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Last Updated: October 17, 2019

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Claims for Patent: 9,642,872

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Summary for Patent: 9,642,872
Title:Treatment of B-cell lymphoma with microRNA
Abstract: The invention relates to microRNA-34a and related microRNAs for use in the treatment of B-cell lymphoma. Likewise it relates to microRNA-34a for use in the preparation of a medicament for the treatment of B-cell lymphoma, and for a method of treatment of B-cell lymphoma comprising administering microRNA-34a. These claims are based on the observation that microRNA-34a shows strong anti-proliferative effects when overexpressed in diffuse large B-cell lymphoma (gDLBCL) cell lines, or when delivered intratumorally or systemically in xenograft models of DLBCL.
Inventor(s): Craig; Vanessa (Zurich, CH), Mueller; Anne (Dubendorf, CH)
Assignee: UNIVERSITY OF ZURICH (Zurich, CH)
Application Number:14/565,049
Patent Claims:1. A method of treating a B-cell lymphoma characterized by over-expression of Myc, comprising administering to an individual in need thereof a therapeutically effective amount of a composition comprising: (a) a synthetic oligonucleotide duplex comprising a first oligonucleotide strand consisting of a miR-34 sequence selected from the group consisting of: microRNA-34a (SEQ ID NO: 1), microRNA-34b (SEQ ID NO: 2), microRNA-34c-5p (SEQ ID NO: 3), and microRNA-34c-3p (SEQ ID NO: 4), and a second oligonucleotide strand comprising a sequence that is complementary to the first strand; and (b) a pharmaceutically acceptable carrier.

2. The method of claim 1, wherein the second oligonucleotide strand has a chemically modified nucleotide.

3. The method of claim 2, wherein the chemically modified nucleotide is a 2'-O-methylpurine, or a 2'-O-fluoropyrimidine.

4. The method of claim 1, wherein the synthetic oligonucleotide is bound at the 3' hydroxy group to a cholesterol.

5. The method of claim 1, wherein the composition comprises a liposome.

6. The method of claim 5, wherein the liposome is a pegylated liposome.

7. The method of claim 1, wherein the composition comprises a neutral lipid emulsion.

8. The method of claim 1, further comprising administering a second anticancer therapeutic agent to the patient.

9. The method of claim 8, wherein the second anticancer therapeutic agent is cyclophosphamide, hydroxydaunorubicin, vincristine, prednisone/prednisolone, rituximab, or combinations thereof.

10. The method of claim 1, wherein administering the composition comprises intratumoral, subcutaneous, intravenous, intrahepatic, or intramuscular administration.

11. The method of claim 1, wherein the B-cell lymphoma is selected from the group consisting of gastric B-cell lymphoma, non-gastric diffuse large B-cell lymphoma, extranodal diffuse large B-cell lymphoma, Burkitt lymphoma and chronic lymphocytic leukemia.

12. The method of claim 1, wherein B-cell lymphoma is high-grade gastric diffuse large B-cell lymphoma.

Summary for Patent:   Start Trial

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
10182950Sep 30, 2010

Details for Patent 9,642,872

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech RITUXAN rituximab VIAL 103705 001 1997-11-26   Start Trial UNIVERSITY OF ZURICH (Zurich, CH) 2030-09-30 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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