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Last Updated: April 27, 2024

Claims for Patent: 9,642,872

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Summary for Patent: 9,642,872

Title:	Treatment of B-cell lymphoma with microRNA
Abstract:	The invention relates to microRNA-34a and related microRNAs for use in the treatment of B-cell lymphoma. Likewise it relates to microRNA-34a for use in the preparation of a medicament for the treatment of B-cell lymphoma, and for a method of treatment of B-cell lymphoma comprising administering microRNA-34a. These claims are based on the observation that microRNA-34a shows strong anti-proliferative effects when overexpressed in diffuse large B-cell lymphoma (gDLBCL) cell lines, or when delivered intratumorally or systemically in xenograft models of DLBCL.
Inventor(s):	Craig; Vanessa (Zurich, CH), Mueller; Anne (Dubendorf, CH)
Assignee:	UNIVERSITY OF ZURICH (Zurich, CH)
Application Number:	14/565,049
Patent Claims:	1. A method of treating a B-cell lymphoma characterized by over-expression of Myc, comprising administering to an individual in need thereof a therapeutically effective amount of a composition comprising: (a) a synthetic oligonucleotide duplex comprising a first oligonucleotide strand consisting of a miR-34 sequence selected from the group consisting of: microRNA-34a (SEQ ID NO: 1), microRNA-34b (SEQ ID NO: 2), microRNA-34c-5p (SEQ ID NO: 3), and microRNA-34c-3p (SEQ ID NO: 4), and a second oligonucleotide strand comprising a sequence that is complementary to the first strand; and (b) a pharmaceutically acceptable carrier. 2. The method of claim 1, wherein the second oligonucleotide strand has a chemically modified nucleotide. 3. The method of claim 2, wherein the chemically modified nucleotide is a 2'-O-methylpurine, or a 2'-O-fluoropyrimidine. 4. The method of claim 1, wherein the synthetic oligonucleotide is bound at the 3' hydroxy group to a cholesterol. 5. The method of claim 1, wherein the composition comprises a liposome. 6. The method of claim 5, wherein the liposome is a pegylated liposome. 7. The method of claim 1, wherein the composition comprises a neutral lipid emulsion. 8. The method of claim 1, further comprising administering a second anticancer therapeutic agent to the patient. 9. The method of claim 8, wherein the second anticancer therapeutic agent is cyclophosphamide, hydroxydaunorubicin, vincristine, prednisone/prednisolone, rituximab, or combinations thereof. 10. The method of claim 1, wherein administering the composition comprises intratumoral, subcutaneous, intravenous, intrahepatic, or intramuscular administration. 11. The method of claim 1, wherein the B-cell lymphoma is selected from the group consisting of gastric B-cell lymphoma, non-gastric diffuse large B-cell lymphoma, extranodal diffuse large B-cell lymphoma, Burkitt lymphoma and chronic lymphocytic leukemia. 12. The method of claim 1, wherein B-cell lymphoma is high-grade gastric diffuse large B-cell lymphoma.

Details for Patent 9,642,872

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Genentech, Inc.	RITUXAN	rituximab	Injection	103705	11/26/1997	⤷ Try a Trial	2030-09-30
Idec Pharmaceuticals Corp.	RITUXAN	rituximab	Injection	103737	02/19/2002	⤷ Try a Trial	2030-09-30
Genentech, Inc.	RITUXAN HYCELA	rituximab and hyaluronidase human	Injection	761064	06/22/2017	⤷ Try a Trial	2030-09-30
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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