Claims for Patent: 9,487,809

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Summary for Patent: 9,487,809

Title:	Decreasing lactate level and increasing polypeptide production by downregulating the expression of lactate dehydrogenase and pyruvate dehydrogenase kinase
Abstract:	The present invention provides methods and compositions for reducing lactate production and increasing polypeptide production in cultured cells. In one aspect, the invention provides a method comprising culturing cells expressing a) a small interfering RNA (siRNA) specific for a lactate dehydrogenase (LDH) and b) an siRNA specific for a pyruvate dehydrogenase kinase (PDHK). In another aspect, the invention provides cultured cells or vectors comprising an siRNA specific for a LDH and an siRNA specific for a PDHK.
Inventor(s):	Zhou Meixia, Snedecor Bradley Richard, Ng Chi Kin Domingos, Shen Amy
Assignee:	Genentech, Inc.
Application Number:	US13688075
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 9,487,809

Details for Patent 9,487,809

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Genentech, Inc.	AVASTIN	bevacizumab	Injection	125085	February 26, 2004	9,487,809	2032-11-28
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 9,487,809

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Country	Patent Number	Estimated Expiration
World Intellectual Property Organization (WIPO)	2011150241	⤷ Get Started Free
United States of America	2020377919	⤷ Get Started Free
United States of America	2019040435	⤷ Get Started Free
United States of America	2017191102	⤷ Get Started Free
United States of America	2013084605	⤷ Get Started Free
United States of America	11046987	⤷ Get Started Free
>Country	>Patent Number	>Estimated Expiration

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