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Last Updated: March 28, 2024

Claims for Patent: 9,512,216


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Summary for Patent: 9,512,216
Title:Use of TNF.alpha. inhibitor
Abstract: The invention describes methods of treating erosive polyarthritis comprising administering a TNF.alpha. antibody, or antigen-binding portion thereof. The invention also describes a method for testing the efficacy of a TNF.alpha. antibody, or antigen-binding portion thereof, for the treatment of erosive polyarthritis.
Inventor(s): Hoffman; Rebecca S. (Wilmette, IL), Weinberg; Mark (Northbrook, IL), Taylor; Lori K. (Boston, MA), Chartash; Elliot K. (Marietta, GA), Yan; Philip (Vernon Hills, IL), Granneman; George R. (Marco Island, FL)
Assignee: AbbVie Biotechnology Ltd. (Hamilton, BM)
Application Number:15/173,191
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 9,512,216
Patent Claims:1. A method for treating moderate to severe chronic plaque psoriasis, comprising subcutaneously administering to an adult patient having moderate to severe chronic plaque psoriasis an initial dose of 80 mg of adalimumab, followed by 40 mg of adalimumab every other week starting one week after said first dosing, wherein the patient achieves at least Psoriasis Area and Severity Index (PASI) 75 response at week 12 of the treatment.

2. The method of claim 1, wherein at least 5% body surface area (BSA) of the patient is affected by the moderate to severe chronic plaque psoriasis.

3. The method of claim 1, wherein adalimumab is comprised in pre-filled syringes for subcutaneous injection.

4. The method of claim 1, wherein adalimumab is formulated in a pharmaceutical composition and at a concentration of 50 mg/ml.

5. The method of claim 3, wherein adalimumab is formulated in a pharmaceutical composition and at a concentration of 50 mg/ml.

6. The method of claim 2, wherein adalimumab is comprised in pre-filled syringes for subcutaneous injection.

7. The method of claim 2, wherein adalimumab is formulated in a pharmaceutical composition and at a concentration of 50 mg/ml.

8. The method of claim 6, wherein adalimumab is formulated in a pharmaceutical composition and at a concentration of 50 mg/ml.

9. A method for treating moderate to severe chronic plaque psoriasis, comprising subcutaneously administering to an adult patient having moderate to severe chronic plaque psoriasis an initial dose of 80 mg of adalimumab, followed by 40 mg of adalimumab every other week starting one week after said first dosing.

10. The method of claim 9, wherein at least 5% body surface area (BSA) of the patient is affected by the moderate to severe chronic plaque psoriasis.

11. The method of claim 9, wherein adalimumab is comprised in pre-filled syringes for subcutaneous injection.

12. The method of claim 9, wherein adalimumab is formulated in a pharmaceutical composition and at a concentration of 50 mg/ml.

13. The method of claim 11, wherein adalimumab is formulated in a pharmaceutical composition and at a concentration of 50 mg/ml.

14. The method of claim 10, wherein adalimumab is comprised in pre-filled syringes for subcutaneous injection.

15. The method of claim 10, wherein adalimumab is formulated in a pharmaceutical composition and at a concentration of 50 mg/ml.

16. The method of claim 15, wherein adalimumab is formulated in a pharmaceutical composition and at a concentration of 50 mg/ml.

Details for Patent 9,512,216

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Abbvie Inc. HUMIRA adalimumab Injection 125057 12/31/2002 ⤷  Try a Trial 2021-03-07
Abbvie Inc. HUMIRA adalimumab Injection 125057 02/21/2008 ⤷  Try a Trial 2021-03-07
Abbvie Inc. HUMIRA adalimumab Injection 125057 04/24/2013 ⤷  Try a Trial 2021-03-07
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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