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Last Updated: April 26, 2024

Claims for Patent: 9,192,653

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Summary for Patent: 9,192,653

Title:	Protecting and repairing cartilage and musculoskeletal soft tissues
Abstract:	Provided herein are compositions and methods related to promoting protection or repair of articular cartilage and/or musculoskeletal soft tissue by contacting the cartilage, tissues or cellular components thereof with a parathyroid hormone/parathyroid hormone-related protein (PTH/PTHrP) receptor agonist or releasing factor.
Inventor(s):	Rosier; Randy N. (Rochester, NY), Zuscik; Michael J. (North Chilli, NY), Sampson; Erik (Rochester, NY), Bukata; Susan V. (Pittsford, NY), Puzas; J. Edward (Pittsford, NY), Awad; Hani (Rochester, NY)
Assignee:	University of Rochester (Rochester, NY)
Application Number:	13/971,366
Patent Claims:	1. A method of promoting repair of musculoskeletal soft tissue in a subject comprising a. selecting a subject having injured musculoskeletal soft tissue; and b. administering intermittently to the subject a parathyroid hormone/parathyroid hormone-related protein (PTH/PTHrP) receptor agonist, wherein the musculoskeletal soft tissue is cartilage, meniscal cartilage, a ligament or a tendon. 2. The method of claim 1, wherein the musculoskeletal soft tissue is injured by trauma. 3. The method of claim 1, wherein the musculoskeletal soft tissue is injured by or treated by surgery. 4. The method of claim 1, wherein the musculoskeletal soft tissue is injured by an ischemic event. 5. The method of claim 1, wherein the musculoskeletal soft tissue is injured by a disease or condition. 6. The method of claim 5, wherein the disease or condition is an infection. 7. The method of claim 5, wherein the disease or condition is inherited. 8. The method of claim 5, wherein the disease or condition is an ischemic condition. 9. The method of claim 1, wherein the PTH/PTHrP receptor agonist is a peptide agonist. 10. The method of claim 9, wherein the peptide agonist is teriparatide. 11. The method of claim 1, wherein the subject does not have osteoporosis. 12. The method of claim 1, wherein the subject does not have a bone fracture.

Details for Patent 9,192,653

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Nps Pharmaceuticals, Inc.	NATPARA	parathyroid hormone	For Injection	125511	01/23/2015	⤷ Try a Trial	2028-10-13
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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