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Last Updated: April 25, 2024

Claims for Patent: 8,986,693

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Summary for Patent: 8,986,693

Title:	Use of TNF.alpha. inhibitor for treatment of psoriasis
Abstract:	The invention describes methods of treating erosive polyarthritis comprising administering a TNF.alpha. antibody, or antigen-binding portion thereof. The invention also describes a method for testing the efficacy of a TNF.alpha. antibody, or antigen-binding portion thereof, for the treatment of erosive polyarthritis.
Inventor(s):	Hoffman; Rebecca S. (Wilmette, IL), Weinberg; Mark (Northbrook, IL), Taylor; Lori K. (Boston, MA), Chartash; Elliot K. (Marietta, GA), Yan; Philip (Vernon Hills, IL), Granneman; George R. (Marco Island, FL)
Assignee:	AbbVie Biotechnology Ltd. (Hamilton, BM)
Application Number:	14/510,821
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 8,986,693
Patent Claims:	1. A method for treating moderate to severe chronic plaque psoriasis, comprising subcutaneously administering to an adult patient having moderate to severe chronic plaque psoriasis a first dose of 80 mg of adalimumab, followed by 40 mg of adalimumab every other week starting one week after said first dosing, wherein the patient achieves at least Psoriasis Area and Severity Index (PASI) 90 response at week 12 of the treatment. 2. The method of claim 1, wherein adalimumab is comprised in pre-filled syringes for subcutaneous injection. 3. A method for treating moderate to severe chronic plaque psoriasis, comprising subcutaneously administering to an adult patient having moderate to severe chronic plaque psoriasis an initial dose of 80 mg of adalimumab, followed by 40 mg of adalimumab every other week starting one week after said initial dosing, wherein the patient achieves at least PASI 75 response at week 24 of the treatment. 4. The method of claim 3, wherein adalimumab is comprised in pre-filled syringes for subcutaneous injection. 5. A method for treating moderate to severe chronic plaque psoriasis, comprising subcutaneously administering to an adult patient having moderate to severe chronic plaque psoriasis an initial dose of 80 mg of adalimumab, followed by 40 mg of adalimumab every other week starting one week after said initial dosing, wherein when said method is used to treat a population of patients with moderate to severe chronic plaque psoriasis, at least 47% of said patients achieve at least PASI 75 response at week 12 of the treatment. 6. The method of claim 5, wherein adalimumab is comprised in pre-filled syringes for subcutaneous injection. 7. A method for treating moderate to severe chronic plaque psoriasis, comprising subcutaneously administering to an adult patient having moderate to severe chronic plaque psoriasis an initial dose of 80 mg of adalimumab, followed by 40 mg of adalimumab every other week starting one week after said initial dosing, wherein when said method is used to treat a population of patients with moderate to severe chronic plaque psoriasis, at least 53% of said patients achieve at least PASI 75 response at week 24 of the treatment. 8. The method of claim 7, wherein adalimumab is comprised in pre-filled syringes for subcutaneous injection.

Details for Patent 8,986,693

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Abbvie Inc.	HUMIRA	adalimumab	Injection	125057	12/31/2002	⤷ Try a Trial	2021-03-07
Abbvie Inc.	HUMIRA	adalimumab	Injection	125057	02/21/2008	⤷ Try a Trial	2021-03-07
Abbvie Inc.	HUMIRA	adalimumab	Injection	125057	04/24/2013	⤷ Try a Trial	2021-03-07
Abbvie Inc.	HUMIRA	adalimumab	Injection	125057	09/23/2014	⤷ Try a Trial	2021-03-07
Abbvie Inc.	HUMIRA	adalimumab	Injection	125057	11/23/2015	⤷ Try a Trial	2021-03-07
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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