.

BioPharmaceutical Business Intelligence

  • Identify first generic entrants
  • Uncover prior art in expired and abandoned patents
  • Drug patents in 130+ countries

► See Plans & Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving 500+ biopharmaceutical companies globally:

US Department of Justice
Covington
US Army
UBS
Merck
McKinsey
Novartis
Citi
Baxter
Healthtrust

Generated: September 22, 2017

DrugPatentWatch Database Preview

Claims for Patent: ► Subscribe

« Back to Dashboard

Summary for Patent: ► Subscribe

Title:Serological markers of inflammatory bowel disease phenotype and disease progression
Abstract: Disclosed are novel biomarkers and methods related to diagnostic tests for the detection and characterization of inflammatory bowel diseases, such as Crohn\'s disease and ulcerative colitis. In particular, the instant invention relates to novel biomarkers and methods of using such biomarkers to predict disease behavior and severity, to differentiate among disease types, and to optimize selection of treatment options in individuals suspected of having an inflammatory bowel disease.
Inventor(s): Denson; Lee (Wyoming, OH), Trapnel; Bruce Colston (Hamilton, OH), Uchida; Kanji (Tokyo, JP)
Assignee: Children\'s Hospital Medical Center (Cincinnati, OH)
Application Number:14/686,628
Patent Claims:1. A method for the diagnosis and treatment of an inflammatory bowel disease in a subject comprising: (a) measuring the concentration of anti-GM-CSF antibodies in a serum sample obtained from the subject; (b) diagnosing whether the subject has an inflammatory bowel disease, or the severity of an inflammatory bowel disease, based upon an increased concentration of the anti-GM-CSF antibodies in the sample as compared to the concentration of anti-GM-CSF antibodies in serum from a subject not having an inflammatory bowel disease; and (c) administering a therapy to the diagnosed subject, wherein the therapy is selected from the group consisting of an effective amount of anti-TNF.alpha. antibodies, an effective amount of GM-CSF, and surgery.

2. The method according to claim 1, wherein the inflammatory bowel disease is selected from the group consisting of small bowel Crohn's disease (CD.sub.SB), Colonic Crohn's disease (CD.sub.C), and Ulcerative Colitis (UC).

3. The method according to claim 1, wherein the increased concentration of anti-GM-CSF antibodies is indicative of the severity of the inflammatory bowel disease.

4. The method of claim 1, wherein the concentration of anti-GM-CSF antibodies in the sample is indicative of a stricturing or penetrating disease state.

5. The method of claim 1, wherein the therapy is an effective amount of anti-TNF.alpha. antibodies.

6. The method according to claim 1, further comprising detecting the level of GM-CSF dependent up-regulation of cell surface CD11b in the sample.

7. The method according to claim 1, wherein (a) further comprises: washing the complex to remove non-specifically bound components; and detecting the antigen-antibody complex.

8. The method of claim 1, wherein the GM-CSF comprises sargramostim.

9. A method for the prognosis and treatment of an inflammatory bowel disease in a patient comprising: (a) determining the concentration of anti-GM-CSF antibodies in a serum sample obtained from the patient comprising contacting the sample with an immobilized GM-CSF; and (b) determining whether the patient has an increased risk of the inflammatory bowel disease progressing based upon increased binding of the GM-CSF to the anti-GM-CSF antibodies as compared to the binding of GM-CSF to anti-GM-CSF antibodies in a serum sample from a subject not having an inflammatory bowel disease; and (c) administering an effective amount of anti-TNF.alpha. antibodies to the patient having the increased risk of disease progression.

10. The method of claim 9, wherein the concentration of anti-GM-CSF antibodies in the sample obtained from the patient is greater than or equal to about 1.5 .mu.g/ml is indicative of an increased risk of disease progression.

11. A method for the prognosis and targeted treatment of an inflammatory bowel disease in a patient comprising: (a) measuring an increased concentration of anti-GM-CSF antibodies in a serum sample obtained from the patient compared to the concentration of anti-GM-CSF antibodies in a sample from a subject not having an inflammatory bowel disease (b) determining whether the patient has an increased risk of inflammatory bowel disease progression when the increased concentration of anti-GM-CSF antibodies is measured; and (c) administering an effective amount of anti-TNF.alpha. antibodies to the patient having an increased risk of inflammatory bowel disease progression.

12. The method according to claim 11, wherein the inflammatory bowel disease is selected from the group consisting of small bowel Crohn's disease (CD.sub.SB), Colonic Crohn's disease (CD.sub.C), and Ulcerative Colitis (UC).

13. The method of claim 11, wherein the sample obtained from the patient comprises an antibody selected from the group consisting of anti-saccharomyces cervisiae antibody, anti-neutrophil cytoplasmic antibody with perinuclear staining, anti-CBir1 antibody, anti-I2 antibody, and anti-OmpC antibody.

14. The method according to claim 11, wherein the concentration of anti GM-CSF antibodies is determined by a method comprising: providing an immobilized GM-CSF; contacting the sample with the GM-CSF to form an antigen-antibody complex; washing the complex to remove non-specifically bound components; and detecting the antigen-antibody complex.

15. The method of claim 14, wherein the immobilized GM-CSF is sararamostim.

16. The method of claim 11, wherein the concentration of the anti-GM-CSF antibodies in a serum sample obtained from the patient is greater than 1.5 .mu.g/ml.

17. The method of claim 11, wherein (a) comprises comparing the concentration of anti-GM-CSF antibodies in a serum sample obtained from the patient compared to the concentration of anti-GM-CSF antibodies in a sample from a subject not having an inflammatory bowel disease.

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Inventors Patent Expiration Status Orphan Source
Berlex Labs
LEUKINE
sargramostim
VIAL1033620011991-03-05► Subscribe Children\'s Hospital Medical Center (Cincinnati, OH) Denson; Lee (Wyoming, OH), Trapnel; Bruce Colston (Hamilton, OH), Uchida; Kanji (Tokyo, JP) ► SubscribeRXsearch
Berlex Labs
LEUKINE
sargramostim
VIAL1033620021991-03-05► Subscribe Children\'s Hospital Medical Center (Cincinnati, OH) Denson; Lee (Wyoming, OH), Trapnel; Bruce Colston (Hamilton, OH), Uchida; Kanji (Tokyo, JP) ► SubscribeRXsearch
This preview shows a limited data set
Subscribe for full access, or try a Trial

Export unavailable in trial.
Subscribe for complete access.

International Patent Family for Patent: ► Subscribe

Country Document Number Publication Date
United States of America2010255513Oct 07, 2010
United States of America2013273566Oct 17, 2013
United States of America2015293113Oct 15, 2015
This preview shows a limited data set
Subscribe for full access, or try a Trial

Export unavailable in trial.
Subscribe for complete access.


« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

Serving 500+ biopharmaceutical companies globally:

Julphar
Deloitte
Colorcon
Daiichi Sankyo
QuintilesIMS
Chubb
Covington
Fuji
Baxter
Teva

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

Copyright 2002-2017 thinkBiotech LLC
ISSN: 2162-2639

Secure SSL Encrypted Heap | Mobile and Web Analytics
Privacy and Cookies
Terms & Conditions

Follow DrugPatentWatch:



Google
Twitter
Google Plus
botpot