Inhalation Solution Alinia Alocril Alphagan Alrex Alvesco Amprenavir Oral Solution Analpram-HC Arformoterol Tartrate Inhalation Solution (Brovana) Aristospan Injection 20 mg (Triamcinolone Hexacetonide Injectable Suspension) Asacol Asmanex Astepro Astepro (Azelastine Hydrochloride Nasal Spray) Atrovent Nasal Spray (Ipratropium Bromide Nasal Spray) Atrovent Nasal Spray 0.06 Augmentin ES-600 Azasite (Azithromycin Ophthalmic Solution) Azelaic Acid (Finacea Gel) Azelastine Hydrochloride Nasal Spray (Astepro) Azelex (Azelaic Acid Cream) Azopt (Brinzolamide Ophthalmic Suspension) Bacteriostatic Saline Balanced Salt Bepotastine Bactroban Nasal Bactroban Beclovent Benzac W Betimol Betoptic S Bepreve Bimatoprost Ophthalmic Solution Bleph 10 (Sulfacetamide Sodium Ophthalmic Solution 10%) Brinzolamide Ophthalmic Suspension (Azopt) Bromfenac Ophthalmic Solution (Xibrom) Bromhist Brovana (Arformoterol Tartrate Inhalation Solution) Budesonide Inhalation Suspension (Pulmicort Respules) Cambia (Diclofenac Potassium for Oral Solution) Capex Carac Carboxine-PSE Carnitor Cayston (Aztreonam for Inhalation Solution) Cellcept Centany Cerumenex Ciloxan Ophthalmic Solution (Ciprofloxacin HCL Ophthalmic Solution) Ciprodex Ciprofloxacin HCL Ophthalmic Solution (Ciloxan Ophthalmic Solution) Clemastine Fumarate Syrup (Clemastine Fumarate Syrup) CoLyte (PEG Electrolytes Solution) Combiven Comtan Condylox Cordran Cortisporin Ophthalmic Suspension Cortisporin Otic Suspension Cromolyn Sodium Inhalation Solution (Intal Nebulizer Solution) Cromolyn Sodium Ophthalmic Solution (Opticrom) Crystalline Amino Acid Solution with Electrolytes (Aminosyn Electrolytes) Cutivate Cuvposa (Glycopyrrolate Oral Solution) Cyanocobalamin (CaloMist Nasal Spray) Cyclosporine Oral Solution (Gengraf Oral Solution) Cyclogyl Cysview (Hexaminolevulinate Hydrochloride Intravesical Solution) DermOtic Oil (Fluocinolone Acetonide Oil Ear Drops) Desmopressin Acetate Nasal Spray DDAVP Derma-Smoothe/FS Dexamethasone Intensol Dianeal Low Calcium Dianeal PD Diclofenac Potassium for Oral Solution (Cambia) Didanosine Pediatric Powder for Oral Solution (Videx) Differin Dilantin 125 (Phenytoin Oral Suspension) Ditropan Dorzolamide Hydrochloride Ophthalmic Solution (Trusopt) Dorzolamide Hydrochloride-Timolol Maleate Ophthalmic Solution (Cosopt) Dovonex Scalp (Calcipotriene Solution) Doxycycline Calcium Oral Suspension (Vibramycin Oral) Efudex Elaprase (Idursulfase Solution) Elestat (Epinastine HCl Ophthalmic Solution) Elocon Epinastine HCl Ophthalmic Solution (Elestat) Epivir HBV Epogen (Epoetin alfa) Erythromycin Topical Solution 1.5% (Staticin) Ethiodol (Ethiodized Oil) Ethosuximide Oral Solution (Zarontin Oral Solution) Eurax Extraneal (Icodextrin Peritoneal Dialysis Solution) Felbatol Feridex I.V. (Ferumoxides Injectable Solution) Flovent Floxin Otic (Ofloxacin Otic Solution) Flo-Pred (Prednisolone Acetate Oral Suspension) Fluoroplex Flunisolide Nasal Solution (Flunisolide Nasal Spray 0.025%) Fluorometholone Ophthalmic Suspension (FML) Flurbiprofen Sodium Ophthalmic Solution (Ocufen) FML Foradil Formoterol Fumarate Inhalation Solution (Perforomist) Fosamax Furadantin (Nitrofurantoin Oral Suspension) Furoxone Gammagard Liquid (Immune Globulin Intravenous (Human) 10%) Gantrisin (Acetyl Sulfisoxazole Pediatric Suspension) Gatifloxacin Ophthalmic Solution (Zymar) Gengraf Oral Solution (Cyclosporine Oral Solution) Glycopyrrolate Oral Solution (Cuvposa) Halcinonide Topical Solution (Halog Solution) Halog Solution (Halcinonide Topical Solution) HEP-LOCK U/P (Preservative-Free Heparin Lock Flush Solution) Heparin Lock Flush Solution (Hepflush 10) Hexaminolevulinate Hydrochloride Intravesical Solution (Cysview) Hydrocodone Bitartrate and Acetaminophen Oral Solution (Lortab Elixir) Hydroquinone 3% Topical Solution (Melquin-3 Topical Solution) IAP Antagonist Isopto Ipratropium Bromide Nasal Spray (Atrovent Nasal Spray) Itraconazole Oral Solution (Sporanox Oral Solution) Ketorolac Tromethamine Ophthalmic Solution (Acular LS) Kaletra Lanoxin Lexiva Leuprolide Acetate for Depot Suspension (Lupron Depot 11.25 mg) Levobetaxolol Hydrochloride Ophthalmic Suspension (Betaxon) Levocarnitine Tablets, Oral Solution, Sugar-Free (Carnitor) Levofloxacin Ophthalmic Solution 0.5% (Quixin) Lidocaine HCl Sterile Solution (Xylocaine MPF Sterile Solution) Lok Pak (Heparin Lock Flush Solution) Lorazepam Intensol Lortab Elixir (Hydrocodone Bitartrate and Acetaminophen Oral Solution) Lotemax (Loteprednol Etabonate Ophthalmic Suspension) Loteprednol Etabonate Ophthalmic Suspension (Alrex) Low Calcium Peritoneal Dialysis Solutions (Dianeal Low Calcium) Lumigan (Bimatoprost Ophthalmic Solution 0.03% for Glaucoma) Lupron Depot 11.25 mg (Leuprolide Acetate for Depot Suspension) Megestrol Acetate Oral Suspension (Megestrol Acetate Oral Suspension) MEK Inhibitor Mepron Mesnex Mestinon Mesalamine Rectal Suspension Enema (Rowasa) Melquin-3 Topical Solution (Hydroquinone 3% Topical Solution) MetMab Methyldopate Hcl (Methyldopate Hydrochloride Injection, Solution) Methylin Oral Solution (Methylphenidate HCl Oral Solution 5 mg/5 mL and 10 mg/5 mL) Methylprednisolone Acetate Injectable Suspension (Depo Medrol) Methylphenidate HCl Oral Solution 5 mg/5 mL and 10 mg/5 mL (Methylin Oral Solution) Methylprednisolone sodium succinate (Solu Medrol) Metipranolol Ophthalmic Solution (Optipranolol) Migranal Miochol-E (Acetylcholine Chloride Intraocular Solution) Micro-K for Liquid Suspension (Potassium Chloride Extended Release Formulation for Liquid Suspension) Minocin (Minocycline Hydrochloride Oral Suspension) Nasacort Neomycin and Polymyxin B Sulfates and Hydrocortisone Nepafenac Ophthalmic Suspension (Nevanac) Nevanac (Nepafenac Ophthalmic Suspension) Nitrofurantoin Oral Suspension (Furadantin) Noxafil (Posaconazole Oral Suspension) Nystatin (oral) (Nystatin Oral Suspension) Nystatin Oral Suspension (Nystatin (oral)) Ocufen (Flurbiprofen Sodium Ophthalmic Solution) Ofloxacin Ophthalmic Solution (Ofloxacin Ophthalmic Solution) Ofloxacin Otic Solution (Floxin Otic) Olopatadine Hydrochloride Ophthalmic Solution (Pataday) Opticrom (Cromolyn Sodium Ophthalmic Solution) Optipranolol (Metipranolol Ophthalmic Solution) Patanol Pediapred PerioGard Phenytoin Oral Suspension (Dilantin 125) Phisohex Posaconazole Oral Suspension (Noxafil) Potassium Chloride Extended Release Formulation for Liquid Suspension (Micro-K for Liquid Suspension) Pataday (Olopatadine Hydrochloride Ophthalmic Solution) Patanase Nasal Spray (Olopatadine Hydrochloride Nasal Spray) PEG Electrolytes Solution (CoLyte) Pemirolast Potassium Ophthalmic Solution (Alamast) Penlac (Ciclopirox Topical Solution) PENNSAID (Diclofenac Sodium Topical Solution) Perforomist (Formoterol Fumarate Inhalation Solution) Peritoneal Dialysis Solution Phenylephrine Hydrochloride Ophthalmic Solution (Neo-Synephrine) Phospholine Iodide (Echothiophate Iodide for Ophthalmic Solution) Podofilox (Podofilox Topical Solution) Pred Forte (Prednisolone Acetate Ophthalmic Suspension) Pralatrexate Solution for Intravenous Injection (Folotyn) Pred Mild Prednisone Intensol Prednisolone Acetate Ophthalmic Suspension (Pred Forte) Prevacid PrismaSol Solution (Sterile Hemofiltration Hemodiafiltration Solution) ProAir Proglycem ProHance (Gadoteridol Injection Solution) Proparacaine Hydrochloride Ophthalmic Solution (Alcaine) Propine Pulmicort Pulmozyme Quixin (Levofloxacin Ophthalmic Solution 0.5%) QVAR Rapamune Rebetol Relacon-HC Rotarix (Rotavirus Vaccine, Live, Oral Suspension) Rotavirus Vaccine, Live, Oral Suspension (Rotarix) Rowasa (Mesalamine Rectal Suspension Enema) Sabril (Vigabatrin Oral Solution) Sacrosidase Oral Solution (Sucraid) Sandimmune Sepra Serevent Diskus Solu Cortef (Hydrocortisone Sodium Succinate) Solu Medrol (Methylprednisolone sodium succinate) Spiriva Sporanox Oral Solution (Itraconazole Oral Solution) Staticin (Erythromycin Topical Solution 1.5%) Stalevo Starlix Sterile Hemofiltration Hemodiafiltration Solution (PrismaSol Solution) Stimate Sucralfate (Carafate Suspension) Sulfacetamide Sodium Ophthalmic Solution 10% (Bleph 10) Synarel Nasal Solution (Nafarelin Acetate Nasal Solution for Endometriosis) Taclonex Scalp (Calcipotriene and Betamethasone Dipropionate Topical Suspension) Tamiflu Tobi TobraDex Tobradex ST (Tobramycin/Dexamethasone Ophthalmic Suspension 0.3%/0.05%) Tobramycin/Dexamethasone Ophthalmic Suspension 0.3%/0.05% (Tobradex ST) Timolol Timoptic Travatan Z Treprostinil Inhalation Solution (Tyvaso) Trusopt (Dorzolamide Hydrochloride Ophthalmic Solution) Tyvaso (Treprostinil Inhalation Solution) Ventolin Vfend Vibramycin Oral (Doxycycline Calcium Oral Suspension) Videx (Didanosine Pediatric Powder for Oral Solution) Vigabatrin Oral Solution (Sabril) Viokase Viracept Viramune Vitamin K1 (Fluid Colloidal Solution of Vitamin K1) Voltaren Ophthalmic (Diclofenac Sodium Ophthalmic Solution) Zarontin Oral Solution (Ethosuximide Oral Solution) Ziagen Zyvox Zymar (Gatifloxacin Ophthalmic Solution) Zymaxid (Gatifloxacin Ophthalmic Solution) DRUG CLASSES 5-alpha-reductase inhibitors 5-aminosalicylates 5HT3 receptor antagonists adamantane antivirals adrenal cortical steroids adrenal corticosteroid inhibitors adrenergic bronchodilators agents for hypertensive emergencies agents for pulmonary hypertension aldosterone receptor antagonists alkylating agents alpha-adrenoreceptor antagonists alpha-glucosidase inhibitors alternative medicines amebicides aminoglycosides aminopenicillins aminosalicylates amylin analogs Analgesic Combinations Analgesics androgens and anabolic steroids angiotensin converting enzyme inhibitors angiotensin II inhibitors anorectal preparations anorexiants antacids anthelmintics anti-angiogenic ophthalmic agents anti-CTLA-4 monoclonal antibodies anti-infectives antiadrenergic agents, centrally acting antiadrenergic agents, peripherally acting antiandrogens antianginal agents antiarrhythmic agents antiasthmatic combinations antibiotics/antineoplastics anticholinergic antiemetics anticholinergic antiparkinson agents anticholinergic bronchodilators anticholinergic chronotropic agents anticholinergics/antispasmodics anticoagulants anticonvulsants antidepressants antidiabetic agents antidiabetic combinations antidiarrheals antidiuretic hormones antidotes antiemetic/antivertigo agents antifungals antigonadotropic agents antigout agents antihistamines antihyperlipidemic agents antihyperlipidemic combinations antihypertensive combinations antihyperuricemic agents antimalarial agents antimalarial combinations antimalarial quinolines antimetabolites antimigraine agents antineoplastic detoxifying agents antineoplastic interferons antineoplastic monoclonal antibodies antineoplastics antiparkinson agents antiplatelet agents antipseudomonal penicillins antipsoriatics antipsychotics antirheumatics antiseptic and germicides antithyroid agents antitoxins and antivenins antituberculosis agents antituberculosis combinations antitussives antiviral agents antiviral combinations antiviral interferons anxiolytics, sedatives, and hypnotics aromatase inhibitors atypical antipsychotics azole antifungals bacterial vaccines barbiturate anticonvulsants barbiturates BCR-ABL tyrosine kinase inhibitors benzodiazepine anticonvulsants benzodiazepines beta-adrenergic blocking agents beta-lactamase inhibitors bile acid sequestrants biologicals bisphosphonates bone resorption inhibitors bronchodilator combinations bronchodilators calcitonin calcium channel blocking agents carbamate anticonvulsants carbapenems carbonic anhydrase inhibitor anticonvulsants carbonic anhydrase inhibitors cardiac stressing agents cardioselective beta blockers cardiovascular agents catecholamines CD20 monoclonal antibodies CD33 monoclonal antibodies CD52 monoclonal antibodies central nervous system agents cephalosporins cerumenolytics chelating agents chemokine receptor antagonist chloride channel activators cholesterol absorption inhibitors cholinergic agonists cholinergic muscle stimulants cholinesterase inhibitors CNS stimulants coagulation modifiers colony stimulating factors contraceptives corticotropin coumarins and indandiones cox-2 inhibitors decongestants dermatological agents diagnostic radiopharmaceuticals dibenzazepine anticonvulsants digestive enzymes dipeptidyl peptidase 4 inhibitors diuretics dopaminergic antiparkinsonism agents drugs used in alcohol dependence echinocandins EGFR inhibitors estrogen receptor antagonists estrogens expectorants factor Xa inhibitors fatty acid derivative anticonvulsants fibric acid derivatives first generation cephalosporins fourth generation cephalosporins functional bowel disorder agents gallstone solubilizing agents gamma-aminobutyric acid analogs gamma-aminobutyric acid reuptake inhibitors gamma-aminobutyric acid transaminase inhibitors gastrointestinal agents general anesthetics genitourinary tract agents GI stimulants glucocorticoids glucose elevating agents glycopeptide antibiotics glycoprotein platelet inhibitors glycylcyclines gonadotropin releasing hormones gonadotropin-releasing hormone antagonists gonadotropins group I antiarrhythmics group II antiarrhythmics group III antiarrhythmics group IV antiarrhythmics group V antiarrhythmics growth hormone receptor blockers growth hormones H. pylori eradication agents H2 antagonists hematopoietic stem cell mobilizer heparin antagonists heparins HER2 inhibitors herbal products histone deacetylase inhibitors hormone replacement therapy hormones hormones/antineoplastics hydantoin anticonvulsants illicit (street) drugs immune globulins immunologic agents immunosuppressive agents impotence agents in vivo diagnostic biologicals incretin mimetics inhaled anti-infectives inhaled corticosteroids inotropic agents insulin insulin-like growth factor integrase strand transfer inhibitor interferons intravenous nutritional products iodinated contrast media ionic iodinated contrast media iron products ketolides laxatives leprostatics leukotriene modifiers lincomycin derivatives lipoglycopeptides local injectable anesthetics loop diuretics lung surfactants lymphatic staining agents lysosomal enzymes macrolide derivatives macrolides magnetic resonance imaging contrast media mast cell stabilizers medical gas meglitinides metabolic agents methylxanthines mineralocorticoids minerals and electrolytes miscellaneous agents miscellaneous analgesics miscellaneous antibiotics miscellaneous anticonvulsants miscellaneous antidepressants miscellaneous antidiabetic agents miscellaneous antiemetics miscellaneous antifungals miscellaneous antihyperlipidemic agents miscellaneous antimalarials miscellaneous antineoplastics miscellaneous antiparkinson agents miscellaneous antipsychotic agents miscellaneous antituberculosis agents miscellaneous antivirals miscellaneous anxiolytics, sedatives and hypnotics miscellaneous biologicals miscellaneous bone resorption inhibitors miscellaneous cardiovascular agents miscellaneous central nervous system agents miscellaneous coagulation modifiers miscellaneous diuretics miscellaneous genitourinary tract agents miscellaneous GI agents miscellaneous hormones miscellaneous metabolic agents miscellaneous ophthalmic agents miscellaneous otic agents miscellaneous respiratory agents miscellaneous sex hormones miscellaneous topical agents miscellaneous uncategorized agents miscellaneous vaginal agents mitotic inhibitors monoamine oxidase inhibitors monoclonal antibodies mouth and throat products mTOR inhibitors mTOR kinase inhibitors mucolytics multikinase inhibitors muscle relaxants mydriatics narcotic analgesic combinations narcotic analgesics nasal anti-infectives nasal antihistamines and decongestants nasal lubricants and irrigations nasal preparations nasal steroids natural penicillins neuraminidase inhibitors neuromuscular blocking agents next generation cephalosporins nicotinic acid derivatives nitrates NNRTIs non-cardioselective beta blockers non-iodinated contrast media non-ionic iodinated contrast media non-sulfonylureas nonsteroidal anti-inflammatory agents norepinephrine reuptake inhibitors norepinephrine-dopamine reuptake inhibitors nucleoside reverse transcriptase inhibitors (NRTIs) nutraceutical products nutritional products ophthalmic anesthetics ophthalmic anti-infectives ophthalmic anti-inflammatory agents ophthalmic antihistamines and decongestants ophthalmic diagnostic agents ophthalmic glaucoma agents ophthalmic lubricants and irrigations ophthalmic preparations ophthalmic steroids ophthalmic steroids with anti-infectives ophthalmic surgical agents oral nutritional supplements otic anesthetics otic anti-infectives otic preparations otic steroids otic steroids with anti-infectives oxazolidinedione anticonvulsants parathyroid hormone and analogs penicillinase resistant penicillins penicillins peripheral opioid receptor antagonists peripheral vasodilators peripherally acting antiobesity agents phenothiazine antiemetics phenothiazine antipsychotics phenylpiperazine antidepressants plasma expanders platelet aggregation inhibitors platelet-stimulating agents polyenes potassium-sparing diuretics probiotics progesterone receptor modulators progestins prolactin inhibitors prostaglandin D2 antagonists protease inhibitors proton pump inhibitors psoralens psychotherapeutic agents psychotherapeutic combinations purine nucleosides pyrrolidine anticonvulsants quinolones radiocontrast agents radiologic adjuncts radiologic agents radiologic conjugating agents radiopharmaceuticals RANK ligand inhibitors recombinant human erythropoietins renin inhibitors respiratory agents respiratory inhalant products rifamycin derivatives salicylates sclerosing agents second generation cephalosporins selective estrogen receptor modulators selective serotonin reuptake inhibitors serotonin-norepinephrine reuptake inhibitors serotoninergic neuroenteric modulators sex hormone combinations sex hormones skeletal muscle relaxant combinations skeletal muscle relaxants smoking cessation agents somatostatin and somatostatin analogs spermicides statins sterile irrigating solutions streptomyces derivatives succinimide anticonvulsants sulfonamides sulfonylureas synthetic ovulation stimulants tetracyclic antidepressants tetracyclines therapeutic radiopharmaceuticals thiazide diuretics thiazolidinediones thioxanthenes third generation cephalosporins thrombin inhibitors thrombolytics thyroid drugs tocolytic agents topical acne agents topical agents topical anesthetics topical anti-infectives topical antibiotics topical antifungals topical antihistamines topical antipsoriatics topical antivirals topical astringents topical debriding agents topical depigmenting agents topical emollients topical keratolytics topical steroids topical steroids with anti-infectives toxoids triazine anticonvulsants tricyclic antidepressants trifunctional monoclonal antibodies tumor necrosis factor (TNF) inhibitors tyrosine kinase inhibitors ultrasound contrast media upper respiratory combinations urea anticonvulsants urinary anti-infectives urinary antispasmodics urinary pH modifiers uterotonic agents vaccine vaccine combinations vaginal anti-infectives vaginal preparations vasodilators vasopressin antagonists vasopressors VEGF/VEGFR inhibitors viral vaccines viscosupplementation agents vitamin and mineral combinations vitamins DIAGNOSTIC TESTS 17-Hydroxyprogesterone ACE (Angiotensin I converting enzyme) Acetaminophen Acid phosphatase ACTH Activated clotting time Activated protein C resistance Adrenocorticotropic hormone (ACTH) Alanine aminotransferase (ALT) Albumin Aldolase Aldosterone Alkaline phosphatase Alkaline phosphatase (ALP) Alpha1-antitrypsin Alpha-fetoprotein Alpha-fetoprotien Ammonia levels Amylase ANA (antinuclear antibodies) ANA (antinuclear antibodies) Angiotensin-converting enzyme (ACE) Anion gap Anticardiolipin antibody Anticardiolipin antivbodies (ACA) Anti-centromere antibody Antidiuretic hormone Anti-DNA Anti-Dnase-B Anti-Gliadin antibody Anti-glomerular basement membrane antibody Anti-HBc (Hepatitis B core antibodies Anti-HBs (Hepatitis B surface antibody Antiphospholipid antibody Anti-RNA polymerase Anti-Smith (Sm) antibodies Anti-Smooth Muscle antibody Antistreptolysin O (ASO) Antithrombin III Anti-Xa activity Anti-Xa assay Apolipoproteins Arsenic Aspartate aminotransferase (AST) B12 Basophil Beta-2-Microglobulin Beta-hydroxybutyrate B-HCG Bilirubin Bilirubin, direct Bilirubin, indirect Bilirubin, total Bleeding time Blood gases (arterial) Blood urea nitrogen (BUN) BUN BUN (blood urea nitrogen) CA 125 CA 15-3 CA 19-9 Calcitonin Calcium Calcium (ionized) Carbon monoxide (CO) Carcinoembryonic antigen (CEA) CBC CEA CEA (carcinoembryonic antigen) Ceruloplasmin CHSOChloride Cholesterol Cholesterol, HDL Clot lysis time Clot retraction time CMP CO2 Cold agglutinins Complement C3 Copper Corticotrophin releasing hormone (CRH) stimulation test Cortisol Cortrosyn stimulation test C-peptide CPK (Total) CPK-MB C-reactive protein Creatinine Creatinine kinase (CK) Cryoglobulins DAT (Direct antiglobulin test) D-Dimer Dexamethasone suppression test DHEA-S Dilute Russell viper venom Elliptocytes Eosinophil Erythrocyte sedimentation rate (ESR) Estradiol Estriol Ethanol Ethylene glycol Euglobulin lysis Factor V Leiden Factor VIII inhibitor Factor VIII level Ferritin Fibrin split products Fibrinogen Folate Folate (serum Fractional excretion of sodium (FENA) FSH (follicle stimulating factor) FTA-ABS Gamma glutamyl transferase (GGT) Gastrin GGTP (Gamma glutamyl transferase) Glucose Growth hormone Haptoglobin HBeAg (Hepatitis Be antigen) HBs-Ag (Hepatitis B surface antigen) Helicobacter pylori Hematocrit Hematocrit (HCT) Hemoglobin Hemoglobin A1C Hemoglobin electrophoresis Hepatitis A antibodies Hepatitis C antibodies IAT (Indirect antiglobulin test) Immunofixation (IFE) Iron Lactate dehydrogenase (LDH) Lactic acid (lactate) LDH LH (Leutinizing hormone Lipase Lupus anticoagulant Lymphocyte Magnesium MCH (mean corpuscular hemoglobin MCHC (mean corpuscular hemoglobin concentration) MCV (mean corpuscular volume) Methylmalonate Monocyte MPV (mean platelet volume) Myoglobin Neutrophil Parathyroid hormone (PTH) Phosphorus Platelets (plt) Potassium Prealbumin Prolactin Prostate specific antigen (PSA) Protein C Protein S PSA (prostate specific antigen) PT (Prothrombin time) PTT (Partial thromboplastin time) RDW (red cell distribution width) Renin Rennin Reticulocyte count reticulocytes Rheumatoid factor (RF) Sed Rate Serum glutamic-pyruvic transaminase (SGPT Serum protein electrophoresis (SPEP) Sodium T3-resin uptake (T3RU) T4, Free Thrombin time Thyroid stimulating hormone (TSH) Thyroxine (T4) Total iron binding capacity (TIBC) Total protein Transferrin Transferrin saturation Triglyceride (TG) Troponin Uric acid Vitamin B12 White blood cells (WBC) and Widal test. 5. The syringe barrel of claim 2, in which the plunger has an outer sliding surface configured to slide within the lumen along the inner sliding surface. 6. The syringe barrel of claim 5, in which the outer sliding surface is a PECVD treated surface. 7. The syringe barrel of claim 1, in which the syringe barrel comprising a surface to be lubricated comprises COC (cyclic olefin copolymer), COP (cyclic olefin polymer), PET (polyethylene terephthalate), polypropylene (PP), or a combination of two or more thereof. 8. The syringe barrel of claim 1, in which a deposit of fluid lubricant is formed on the PECVD treated surface by spraying a liquid lubricant. 9. The syringe barrel of claim 1, in which at least a portion of the wall comprises glass. 10. The syringe barrel of claim 1, in which the primer coating or layer is between 10 and 1000 nm thick. 11. The syringe barrel of claim 1, in which the primer has a contact angle (with distilled water) of from 70.degree. to 130.degree.. 12. The syringe barrel of claim 1, in which the lubricant has a contact angle (with distilled water) of from 90.degree. to 150.degree.. 13. The syringe barrel of claim 1, in which the lubricant has a molecular weight of from about 1900 to about 37,000. 14. The invention of claim 1, in which the lubricant has a viscosity of from about 20 CSt. to about 13,000 CSt. 15. The syringe barrel of claim 1, further comprising a barrier coating or layer between the primer coating or layer and the syringe barrel surface. 16. The syringe barrel of claim 15, further comprising an adhesion layer between the barrier coating or layer and the syringe barrel surface. 17. A method of making the syringe barrel of claim 1, comprising: A. providing an syringe barrel having a surface to be lubricated; B. applying to the surface a primer coating or layer of SiO.sub.xC.sub.y or SiN.sub.xC.sub.y: by chemical vapor deposition of a polysiloxane or polysilazane precursor, in the presence of oxygen; applied either directly to the syringe barrel surface or with one or more intervening coatings or layers between the primer coating or layer and the syringe barrel surface; in which x is from about 0.5 to about 2.4 and y is from about 0.6 to about 3; the primer coating or layer having a first primer surface facing away from the syringe barrel surface and a second primer surface facing the syringe barrel surface; and C. adhering a first deposit of lubricant to the first primer surface. 18. The method of claim 17, further comprising placing a fluid in the lumen via the opening and closing the opening with a closure. 19. The method of claim 18, in which the fluid is an aqueous liquid. 20. The method of claim 18, in which the fluid comprises a drug. 21. The method of claim 20, in which the drug is a parenteral drug.

Details for Patent 9,662,450

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Emd Serono, Inc.	PERGONAL	menotropins	For Injection	017646	08/22/1975		2029-05-13
Emd Serono, Inc.	PERGONAL	menotropins	For Injection	017646	05/20/1985		2029-05-13
Eli Lilly And Company	HUMATROPE	somatropin	For Injection	019640	06/23/1987		2029-05-13
Eli Lilly And Company	HUMATROPE	somatropin	For Injection	019640	10/16/1986		2029-05-13
Eli Lilly And Company	HUMATROPE	somatropin	For Injection	019640	02/04/1999		2029-05-13
Emd Serono, Inc.	SAIZEN	somatropin	For Injection	019764	10/08/1996		2029-05-13
Emd Serono, Inc.	SAIZEN	somatropin	For Injection	019764	08/29/2000		2029-05-13