Claims for Patent: 9,078,892

Summary for Patent: 9,078,892

Title:	Methods for treating pain and for treating a medication overuse disorder
Abstract:	An acute pain medication overuse disorder (such as a medication overuse headache disorder) can be treated by administration of a botulinum toxin to a patient. The botulinum toxin can be botulinum toxin type A and the botulinum toxin can be administered to or to the vicinity of where a patient experiences or is predisposed to experience pain or a headache.
Inventor(s):	Turkel; Catherine C. (Newport Coast, CA), Brin; Mitchell F. (Newport Beach, CA)
Assignee:	Allergan, Inc. (Irvine, CA)
Application Number:	10/789,180
Patent Claims:	1. A method for treating an acute pain medication overuse disorder caused by overuse of acute pain medication, the method comprising a step of consecutive local administration by intramuscular or subcutaneous administration to locations on or within the head of a patient a pure botulinum type A and type B toxin, wherein the pure botulinum toxin has a molecular weight of about 150 kDa, to a patient with acute pain medication overuse disorder associated with overuse of acute pain medication, wherein the patient takes acute pain medication prior to experiencing pain and experiences pain after the intake of acute pain medication, thereby treating the acute pain medication overuse disorder caused by the overuse of acute pain medication. 2. The method of claim 1, wherein the administration of botulinum toxin type A is followed by administration of the botulinum toxin type B. 3. The method of claim 2, wherein the botulinum toxin type A is administered until a loss of clinical response or neutralizing antibodies develop before administration of the botulinum toxin type B. 4. The method of claim 1, wherein the local administration of the botulinum toxin is to a facial muscle of the patient. 5. The method of claim 1, wherein the local administration is to the forehead of the patient. 6. The method of claim 1, wherein the local administration of the botulinum toxin is to a subdermal location or to a muscle location from which the patient perceives a pain to arise. 7. A method for treating an acute pain medication overuse disorder, the method comprising a step of concurrent local administration by intramuscular or subcutaneous administration to locations on or within the head of a patient of a pure botulinum toxin type A and type B toxin, wherein the pure botulinum toxin has a molecular weight of about 150 kDa, to a patient who is overusing acute pain medication, wherein the patient takes acute pain medication prior to experiencing pain and experiences pain after the intake of acute pain medication, thereby alleviating an acute pain medication overuse disorder. 8. The method of claim 1, wherein the acute pain medication overuse disorder is medication overuse headache, and the administration of the botulinum toxin is effective in reducing the number of headaches experienced by the patient. 9. The method of claim 1, wherein the administration of the botulinum toxin is effective in reducing the use of the acute pain medication. 10. The method of claim 9, wherein the acute pain medication comprises a medication selected from the group consisting of narcotic medications and triptan medications. 11. The method of claim 7, wherein the acute pain medication overuse disorder is medication overuse headache, and the administration of the botulinum toxin type A is effective in reducing the number of headaches experienced by the patient. 12. The method of claim 7, wherein the administration of the botulinum toxin type A is effective in reducing the use of the acute pain medication. 13. The method of claim 12, wherein the acute pain medication comprises a medication selected from the group consisting of narcotic medications and triptan medications. 14. A method for treating an acute pain medication disorder caused by overuse of acute pain medication, the method comprising a step of local administration to locations on or within the head of a patient a composition comprising a botulinum toxin type A and a botulinum toxin type B to a patient who is overusing acute pain medication and is diagnosed with a medication overuse headache, wherein the patient takes acute pain medication prior to experiencing pain and experiences pain after the intake of acute pain medication and wherein the administration of the composition is effective in reducing the number of headaches experienced by the patient and in reducing the use of the acute pain medication. 15. The method of claim 14, wherein the administration of the botulinum toxin is effective in reducing the use of a medication selected from the group consisting of narcotic medications and triptan medications. 16. The method of claim 14, wherein the effects of administering the botulinum toxin are observed within about 30 days after administration of the botulinum toxin. 17. The method of claim 14, wherein the patient experiences a headache frequency greater than 15 days per month after the intake of analgesics or ergots more than 15 times per month for at least 3 months.

Details for Patent 9,078,892

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Solstice Neurosciences, Llc	MYOBLOC	rimabotulinumtoxinb	Injection	103846	12/08/2000		2039-03-29