Last Updated: July 25, 2026

Claims for Patent: 9,115,381

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Summary for Patent: 9,115,381

Title:	Method of increasing the productivity of eucaryotic cells in the production of recombinant FVIII
Abstract:	A method of increasing productivity, in particularly cell-specific productivity, of recombinant factor VIII (rFVIII) produced in a eukaryotic cell suspension during culturing of the eucaryotic cell suspension in a culturing medium containing not more than 500 μM CaCl2, at least a non-ionic detergent and other nutrient components needed for the cells to grow and produce rFVIII, the cell suspension is cultured under conditions inducing a shear stress mechanically to the eucaryotic cell suspension by adding a power density of at least 3 W/m3.
Inventor(s):	Peter Aizawa, Irene Agerkvist
Assignee:	Octapharma AG
Application Number:	US14/113,923

Details for Patent 9,115,381

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Octapharma Pharmazeutika Produktionsges.m.b.h.	NUWIQ	antihemophilic factor (recombinant)	For Injection	125555	September 04, 2015	⤷ Start Trial	2032-05-14
Octapharma Pharmazeutika Produktionsges.m.b.h.	NUWIQ	antihemophilic factor (recombinant)	For Injection	125555	July 07, 2017	⤷ Start Trial	2032-05-14
Octapharma Pharmazeutika Produktionsges.m.b.h.	NUWIQ	antihemophilic factor (recombinant)	For Injection	125555	December 07, 2021	⤷ Start Trial	2032-05-14
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 9,115,381

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Country	Patent Number	Estimated Expiration
World Intellectual Property Organization (WIPO)	2012156356	⤷ Start Trial
United States of America	2014051123	⤷ Start Trial
Russian Federation	2600886	⤷ Start Trial
Russian Federation	2013155382	⤷ Start Trial
South Korea	20140021009	⤷ Start Trial
South Korea	101980164	⤷ Start Trial
Japan	6178786	⤷ Start Trial
>Country	>Patent Number	>Estimated Expiration

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