Claims for Patent: 9,107,982

Summary for Patent: 9,107,982

Title:	Cultured tissue transplant device
Abstract:	A device for transplanting a graft such as a layer or layers of cultivated, autologous, allogenic or xenogenic cells to cover an accidental or surgical wound. The graft is cultivated and carried on a bed of collagen or other dissolvable or releasable material mounted on a protective substrate molded to conform to the profile of the wounded area and provided with a lateral attachment zone. The device facilitates the graft cultured in vitro to the recipient surface.
Inventor(s):	Chen; Paul Hong-Dze (Rancho Santa Fe, CA)
Assignee:
Application Number:	13/436,255
Patent Claims:	1. A living cell transplant device for treatment of a surgical or accidental corneal wound, wherein the device comprises: a. a removable substrate formed in the shape of an ophthalmic conformer having a central zone and a lateral zone peripheral to the central zone, wherein the central zone comprises a concave posterior face and a convex anterior face, and wherein the substrate further comprises an ophthalmologically acceptable material; b. a releasable layer, coating the concave posterior face; c. a plurality of living, transplantable cells upon the releasable layer, wherein the releasable layer is designed to facilitate release of the living, transplantable cells upon the corneal wound to effect transplantation thereof; and d. means for attaching the substrate formed in the shape of an ophthalmic conformer around the wound. 2. The device of claim 1, wherein the means for attaching the substrate in the form of an ophthalmic conformer comprises at least one patch of adhesive material applied to the posterior face. 3. The device of claim 1, which further comprises a means for dissolving the releasable layer. 4. The device of claim 1, wherein the releasable layer is selected from the group consisting of collagen, amniotic membrane, cellulose, gelatin, and agarose. 5. The device of claim 2, wherein the adhesive material is selected from the group consisting of fibrin and cyanoacrylate. 6. The device of claim 1, which further comprises at least one partition projecting from the concave posterior face and dividing the central zone into separate areas. 7. The device of claim 1, wherein the means for attaching the removable substrate formed in the shape of an ophthalmic conformer is at least one embedded suture in the central zone. 8. The device of claim 1, wherein the means for attaching the removable substrate formed in the shape of an ophthalmic conformer is at least one embedded suture in the lateral zone. 9. The device of claim 1, which further comprises a protective viscoelastic layer. 10. The device of claim 1, wherein said dissolving means is selected from the group consisting of collagenase, gelatinase, hyaluronidase, trypsin, and papain. 11. A living cell transplant device for treatment of a surgical or accidental corneal wound, wherein the device comprises: a. a removable substrate formed in the shape of an ophthalmic conformer having a central zone and a lateral zone peripheral to the central zone, wherein the central zone comprises a concave posterior face and a convex anterior face, and wherein the substrate further comprises an ophthalmologically acceptable material; b. a releasable layer, coating the concave posterior face; c. a plurality of living, transplantable cells embedded within the releasable layer, wherein the releasable layer is designed to facilitate release of the living, transplantable cells upon the corneal wound to effect transplantation thereof; and d. an attacher, wherein said attacher attaches the substrate formed in the shape of an ophthalmic conformer around the wound. 12. The device of claim 11, wherein the attacher comprises at least one patch of adhesive material applied to the posterior face. 13. The device of claim 11, further comprising a dissolving agent for dissolving the releasable layer. 14. The device of claim 11, wherein the releasable layer is selected from the group consisting of collagen, amniotic membrane, cellulose, gelatin, and agarose. 15. The device of claim 12, wherein the adhesive material is selected from the group consisting of fibrin and cyanoacrylate. 16. The device of claim 11, which further comprises at least one partition projecting from the concave posterior face and dividing the central zone into separate areas. 17. The device of claim 11, wherein the attacher comprises embedded sutures in the central or lateral zone. 18. The device of claim 11, which further comprises a protective viscoelastic layer placed upon the releasable layer. 19. A living cell transplant device for treatment of a surgical or accidental corneal wound, wherein the device comprises: a. a removable substrate formed in the shape of a contact lens having a central zone and a lateral zone peripheral to the central zone, wherein the central zone comprises a concave posterior face and a convex anterior face, and wherein the substrate further comprises an ophthalmologically acceptable contact lens material; b. a releasable layer, coating the concave posterior face; c. a plurality of living, transplantable cells upon the releasable layer, wherein the releasable layer is designed to facilitate release of the living, transplantable cells upon the corneal wound to effect transplantation thereof; and d. an attacher for attaching the substrate formed in the shape of a contact lens around the wound. 20. The device of claim 19, wherein the attacher comprises at least one patch of adhesive material applied to the posterior face. 21. The device of claim 19, which further comprises a dissolving agent for dissolving the releasable layer. 22. The device of claim 19, wherein the releasable layer is selected from the group consisting of collagen, amniotic membrane, cellulose, gelatin, and agarose. 23. The device of claim 20, wherein the adhesive material is selected from the group consisting of fibrin and cyanoacrylate. 24. The device of claim 19, which further comprises at least one partition projecting from the concave posterior face and dividing the central zone into separate areas. 25. The device of claim 19, wherein the attacher comprises embedded sutures in the central zone. 26. The device of claim 19, wherein the attacher comprises embedded sutures in the lateral zone. 27. The device of claim 19, which further comprises a protective viscoelastic layer placed upon the releasable layer. 28. A living cell transplant device for treatment of a surgical or accidental corneal wound, wherein the device comprises: a. a removable substrate formed in the shape of a contact lens having a central zone and a lateral zone peripheral to the central zone, wherein the central zone comprises a concave posterior face and a convex anterior face, and wherein the substrate further comprises an ophthalmologically acceptable contact lens material; b. a releasable layer, coating the concave posterior face; c. a plurality of living, transplantable cells embedded within the releasable layer, wherein the releasable layer is designed to facilitate release of the living, transplantable cells upon the corneal wound to effect transplantation thereof; and d. an attacher for attaching the substrate formed in the shape of a contact lens around the wound. 29. The device of claim 28, wherein the attacher comprises at least one patch of adhesive material applied to the posterior face. 30. The device of claim 28, which further comprises a dissolving agent for dissolving the releasable layer. 31. The device of claim 28, wherein the releasable layer is selected from the group consisting of collagen, amniotic membrane, cellulose, gelatin, and agarose. 32. The device of claim 29, wherein the adhesive material is selected from the group consisting of fibrin and cyanoacrylate. 33. The device of claim 28, which further comprises at least one partition projecting from the concave posterior face and dividing the central zone into separate areas. 34. The device of claim 28, wherein the attacher comprises embedded sutures in the central zone. 35. The device of claim 28, wherein the attacher comprises embedded sutures in the lateral zone. 36. The device of claim 28, which further comprises a protective viscoelastic layer placed upon the releasable layer.

Details for Patent 9,107,982

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Bausch & Lomb Incorporated	VITRASE	hyaluronidase	Injection	021640	05/05/2004		2025-11-09
Bausch & Lomb Incorporated	VITRASE	hyaluronidase	Injection	021640	12/02/2004		2025-11-09
Amphastar Pharmaceuticals, Inc.	AMPHADASE	hyaluronidase	Injection	021665	10/26/2004		2025-11-09
Akorn, Inc.	HYDASE	hyaluronidase	Injection	021716	10/25/2005		2025-11-09
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995	06/04/1965		2025-11-09