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Last Updated: April 27, 2024

Claims for Patent: 9,056,059

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Summary for Patent: 9,056,059

Title:	Cosmetic neurotoxin compositions and methods
Abstract:	Cosmetic compositions include a Clostridial neurotoxin component and a microsphere component. In certain compositions, the composition includes a botulinum toxin and a plurality of swellable microspheres. The compositions are administered to individuals, by injection and the like, to treat a cosmetic defect of deficiency.
Inventor(s):	First; Eric R. (Morristown, NJ)
Assignee:	Allergan, Inc. (Irvine, CA)
Application Number:	14/143,316
Patent Claims:	1. A composition useful for treating a cosmetic defect in an individual, comprising a botulinum toxin component; and a microsphere component comprising a plurality of swellable microspheres; the composition being free of a botulinum toxoid. 2. The composition of claim 1, wherein the botulinum toxin component comprises a botulinum toxin selected from the group consisting of botulinum toxins types A, B, C, D, E, F, G, and mixtures thereof. 3. The composition of claim 1, wherein the botulinum toxin component comprises only botulinum toxin type A. 4. The composition of claim 1, wherein the botulinum toxin component comprises an amount of botulinum toxin in a range from about 10 units to about 2,000 units of a botulinum toxin type A. 5. The composition of claim 1, wherein the botulinum toxin component comprises an amount of botulinum toxin in a range from about 100 units to about 30,000 units of a botulinum toxin type B. 6. The composition of claim 1, wherein the microsphere component has an average microsphere diameter, and the average microsphere diameter after administration to the individual is between about one to about four times greater than the average microsphere diameter before administration. 7. The composition of claim 1, wherein the microspheres comprise an agent selected from the group consisting of radio-pacifying agents, contrast agents, targeting agents, and mixtures thereof. 8. The composition of claim 1, further comprising a carrier component. 9. The composition of claim 8, wherein the carrier component is an aqueous composition. 10. The composition of claim 8, wherein the carrier component is saline. 11. The composition of claim 1, wherein the composition is an injectable composition effective in treating wrinkles. 12. The composition of claim 11, wherein the wrinkles are selected from a group consisting of marrionette lines, glabellar lines, crows feet, brow furrows, and combinations thereof. 13. The composition of claim 11, wherein the plurality of microspheres have an average microsphere diameter, and wherein the average microsphere diameter increases after injection into the individual from about one time to about four times the average microsphere diameter prior to injection. 14. The composition of claim 1, further comprising at least one additional botulinum toxin selected from the group consisting of botulinum toxin types B, C, D, E, F, and G. 15. A method of treating a cosmetic defect, comprising administering the composition of claim 1 to an individual. 16. The method of claim 15, wherein the cosmetic defect is a wrinkle. 17. The method of claim 15, wherein the cosmetic defect is a condition selected from the group consisting of marionette lines, glabellar lines, crows feet, brow furrows, and combinations thereof. 18. The method of claim 15, wherein the administering comprises injecting a composition comprising a botulinum toxin type A.

Details for Patent 9,056,059

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Solstice Neurosciences, Llc	MYOBLOC	rimabotulinumtoxinb	Injection	103846	12/08/2000	⤷ Try a Trial	2024-10-01
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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