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Last Updated: December 28, 2025

Claims for Patent: 9,388,402

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Summary for Patent: 9,388,402

Title:	Method for improved isolation of recombinantly produced proteins
Abstract:	The present invention provides a method for increasing the yield of a protein produced by cultivating eukaryotic cells and adding an ionic substance to the culture medium prior to harvest of the protein. Suitable ionic substances are the salts of the Hofmeister series, amino acids and peptone.
Inventor(s):	Stefan Winge
Assignee:	Octapharma AG
Application Number:	US11/887,677

Details for Patent 9,388,402

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Octapharma Pharmazeutika Produktionsges.m.b.h.	NUWIQ	antihemophilic factor (recombinant)	For Injection	125555	September 04, 2015	9,388,402	2026-03-29
Octapharma Pharmazeutika Produktionsges.m.b.h.	NUWIQ	antihemophilic factor (recombinant)	For Injection	125555	July 07, 2017	9,388,402	2026-03-29
Octapharma Pharmazeutika Produktionsges.m.b.h.	NUWIQ	antihemophilic factor (recombinant)	For Injection	125555	December 07, 2021	9,388,402	2026-03-29
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 9,388,402

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Country	Patent Number	Estimated Expiration
World Intellectual Property Organization (WIPO)	2006103258	⤷ Get Started Free
United States of America	2017183703	⤷ Get Started Free
United States of America	2009088370	⤷ Get Started Free
United States of America	10626431	⤷ Get Started Free
Slovenia	1863920	⤷ Get Started Free
Portugal	1863920	⤷ Get Started Free
>Country	>Patent Number	>Estimated Expiration

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