Claims for Patent: 9,340,528

Summary for Patent: 9,340,528

Title:	Substituted aminoquinoxalines as tyrosine threonine kinase inhibitors
Abstract:	The present invention relates to substituted aminoquinoxaline compounds of general formula (I) in which (II), R.sup.2, R.sup.3, R.sup.4, R.sup.6, R.sup.7, n and m are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds. ##STR00001##
Inventor(s):	Bader; Benjamin (Berlin, DE), Bomer; Ulf (Glienicke, DE), Ince; Stuart (Berlin, DE), Koppitz; Marcus (Berlin, DE), Lienau; Philip (Berlin, DE), Marquardt; Tobias (Berlin, DE), Nguyen; Duy (Berlin, DE), Prechtl; Stefan (Berlin, DE), Siemeister; Gerhard (Berlin, DE), Wegscheid-Gerlach; Christof (Marburg, DE)
Assignee:	BAYER PHARMA AKTIENGESELLSCHAFT (Berlin, DE)
Application Number:	13/393,583
Patent Claims:	1. A compound of general formula (I): ##STR00752## in which: ##STR00753## represents a 4-, 5-, 6-, 7-, 8-, 9- or 10-membered heterocyclic ring, optionally further containing 1 heteroatom-containing group selected from O and NR.sup.1 in which R.sup.1 represents hydrogen, or a group selected from: C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkyl-, C.sub.1-C.sub.6-alkoxy-, hydroxyl-C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkoxy-, C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6--, aryloxy-C.sub.1-C.sub.6-alkyl-, C.sub.2-C.sub.10-alkenyl-, C.sub.2-C.sub.10-alkynyl-, C.sub.3-C.sub.10-cycloalkyl-, 3- to 10-membered heterocycloalkyl-, aryl-, heteroaryl-, --C.sub.1-C.sub.6-alkylene-aryl, a 4- or 5-(1,3-benzodioxolinyl)- group, --C.sub.1-C.sub.6-alkylene-heteroaryl, C.sub.1-C.sub.6-alkylene-aryl-, C.sub.1-C.sub.6-alkylene-heteroaryl-, --C.sub.1-C.sub.6-alkylene-C.sub.3-C.sub.10-cycloalkyl, --C.sub.1-C.sub.6-alkylene-(3- to 10-membered heterocycloalkyl), --C(.dbd.O)R.sup.8, --C(.dbd.O)O--C.sub.1-C.sub.6-alkyl, --C(.dbd.O)O--C.sub.3-C.sub.10-cycloalkyl, --C(.dbd.O)NR.sup.9R.sup.10, --S(.dbd.O)R.sup.8, --S(.dbd.O).sub.2R.sup.8, --S(.dbd.O).sub.2NR.sup.9R.sup.10; wherein said group is optionally substituted one or more times, identically or differently, with a substituent selected from: halo-, hydroxyl-, cyano-, nitro-, C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkyl-, C.sub.1-C.sub.6-alkoxy-, halo-C.sub.1-C.sub.6-alkoxy-, hydroxy-C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, C.sub.2-C.sub.10-alkenyl-, C.sub.2-C.sub.10-alkynyl-, C.sub.3-C.sub.10-cycloalkyl-, 3- to 10-membered heterocycloalkyl-, aryl-, heteroaryl-, C.sub.1-C.sub.6-alkylene-aryl-, C.sub.1-C.sub.6-alkylene-heteroaryl-, --C.sub.1-C.sub.6-alkylene-C.sub.3-C.sub.10-cycloalkyl, --C.sub.1-C.sub.6-alkylene-(3- to 10-membered heterocycloalkyl), --OR.sup.8, --C(.dbd.O)H, --C(.dbd.O)R.sup.8--, C(.dbd.O)OH, --C(.dbd.O)O--C.sub.1-C.sub.6-alkyl, --C(.dbd.O)O--C.sub.3-C.sub.10-cycloalkyl, --OC(.dbd.O)--C.sub.1-C.sub.6-alkyl, --OC(.dbd.O)--C.sub.3-C.sub.10-cycloalkyl, --N(H)C(.dbd.O)R.sup.8, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)R.sup.8, --N(H)S(.dbd.O).sub.2R.sup.8, --N(C.sub.1-C.sub.6-alkyl)S(.dbd.O).sub.2R.sup.8, --C(.dbd.O)NR.sup.9R.sup.10, --OC(.dbd.O)NR.sup.9R.sup.10, --N(H)C(.dbd.O)OR.sup.8, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)OR.sup.8, --N(H)C(.dbd.O)NR.sup.9R.sup.10, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)NR.sup.9R.sup.10, --SR.sup.8, --S(.dbd.O)R.sup.8, --S(.dbd.O).sub.2R.sup.8, --S(.dbd.O).sub.2NR.sup.9R.sup.10, --NR.sup.9R.sup.10; R.sup.1 and R.sup.7 can form together a 5-7 membered ring which is optionally substituted with .dbd.O; R.sup.2, R.sup.3, R.sup.4, R.sup.6, represent hydrogen; R.sup.5, R.sup.7 represent, independently from each other, a substituent selected from hydrogen, halo-, hydroxyl-, cyano-, nitro-, or a substituent group selected from: C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkyl-, C.sub.1-C.sub.6-alkoxy-, halo-C.sub.1-C.sub.6-alkoxy-, C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, C.sub.2-C.sub.10-alkenyl-, C.sub.2-C.sub.10-alkynyl-, C.sub.3-C.sub.10-cycloalkyl-, 3- to 10-membered heterocycloalkyl-, aryl-, heteroaryl-, --C.sub.1-C.sub.6-alkylene-aryl, C.sub.1-C.sub.6-alkylene-aryl-, C.sub.1-C.sub.6-alkylene-heteroaryl-, --C.sub.1-C.sub.6-alkylene-C.sub.3-C.sub.10-cycloalkyl, --C.sub.1-C.sub.6-alkylene-(3- to 10-membered heterocycloalkyl), --OR.sup.8, --C(.dbd.O)H, --C(.dbd.O)R.sup.8, --C(.dbd.O)OH, --C(.dbd.O)O--C.sub.1-C.sub.6-alkyl, --C(.dbd.O)O--C.sub.3-C.sub.10-cycloalkyl, --OC(.dbd.O)--C.sub.1-C.sub.6-alkyl, --OC(.dbd.O)--C.sub.3-C.sub.10-cycloalkyl, --N(H)C(.dbd.O)R.sup.8, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)R.sup.8, --N(H)S(.dbd.O).sub.2R.sup.8, --N(C.sub.1-C.sub.6-alkyl)S(.dbd.O).sub.2R.sup.8, --C(.dbd.O)NR.sup.9R.sup.10, --OC(.dbd.O)NR.sup.9R.sup.10, --N(H)C(.dbd.O)OR.sup.8, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)OR.sup.8, --N(H)C(.dbd.O)NR.sup.9R.sup.10, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)NR.sup.9R.sup.10, --SR.sup.8, --S(.dbd.O)R.sup.8, --S(.dbd.O).sub.2R.sup.8, --S(.dbd.O).sub.2NR.sup.9R.sup.10, --NR.sup.9R.sup.10; wherein, when m or n represent, independently from each other, an integer of 2, or 3, then said substituent or substituent group is, independently from each other, identical or different; wherein said substituent group is optionally substituted one or more times, identically or differently, with a substituent selected from: halo-, hydroxyl-, cyano-, nitro-, C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkyl-, C.sub.1-C.sub.6-alkoxy-, halo-C.sub.1-C.sub.6-alkoxy-, hydroxy-C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, C.sub.2-C.sub.10-alkenyl-, C.sub.2-C.sub.10-alkynyl-, C.sub.3-C.sub.10-cycloalkyl-, 3- to 10-membered heterocycloalkyl-, aryl-, heteroaryl-, a 4- or 5-(1,3-benzodioxolinyl)- group, C.sub.1-C.sub.6-alkylene-aryl-, C.sub.1-C.sub.6-alkylene-heteroaryl-, --C.sub.1-C.sub.6-alkylene-C.sub.3-C.sub.10-cycloalkyl, --C.sub.1-C.sub.6-alkylene-(3- to 10-membered heterocycloalkyl), --C(.dbd.O)H, --C(.dbd.O)--C.sub.1-C.sub.6-alkyl, C(.dbd.O)OH, --C(.dbd.O)O--C.sub.1-C.sub.6-alkyl, --C(.dbd.O)O--C.sub.3-C.sub.10-cycloalkyl, --OC(.dbd.O)--C.sub.1-C.sub.6-alkyl, --OC(.dbd.O)--C.sub.3-C.sub.10-cycloalkyl, --N(H)C(.dbd.O)--C.sub.1-C.sub.6-alkyl, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)--C.sub.1-C.sub.6-alkyl, --N(H)S(.dbd.O).sub.2--C.sub.1-C.sub.6-alkyl, --N(C.sub.1-C.sub.6-alkyl)S(.dbd.O).sub.2--C.sub.1-C.sub.6-alkyl, --C(.dbd.O)NH.sub.2, --C(.dbd.O)N(H)C.sub.1-C.sub.6-alkyl, --C(.dbd.O)N(C.sub.1-C.sub.6-alkyl).sub.2, --OC(.dbd.O)N(H)C.sub.1-C.sub.6-alkyl, --OC(.dbd.O)N(C.sub.1-C.sub.6-alkyl).sub.2, --N(H)C(.dbd.O)O--C.sub.1-C.sub.6-alkyl, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)O--C.sub.1-C.sub.6-alkyl, --N(H)C(.dbd.O)NH.sub.2, --N(H)C(.dbd.O)N(H)C.sub.1-C.sub.6-alkyl, --N(H)C(.dbd.O)N(C.sub.1-C.sub.6-alkyl).sub.2, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)NH.sub.2, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)N(H)C.sub.1-C.sub.6-alkyl, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)N(C.sub.1-C.sub.6-alkyl).sub.2, --S--C.sub.1-C.sub.6-alkyl, --S(.dbd.O) --C.sub.1-C.sub.6-alkyl, --S(.dbd.O).sub.2--C.sub.1-C.sub.6-alkyl, --S(.dbd.O).sub.2NH.sub.2, --S(.dbd.O).sub.2N(H)C.sub.1-C.sub.6-alkyl, --S(.dbd.O).sub.2N(C.sub.1-C.sub.6-alkyl).sub.2, --NH.sub.2, --N(H)C.sub.1-C.sub.6-alkyl, --N(C.sub.1-C.sub.6-alkyl).sub.2; R.sub.8 represents a group selected from: C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkyl-, C.sub.1-C.sub.6-alkoxy-, halo-C.sub.1-C.sub.6-alkoxy-, C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, hydroxy-C.sub.1-C.sub.6-alkyl, C.sub.2-C.sub.10-alkenyl-, C.sub.2-C.sub.10-alkynyl-, C.sub.3-C.sub.10-cycloalkyl-, 3- to 10-membered heterocycloalkyl-, aryl-, heteroaryl-, C.sub.1-C.sub.6-alkylene-aryl-, C.sub.1-C.sub.6-alkylene-heteroaryl-, --C.sub.1-C.sub.6-alkylene-C.sub.3-C.sub.10-cycloalkyl, --C.sub.1-C.sub.6-alkylene-aryl, --C.sub.1-C.sub.6-alkylene-heteroaryl, --C.sub.1-C.sub.6-alkylene-(3- to 10-membered heterocycloalkyl), --NR.sup.9R.sup.10; wherein said group is optionally substituted one or more times, identically or differently, with a substituent selected from: halo-, hydroxyl-, cyano-, nitro-, C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkyl-, C.sub.1-C.sub.6-alkoxy-, halo-C.sub.1-C.sub.6-alkoxy-, hydroxy-C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, C.sub.2-C.sub.10-alkenyl-, C.sub.2-C.sub.10-alkynyl-, C.sub.3-C.sub.10-cycloalkyl-, 3- to 10-membered heterocycloalkyl-, aryl-, heteroaryl-, C.sub.1-C.sub.6-alkylene-aryl-, C.sub.1-C.sub.6-alkylene-heteroaryl-, --C.sub.1-C.sub.6-alkylene-C.sub.3-C.sub.10-cycloalkyl, --C.sub.1-C.sub.6-alkylene-(3- to 10-membered heterocycloalkyl), --C(.dbd.O)H, --C(.dbd.O)R.sup.11--, C(.dbd.O)OH, --C(.dbd.O)O--C.sub.1-C.sub.6-alkyl, --C(.dbd.O)O--C.sub.3-C.sub.10-cycloalkyl, --OC(.dbd.O)--C.sub.1-C.sub.6-alkyl, --OC(.dbd.O)--C.sub.3-C.sub.10-cycloalkyl, --N(H)C(.dbd.O)R.sup.11, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)R.sup.11, --N(H)S(.dbd.O).sub.2R.sup.11, --N(C.sub.1-C.sub.6-alkyl)S(.dbd.O).sub.2R.sup.11, --C(.dbd.O)NR.sup.9R.sup.10, --OC(.dbd.O)NR.sup.9R.sup.10, --N(H)C(.dbd.O)OR.sup.11, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)OR.sup.11, --N(H)C(.dbd.O)NR.sup.9R.sup.10, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)NR.sup.9R.sup.10, --SR.sup.11, --S(.dbd.O)R.sup.11, --S(.dbd.O).sub.2R.sup.11, --S(.dbd.O).sub.2NR.sup.9R.sup.10, --NR.sup.9R.sup.10; R.sup.9, R.sup.10 represent independently from each other hydrogen, or a group selected from: C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkyl-, C.sub.1-C.sub.6-alkoxy-, halo-C.sub.1-C.sub.6-alkoxy-, C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, C.sub.2-C.sub.10-alkenyl-, C.sub.2-C.sub.10-alkynyl-, C.sub.3-C.sub.10-cycloalkyl-, 3- to 10-membered heterocycloalkyl-, aryl-, heteroaryl-, --C.sub.1-C.sub.6-alkylene-aryl, C.sub.1-C.sub.6-alkylene-aryl-, C.sub.1-C.sub.6-alkylene-heteroaryl-, --C.sub.1-C.sub.6-alkylene-C.sub.3-C.sub.10-cycloalkyl, --C.sub.1-C.sub.6-alkylene-(3- to 10-membered heterocycloalkyl), R.sup.9 and R.sup.10 can form together a 5-7 saturated or partially unsaturated heterocyclic ring, which optionally further contains 1 heteroatom-containing group selected from O; R.sup.11 represents C.sub.1-C.sub.6-alkyl-; n, m represent, independently from each other, an integer of 0, 1, 2, or 3; or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same. 2. The compound according to claim 1, wherein: ##STR00754## represents a 4- to 6-membered heterocyclic ring, optionally further containing 1 heteroatom-containing groups selected from O and NR.sup.1 in which R.sup.1 represents hydrogen, or a group selected from: C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkyl-, C.sub.1-C.sub.6-alkoxy-, hydroxyl-C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkoxy-, C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6--, aryloxy-C.sub.1-C.sub.6-alkyl-, C.sub.3-C.sub.7-cycloalkyl-, 3- to 7-membered heterocycloalkyl-, aryl-, heteroaryl-, --C.sub.1-C.sub.6-alkylene-aryl, a 4- or 5-(1,3-benzodioxolinyl)- group, --C.sub.1-C.sub.6-alkylene-heteroaryl, C.sub.1-C.sub.6-alkylene-aryl-, C.sub.1-C.sub.6-alkylene-heteroaryl-, --C.sub.1-C.sub.6-alkylene-C.sub.3-C.sub.7-cycloalkyl, --C.sub.1-C.sub.6-alkylene-(3- to 7-membered heterocycloalkyl), --C(.dbd.O)R.sup.8, --C(.dbd.O)O--C.sub.1-C.sub.6-alkyl, --C(.dbd.O)O--C.sub.3-C.sub.7-cycloalkyl, --C(.dbd.O)NR.sup.9R.sup.10, --S(.dbd.O)R.sup.8, --S(.dbd.O).sub.2R.sup.8, --S(.dbd.O).sub.2NR.sup.9R.sup.10; wherein said group is optionally substituted one or more times, identically or differently, with a substituent selected from: halo-, hydroxyl-, cyano-, nitro-, C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkyl-, C.sub.1-C.sub.6-alkoxy-, halo-C.sub.1-C.sub.6-alkoxy-, hydroxy-C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, C.sub.3-C.sub.7-cycloalkyl-, 3- to 7-membered heterocycloalkyl-, aryl-, heteroaryl-, C.sub.1-C.sub.6-alkylene-aryl-, C.sub.1-C.sub.6-alkylene-heteroaryl-, --C.sub.1-C.sub.6-alkylene-C.sub.3-C.sub.7-cycloalkyl, --C.sub.1-C.sub.6-alkylene-(3- to 7-membered heterocycloalkyl), --OR.sup.8, --C(.dbd.O)H, --C(.dbd.O)R.sup.8--, C(.dbd.O)OH, --C(.dbd.O)O--C.sub.1-C.sub.6-alkyl, --C(.dbd.O)O--C.sub.3-C.sub.7-cycloalkyl, --OC(.dbd.O)--C.sub.1-C.sub.6-alkyl, --OC(.dbd.O)--C.sub.3-C.sub.7-cycloalkyl, --N(H)C(.dbd.O)R.sup.8, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)R.sup.8, --N(H)S(.dbd.O).sub.2R.sup.8, --N(C.sub.1-C.sub.6-alkyl)S(.dbd.O).sub.2R.sup.8, --C(.dbd.O)NR.sup.9R.sup.10, --OC(.dbd.O)NR.sup.9R.sup.10, --N(H)C(.dbd.O)OR.sup.8, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)OR.sup.8, --N(H)C(.dbd.O)NR.sup.9R.sup.10, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)NR.sup.9R.sup.10, --SR.sup.8, --S(.dbd.O)R.sup.8, --S(.dbd.O).sub.2R.sup.8, --S(.dbd.O).sub.2NR.sup.9R.sup.10, --NR.sup.9R.sup.10; R.sup.1 and R.sup.7 can form together a 5-6 membered ring which is optionally substituted with .dbd.O; R.sup.2, R.sup.3, R.sup.4, R.sup.6, represent hydrogen; R.sup.5, R.sup.7 represent, independently from each other, a substituent selected from hydrogen, halo-, hydroxyl-, cyano-, nitro-, or a substituent group selected from: C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkyl-, C.sub.1-C.sub.6-alkoxy-, halo-C.sub.1-C.sub.6-alkoxy-, C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, C.sub.3-C.sub.7-cycloalkyl-, 3- to 7-membered heterocycloalkyl-, aryl-, heteroaryl-, --C.sub.1-C.sub.6-alkylene-aryl, C.sub.1-C.sub.6-alkylene-aryl-, C.sub.1-C.sub.6-alkylene-heteroaryl-, --C.sub.1-C.sub.6-alkylene-C.sub.3-C.sub.7-cycloalkyl, --C.sub.1-C.sub.6-alkylene-(3- to 7-membered heterocycloalkyl), --OR.sup.8, --C(.dbd.O)H, --C(.dbd.O)R.sup.8, --C(.dbd.O)OH, --C(.dbd.O)O--C.sub.1-C.sub.6-alkyl, --C(.dbd.O)O--C.sub.3-C.sub.7-cycloalkyl, --OC(.dbd.O)--C.sub.1-C.sub.6-alkyl, --OC(.dbd.O)--C.sub.3-C.sub.7-cycloalkyl, --N(H)C(.dbd.O)R.sup.8, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)R.sup.8, --N(H)S(.dbd.O).sub.2R.sup.8, --N(C.sub.1-C.sub.6-alkyl)S(.dbd.O).sub.2R.sup.8, --C(.dbd.O)NR.sup.9R.sup.10, --OC(.dbd.O)NR.sup.9R.sup.10, --N(H)C(.dbd.O)OR.sup.8, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)OR.sup.8, --N(H)C(.dbd.O)NR.sup.9R.sup.10, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)NR.sup.9R.sup.10, --SR.sup.8, --S(.dbd.O)R.sup.8, --S(--C.sub.1-C.sub.6-alkylene-aryl, .dbd.O).sub.2R.sup.8, --S(.dbd.O).sub.2NR.sup.9R.sup.10, --NR.sup.9R.sup.10; wherein, when m or n represent, independently from each other, an integer of 2 or 3, then said substituent or substituent group is, independently from each other, identical or different; wherein said substituent group is optionally substituted one or more times, identically or differently, with a substituent selected from: halo-, hydroxyl-, cyano-, nitro-, C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkyl-, C.sub.1-C.sub.6-alkoxy-, halo-C.sub.1-C.sub.6-alkoxy-, hydroxy-C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, C.sub.3-C.sub.7-cycloalkyl-, 3- to 7-membered heterocycloalkyl-, aryl-, heteroaryl-, a 4- or 5-(1,3-benzodioxolinyl)- group, C.sub.1-C.sub.6-alkylene-aryl-, C.sub.1-C.sub.6-alkylene-heteroaryl-, --C.sub.1-C.sub.6-alkylene-C.sub.3-C.sub.7-cycloalkyl, --C.sub.1-C.sub.6-alkylene-(3- to 7-membered heterocycloalkyl), --C(.dbd.O)H, --C(.dbd.O)--C.sub.1-C.sub.6-alkyl, C(.dbd.O)OH, --C(.dbd.O)O--C.sub.1-C.sub.6-alkyl, --C(.dbd.O)O--C.sub.3-C.sub.7-cycloalkyl, --OC(.dbd.O)--C.sub.1-C.sub.6-alkyl, --OC(.dbd.O)--C.sub.3-C.sub.7-cycloalkyl, --N(H)C(.dbd.O)--C.sub.1-C.sub.6-alkyl, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)--C.sub.1-C.sub.6-alkyl, --N(H)S(.dbd.O).sub.2--C.sub.1-C.sub.6-alkyl, --N(C.sub.1-C.sub.6-alkyl)S(.dbd.O).sub.2--C.sub.1-C.sub.6-alkyl, --C(.dbd.O)NH.sub.2, --C(.dbd.O)N(H)C.sub.1-C.sub.6-alkyl, --C(.dbd.O)N(C.sub.1-C.sub.6-alkyl).sub.2, --OC(.dbd.O)N(H)C.sub.1-C.sub.6-alkyl, --OC(.dbd.O)N(C.sub.1-C.sub.6-alkyl).sub.2, --N(H)C(.dbd.O)O--C.sub.1-C.sub.6-alkyl, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)O--C.sub.1-C.sub.6-alkyl, --N(H)C(.dbd.O)NH.sub.2, --N(H)C(.dbd.O)N(H)C.sub.1-C.sub.6-alkyl, --N(H)C(.dbd.O)N(C.sub.1-C.sub.6-alkyl).sub.2, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)NH.sub.2, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)N(H)C.sub.1-C.sub.6-alkyl, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)N(C.sub.1-C.sub.6-alkyl).sub.2, --S--C.sub.1-C.sub.6-alkyl, --S(.dbd.O)--C.sub.1-C.sub.6-alkyl, --S(.dbd.O).sub.2--C.sub.1-C.sub.6-alkyl, --S(.dbd.O).sub.2NH.sub.2, --S(.dbd.O).sub.2N(H)C.sub.1-C.sub.6-alkyl, --S(.dbd.O).sub.2N(C.sub.1-C.sub.6-alkyl).sub.2, --NH.sub.2, --N(H)C.sub.1-C.sub.6-alkyl, --N(C.sub.1-C.sub.6-alkyl).sub.2; R.sub.8 represents a group selected from: C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkyl-, C.sub.1-C.sub.6-alkoxy-, halo-C.sub.1-C.sub.6-alkoxy-, C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, hydroxy-C.sub.1-C.sub.6-alkyl, C.sub.3-C.sub.7-cycloalkyl-, 3- to 7-membered heterocycloalkyl-, aryl-, heteroaryl-, C.sub.1-C.sub.6-alkylene-aryl-, C.sub.1-C.sub.6-alkylene-heteroaryl-, --C.sub.1-C.sub.6-alkylene-C.sub.3-C.sub.7-cycloalkyl, --C.sub.1-C.sub.6-alkylene-aryl, --C.sub.1-C.sub.6-alkylene-heteroaryl, --C.sub.1-C.sub.6-alkylene-(3- to 7-membered heterocycloalkyl), --NR.sup.9R.sup.10; wherein said group is optionally substituted one or more times, identically or differently, with a substituent selected from: halo-, hydroxyl-, cyano-, nitro-, C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkyl-, C.sub.1-C.sub.6-alkoxy-, halo-C.sub.1-C.sub.6-alkoxy-, hydroxy-C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, C.sub.3-C.sub.7-cycloalkyl-, 3- to 7-membered heterocycloalkyl-, aryl-, heteroaryl-, C.sub.1-C.sub.6-alkylene-aryl-, C.sub.1-C.sub.6-alkylene-heteroaryl-, --C.sub.1-C.sub.6-alkylene-C.sub.3-C.sub.7-cycloalkyl, --C.sub.1-C.sub.6-alkylene-(3- to 7-membered heterocycloalkyl), --C(.dbd.O)H, --C(.dbd.O)R.sup.11--, C(.dbd.O)OH, --C(.dbd.O)O--C.sub.1-C.sub.6-alkyl, --C(.dbd.O)O--C.sub.3-C.sub.7-cycloalkyl, --OC(.dbd.O)--C.sub.1-C.sub.6-alkyl, --OC(.dbd.O)--C.sub.3-C.sub.7-cycloalkyl, --N(H)C(.dbd.O)R.sup.11, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)R.sup.11, --N(H)S(.dbd.O).sub.2R.sup.11, --N(C.sub.1-C.sub.6-alkyl)S(.dbd.O).sub.2R.sup.11, --C(.dbd.O)NR.sup.9R.sup.10, --OC(.dbd.O)NR.sup.9R.sup.10, --N(H)C(.dbd.O)OR.sup.11, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)OR.sup.11, --N(H)C(.dbd.O)NR.sup.9R.sup.10, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)NR.sup.9R.sup.10, --SR.sup.11, --S(.dbd.O)R.sup.11, --S(.dbd.O).sub.2R.sup.11, --S(.dbd.O).sub.2NR.sup.9R.sup.10, --NR.sup.9R.sup.10; R.sup.9, R.sup.10 represent independently from each other hydrogen, or a group selected from: C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkyl-, C.sub.1-C.sub.6-alkoxy-, halo-C.sub.1-C.sub.6-alkoxy-, C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, C.sub.3-C.sub.7-cycloalkyl-, 3- to 7-membered heterocycloalkyl-, aryl-, heteroaryl-, --C.sub.1-C.sub.6-alkylene-aryl, C.sub.1-C.sub.6-alkylene-aryl-, C.sub.1-C.sub.6-alkylene-heteroaryl-, --C.sub.1-C.sub.6-alkylene-C.sub.3-C.sub.7-cycloalkyl, --C.sub.1-C.sub.6-alkylene-(3- to 7-membered heterocycloalkyl), R.sup.9 and R.sup.10 can form together a 5-7 saturated or partially unsaturated heterocyclic ring, which optionally further contains 1 heteroatom-containing group selected from O; R.sup.11 represents C.sub.1-C.sub.6-alkyl-; n, m represent, independently from each other, an integer of 0, 1, 2, or 3. 3. The compound according to claim 1, wherein: ##STR00755## represents a 4- to 6-membered heterocyclic ring, optionally further containing 1 heteroatom-containing group selected from O and NR.sup.1 in which R.sup.1 represents hydrogen, or a group selected from: C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkyl-, C.sub.1-C.sub.6-alkoxy-, hydroxyl-C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkoxy-, C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6--, aryloxy-C.sub.1-C.sub.6-alkyl-, C.sub.3-C.sub.7-cycloalkyl-, 3- to 7-membered heterocycloalkyl-, aryl-, heteroaryl-, --C.sub.1-C.sub.6-alkylene-aryl, a 4- or 5-(1,3-benzodioxolinyl)- group, --C.sub.1-C.sub.6-alkylene-heteroaryl, C.sub.1-C.sub.6-alkylene-aryl-, C.sub.1-C.sub.6-alkylene-heteroaryl-, --C.sub.1-C.sub.6-alkylene-C.sub.3-C.sub.7-cycloalkyl, --C.sub.1-C.sub.6-alkylene-(3- to 7-membered heterocycloalkyl), --C(.dbd.O)R.sup.8, --C(.dbd.O)O--C.sub.1-C.sub.6-alkyl, --C(.dbd.O)O--C.sub.3-C.sub.7-cycloalkyl, --C(.dbd.O)NR.sup.9R.sup.10, --S(.dbd.O)R.sup.8, --S(.dbd.O).sub.2R.sup.8, --S(.dbd.O).sub.2NR.sup.9R.sup.10; wherein said group is optionally substituted one or more times, identically or differently, with a substituent selected from: halo-, hydroxyl-, cyano-, nitro-, C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkyl-, C.sub.1-C.sub.6-alkoxy-, halo-C.sub.1-C.sub.6-alkoxy-, hydroxy-C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, C.sub.3-C.sub.7-cycloalkyl-, 3- to 7-membered heterocycloalkyl-, aryl-, heteroaryl-, C.sub.1-C.sub.6-alkylene-aryl-, C.sub.1-C.sub.6-alkylene-heteroaryl-, --C.sub.1-C.sub.6-alkylene-C.sub.3-C.sub.7-cycloalkyl, --C.sub.1-C.sub.6-alkylene-(3- to 7-membered heterocycloalkyl), --OR.sup.8, --C(.dbd.O)H, --C(.dbd.O)R.sup.8--, C(.dbd.O)OH, --C(.dbd.O)O--C.sub.1-C.sub.6-alkyl, --C(.dbd.O)O--C.sub.3-C.sub.7-cycloalkyl, --OC(.dbd.O)--C.sub.1-C.sub.6-alkyl, --OC(.dbd.O)--C.sub.3-C.sub.7-cycloalkyl, --N(H)C(.dbd.O)R.sup.8, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)R.sup.8, --N(H)S(.dbd.O).sub.2R.sup.8, --N(C.sub.1-C.sub.6-alkyl)S(.dbd.O).sub.2R.sup.8, --C(.dbd.O)NR.sup.9R.sup.10, --OC(.dbd.O)NR.sup.9R.sup.10, --N(H)C(.dbd.O)OR.sup.8, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)OR.sup.8, --N(H)C(.dbd.O)NR.sup.9R.sup.10, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)NR.sup.9R.sup.10, --SR.sup.8, --S(.dbd.O)R.sup.8, --S(.dbd.O).sub.2R.sup.8, --S(.dbd.O).sub.2NR.sup.9R.sup.10, --NR.sup.9R.sup.10; R.sup.1 and R.sup.7 can form together a 5-6 membered ring which is optionally substituted with .dbd.O; R.sup.2, R.sup.3, R.sup.4, R.sup.6, represent hydrogen; R.sup.5, R.sup.7 represent, independently from each other, a substituent selected from hydrogen, halo-, hydroxyl-, cyano-, nitro-, or a substituent group selected from: C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkyl-, C.sub.1-C.sub.6-alkoxy-, halo-C.sub.1-C.sub.6-alkoxy-, C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, C.sub.3-C.sub.7-cycloalkyl-, 3- to 7-membered heterocycloalkyl-, aryl-, heteroaryl-, --C.sub.1-C.sub.6-alkylene-aryl, C.sub.1-C.sub.6-alkylene-aryl-, C.sub.1-C.sub.6-alkylene-heteroaryl-, --C.sub.1-C.sub.6-alkylene-C.sub.3-C.sub.7-cycloalkyl, --C.sub.1-C.sub.6-alkylene-(3- to 7-membered heterocycloalkyl), --OR.sup.8, --C(.dbd.O)H, --C(.dbd.O)R.sup.8, --C(.dbd.O)OH, --C(.dbd.O)O--C.sub.1-C.sub.6-alkyl, --C(.dbd.O)O--C.sub.3-C.sub.7-cycloalkyl, --OC(.dbd.O)--C.sub.1-C.sub.6-alkyl, --OC(.dbd.O)--C.sub.3-C.sub.7-cycloalkyl, --N(H)C(.dbd.O)R.sup.8, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)R.sup.8, --N(H)S(.dbd.O).sub.2R.sup.8, --N(C.sub.1-C.sub.6-alkyl)S(.dbd.O).sub.2R.sup.8, --C(.dbd.O)NR.sup.9R.sup.10, --OC(.dbd.O)NR.sup.9R.sup.10, --N(H)C(.dbd.O)OR.sup.8, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)OR.sup.8, --N(H)C(.dbd.O)NR.sup.9R.sup.10, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)NR.sup.9R.sup.10, --SR.sup.8, --S(.dbd.O)R.sup.8, --S(--C.sub.1-C.sub.6-alkylene-aryl, .dbd.O).sub.2R.sup.8, --S(.dbd.O).sub.2NR.sup.9R.sup.10, --NR.sup.9R.sup.10; wherein, when m or n represent, independently from each other, an integer of 2 or 3, then said substituent or substituent group is, independently from each other, identical or different; wherein said substituent group is optionally substituted one or more times, identically or differently, with a substituent selected from: halo-, hydroxyl-, cyano-, nitro-, C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkyl-, C.sub.1-C.sub.6-alkoxy-, halo-C.sub.1-C.sub.6-alkoxy-, hydroxy-C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, C.sub.3-C.sub.7-cycloalkyl-, 3- to 7-membered heterocycloalkyl-, aryl-, heteroaryl-, a 4- or 5-(1,3-benzodioxolinyl)- group, C.sub.1-C.sub.6-alkylene-aryl-, C.sub.1-C.sub.6-alkylene-heteroaryl-, --C.sub.1-C.sub.6-alkylene-C.sub.3-C.sub.7-cycloalkyl, --C.sub.1-C.sub.6-alkylene-(3- to 7-membered heterocycloalkyl), --C(.dbd.O)H, --C(.dbd.O)--C.sub.1-C.sub.6-alkyl, C(.dbd.O)OH, --C(.dbd.O)O--C.sub.1-C.sub.6-alkyl, --C(.dbd.O)O--C.sub.3-C.sub.7-cycloalkyl, --OC(.dbd.O)--C.sub.1-C.sub.6-alkyl, --OC(.dbd.O)--C.sub.3-C.sub.7-cycloalkyl, --N(H)C(.dbd.O)--C.sub.1-C.sub.6-alkyl, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)--C.sub.1-C.sub.6-alkyl, --N(H)S(.dbd.O).sub.2--C.sub.1-C.sub.6-alkyl, --N(C.sub.1-C.sub.6-alkyl)S(.dbd.O).sub.2--C.sub.1-C.sub.6-alkyl, --C(.dbd.O)NH.sub.2, --C(.dbd.O)N(H)C.sub.1-C.sub.6-alkyl, --C(.dbd.O)N(C.sub.1-C.sub.6-alkyl).sub.2, --OC(.dbd.O)N(H)C.sub.1-C.sub.6-alkyl, --OC(.dbd.O)N(C.sub.1-C.sub.6-alkyl).sub.2, --N(H)C(.dbd.O)O--C.sub.1-C.sub.6-alkyl, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)O--C.sub.1-C.sub.6-alkyl, --N(H)C(.dbd.O)NH.sub.2, --N(H)C(.dbd.O)N(H)C.sub.1-C.sub.6-alkyl, --N(H)C(.dbd.O)N(C.sub.1-C.sub.6-alkyl).sub.2, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)NH.sub.2, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)N(H)C.sub.1-C.sub.6-alkyl, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)N(C.sub.1-C.sub.6-alkyl).sub.2, --S--C.sub.1-C.sub.6-alkyl, --S(.dbd.O)--C.sub.1-C.sub.6-alkyl, --S(.dbd.O).sub.2--C.sub.1-C.sub.6-alkyl, --S(.dbd.O).sub.2NH.sub.2, --S(.dbd.O).sub.2N(H)C.sub.1-C.sub.6-alkyl, --S(.dbd.O).sub.2N(C.sub.1-C.sub.6-alkyl).sub.2, --NH.sub.2, --N(H)C.sub.1-C.sub.6-alkyl, --N(C.sub.1-C.sub.6-alkyl).sub.2;R.sub.8 represents a group selected from: C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkyl-, C.sub.1-C.sub.6-alkoxy-, halo-C.sub.1-C.sub.6-alkoxy-, C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, hydroxy-C.sub.1-C.sub.6-alkyl, C.sub.3-C.sub.7-cycloalkyl-, 3- to 7-membered heterocycloalkyl-, aryl-, heteroaryl-, C.sub.1-C.sub.6-alkylene-aryl-, C.sub.1-C.sub.6-alkylene-heteroaryl-, --C.sub.1-C.sub.6-alkylene-C.sub.3-C.sub.7-cycloalkyl, --C.sub.1-C.sub.6-alkylene-aryl, --C.sub.1-C.sub.6-alkylene-heteroaryl, --C.sub.1-C.sub.6-alkylene-(3- to 7-membered heterocycloalkyl), --NR.sup.9R.sup.10; wherein said group is optionally substituted one or more times, identically or differently, with a substituent selected from: halo-, hydroxyl-, cyano-, nitro-, C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkyl-, C.sub.1-C.sub.6-alkoxy-, halo-C.sub.1-C.sub.6-alkoxy-, hydroxy-C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, C.sub.3-C.sub.7-cycloalkyl-, 3- to 7-membered heterocycloalkyl-, aryl-, heteroaryl-, C.sub.1-C.sub.6-alkylene-aryl-, C.sub.1-C.sub.6-alkylene-heteroaryl-, --C.sub.1-C.sub.6-alkylene-C.sub.3-C.sub.7-cycloalkyl, --C.sub.1-C.sub.6-alkylene-(3- to 7-membered heterocycloalkyl), --C(.dbd.O)H, --C(.dbd.O)R.sup.11--, C(.dbd.O)OH, --C(.dbd.O)O--C.sub.1-C.sub.6-alkyl, --C(.dbd.O)O--C.sub.3-C.sub.7-cycloalkyl, --OC(.dbd.O)--C.sub.1-C.sub.6-alkyl, --OC(.dbd.O)--C.sub.3-C.sub.7-cycloalkyl, --N(H)C(.dbd.O)R.sup.11, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)R.sup.11, --N(H)S(.dbd.O).sub.2R.sup.11, --N(C.sub.1-C.sub.6-alkyl)S(.dbd.O).sub.2R.sup.11, --C(.dbd.O)NR.sup.9R.sup.10, --OC(.dbd.O)NR.sup.9R.sup.10, --N(H)C(.dbd.O)OR.sup.11, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)OR.sup.11, --N(H)C(.dbd.O)NR.sup.9R.sup.10, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)NR.sup.9R.sup.10, --SR.sup.11, --S(.dbd.O)R.sup.11, --S(.dbd.O).sub.2R.sup.11, --S(.dbd.O).sub.2NR.sup.9R.sup.10, --NR.sup.9R.sup.10; R.sup.9, R.sup.10 represent independently from each other hydrogen, or a group selected from: C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkyl-, C.sub.1-C.sub.6-alkoxy-, halo-C.sub.1-C.sub.6-alkoxy-, C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, C.sub.3-C.sub.7-cycloalkyl-, 3- to 7-membered heterocycloalkyl-, aryl-, heteroaryl-, --C.sub.1-C.sub.6-alkylene-aryl, C.sub.1-C.sub.6-alkylene-aryl-, C.sub.1-C.sub.6-alkylene-heteroaryl-, --C.sub.1-C.sub.6-alkylene-C.sub.3-C.sub.7-cycloalkyl, --C.sub.1-C.sub.6-alkylene-(3- to 7-membered heterocycloalkyl), R.sup.9 and R.sup.10 can form together a 5-7 saturated or partially unsaturated heterocyclic ring, which optionally further contains 1 heteroatom-containing group selected from O; R.sup.11 represents C.sub.1-C.sub.6-alkyl-; n, m represent, independently from each other, an integer of 0, 1, 2, or 3. 4. The compound according to claim 1, which is selected from the group consisting of: 7-(2-methoxy-phenyl)-2-morpholin-4-yl-quinoxaline; 2-(morpholin-4-yl)-7-phenylquinoxaline; 7-(2,4-dichlorophenyl)-2-(morpholin-4-yl)quinoxaline; 7-(3-methoxyphenyl)-2-(morpholin-4-yl)quinoxaline; 2-(morpholin-4-yl)-7-(4-phenoxyphenyl)quinoxaline; 7-(biphenyl-4-yl)-2-(morpholin-4-yl)quinoxaline; 7-(3-methylphenyl)-2-(morpholin-4-yl)quinoxaline; 7-(3-chlorophenyl)-2-(morpholin-4-yl)quinoxaline; 7-(3,4-dimethoxyphenyl)-2-(morpholin-4-yl)quinoxaline; 7-(3,5-dichlorophenyl)-2-(morpholin-4-yl)quinoxaline; 7-(4-methylphenyl)-2-(morpholin-4-yl)quinoxaline; 7-(2,4-dimethoxyphenyl)-2-(morpholin-4-yl)quinoxaline; 7-(2-fluoro-4-methylphenyl)-2-(morpholin-4-yl)quinoxaline; {4-[3-(morpholin-4-yl)quinoxalin-6-yl]phenyl}methanol; 4-[3-(morpholin-4-yl)quinoxalin-6-yl]benzonitrile; 7-(4-fluorophenyl)-2-(morpholin-4-yl)quinoxaline; 4-[3-(morpholin-4-yl)quinoxalin-6-yl]phenol; 2-(morpholin-4-yl)-7-[3-(trifluoromethyl)phenyl]quinoxaline; 7-(2-fluoro-5-methoxyphenyl)-2-(morpholin-4-yl)quinoxaline; 7-(5-fluoro-2-methoxyphenyl)-2-(morpholin-4-yl)quinoxaline; 7-[4-(methylsulfanyl)phenyl]-2-(morpholin-4-yl)quinoxaline; 1-{4-[3-(morpholin-4-yl)quinoxalin-6-yl]phenyl}ethanone; 7-(4-methoxy-2-methylphenyl)-2-(morpholin-4-yl)quinoxaline; 7-(4-tert-butylphenyl)-2-(morpholin-4-yl)quinoxaline; 7-(2,6-dimethoxyphenyl)-2-(morpholin-4-yl)quinoxaline; 2-(morpholin-4-yl)-7-(3-nitrophenyl)quinoxaline; 7-(4-chlorophenyl)-2-(morpholin-4-yl)quinoxaline; 7-(5-chloro-2-methoxyphenyl)-2-(morpholin-4-yl)quinoxaline; 7-(4-chloro-2-methylphenyl)-2-(morpholin-4-yl)quinoxaline; 1-{3-[3-(morpholin-4-yl)quinoxalin-6-yl]phenyl}ethanone; 7-[2-(methylsulfanyl)phenyl]-2-(morpholin-4-yl)quinoxaline; 2-(morpholin-4-yl)-7-[4-(propan-2-yl)phenyl]quinoxaline; 7-(3-fluorophenyl)-2-(morpholin-4-yl)quinoxaline; 2-(morpholin-4-yl)-7-[2-(trifluoromethoxy)phenyl]quinoxaline; 7-(biphenyl-3-yl)-2-(morpholin-4-yl)quinoxaline; 2-(morpholin-4-yl)-7-[3-(propan-2-yl)phenyl]quinoxaline; 2-(morpholin-4-yl)-7-(2-phenoxyphenyl)quinoxaline; {3-[3-(morpholin-4-yl)quinoxalin-6-yl]phenyl}methanol; 7-[3-(methylsulfanyl)phenyl]-2-(morpholin-4-yl)quinoxaline; 7-(2-chlorophenyl)-2-(morpholin-4-yl)quinoxaline; 2-(morpholin-4-yl)-7-[4-(trifluoromethoxy)phenyl]quinoxaline; 2-(morpholin-4-yl)-7-[4-(trifluoromethyl)phenyl]quinoxaline; 3-[3-(morpholin-4-yl)quinoxalin-6-yl]phenol; N,N-dimethyl-4-[3-(morpholin-4-yl)quinoxalin-6-yl]benzamide; 7-(3-chloro-4-methylphenyl)-2-(morpholin-4-yl)quinoxaline; N-methyl-3-[3-(morpholin-4-yl)quinoxalin-6-yl]benzamide; N-methyl-4-[3-(morpholin-4-yl)quinoxalin-6-yl]benzamide; N-{2-[3-(morpholin-4-yl)quinoxalin-6-yl]phenyl}acetamide; 7-(2-fluorophenyl)-2-(morpholin-4-yl)quinoxaline; 7-(4-ethoxyphenyl)-2-(morpholin-4-yl)quinoxaline; 7-(2,5-dimethoxyphenyl)-2-(morpholin-4-yl)quinoxaline; 7-(3-fluoro-4-methoxyphenyl)-2-(morpholin-4-yl)quinoxaline; 7-(2-methylphenyl)-2-(morpholin-4-yl)quinoxaline; 2-(morpholin-4-yl)-7-[3-(propan-2-yloxy)phenyl]quinoxaline; 2-(morpholin-4-yl)-7-(4-nitrophenyl)quinoxaline; 7-[2-(benzyloxy)phenyl]-2-(morpholin-4-yl)quinoxaline; N-{3-[3-(morpholin-4-yl)quinoxalin-6-yl]phenyl}methanesulfonamide; 2-(morpholin-4-yl)-7-[4-(propan-2-yloxy)phenyl]quinoxaline; N-{3-[3-(morpholin-4-yl)quinoxalin-6-yl]phenyl}acetamide; 7-(3,4-difluorophenyl)-2-(morpholin-4-yl)quinoxaline; 7-(4-methoxy-3,5-dimethylphenyl)-2-(morpholin-4-yl)quinoxaline; 7-(3,5-difluorophenyl)-2-(morpholin-4-yl)quinoxaline; 3-[3-(morpholin-4-yl)quinoxalin-6-yl]benzonitrile; 7-(2,4-difluorophenyl)-2-(morpholin-4-yl)quinoxaline; 7-(2,3-difluorophenyl)-2-(morpholin-4-yl)quinoxaline; 7-(2,5-difluorophenyl)-2-(morpholin-4-yl)quinoxaline; methyl 3-[3-(morpholin-4-yl)quinoxalin-6-yl]benzoate; 7-(2-fluoro-3-methoxyphenyl)-2-(morpholin-4-yl)quinoxaline; methyl 2-[3-(morpholin-4-yl)quinoxalin-6-yl]benzoate; 3-[3-(morpholin-4-yl)quinoxalin-6-yl]benzamide; 1-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-3-{4-[3-- (morpholin-4-yl)quinoxalin-6-yl]phenyl}urea; 7-(3,5-dimethylphenyl)-2-(morpholin-4-yl)quinoxaline; N-{4-[3-(morpholin-4-yl)quinoxalin-6-yl]phenyl}acetamide; 7-(3-fluoro-5-methoxyphenyl)-2-(morpholin-4-yl)quinoxaline; 7-(3,4-dichlorophenyl)-2-(morpholin-4-yl)quinoxaline; 7-[4-(methylsulfonyl)phenyl]-2-(morpholin-4-yl)quinoxaline; 2-chloro-N-cyclopropyl-4-[3-(morpholin-4-yl)quinoxalin-6-yl]benzamide; 2-chloro-N-methyl-4-[3-(morpholin-4-yl)quinoxalin-6-yl]benzamide; 7-[4-(2-methylpropoxy)phenyl]-2-(morpholin-4-yl)quinoxaline; 7-(2-chloro-5-methylphenyl)-2-(morpholin-4-yl)quinoxaline; N-{3-[3-(morpholin-4-yl)quinoxalin-6-yl]benzyl}acetamide; N-{4-[3-(morpholin-4-yl)quinoxalin-6-yl]benzyl}acetamide; 3-[3-(morpholin-4-yl)quinoxalin-6-yl]-N-phenylbenzamide; N-cyclopropyl-3-[3-(morpholin-4-yl)quinoxalin-6-yl]benzamide; 3-[3-(morpholin-4-yl)quinoxalin-6-yl]-N-(propan-2-yl)benzamide; N-benzyl-3-[3-(morpholin-4-yl)quinoxalin-6-yl]benzamide; {3-[3-(morpholin-4-yl)quinoxalin-6-yl]phenyl}(pyrrolidin-1-yl)methanone; N,N-diethyl-3-[3-(morpholin-4-yl)quinoxalin-6-yl]benzamide; 4-[3-(morpholin-4-yl)quinoxalin-6-yl]-N-phenylbenzamide; 7-[3-(methoxymethyl)phenyl]-2-(morpholin-4-yl)quinoxaline; {4-[3-(morpholin-4-yl)quinoxalin-6-yl]phenyl}(pyrrolidin-1-yl)methanone; 7-(2,3-dimethoxyphenyl)-2-(morpholin-4-yl)quinoxaline; 7-(2,4-dimethylphenyl)-2-(morpholin-4-yl)quinoxaline; 7-(2,5-dimethylphenyl)-2-(morpholin-4-yl)quinoxaline; 7-(2,3-dimethylphenyl)-2-(morpholin-4-yl)quinoxaline; 7-(2,5-dichlorophenyl)-2-(morpholin-4-yl)quinoxaline; 2-[3-(morpholin-4-yl)quinoxalin-6-yl]phenol; 7-(3-ethoxyphenyl)-2-(morpholin-4-yl)quinoxaline; 4-[3-(morpholin-4-yl)quinoxalin-6-yl]-N-(propan-2-yl)benzamide; N-cyclopropyl-4-[3-(morpholin-4-yl)quinoxalin-6-yl]benzamide; {4-[3-(morpholin-4-yl)quinoxalin-6-yl]phenyl}(piperidin-1-yl)methanone; 2-chloro-N-cyclopropyl-5-[3-(morpholin-4-yl)quinoxalin-6-yl]benzamide; 2-fluoro-5-[3-(morpholin-4-yl)quinoxalin-6-yl]-N-(propan-2-yl)benzamide; N,N-dimethyl-2-[3-(morpholin-4-yl)quinoxalin-6-yl]benzamide; 2-fluoro-4-[3-(morpholin-4-yl)quinoxalin-6-yl]-N-(propan-2-yl)benzamide; 7-[4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]-2-(morpholin-4-yl)quinoxaline- ; 7-[3-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]-2-(morpholin-4-yl)quinoxalin- e; 2,6-dimethyl-4-[3-(morpholin-4-yl)quinoxalin-6-yl]phenol; 3-[3-(morpholin-4-yl)quinoxalin-6-yl]benzoic acid; 7-(2-chloro-5-methoxyphenyl)-2-(morpholin-4-yl)quinoxaline; {2-[3-(morpholin-4-yl)quinoxalin-6-yl]phenyl}methanol; 7-(5-fluoro-2-methylphenyl)-2-(morpholin-4-yl)quinoxaline; N,N-dimethyl-3-[3-(morpholin-4-yl)quinoxalin-6-yl]benzamide; 4-[3-(morpholin-4-yl)quinoxalin-6-yl]benzamide; N-{2-[3-(morpholin-4-yl)quinoxalin-6-yl]phenyl}methanesulfonamide; 7-[2-(methylsulfonyl)phenyl]-2-(morpholin-4-yl)quinoxaline; 7-[3-(methylsulfonyl)phenyl]-2-(morpholin-4-yl)quinoxaline; 2-fluoro-4-[3-(morpholin-4-yl)quinoxalin-6-yl]benzonitrile; morpholin-4-yl{4-[3-(morpholin-4-yl)quinoxalin-6-yl]phenyl}methanone; N-benzyl-4-[3-(morpholin-4-yl)quinoxalin-6-yl]benzamide; 3-methyl-4-[3-(morpholin-4-yl)quinoxalin-6-yl]phenol; N,N-dimethyl-2-[3-(morpholin-4-yl)quinoxalin-6-yl]benzenesulfonamide; 5-{4-[3-(morpholin-4-yl)quinoxalin-6-yl]phenyl}imidazolidine-2,4-dione; {3-[3-(morpholin-4-yl)quinoxalin-6-yl]phenyl}(piperidin-1-yl)methanone; N,N-dimethyl-4-[3-(morpholin-4-yl)quinoxalin-6-yl]aniline; 2-(morpholin-4-yl)-7-[4-(morpholin-4-yl)phenyl]quinoxaline; N-[2-(dimethylamino)ethyl]-3-[3-(morpholin-4-yl)quinoxalin-6-yl]benzamide- ; N-{4-[3-(morpholin-4-yl)quinoxalin-6-yl]benzyl}methanesulfonamide; N-{3-[3-(morpholin-4-yl)quinoxalin-6-yl]benzyl}methanesulfonamide; 4-[3-(morpholin-4-yl)quinoxalin-6-yl]benzenesulfonamide; 3-[3-(morpholin-4-yl)quinoxalin-6-yl]benzenesulfonamide; N,N-dimethyl-4-[3-(morpholin-4-yl)quinoxalin-6-yl]benzenesulfonamide; N-methyl-4-[3-(morpholin-4-yl)quinoxalin-6-yl]benzenesulfonamide; N,N-dimethyl-3-[3-(morpholin-4-yl)quinoxalin-6-yl]benzenesulfonamide; N-cyclopropyl-4-[3-(morpholin-4-yl)quinoxalin-6-yl]benzenesulfonamide; N-methyl-3-[3-(morpholin-4-yl)quinoxalin-6-yl]benzenesulfonamide; {2-fluoro-5-[3-(morpholin-4-yl)quinoxalin-6-yl]phenyl}methanol; 2-fluoro-5-[3-(morpholin-4-yl)quinoxalin-6-yl]phenol; 2-methyl-4-[3-(morpholin-4-yl)quinoxalin-6-yl]aniline; 2-fluoro-4-[3-(morpholin-4-yl)quinoxalin-6-yl]phenol; 7-(2-methoxy-phenyl)-2-piperidin-1-yl-quinoxaline; 7-phenyl-2-(piperidin-1-yl)quinoxaline; 7-(2,4-dichlorophenyl)-2-(piperidin-1-yl)quinoxaline; 7-(3-methoxyphenyl)-2-(piperidin-1-yl)quinoxaline; 7-(4-phenoxyphenyl)-2-(piperidin-1-yl)quinoxaline; 7-(biphenyl-4-yl)-2-(piperidin-1-yl)quinoxaline; 7-(3-methylphenyl)-2-(piperidin-1-yl)quinoxaline; 7-(3-chlorophenyl)-2-(piperidin-1-yl)quinoxaline; 7-(3,4-dimethoxyphenyl)-2-(piperidin-1-yl)quinoxaline; 7-(3,5-dichlorophenyl)-2-(piperidin-1-yl)quinoxaline; 7-(4-methylphenyl)-2-(piperidin-1-yl)quinoxaline; 7-(2,4-dimethoxyphenyl)-2-(piperidin-1-yl)quinoxaline; 7-(2-fluoro-4-methylphenyl)-2-(piperidin-1-yl)quinoxaline; {4-[3-(piperidin-1-yl)quinoxalin-6-yl]phenyl}methanol; 4-[3-(piperidin-1-yl)quinoxalin-6-yl]benzonitrile; 7-(4-fluorophenyl)-2-(piperidin-1-yl)quinoxaline; 4-[3-(piperidin-1-yl)quinoxalin-6-yl]phenol; 2-(piperidin-1-yl)-7-[3-(trifluoromethyl)phenyl]quinoxaline; 7-(2-fluoro-5-methoxyphenyl)-2-(piperidin-1-yl)quinoxaline; 7-(5-fluoro-2-methoxyphenyl)-2-(piperidin-1-yl)quinoxaline; 7-[4-(methylsulfanyl)phenyl]-2-(piperidin-1-yl)quinoxaline; 1-{4-[3-(piperidin-1-yl)quinoxalin-6-yl]phenyl}ethanone; 7-(4-methoxy-2-methylphenyl)-2-(piperidin-1-yl)quinoxaline; 7-(4-tert-butylphenyl)-2-(piperidin-1-yl)quinoxaline; 7-(3-nitrophenyl)-2-(piperidin-1-yl)quinoxaline; 7-(4-chlorophenyl)-2-(piperidin-1-yl)quinoxaline; 7-(5-chloro-2-methoxyphenyl)-2-(piperidin-1-yl)quinoxaline; 7-(4-chloro-2-methylphenyl)-2-(piperidin-1-yl)quinoxaline; 1-{3-[3-(piperidin-1-yl)quinoxalin-6-yl]phenyl}ethanone; 7-[2-(methylsulfanyl)phenyl]-2-(piperidin-1-yl)quinoxaline; 2-(piperidin-1-yl)-7-[4-(propan-2-yl)phenyl]quinoxaline; 7-(3-fluorophenyl)-2-(piperidin-1-yl)quinoxaline; 2-(piperidin-1-yl)-7-[2-(trifluoromethoxy)phenyl]quinoxaline; 7-(biphenyl-3-yl)-2-(piperidin-1-yl)quinoxaline; 2-(piperidin-1-yl)-7-[3-(propan-2-yl)phenyl]quinoxaline; 7-(2-phenoxyphenyl)-2-(piperidin-1-yl)quinoxaline; {3-[3-(piperidin-1-yl)quinoxalin-6-yl]phenyl}methanol; 7-[3-(methylsulfanyl)phenyl]-2-(piperidin-1-yl)quinoxaline; 2-(piperidin-1-yl)-7-[2-(trifluoromethyl)phenyl]quinoxaline; 7-(2-chlorophenyl)-2-(piperidin-1-yl)quinoxaline; 2-(piperidin-1-yl)-7-[4-(trifluoromethoxy)phenyl]quinoxaline; 2-(piperidin-1-yl)-7-[4-(trifluoromethyl)phenyl]quinoxaline; 3-[3-(piperidin-1-yl)quinoxalin-6-yl]phenol; N,N-dimethyl-4-[3-(piperidin-1-yl)quinoxalin-6-yl]benzamide; 7-(3-chloro-4-methylphenyl)-2-(piperidin-1-yl)quinoxaline; N-methyl-3-[3-(piperidin-1-yl)quinoxalin-6-yl]benzamide; N-methyl-4-[3-(piperidin-1-yl)quinoxalin-6-yl]benzamide; N-{2-[3-(piperidin-1-yl)quinoxalin-6-yl]phenyl}acetamide; 7-(2-fluorophenyl)-2-(piperidin-1-yl)quinoxaline; 7-(4-ethoxyphenyl)-2-(piperidin-1-yl)quinoxaline; 7-(2,5-dimethoxyphenyl)-2-(piperidin-1-yl)quinoxaline; 7-(3-fluoro-4-methoxyphenyl)-2-(piperidin-1-yl)quinoxaline; 7-(2-methylphenyl)-2-(piperidin-1-yl)quinoxaline; 7-(2,6-dimethylphenyl)-2-(piperidin-1-yl)quinoxaline; 2-(piperidin-1-yl)-7-[3-(propan-2-yloxy)phenyl]quinoxaline; 7-(4-nitrophenyl)-2-(piperidin-1-yl)quinoxaline; 7-[2-(benzyloxy)phenyl]-2-(piperidin-1-yl)quinoxaline; N-{3-[3-(piperidin-1-yl)quinoxalin-6-yl]phenyl}methanesulfonamide; 2-(piperidin-1-yl)-7-[4-(propan-2-yloxy)phenyl]quinoxaline; N-{3-[3-(piperidin-1-yl)quinoxalin-6-yl]phenyl}acetamide; 7-(2,6-difluorophenyl)-2-(piperidin-1-yl)quinoxaline; 7-(3,4-difluorophenyl)-2-(piperidin-1-yl)quinoxaline; 7-(4-methoxy-3,5-dimethylphenyl)-2-(piperidin-1-yl)quinoxaline; 7-(3,5-difluorophenyl)-2-(piperidin-1-yl)quinoxaline; 3-[3-(piperidin-1-yl)quinoxalin-6-yl]benzonitrile; 7-(2,4-difluorophenyl)-2-(piperidin-1-yl)quinoxaline; 7-(2,3-difluorophenyl)-2-(piperidin-1-yl)quinoxaline; 7-(2,5-difluorophenyl)-2-(piperidin-1-yl)quinoxaline; methyl 3-[3-(piperidin-1-yl)quinoxalin-6-yl]benzoate; 7-(2-fluoro-3-methoxyphenyl)-2-(piperidin-1-yl)quinoxaline; methyl 2-[3-(piperidin-1-yl)quinoxalin-6-yl]benzoate; 3-[3-(piperidin-1-yl)quinoxalin-6-yl]benzamide; 1-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-3-{4-[3-- (piperidin-1-yl)quinoxalin-6-yl]phenyl}urea; 7-(3,5-dimethylphenyl)-2-(piperidin-1-yl)quinoxaline; N-{4-[3-(piperidin-1-yl)quinoxalin-6-yl]phenyl}acetamide; 7-(3-fluoro-5-methoxyphenyl)-2-(piperidin-1-yl)quinoxaline; 7-(3,4-dichlorophenyl)-2-(piperidin-1-yl)quinoxaline; 7-[4-(methylsulfonyl)phenyl]-2-(piperidin-1-yl)quinoxaline; 2-chloro-N-cyclopropyl-4-[3-(piperidin-1-yl)quinoxalin-6-yl]benzamide; 2-chloro-N-methyl-4-[3-(piperidin-1-yl)quinoxalin-6-yl]benzamide; 7-[4-(2-methylpropoxy)phenyl]-2-(piperidin-1-yl)quinoxaline; 7-(2-chloro-5-methylphenyl)-2-(piperidin-1-yl)quinoxaline; N-{3-[3-(piperidin-1-yl)quinoxalin-6-yl]benzyl}acetamide; N-{4-[3-(piperidin-1-yl)quinoxalin-6-yl]benzyl}acetamide; N-phenyl-3-[3-(piperidin-1-yl)quinoxalin-6-yl]benzamide; 3-[3-(piperidin-1-yl)quinoxalin-6-yl]-N-(propan-2-yl)benzamide; N-benzyl-3-[3-(piperidin-1-yl)quinoxalin-6-yl]benzamide; {3-[3-(piperidin-1-yl)quinoxalin-6-yl]phenyl}(pyrrolidin-1-yl)methanone; N,N-diethyl-3-[3-(piperidin-1-yl)quinoxalin-6-yl]benzamide; N-phenyl-4-[3-(piperidin-1-yl)quinoxalin-6-yl]benzamide; 7-[3-(methoxymethyl)phenyl]-2-(piperidin-1-yl)quinoxaline; {4-[3-(piperidin-1-yl)quinoxalin-6-yl]phenyl}(pyrrolidin-1-yl)methanone; 7-(2,3-dimethoxyphenyl)-2-(piperidin-1-yl)quinoxaline; 7-(2,4-dimethylphenyl)-2-(piperidin-1-yl)quinoxaline; 7-(2,5-dimethylphenyl)-2-(piperidin-1-yl)quinoxaline; 7-(2,3-dimethylphenyl)-2-(piperidin-1-yl)quinoxaline; 7-(2,5-dichlorophenyl)-2-(piperidin-1-yl)quinoxaline; 7-(2,3-dichlorophenyl)-2-(piperidin-1-yl)quinoxaline; 2-[3-(piperidin-1-yl)quinoxalin-6-yl]phenol; 7-(3-ethoxyphenyl)-2-(piperidin-1-yl)quinoxaline; 4-[3-(piperidin-1-yl)quinoxalin-6-yl]-N-(propan-2-yl)benzamide; N-cyclopropyl-4-[3-(piperidin-1-yl)quinoxalin-6-yl]benzamide; piperidin-1-yl{4-[3-(piperidin-1-yl)quinoxalin-6-yl]phenyl}methanone; 2-chloro-N-cyclopropyl-5-[3-(piperidin-1-yl)quinoxalin-6-yl]benzamide; 2-fluoro-5-[3-(piperidin-1-yl)quinoxalin-6-yl]-N-(propan-2-yl)benzamide; N,N-dimethyl-2-[3-(piperidin-1-yl)quinoxalin-6-yl]benzamide; 2-fluoro-4-[3-(piperidin-1-yl)quinoxalin-6-yl]-N-(propan-2-yl)benzamide; 7-[4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]-2-(piperidin-1-yl)quinoxaline- ; 2-(piperidin-1-yl)-7-[4-(1H-pyrrol-1-ylsulfonyl)phenyl]quinoxaline; 7-[3-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]-2-(piperidin-1-yl)quinoxaline- ; 7-(3,5-dimethoxyphenyl)-2-(piperidin-1-yl)quinoxaline; 2-(piperidin-1-yl)-7-[3-(1H-tetrazol-5-yl)phenyl]quinoxaline; 2,6-dimethyl-4-[3-(piperidin-1-yl)quinoxalin-6-yl]phenol; 3-[3-(piperidin-1-yl)quinoxalin-6-yl]benzoic acid; 7-(2-chloro-5-methoxyphenyl)-2-(piperidin-1-yl)quinoxaline; {2-[3-(piperidin-1-yl)quinoxalin-6-yl]phenyl}methanol; 7-(5-fluoro-2-methylphenyl)-2-(piperidin-1-yl)quinoxaline; N,N-dimethyl-3-[3-(piperidin-1-yl)quinoxalin-6-yl]benzamide; 4-[3-(piperidin-1-yl)quinoxalin-6-yl]benzamide; N-{2-[3-(piperidin-1-yl)quinoxalin-6-yl]phenyl}methanesulfonamide; 7-[3-(methylsulfonyl)phenyl]-2-(piperidin-1-yl)quinoxaline; 2-fluoro-4-[3-(piperidin-1-yl)quinoxalin-6-yl]benzonitrile; morpholin-4-yl{4-[3-(piperidin-1-yl)quinoxalin-6-yl]phenyl}methanone; N-benzyl-4-[3-(piperidin-1-yl)quinoxalin-6-yl]benzamide; 3-methyl-4-[3-(piperidin-1-yl)quinoxalin-6-yl]phenol; N,N-dimethyl-2-[3-(piperidin-1-yl)quinoxalin-6-yl]benzenesulfonamide; piperidin-1-yl{3-[3-(piperidin-1-yl)quinoxalin-6-yl]phenyl}methanone; N,N-dimethyl-4-[3-(piperidin-1-yl)quinoxalin-6-yl]aniline; 7-[4-(morpholin-4-yl)phenyl]-2-(piperidin-1-yl)quinoxaline; N-[2-(dimethylamino)ethyl]-3-[3-(piperidin-1-yl)quinoxalin-6-yl]benzamide- ; N-{4-[3-(piperidin-1-yl)quinoxalin-6-yl]benzyl}methanesulfonamide; N-{3-[3-(piperidin-1-yl)quinoxalin-6-yl]benzyl}methanesulfonamide; 4-[3-(piperidin-1-yl)quinoxalin-6-yl]benzenesulfonamide; 3-[3-(piperidin-1-yl)quinoxalin-6-yl]benzenesulfonamide; N,N-dimethyl-4-[3-(piperidin-1-yl)quinoxalin-6-yl]benzenesulfonamide; N-methyl-4-[3-(piperidin-1-yl)quinoxalin-6-yl]benzenesulfonamide; N,N-dimethyl-3-[3-(piperidin-1-yl)quinoxalin-6-yl]benzenesulfonamide; N-cyclopropyl-4-[3-(piperidin-1-yl)quinoxalin-6-yl]benzenesulfonamide; N-methyl-3-[3-(piperidin-1-yl)quinoxalin-6-yl]benzenesulfonamide; {2-fluoro-5-[3-(piperidin-1-yl)quinoxalin-6-yl]phenyl}methanol; 2-fluoro-5-[3-(piperidin-1-yl)quinoxalin-6-yl]phenol; 2-methyl-4-[3-(piperidin-1-yl)quinoxalin-6-yl]aniline; 2-phenyl-N-{4-[3-(piperidin-1-yl)quinoxalin-6-yl]phenyl}acetamide; 2-fluoro-4-[3-(piperidin-1-yl)quinoxalin-6-yl]phenol; 4-(3-pyrrolidin-1-yl-quinoxalin-6-yl)-phenol; 4-[3-(4-methylpiperazin-1-yl)quinoxalin-6-yl]phenol; 4-[3-(3-methylpiperidin-1-yl)quinoxalin-6-yl]phenol; 4-[3-(4-methylpiperidin-1-yl)quinoxalin-6-yl]phenol; 4-[3-(morpholin-4-yl)quinoxalin-6-yl]phenol; 4-[3-(4-phenylpiperazin-1-yl)quinoxalin-6-yl]phenol; 4-{3-[4-(pyridin-2-yl)piperazin-1-yl]quinoxalin-6-yl}phenol; benzyl 4-[7-(4-hydroxyphenyl)quinoxalin-2-yl]piperazine-1-carboxylate; 1-[7-(4-hydroxyphenyl)quinoxalin-2-yl]piperidine-3-carboxamide; 4-(3-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}quinoxalin-6-yl)phenol; 4-[3-(3,4-dihydroisoquinolin-2(1H)-yl)quinoxalin-6-yl]phenol; 4-[3-(4-benzylpiperazin-1-yl)quinoxalin-6-yl]phenol; 4-{3-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}phenol- ; 4-{3-[4-(2-phenylethyl)piperazin-1-yl]quinoxalin-6-yl}phenol; 4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}phenol; 4-(3-{4-[4-(trifluoromethyl)phenyl]piperazin-1-yl}quinoxalin-6-yl)phenol; 4-{3-[4-(pyrazin-2-yl)piperazin-1-yl]quinoxalin-6-yl}phenol; 4-(3-{4-[2-(dimethylamino)ethyl]piperazin-1-yl}quinoxalin-6-yl)phenol; 4-(3-{4-[2-(morpholin-4-yl)ethyl]piperazin-1-yl}quinoxalin-6-yl)phenol; 2-{4-[7-(4-hydroxyphenyl)quinoxalin-2-yl]piperazin-1-yl}-N,N-dimethylacet- amide; 4-(3-{4-[3-(morpholin-4-yl)propyl]piperazin-1-yl}quinoxalin-6-yl)ph- enol; 4-[3-(4-benzylpiperidin-1-yl)quinoxalin-6-yl]phenol; 4-[3-(4-methyl-1,4-diazepan-1-yl)quinoxalin-6-yl]phenol; 4-[3-(4-benzyl-1,4-diazepan-1-yl)quinoxalin-6-yl]phenol; 4-{3-[4-(2-phenylethyl)-1,4-diazepan-1-yl]quinoxalin-6-yl}phenol; 4-[3-(1,4'-bipiperidin-1'-yl)quinoxalin-6-yl]phenol; 4-{3-[4-(diphenylmethyl)piperazin-1-yl]quinoxalin-6-yl}phenol; 4-[3-(4-phenylpiperidin-1-yl)quinoxalin-6-yl]phenol; 1-{4-[7-(4-hydroxyphenyl)quinoxalin-2-yl]piperazin-1-yl}ethanone; 4-{3-[4-(methylsulfonyl)piperazin-1-yl]quinoxalin-6-yl}phenol; 4-{3-[4-(1-phenylethyl)piperazin-1-yl]quinoxalin-6-yl}phenol; 4-{3-[4-(2-phenoxyethyl)piperazin-1-yl]quinoxalin-6-yl}phenol; 4-{3-[4-(3-phenylpropyl)piperazin-1-yl]quinoxalin-6-yl}phenol; 4-{3-[4-(pyridin-2-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}phenol; 4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}phenol; {4-[7-(4-hydroxyphenyl)quinoxalin-2-yl]piperazin-1-yl}(pyrrolidin-1-yl)me- thanone; 4-{3-[4-(3-phenoxypropyl)piperazin-1-yl]quinoxalin-6-yl}phenol; 3-({4-[7-(4-hydroxyphenyl)quinoxalin-2-yl]piperazin-1-yl}methyl)benzonitr- ile; 4-({4-[7-(4-hydroxyphenyl)quinoxalin-2-yl]piperazin-1-yl}methyl)benzo- nitrile; methyl 4-[7-(4-hydroxyphenyl)quinoxalin-2-yl]piperazine-1-carboxylate; 3-{4-[7-(4-hydroxyphenyl)quinoxalin-2-yl]piperazin-1-yl}benzonitrile; N-[3-(3-morpholin-4-yl-quinoxalin-6-yl)-phenyl]-succinamide; N-{4-[3-(morpholin-4-yl)quinoxalin-6-yl]phenyl}cyclohexanecarboxamide; N-{4-[3-(morpholin-4-yl)quinoxalin-6-yl]phenyl}-2-phenylacetamide; N-{4-[3-(morpholin-4-yl)quinoxalin-6-yl]phenyl}benzamide; N-{4-[3-(morpholin-4-yl)quinoxalin-6-yl]phenyl}cyclopropanecarboxamide; N-{4-[3-(morpholin-4-yl)quinoxalin-6-yl]phenyl}pyridine-2-carboxamide; N-{4-[3-(morpholin-4-yl)quinoxalin-6-yl]phenyl}-1H-indole-2-carboxamide; N-{4-[3-(morpholin-4-yl)quinoxalin-6-yl]phenyl}furan-2-carboxamide; N-{4-[3-(morpholin-4-yl)quinoxalin-6-yl]phenyl}but-2-ynamide; N-{4-[3-(morpholin-4-yl)quinoxalin-6-yl]phenyl}propanamide; N-{4-[3-(morpholin-4-yl)quinoxalin-6-yl]phenyl}cyclopentanecarboxamide; N-{4-[3-(morpholin-4-yl)quinoxalin-6-yl]phenyl}-3-(trifluoromethyl)benzam- ide; N-{4-[3-(morpholin-4-yl)quinoxalin-6-yl]phenyl}-2-[3-(trifluoromethyl- )phenyl]acetamide; N-{4-[3-(morpholin-4-yl)quinoxalin-6-yl]phenyl}-3-[3-(trifluoromethyl)phe- nyl]propanamide; 2-cyclopropyl-N-{4-[3-(morpholin-4-yl)quinoxalin-6-yl]phenyl}acetamide; N-[3-(3-morpholin-4-yl-quinoxalin-6-yl)-phenyl]-3-trifluoromethyl-benzene- sulfonamide; N-{4-[3-(morpholin-4-yl)quinoxalin-6-yl]phenyl}benzenesulfonamide; 1-methyl-3-[3-(3-morpholin-4-yl-quinoxalin-6-yl)-phenyl]-urea; 1-methyl-3-{4-[3-(morpholin-4-yl)quinoxalin-6-yl]phenyl}urea; 1-{4-[3-(morpholin-4-yl)quinoxalin-6-yl]phenyl}-3-[3-(trifluoromethyl)phe- nyl]urea; 1-(2-fluorophenyl)-3-{4-[3-(morpholin-4-yl)quinoxalin-6-yl]pheny- l}urea; 1-{4-[3-(morpholin-4-yl)quinoxalin-6-yl]phenyl}-3-[4-(trifluoromet- hyl)phenyl]urea; 1-benzyl-3-{4-[3-(morpholin-4-yl)quinoxalin-6-yl]phenyl}urea; 1-{4-[3-(morpholin-4-yl)quinoxalin-6-yl]phenyl}-3-(2-phenylethyl)urea; 1-{4-[3-(morpholin-4-yl)quinoxalin-6-yl]phenyl}-3-pyridin-3-ylurea; 1-ethyl-3-{4-[3-(morpholin-4-yl)quinoxalin-6-yl]phenyl}urea; 1-[2-fluoro-5-(trifluoromethyl)phenyl]-3-{4-[3-(morpholin-4-yl)quinoxalin- -6-yl]phenyl}urea; 2-phenyl-N-{4-[3-(4-pyridin-4-yl-piperazin-1-yl)-quinoxalin-6-yl]-phenyl}- -acetamide; 2-(2-fluorophenyl)-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-y- l}phenyl)acetamide; 2-phenyl-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)p- ropanamide; 3-phenyl-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)p- ropanamide; 2-(pyridin-3-yl)-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}- phenyl)acetamide; 2-(pyridin-2-yl)-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}- phenyl)acetamide; 2-cyclopropyl-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}phe- nyl)acetamide; 3-(pyridin-4-yl)-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}- phenyl)propanamide; N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)cyclohexan- ecarboxamide; N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)benzamide; N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)propanamid- e; 2-hydroxy-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}pheny- l)acetamide; 4-fluoro-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)b- enzamide; 3-methyl-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl- }phenyl)butanamide; 4-(acetylamino)-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}p- henyl)benzamide; 1-methyl-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)-- 1H-indole-2-carboxamide; N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)butanediam- ide; 2-(4-chlorophenyl)-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin- -6-yl}phenyl)acetamide; 1-methyl-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)-- 1H-pyrrole-2-carboxamide; N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)hexanamide- ; 3-cyano-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)b- enzamide; 1-phenyl-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl- }phenyl)cyclopropanecarboxamide; 3-cyclohexyl-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}phen- yl)propanamide; N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)furan-3-ca- rboxamide; 2-(2-methoxyphenyl)-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]qui- noxalin-6-yl}phenyl)acetamide; N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)-3-(triflu- oromethyl)benzamide; 2-(2-chlorophenyl)-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-y- l}phenyl)acetamide; 2-methoxy-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)- acetamide; N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)- -2-(thiophen-2-yl)acetamide; 2-(biphenyl-4-yl)-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl- }phenyl)acetamide; N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)-4-(triflu- oromethyl)benzamide; 2-(1H-imidazol-4-yl)-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6- -yl}phenyl)acetamide; N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)-2-(thioph- en-3-yl)acetamide; N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)-2-[4-(tri- fluoromethyl)phenyl]acetamide; N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)-2-[2-(tri- fluoromethyl)phenyl]acetamide; 2-hydroxy-2-phenyl-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-y- l}phenyl)acetamide; N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)thiophene-- 3-carboxamide; 2-(3-fluorophenyl)-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-y- l}phenyl)acetamide; 5-oxo-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)prol- inamide; N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)-1- H-benzimidazole-5-carboxamide; 2-(1,3-benzodioxol-5-yl)-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxal- in-6-yl}phenyl)acetamide; 6-phenyl-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)h- exanamide; N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)- tetrahydrofuran-2-carboxamide; 2-(3-chlorophenyl)-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-y- l}phenyl)acetamide; 4-cyano-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)be- nzamide; N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)cy- clobutanecarboxamide; 2-(4-fluorophenyl)-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-y- l}phenyl)acetamide; 2-fluoro-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)b- enzamide; 3-fluoro-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl- }phenyl)benzamide; N-{4-[3-(Pyridin-4-yl-piperazin-1-yl)-quinoxalin-6-yl]-phenyl}-2-ure ido-acetamide; N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)pyridine-4- -carboxamide; 2-(1H-indol-3-yl)-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl- }phenyl)acetamide; 2-(3-methoxyphenyl)-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-- yl}phenyl)acetamide; 4-phenyl-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)b- utanamide; 1-methyl-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-y- l}phenyl)-1H-pyrazole-3-carboxamide; N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)cyclopenta- necarboxamide; N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)cyclopropa- necarboxamide; N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)thiophene-- 2-carboxamide; 2-(4-methylphenyl)-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-y- l}phenyl)acetamide; N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)-1H-pyrazo- le-3-carboxamide; 2-cyclohexyl-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}phen- yl)acetamide; 2-(4-methoxyphenyl)-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-- yl}phenyl)acetamide; 2-(2-methylphenyl)-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-y- l}phenyl)acetamide; 2-(3-methylphenyl)-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-y- l}phenyl)acetamide; 2-[4-(dimethylamino)phenyl]-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quino- xalin-6-yl}phenyl)acetamide; N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)tetrahydro- -2H-pyran-4-carboxamide; 5-chloro-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)t- hiophene-2-carboxamide; 3-hydroxy-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)- propanamide; N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)-1H-imidaz- ole-4-carboxamide; 3-cyclopropyl-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}phe- nyl)propanamide; N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)-2-(1H-tet- razol-5-yl)acetamide; 2-{4-[(methylsulfonyl)amino]phenyl}-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-- yl]quinoxalin-6-yl}phenyl)acetamide; 3-[(methylsulfonyl)amino]-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxa- lin-6-yl}phenyl)benzamide; 1-cyano-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)cy- clopropanecarboxamide; 2-[4-(acetylamino)phenyl]-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxa- lin-6-yl}phenyl)acetamide; N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)pyrimidine- -5-carboxamide; 2-(1,2-benzoxazol-3-yl)-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxali- n-6-yl}phenyl)acetamide; 4-(piperidin-1-yl)-N-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-y- l}phenyl)butanamide; 1-methyl-1-phenyl-3-{4-[3-(4-pyridin-4-yl-piperazin-1-yl)-quinoxalin-6-yl- ]-phenyl}-urea; 1-ethyl-1-methyl-3-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}- phenyl)urea; 1-cyclopropyl-3-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}phe- nyl)urea; 1-benzyl-1-methyl-3-(4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinox- alin-6-yl}phenyl)urea; 2-phenyl-N-{4-[3-(4-pyridin-3-ylmethyl-piperazin-1-yl)-quinoxalin-6-yl]-p- henyl}-acetamide; 2-(2-fluorophenyl)-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxal- in-6-yl}phenyl)acetamide; 2-phenyl-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}ph- enyl)propanamide; 3-phenyl-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}ph- enyl)propanamide; 2-(pyridin-3-yl)-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin- -6-yl}phenyl)acetamide; 2-(pyridin-2-yl)-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin- -6-yl}phenyl)acetamide; 2-cyclopropyl-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-- yl}phenyl)acetamide; 3-(pyridin-4-yl)-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin- -6-yl}phenyl)propanamide; N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)cycl- ohexanecarboxamide; N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)benz- amide; N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}pheny- l)propanamide; N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)pent- anamide; 2-hydroxy-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxali- n-6-yl}phenyl)acetamide; 4-fluoro-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}ph- enyl)benzamide; 3-methyl-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}ph- enyl)butanamide; 4-(acetylamino)-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-- 6-yl}phenyl)benzamide; 1-methyl-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}ph- enyl)-1H-indole-2-carboxamide; N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)buta- nediamide; 2-(4-chlorophenyl)-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-y- l]quinoxalin-6-yl}phenyl)acetamide; 1-methyl-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}ph- enyl)-1H-pyrrole-2-carboxamide; N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)hexa- namide; 3-cyano-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6- -yl}phenyl)benzamide; 1-phenyl-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}ph- enyl)cyclopropanecarboxamide; 3-cyclohexyl-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-y- l}phenyl)propanamide; N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)fura- n-3-carboxamide; 2-(2-methoxyphenyl)-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxa- lin-6-yl}phenyl)acetamide; N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)-3-(- trifluoromethyl)benzamide; 2-(2-chlorophenyl)-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxal- in-6-yl}phenyl)acetamide; 2-methyl-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}ph- enyl)butanamide; N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)-2-[- 3-(trifluoromethyl)phenyl]acetamide; 2-methoxy-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}p- henyl)acetamide; N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)-2-(- thiophen-2-yl)acetamide; 2-(biphenyl-4-yl)-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxali- n-6-yl}phenyl)acetamide; N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)-4-(- trifluoromethyl)benzamide; 6-amino-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}phe- nyl)pyridine-3-carboxamide; 2-(1H-imidazol-4-yl)-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinox- alin-6-yl}phenyl)acetamide; N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)-2-(- thiophen-3-yl)acetamide; N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)pent- -4-ynamide; N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)-2-[- 4-(trifluoromethyl)phenyl]acetamide; N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)-2-[- 2-(trifluoromethyl)phenyl]acetamide; 2-hydroxy-2-phenyl-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxal- in-6-yl}phenyl)acetamide; N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)thio- phene-3-carboxamide; 2-(3-fluorophenyl)-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxal- in-6-yl}phenyl)acetamide; 2-hydroxy-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}p- henyl)propanamide; 5-oxo-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}pheny- l)prolinamide; N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)-1H-- benzimidazole-5-carboxamide; N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)but-- 2-ynamide; 2-(1,3-benzodioxol-5-yl)-N-(4-{3-[4-(pyridin-3-ylmethyl)piperaz- in-1-yl]quinoxalin-6-yl}phenyl)acetamide; 6-phenyl-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}ph- enyl)hexanamide; N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)tetr- ahydrofuran-2-carboxamide; 2-(3-chlorophenyl)-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxal- in-6-yl}phenyl)acetamide; 4-cyano-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}phe- nyl)benzamide; N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)cycl- obutanecarboxamide; 2-(4-fluorophenyl)-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxal- in-6-yl}phenyl)acetamide; N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)fura- n-2-carboxamide; 2-fluoro-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}ph- enyl)benzamide; 3-fluoro-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}ph- enyl)benzamide; N-{4-[3-(4-Pyridin-3-ylmethyl-piperazin-1-yl)-quinoxalin-6-yl]-phenyl}-2-- ureido-acetamide; N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)pyri- dine-4-carboxamide; 2-(1H-indol-3-yl)-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxali- n-6-yl}phenyl)acetamide; 2-(3-methoxyphenyl)-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxa- lin-6-yl}phenyl)acetamide; N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)pyri- dine-3-carboxamide; 2,6-dioxo-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}p- henyl)-1,2,3,6-tetrahydropyrimidine-4-carboxamide; 4-phenyl-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}ph- enyl)butanamide; N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)pyri- dine-2-carboxamide; N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)pyra- zine-2-carboxamide; N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)cycl- opentanecarboxamide; N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)cycl- opropanecarboxamide; N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)thio- phene-2-carboxamide; 2-(4-methylphenyl)-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxal- in-6-yl}phenyl)acetamide; N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)-1H-- pyrazole-3-carboxamide; N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)pyri- dazine-4-carboxamide; 2-cyclohexyl-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-y- l}phenyl)acetamide; 2-(4-methoxyphenyl)-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxa- lin-6-yl}phenyl)acetamide; 2-(2-methylphenyl)-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxal- in-6-yl}phenyl)acetamide; 2-(3-methylphenyl)-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxal- in-6-yl}phenyl)acetamide; 2-[4-(dimethylamino)phenyl]-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl- ]quinoxalin-6-yl}phenyl)acetamide; N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)tetr- ahydro-2H-pyran-4-carboxamide; 5-chloro-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}ph- enyl)thiophene-2-carboxamide; 2-(3-methyl-1,2-oxazol-5-yl)-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-y- l]quinoxalin-6-yl}phenyl)acetamide; 3-hydroxy-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}p- henyl)propanamide; N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)-1H-- imidazole-4-carboxamide; 3-cyclopropyl-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-- yl}phenyl)propanamide; N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)-2-(- 1H-tetrazol-5-yl)acetamide; 2-{4-[(methylsulfonyl)amino]phenyl}-N-(4-{3-[4-(pyridin-3-ylmethyl)pipera- zin-1-yl]quinoxalin-6-yl}phenyl)acetamide; 3-[(methylsulfonyl)amino]-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]q- uinoxalin-6-yl}phenyl)benzamide; N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)-3-s- ulfamoylbenzamide; 2-[4-(acetylamino)phenyl]-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]q- uinoxalin-6-yl}phenyl)acetamide; 2-(4-cyanophenyl)-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxali- n-6-yl}phenyl)acetamide; N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)pyri- midine-5-carboxamide; 2-(1,2-benzoxazol-3-yl)-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]qui- noxalin-6-yl}phenyl)acetamide; 2-(3-cyanophenyl)-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxali- n-6-yl}phenyl)acetamide; 4-(piperidin-1-yl)-N-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxal- in-6-yl}phenyl)butanamide; 1-methyl-1-phenyl-3-{4-[3-(4-pyridin-3-ylmethyl-piperazin-1-yl)-quinoxali- n-6-yl]-phenyl}-urea; 1-pyridin-2-yl-3-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6- -yl}phenyl)urea; 1-pyridin-3-yl-3-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6- -yl}phenyl)urea; 1-pyridin-4-yl-3-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6- -yl}phenyl)urea; 1-cyclopropyl-3-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-- yl}phenyl)urea; 1-benzyl-1-methyl-3-(4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxali- n-6-yl}phenyl)urea; 2-phenyl-N-{4-[3-(2,3,5,6-tetrahydro-[1,2']bipyrazinyl-4-yl)-quinoxalin-6- -yl]-phenyl}-acetamide; 2-(2-fluorophenyl)-N-(4-{3-[4-(pyrazin-2-yl)piperazin-1-yl]quinoxalin-6-y- l}phenyl)acetamide; 2-phenyl-N-(4-{3-[4-(pyrazin-2-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)p- ropanamide; 3-phenyl-N-(4-{3-[4-(pyrazin-2-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)p- ropanamide; N-(4-{3-[4-(pyrazin-2-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)-2-(pyridi- n-3-yl)acetamide; N-(4-{3-[4-(pyrazin-2-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)-2-(pyridi- n-2-yl)acetamide; 2-cyclopropyl-N-(4-{3-[4-(pyrazin-2-yl)piperazin-1-yl]quinoxalin-6-yl}phe- nyl)acetamide; N-(4-{3-[4-(pyrazin-2-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)benzamide; N-(4-{3-[4-(pyrazin-2-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)pentanamid- e; N-(4-{3-[4-(pyrazin-2-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)hexanami- de; 3-cyano-N-(4-{3-[4-(pyrazin-2-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl- )benzamide; 2-methyl-N-(4-{3-[4-(pyrazin-2-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)b- utanamide; N-(4-{3-[4-(pyrazin-2-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)- -2-(thiophen-3-yl)acetamide; 2-(1,3-benzodioxol-5-yl)-N-(4-{3-[4-(pyrazin-2-yl)piperazin-1-yl]quinoxal- in-6-yl}phenyl)acetamide; 6-phenyl-N-(4-{3-[4-(pyrazin-2-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)h- exanamide; N-(4-{3-[4-(pyrazin-2-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)- tetrahydrofuran-2-carboxamide; 4-cyano-N-(4-{3-[4-(pyrazin-2-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)be- nzamide; N-(4-{3-[4-(pyrazin-2-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)cy- clobutanecarboxamide; 2-(3-methoxyphenyl)-N-(4-{3-[4-(pyrazin-2-yl)piperazin-1-yl]quinoxalin-6-- yl}phenyl)acetamide; N-(4-{3-[4-(pyrazin-2-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)pyridine-3- -carboxamide; N-(4-{3-[4-(pyrazin-2-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)pyridine-2- -carboxamide; 1-methyl-N-(4-{3-[4-(pyrazin-2-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)-- 1H-pyrazole-3-carboxamide; N-(4-{3-[4-(pyrazin-2-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)cyclopenta- necarboxamide; 2-(4-methylphenyl)-N-(4-{3-[4-(pyrazin-2-yl)piperazin-1-yl]quinoxalin-6-y- l}phenyl)acetamide; N-(4-{3-[4-(pyrazin-2-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)-1H-pyrazo- le-3-carboxamide; 2-(4-methoxyphenyl)-N-(4-{3-[4-(pyrazin-2-yl)piperazin-1-yl]quinoxalin-6-- yl}phenyl)acetamide; N-(4-{3-[4-(pyrazin-2-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl)pyrimidine- -5-carboxamide; 2-(1,2-benzoxazol-3-yl)-N-(4-{3-[4-(pyrazin-2-yl)piperazin-1-yl]quinoxali- n-6-yl}phenyl)acetamide; 1-benzyl-3-{4-[3-(2,3,5,6-tetrahydro-[1,2']bipyrazinyl-4-yl)-quinoxalin-6- -yl]-phenyl}-urea; 2,6-dimethyl-4-[3-(4-methyl-piperazin-1-yl)-quinoxalin-6-yl]-phenol; 4-[3-(4-benzylpiperazin-1-yl)quinoxalin-6-yl]-2,6-dimethylphenol; 4-[3-(4-benzylpiperidin-1-yl)quinoxalin-6-yl]-2,6-dimethylphenol; 2,6-dimethyl-4-(3-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}quinoxalin- -6-yl)phenol; 4-[3-(1,4'-bipiperidin-1'-yl)quinoxalin-6-yl]-2,6-dimethylphenol; 2,6-dimethyl-4-{3-[4-(pyridin-2-yl)piperazin-1-yl]quinoxalin-6-yl}phenol; 4-{3-[4-(4-fluorophenyl)piperazin-1-yl]quinoxalin-6-yl}-2,6-dimethylpheno- l; 4-{3-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}-2,6- -dimethylphenol; 1-{4-[7-(4-hydroxy-3,5-dimethylphenyl)quinoxalin-2-yl]piperazin-1-yl}etha- none; ethyl 4-[7-(4-hydroxy-3,5-dimethylphenyl)quinoxalin-2-yl]piperazine-1-carboxyla- te; 4-{3-[4-(2-methoxyphenyl)piperazin-1-yl]quinoxalin-6-yl}-2,6-dimethylp- henol; 1-[7-(4-hydroxy-3,5-dimethylphenyl)quinoxalin-2-yl]piperidine-3-car- boxamide; 2,6-dimethyl-4-[3-(4-phenylpiperazin-1-yl)quinoxalin-6-yl]phenol- ; 2,6-dimethyl-4-[3-(pyrrolidin-1-yl)quinoxalin-6-yl]phenol; 4-{3-[4-(diphenylmethyl)piperazin-1-yl]quinoxalin-6-yl}-2,6-dimethylpheno- l; 4-[3-(3,4-dihydroisoquinolin-2(1H)-yl)quinoxalin-6-yl]-2,6-dimethylphen- ol; 2,6-dimethyl-4-{3-[4-(2-methylphenyl)piperazin-1-yl]quinoxalin-6-yl}ph- enol; 2,6-dimethyl-4-{3-[4-(3-methylphenyl)piperazin-1-yl]quinoxalin-6-yl}- phenol; 4-{3-[4-(4-methoxyphenyl)piperazin-1-yl]quinoxalin-6-yl}-2,6-dimet- hylphenol; 2,6-dimethyl-4-{3-[4-(4-methylphenyl)piperazin-1-yl]quinoxalin-- 6-yl}phenol; 2,6-dimethyl-4-{3-[4-(1-phenylethyl)piperazin-1-yl]quinoxalin-6-yl}phenol- ; 2,6-dimethyl-4-{3-[4-(2-phenylethyl)piperazin-1-yl]quinoxalin-6-yl}pheno- l; 2,6-dimethyl-4-{3-[4-(pyridin-4-yl)piperazin-1-yl]quinoxalin-6-yl}pheno- l; 2,6-dimethyl-4-{3-[4-(pyrazin-2-yl)piperazin-1-yl]quinoxalin-6-yl}pheno- l; 2-{4-[7-(4-hydroxy-3,5-dimethylphenyl)quinoxalin-2-yl]piperazin-1-yl}-N- -methyl-N-phenylacetamide; 2,6-dimethyl-4-[3-(4-methyl-1,4-diazepan-1-yl)quinoxalin-6-yl]phenol; 4-[3-(4-ethylpiperazin-1-yl)quinoxalin-6-yl]-2,6-dimethylphenol; 4-{3-[4-(2-chlorobenzyl)piperazin-1-yl]quinoxalin-6-yl}-2,6-dimethylpheno- l; 4-(3-{4-[3-(dimethylamino)propyl]piperazin-1-yl}quinoxalin-6-yl)-2,6-di- methylphenol; 2,6-dimethyl-4-[3-(4-methyl-2-phenylpiperazin-1-yl)quinoxalin-6-yl]phenol- ; 2,6-dimethyl-4-{3-[4-(2-phenoxyethyl)piperazin-1-yl]quinoxalin-6-yl}phen- ol; 2,6-dimethyl-4-{3-[3-(pyridin-3-yl)pyrrolidin-1-yl]quinoxalin-6-yl}phe- nol; 2,6-dimethyl-4-{3-[3-(trifluoromethyl)pyrrolidin-1-yl]quinoxalin-6-yl- }phenol; {4-[7-(4-hydroxy-3,5-dimethylphenyl)quinoxalin-2-yl]piperazin-1-y- l}(pyrrolidin-1-yl)methanone; 2,6-dimethyl-4-{3-[4-(3-phenoxypropyl)piperazin-1-yl]quinoxalin-6-yl}phen- ol; 2,6-dimethyl-4-[3-(4-phenylpiperidin-1-yl)quinoxalin-6-yl]phenol; 4-(3-{4-[2-(dimethylamino)ethyl]piperazin-1-yl}quinoxalin-6-yl)-2,6-dimet- hylphenol; 2,6-dimethyl-4-{3-[4-(pyrimidin-2-yl)piperazin-1-yl]quinoxalin-- 6-yl}phenol; 4-{3-[4-(2-methoxyethyl)piperazin-1-yl]quinoxalin-6-yl}-2,6-dimethylpheno- l; 2,6-dimethyl-4-(3-{4-[2-(morpholin-4-yl)ethyl]piperazin-1-yl}quinoxalin- -6-yl)phenol; benzyl 4-[7-(4-hydroxy-3,5-dimethylphenyl)quinoxalin-2-yl]piperazine-1-carboxyla- te; 4-[3-(4-fluoropiperidin-1-yl)quinoxalin-6-yl]-2,6-dimethylphenol; 2,6-dimethyl-4-{3-[4-(3-phenylpropyl)piperazin-1-yl]quinoxalin-6-yl}pheno- l; 4-{4-[7-(4-hydroxy-3,5-dimethylphenyl)quinoxalin-2-yl]piperazin-1-yl}be- nzonitrile; 2-{4-[7-(4-hydroxy-3,5-dimethylphenyl)quinoxalin-2-yl]piperazin-1-yl}-N,N- -dimethylacetamide; 4-{3-[4-(4-fluorobenzyl)piperazin-1-yl]quinoxalin-6-yl}-2,6-dimethylpheno- l; 2,6-dimethyl-4-(3-{4-[2-(pyrrolidin-1-yl)ethyl]piperazin-1-yl}quinoxali- n-6-yl)phenol; 3-({4-[7-(4-hydroxy-3,5-dimethylphenyl)quinoxalin-2-yl]piperazin-1-yl}met- hyl)benzonitrile; 4-({4-[7-(4-hydroxy-3,5-dimethylphenyl)quinoxalin-2-yl]piperazin-1-yl}met- hyl)benzonitrile; 4-[3-(4-benzyl-1,4-diazepan-1-yl)quinoxalin-6-yl]-2,6-dimethylphenol; 2,6-dimethyl-4-(3-{4-[3-(morpholin-4-yl)propyl]piperazin-1-yl}quinoxalin-- 6-yl)phenol; 2,6-dimethyl-4-{3-[4-(2-phenylethyl)-1,4-diazepan-1-yl]quinoxalin-6-yl}ph- enol; 2,6-dimethyl-4-(3-{4-[3-(pyrrolidin-1-yl)propyl]piperazin-1-yl}quino- xalin-6-yl)phenol; 4-[7-(4-hydroxy-3,5-dimethylphenyl)quinoxalin-2-yl]morpholine-2-carbonitr- ile; 1-[7-(4-hydroxy-3,5-dimethylphenyl)quinoxalin-2-yl]piperidine-3-carbo- nitrile; 2,6-dimethyl-4-[3-(2-phenylpyrrolidin-1-yl)quinoxalin-6-yl]phenol- ; 2,6-dimethyl-4-{3-[3-(pyridin-4-yl)pyrrolidin-1-yl]quinoxalin-6-yl}pheno- l; 4-{3-[4-(3-methoxypropyl)piperazin-1-yl]quinoxalin-6-yl}-2,6-dimethylph- enol; 2,6-dimethyl-4-{3-[4-(pyridin-2-ylmethyl)piperazin-1-yl]quinoxalin-6- -yl}phenol; 2,6-dimethyl-4-{3-[4-(pyridin-3-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}p- henol; 2,6-dimethyl-4-(3-{4-[(1-methylpiperidin-3-yl)methyl]piperazin-1-yl- }quinoxalin-6-yl)phenol; 4-{3-[4-(ethylsulfonyl)piperazin-1-yl]quinoxalin-6-yl}-2,6-dimethylphenol- ; 4-[3-(4,4-dimethylpiperidin-1-yl)quinoxalin-6-yl]-2,6-dimethylphenol; 4-[3-(3,3-difluoroazetidin-1-yl)quinoxalin-6-yl]-2,6-dimethylphenol; 4-{3-[2-(hydroxymethyl)pyrrolidin-1-yl]quinoxalin-6-yl}-2,6-dimethylpheno- l; 4-[3-(3-methoxyazetidin-1-yl)quinoxalin-6-yl]-2,6-dimethylphenol; 4-{3-[4-(3-chlorobenzyl)piperazin-1-yl]quinoxalin-6-yl}-2,6-dimethylpheno- l; 2,6-dimethyl-4-{3-[4-(methylsulfonyl)piperazin-1-yl]quinoxalin-6-yl}phe- nol; 4-[3-(hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)quinoxalin-6-yl]-2,6-di- methylphenol; 4-{3-[4-(2-fluorobenzyl)piperazin-1-yl]quinoxalin-6-yl}-2,6-dimethylpheno- l; 1-[7-(4-hydroxy-3,5-dimethylphenyl)quinoxalin-2-yl]pyrrolidin-3-ol; 1-[7-(4-hydroxy-3,5-dimethylphenyl)quinoxalin-2-yl]piperidine-4-carbonitr- ile; Methyl 4-[7-(4-hydroxy-3,5-dimethylphenyl)quinoxalin-2-yl]piperazine-1-carboxyla- te; 4-[3-(hexahydrocyclopenta[c]pyrrol-2(1H)-yl)quinoxalin-6-yl]-2,6-dimet- hylphenol; 2-[7-(4-hydroxy-3,5-dimethylphenyl)quinoxalin-2-yl]hexahydropyr- rolo[1,2-a]pyrazin-6(2H)-one; 4-[3-(3-benzylazetidin-1-yl)quinoxalin-6-yl]-2,6-dimethylphenol; 2,6-dimethyl-4-{3-[3-(piperidin-1-yl)azetidin-1-yl]quinoxalin-6-yl}phenol- ; 1-[7-(4-hydroxy-3,5-dimethylphenyl)quinoxalin-2-yl]azetidine-3-carbonitr- ile; 4-{3-[3-(hydroxymethyl)pyrrolidin-1-yl]quinoxalin-6-yl}-2,6-dimethylp- henol; 2,6-dimethyl-4-{3-[3-(1H-pyrazol-1-yl)azetidin-1-yl]quinoxalin-6-yl- }phenol; N-{4-[3-(4-benzylpiperazin-1-yl)quinoxalin-6-yl]phenyl}-2-phenyla- cetamide; N-{4-[3-(1,4'-bipiperidin-1'-yl)quinoxalin-6-yl]phenyl}-2-phenyl- acetamide; 2-phenyl-N-(4-{3-[4-(pyridin-2-yl)piperazin-1-yl]quinoxalin-6-y- l}phenyl)acetamide; N-(4-{3-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}phe- nyl)-2-phenylacetamide; N-{4-[3-(4-acetylpiperazin-1-yl)quinoxalin-6-yl]phenyl}-2-phenylacetamide- ; ethyl 4-(7-{4-[(phenylacetyl)amino]phenyl}quinoxalin-2-yl)piperazine-1-c- arboxylate; N-(4-{3-[4-(2-methoxyphenyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)-2-phen- ylacetamide; N-{4-[3-(3-methylpiperidin-1-yl)quinoxalin-6-yl]phenyl}-2-phenylacetamide- ; 1-(7-{4-[(phenylacetyl)amino]phenyl}quinoxalin-2-yl)piperidine-3-carboxa- mide; 2-phenyl-N-{4-[3-(4-phenylpiperazin-1-yl)quinoxalin-6-yl]phenyl}acet- amide; 2-phenyl-N-{4-[3-(pyrrolidin-1-yl)quinoxalin-6-yl]phenyl}acetamide; N-(4-{3-[4-(diphenylmethyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)-2-pheny- lacetamide; N-{4-[3-(3,4-dihydroisoquinolin-2(1H)-yl)quinoxalin-6-yl]phenyl}-2-phenyl- acetamide; N-(4-{3-[4-(3-methoxyphenyl)piperazin-1-yl]quinoxalin-6-yl}phen- yl)-2-phenylacetamide; N-(4-{3-[4-(3-methylphenyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)-2-pheny- lacetamide; N-(4-{3-[4-(4-methoxyphenyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)-2-phen- ylacetamide; N-(4-{3-[4-(4-methylphenyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)-2-pheny- lacetamide; 2-phenyl-N-(4-{3-[4-(1-phenylethyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)- acetamide; 2-phenyl-N-(4-{3-[4-(2-phenylethyl)piperazin-1-yl]quinoxalin-6-- yl}phenyl)acetamide; 2-phenyl-N-[4-(3-{4-[4-(trifluoromethyl)phenyl]piperazin-1-yl}quinoxalin-- 6-yl)phenyl]acetamide; N-methyl-N-phenyl-2-[4-(7-{4-[(phenylacetyl)amino]phenyl}quinoxalin-2-yl)- piperazin-1-yl]acetamide; N-{4-[3-(4-methyl-1,4-diazepan-1-yl)quinoxalin-6-yl]phenyl}-2-phenylaceta- mide; N-{4-[3-(4-ethylpiperazin-1-yl)quinoxalin-6-yl]phenyl}-2-phenylaceta- mide; N-(4-{3-[4-(2-chlorobenzyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)-2-- phenylacetamide; N-[4-(3-{4-[3-(dimethylamino)propyl]piperazin-1-yl}quinoxalin-6-yl)phenyl- ]-2-phenylacetamide; N-{4-[3-(4-methyl-2-phenylpiperazin-1-yl)quinoxalin-6-yl]phenyl}-2-phenyl- acetamide; N-(4-{3-[2-(hydroxymethyl)morpholin-4-yl]quinoxalin-6-yl}phenyl- )-2-phenylacetamide; N-(4-{3-[4-(2-phenoxyethyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)-2-pheny- lacetamide; 2-phenyl-N-(4-{3-[3-(pyridin-3-yl)pyrrolidin-1-yl]quinoxalin-6-yl}phenyl)- acetamide; 2-phenyl-N-(4-{3-[3-(trifluoromethyl)pyrrolidin-1-yl]quinoxalin- -6-yl}phenyl)acetamide; 2-phenyl-N-(4-{3-[4-(pyrrolidin-1-ylcarbonyl)piperazin-1-yl]quinoxalin-6-- yl}phenyl)acetamide; N-(4-{3-[4-(3-phenoxypropyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)-2-phen- ylacetamide; 2-phenyl-N-{4-[3-(4-phenylpiperidin-1-yl)quinoxalin-6-yl]phenyl}acetamide- ; N-[4-(3-{4-[2-(dimethylamino)ethyl]piperazin-1-yl}quinoxalin-6-yl)phenyl- ]-2-phenylacetamide; 2-phenyl-N-(4-{3-[4-(pyrimidin-2-yl)piperazin-1-yl]quinoxalin-6-yl}phenyl- )acetamide; N-(4-{3-[4-(2-methoxyethyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)-2-pheny- lacetamide; N-[4-(3-{4-[2-(morpholin-4-yl)ethyl]piperazin-1-yl}quinoxalin-6-yl)phenyl- ]-2-phenylacetamide; benzyl 4-(7-{4-[(phenylacetyl)amino]phenyl}quinoxalin-2-yl)piperazine-1-carboxyl- ate; N-{4-[3-(4-fluoropiperidin-1-yl)quinoxalin-6-yl]phenyl}-2-phenylaceta- mide; 2-phenyl-N-(4-{3-[4-(3-phenylpropyl)piperazin-1-yl]quinoxalin-6-yl}p- henyl)acetamide; N-(4-{3-[4-(4-cyanophenyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)-2-phenyl- acetamide; N,N-dimethyl-2-[4-(7-{4-[(phenylacetyl)amino]phenyl}quinoxalin-- 2-yl)piperazin-1-yl]acetamide; N-(4-{3-[4-(4-fluorobenzyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)-2-pheny- lacetamide; 2-phenyl-N-[4-(3-{4-[2-(pyrrolidin-1-yl)ethyl]piperazin-1-yl}quinoxalin-6- -yl)phenyl]acetamide; N-(4-{3-[4-(3-cyanobenzyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)-2-phenyl- acetamide; N-(4-{3-[4-(4-cyanobenzyl)piperazin-1-yl]quinoxalin-6-yl}phenyl- )-2-phenylacetamide; N-{4-[3-(4-benzyl-1,4-diazepan-1-yl)quinoxalin-6-yl]phenyl}-2-phenylaceta- mide; 2-phenyl-N-(4-{3-[4-(2-phenylethyl)-1,4-diazepan-1-yl]quinoxalin-6-y- l}phenyl)acetamide; 2-phenyl-N-[4-(3-{4-[3-(pyrrolidin-1-yl)propyl]piperazin-1-yl}quinoxalin-- 6-yl)phenyl]acetamide; N-{4-[3-(2-cyanomorpholin-4-yl)quinoxalin-6-yl]phenyl}-2-phenylacetamide; 2-phenyl-N-{4-[3-(2-phenylpyrrolidin-1-yl)quinoxalin-6-yl]phenyl}acetamid- e; 2-phenyl-N-(4-{3-[3-(pyridin-4-yl)pyrrolidin-1-yl]quinoxalin-6-yl}pheny- l)acetamide; N-(4-{3-[4-(3-methoxypropyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)-2-phen- ylacetamide; 2-phenyl-N-(4-{3-[4-(pyridin-2-ylmethyl)piperazin-1-yl]quinoxalin-6-yl}ph- enyl)acetamide; N-[4-(3-{4-[(1-methylpiperidin-3-yl)methyl]piperazin-1-yl}quinoxalin-6-yl- )phenyl]-2-phenylacetamide; N-(4-{3-[4-(ethylsulfonyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)-2-phenyl- acetamide; N-{4-[3-(4,4-dimethylpiperidin-1-yl)quinoxalin-6-yl]phenyl}-2-p- henylacetamide; N-{4-[3-(3,3-difluoroazetidin-1-yl)quinoxalin-6-yl]phenyl}-2-phenylacetam- ide; N-(4-{3-[2-(hydroxymethyl)pyrrolidin-1-yl]quinoxalin-6-yl}phenyl)-2-p- henylacetamide; N-(4-{3-[4-(3-chlorobenzyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)-2-pheny- lacetamide; N-(4-{3-[4-(methylsulfonyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)-2-pheny- lacetamide; N-{4-[3-(hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)quinoxalin-6-yl]phenyl}-- 2-phenylacetamide; N-(4-{3-[4-(2-fluorobenzyl)piperazin-1-yl]quinoxalin-6-yl}phenyl)-2-pheny- lacetamide; N-{4-[3-(3-hydroxypyrrolidin-1-yl)quinoxalin-6-yl]phenyl}-2-phenylacetami- de; methyl 4-(7-{4-[(phenylacetyl)amino]phenyl}quinoxalin-2-yl)piperazine-- 1-carboxylate; N-{4-[3-(hexahydrocyclopenta[c]pyrrol-2(1H)-yl)quinoxalin-6-yl]phenyl}-2-- phenylacetamide; N-{4-[3-(3-benzylazetidin-1-yl)quinoxalin-6-yl]phenyl}-2-phenylacetamide; 2-phenyl-N-(4-{3-[3-(piperidin-1-yl)azetidin-1-yl]quinoxalin-6-yl}phenyl)- acetamide; N-{4-[3-(3-cyanoazetidin-1-yl)quinoxalin-6-yl]phenyl}-2-phenyla- cetamide; N-(4-{3-[3-(hydroxymethyl)pyrrolidin-1-yl]quinoxalin-6-yl}phenyl- )-2-phenylacetamide; 4-[3-(morpholin-4-yl)quinoxalin-6-yl]benzene-1,2-diamine; N-(3-morpholin-4-yl-quinoxalin-6-yl)-2-phenyl-isobutyramide; 7-(3-methanesulfonyl-phenyl)-2-morpholin-4-yl-quinoxaline; N-[4-(3-morpholin-4-yl-quinoxalin-6-yl)-phenyl]-methanesulfonamide; 1-cyclopropyl-3-[4-(3-morpholin-4-yl-quinoxalin-6-yl)-phenyl]-urea; N,N-dimethyl-N'-{4-[3-(morpholin-4-yl)quinoxalin-6-yl]phenyl}sulfuric diamide; and N-methyl-N'-{4-[3-(morpholin-4-yl)quinoxalin-6-yl]phenyl}sulfuric diamide. 5. A pharmaceutical composition comprising a compound of general formula (I), or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof, or a mixture of same, according to claim 1, and a pharmaceutically acceptable diluent or carrier. 6. A pharmaceutical combination comprising: one or more compounds of general formula (I), or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof, or a mixture of same, according to claim 1; and one or more agents selected from: a taxane, Docetaxel, Paclitaxel, Taxol; an epothilone, Ixabepilone, Patupilone, Sagopilone; Mitoxantrone; Predinisolone; Dexamethasone; Estramustin; Vinblastin; Vincristin; Doxorubicin; Adriamycin; Idarubicin; Daunorubicin; Bleomycin; Etoposide; Cyclophosphamide; Ifosfamide; Procarbazine; Melphalan; 5-Fluorouracil; Capecitabine; Fludarabine; Cytarabine; Ara-C; 2-Chloro-2'-deoxyadenosine; Thioguanine; an anti-androgen, Flutamide, Cyproterone acetate, Bicalutamide; Bortezomib; a platinum derivative, Cisplatin, Carboplatin; Chlorambucil; Methotrexate; and Rituximab.

Details for Patent 9,340,528

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Genentech, Inc.	RITUXAN	rituximab	Injection	103705	11/26/1997		2029-09-04
Idec Pharmaceuticals Corp.	RITUXAN	rituximab	Injection	103737	02/19/2002		2029-09-04
Genentech, Inc.	RITUXAN HYCELA	rituximab and hyaluronidase human	Injection	761064	06/22/2017		2029-09-04