Claims for Patent: 8,925,726

Summary for Patent: 8,925,726

Title:	Blister package for pharmaceutical cartridges
Abstract:	Blister packages are described that comprise a blistered base sheet including one or more cavities and a lid bonded to said blister package. The cavities may include a void, a dome structure, and a shelf. The shelf may be configured to hold a cartridge, and the cartridge may contain a pharmaceutical formulation.
Inventor(s):	Bergey; Michael S. (Valencia, CA)
Assignee:	MannKind Corporation (Valencia, CA)
Application Number:	13/436,698
Patent Claims:	1. A blister package comprising a blistered base sheet comprising one or more cavities having a void, a dome structure, a shelf and a cartridge containing a pharmaceutical formulation comprising a diketopiperazine and an active ingredient; a lid bonded to said blister package; wherein the one or more cavities have an exterior surface and interior surface, and wherein the shelf includes an indentation in the exterior surface. 2. The blister package of claim 1, wherein the indentation is a cartridge top retaining feature in the interior surface of the cavities. 3. The blister package of claim 1, wherein the shelf extends from the dome structure and forms a substantially flat end of the one or more cavities and said indentation which forms a cartridge retaining feature in the interior surface of the one or more cavities. 4. The blister package of claim 1, wherein the cartridge comprising a container and a lid or top that extends over the container. 5. The blister package of claim 1, wherein the diketopiperazine is bis-3,6-(N-fumaryl-4-aminobutyl)-2,5-diketo-diketopiperazine. 6. The blister package of claim 1, wherein the active ingredient is a peptide, protein, a small molecule or a nucleic acid. 7. The blister package of claim 1, wherein the active ingredient is selected from the group consisting of insulin, glucagon like peptide 1, glucagon, oxytocin, oxyntomodulin, peptide YY, sumatriptan, a peptidyl peptidase IV inhibitor, parathyroid hormone, deoxyribonuclease I and active fragments or analogs thereof. 8. The blister package of claim 7 wherein the active ingredient is at least one of insulin, glucagon like peptide 1, glucagon, and a peptidyl peptidase IV inhibitor. 9. The blister package of claim 8 wherein the active ingredient is insulin. 10. The blister package of claim 8 wherein the active ingredient is glucagon like peptide 1. 11. The blister package of claim 8 wherein the active ingredient is glucagon. 12. The blister package of claim 7 wherein the active ingredient is at least one of oxytocin, oxyntomodulin, and peptide YY. 13. The blister package of claim 12 wherein the active ingredient is oxytocin. 14. The blister package of claim 12 wherein the active ingredient is oxyntomodulin. 15. The blister package of claim 12 wherein the active ingredient is peptide YY. 16. The blister package of claim 1, wherein the blistered base sheet comprises at least three layers selected from polyvinyl chloride and ACLAR. 17. The blister package of claim 16, wherein the ACLAR layer forms the middle layer of the blistered base sheet having a thickness of about 230 .mu.m to about 720 .mu.m in thickness. 18. The blister package of claim 1, wherein the lid comprises a foil comprising one or more layers of selected from aluminum, plastic polymer or co-polymer. 19. The blister package of claim 18, wherein the lid has a thickness of about 10 .mu.m to 75 .mu.m. 20. The blister package of claim 1, wherein the blistered base sheet has a thickness greater than 100 .mu.m.

Details for Patent 8,925,726

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Nps Pharmaceuticals, Inc.	NATPARA	parathyroid hormone	For Injection	125511	01/23/2015		2031-04-01