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Last Updated: December 16, 2025

Claims for Patent: 9,364,520

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Summary for Patent: 9,364,520

Title:	Factor VIII conjugates
Abstract:	This invention relates to Factor VIII muteins that are covalently bound, at a predefined site that is not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity and have improved pharmacokinetic properties.
Inventor(s):	Clark Q. Pan, John E. Murphy, Baisong Mei, Jonathan S. Strauss, Hendri Tjandra, Jianmin Chen, Thomas Barnett, Liang Tang, Deqian Wang
Assignee:	Bayer Healthcare LLC
Application Number:	US12/540,703

Details for Patent 9,364,520

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Bayer Healthcare Llc	HELIXATE FS, KOGENATE, KOGENATE FS	antihemophilic factor (recombinant)	For Injection	103332	August 20, 2002	9,364,520	2029-08-13
Bayer Healthcare Llc	HELIXATE FS, KOGENATE, KOGENATE FS	antihemophilic factor (recombinant)	For Injection	103332	June 07, 2007	9,364,520	2029-08-13
Bayer Healthcare Llc	HELIXATE FS, KOGENATE, KOGENATE FS	antihemophilic factor (recombinant)	For Injection	103332	July 31, 2009	9,364,520	2029-08-13
Takeda Pharmaceuticals U.s.a., Inc.	ADYNOVATE	antihemophilic factor (recombinant), pegylated	For Injection	125566	November 13, 2015	9,364,520	2029-08-13
Takeda Pharmaceuticals U.s.a., Inc.	ADYNOVATE	antihemophilic factor (recombinant), pegylated	For Injection	125566	October 25, 2016	9,364,520	2029-08-13
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 9,364,520

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Country	Patent Number	Estimated Expiration
South Africa	200703696	⤷ Get Started Free
World Intellectual Property Organization (WIPO)	2006053299	⤷ Get Started Free
United States of America	9096656	⤷ Get Started Free
United States of America	7632921	⤷ Get Started Free
United States of America	2016051633	⤷ Get Started Free
>Country	>Patent Number	>Estimated Expiration

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