Claims for Patent: 8,822,407

Summary for Patent: 8,822,407

Title:	Preparation of conjugates comprising adenine derivatives and allergenic proteins and their use for specific immunotherapy of allengenic diseases
Abstract:	The present invention refers to the preparation of adenine derivative active esters of formula (I) and use thereof for the preparation of stable conjugates between adenine derivative and allergenic proteins having general structure (II) for the modulation of T.sub.H2 response in allergic diseases. (I, II). ##STR00001##
Inventor(s):	Romagnani; Sergio (Florence, IT), Maggi; Enrico (Florence, IT), Parronchi; Paola (Florence, IT), Guarna; Antonio (Seravezza, IT), Occhiato; Ernesto Giovanni (Florence, IT)
Assignee:	Universita\' Degli Studi di Firenze (Florence, IT)
Application Number:	13/814,370
Patent Claims:	1. A stable conjugated compound of formula (II): ##STR00008## wherein X.dbd.S; n is an number from 2-10; P is a protein, having antigenic activity which is bound through at least one lysine residue to (II); and m is a number ranging from 1 to the number of available lysine residues on said P protein. 2. The compound according to claim 1 wherein P is selected from the group consisting of a bacterial antigen, an inhaled allergen and a food allergen. 3. A method for eliciting an antigen specific immune response against a protein P comprising administering to a subject suffering from an immunological disease caused by said protein a compound of claim 1, in an amount sufficient to elicit an antigen-specific immune response against protein P. 4. The method according to claim 3, wherein said immunological disease is an allergic disease to protein P. 5. A pharmaceutical composition comprising at least one compound of claim 1, and a pharmaceutically acceptable ingredient. 6. A process for the preparation of a compound of claim 1, said process comprising conjugating P with an acid of formula (V): ##STR00009## or a corresponding activated ester to form said compound. 7. The process according to claim 6 wherein (V) is an activated ester of formula (I): ##STR00010## wherein X.dbd.S and n is a number between 2 and 10. 8. A process according to claim 6 wherein said compound of formula (V) or said corresponding activated ester is obtained from a compound of formula (III): ##STR00011## 9. A compound of formula (I): ##STR00012## wherein X.dbd.S and n is a number from 2 and 10. 10. The conjugate according to claim 2 wherein P is selected from the group consisting of a house dust mite Dermatophagoides pteronyssinus (DP) antigen, Der p2 and Ovalbumin. 11. The compound of claim 1, wherein n is 2-4. 12. The compound of claim 1, wherein n is 2. 13. The compound of claim 12, wherein P is Der p2. 14. The compound of claim 13, wherein and m is 1. 15. The compound of claim 1, wherein m is 1. 16. The compound of claim 1, wherein P is Der p2. 17. The compound of claim 1, wherein m is 1 or 2. 18. The compound of claim 12, wherein m is 1 or 2. 19. The compound of claim 9, wherein n is 2-4.

Details for Patent 8,822,407

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Greer Laboratories, Inc.	N/A	insects (whole body), mite dermatophagoides pteronyssinus	Injection	101835	09/15/1958		2030-08-05
Allermed Laboratories, Inc.	N/A	insects (whole body), mite dermatophagoides pteronyssinus	Injection	102213	03/12/1974		2030-08-05