Claims for Patent: 8,729,082

Summary for Patent: 8,729,082

Title:	Substituted imidazoquinoxalines
Abstract:	The present invention relates to substituted imidazoquinoxaline compounds of general formula (I) as inhibitors of Mps-1 Kinase or TTK, and being active against inflammation and cancer. ##STR00001##
Inventor(s):	Koppitz; Marcus (Berlin, DE), Bader; Benjamin (Berlin, DE), Bomer; Ulf (Glienicke, DE), Kreft; Bertolt (Kleinmachnow, DE), Lienau; Philip (Berlin, DE), Marquardt; Tobias (Berlin, DE), Prechtl; Stefan (Berlin, DE), Siemeister; Gerhard (Berlin, DE), Wegscheid-Gerlach; Christof (Marburg, DE)
Assignee:	Bayer Intellectual Property GmbH (Monheim, DE)
Application Number:	13/264,627
Patent Claims:	1. A compound of general formula (I): ##STR00371## in which: R.sup.1 represents a C.sub.2-C.sub.10-alkyl-, halo-C.sub.1-C.sub.10-alkyl-, HO--C.sub.1-C.sub.10-alkyl-, C.sub.1-C.sub.10-alkoxy-C.sub.1-C.sub.10-alkyl-, aryloxy-C.sub.1-C.sub.10-alkyl-, halo-C.sub.1-C.sub.10-alkoxy-C.sub.1-C.sub.10-alkyl-, C.sub.2-C.sub.10-alkenyl-, C.sub.2-C.sub.10-alkynyl-, C.sub.3-C.sub.10-cycloalkyl-, 3- to 10-membered heterocycloalkyl-, aryl-, heteroaryl-, C.sub.1-C.sub.6-alkylene-aryl-, C.sub.1-C.sub.6-alkylene-heteroaryl-, --C.sub.1-C.sub.6-alkylene-C.sub.3-C.sub.10-cycloalkyl, --C.sub.1-C.sub.6-alkylene-(3- to 10-membered hetero cycloalkyl), --C.sub.1-C.sub.6-alkylene-aryl, --C.sub.1-C.sub.6-alkylene-heteroaryl group; wherein said group is optionally substituted one or more times, in the same way or differently, with a substituent selected from: halo-, hydroxyl-, cyano-, nitro-, C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkyl-, C.sub.1-C.sub.6-alkoxy-, halo-C.sub.1-C.sub.6-alkoxy-, C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, C.sub.3-C.sub.10-cycloalkyl-, 3- to 10-membered heterocycloalkyl-, --C(.dbd.O)OH, --C(.dbd.O)O--C.sub.1-C.sub.6-alkyl, --C(.dbd.O)O--C.sub.3-C.sub.10-cycloalkyl, --OC(.dbd.O)--C.sub.1-C.sub.6-alkyl, --OC(.dbd.O)--C.sub.3-C.sub.10-cycloalkyl, --N(H)C(.dbd.O)R.sup.8, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)R.sup.8, --N(H)S(.dbd.O).sub.2R.sup.8, --N(C.sub.1-C.sub.6-alkyl)S(.dbd.O).sub.2R.sup.8, --C(.dbd.O)NR.sup.9R.sup.10, --OC(.dbd.O)NR.sup.9R.sup.10, --N(H)C(.dbd.O)OR.sup.8, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)OR.sup.8, --N(H)C(.dbd.O)NR.sup.9R.sup.10, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)NR.sup.9R.sup.10, --SR.sup.8, --S(.dbd.O)R.sup.8, --S(.dbd.O).sub.2R.sup.8, --S(.dbd.O).sub.2NR.sup.9R.sup.10, --NR.sup.9R.sup.10; R.sup.2 represents a --CN, --NR.sup.9R.sup.10, --OR.sup.9, C.sub.2-C.sub.10-alkenyl-, C.sub.2-C.sub.10-alkynyl-, aryl-, heteroaryl-, C.sub.1-C.sub.6-alkylene-aryl-, C.sub.1-C.sub.6-alkylene-heteroaryl-group; wherein said group is optionally substituted one or more times, in the same way or differently, with a substituent selected from: halo-, hydroxy-, cyano-, nitro-, C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkyl-, HO--C.sub.1-C.sub.6-alkyl-, C.sub.1-C.sub.6-alkoxy-, halo-C.sub.1-C.sub.6-alkoxy-, C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, C.sub.1-C.sub.6-alkyl-C(.dbd.O)N(H)--C.sub.1-C.sub.6-alkyl-, C.sub.3-C.sub.10-cycloalkyl-, 3- to 10-membered hetero cycloalkyl-, --C(.dbd.O)--C.sub.1-C.sub.6-alkyl, --C(.dbd.O)OH, --C(.dbd.O)O--C.sub.1-C.sub.6-alkyl, --C(.dbd.O)O--C.sub.3-C.sub.10-cycloalkyl, --OC(.dbd.O)--C.sub.1-C.sub.6-alkyl, --OC(.dbd.O)--C.sub.3-C.sub.10-cycloalkyl, --N(H)C(.dbd.O)R.sup.8, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)R.sup.8, --N(H)S(.dbd.O).sub.2R.sup.8, --N(C.sub.1-C.sub.6-alkyl)S(.dbd.O).sub.2R.sup.8, --C(.dbd.O)NR.sup.9R.sup.10, --OC(.dbd.O)NR.sup.9R.sup.10, --N(H)C(.dbd.O)OR.sup.8, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)OR.sup.8, --N(H)C(.dbd.O)NR.sup.9R.sup.10, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)NR.sup.9R.sup.10, --SR.sup.8, --S(.dbd.O)R.sup.8, --S(.dbd.O).sub.2R.sup.8, --S(.dbd.O).sub.2NR.sup.9R.sup.10, --NR.sup.9R.sup.10; R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7: represent, independently from each other, a hydrogen atom, a halogen atom, a hydroxy, cyano, nitro, or a group selected from: a C.sub.1-C.sub.6-alkyl, halo-C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-alkoxy, halo-C.sub.1-C.sub.6-alkoxy, C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl, halo-C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl, C.sub.3-C.sub.10-cycloalkyl, 3- to 10-membered heterocycloalkyl, --C(.dbd.O)OH, --C(.dbd.O)O--C.sub.1-C.sub.6-alkyl, --C(.dbd.O)O--C.sub.3-C.sub.10-cycloalkyl, --N(H)C(.dbd.O)R.sup.8, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)R.sup.8, --N(H)S(.dbd.O).sub.2R.sup.8, --N(C.sub.1-C.sub.6-alkyl)S(.dbd.O).sub.2R.sup.8, --C(.dbd.O)NR.sup.9R.sup.10, --OC(.dbd.O)NR.sup.9R.sup.10, --N(H)C(.dbd.O)OR.sup.8, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)OR.sup.8, --N(H)C(.dbd.O)NR.sup.9R.sup.10, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)NR.sup.9R.sup.10, --SR.sup.8, --S(.dbd.O)R.sup.8, --S(.dbd.O).sub.2R.sup.8, --S(.dbd.O).sub.2NR.sup.9R.sup.10, --NR.sup.9R.sup.10, C.sub.2-C.sub.6-alkenyl, C.sub.2-C.sub.6-alkynyl, aryl, heteroaryl, C.sub.1-C.sub.6-alkylene-aryl, C.sub.1-C.sub.6-alkylene-heteroaryl, --C.sub.1-C.sub.6-alkylene-C.sub.3-C.sub.10-cycloalkyl, or C.sub.1-C.sub.6-alkylene-3- to 10-membered heterocycloalkyl group; wherein said group is optionally substituted one or more times, in the same way or differently, with a substituent selected from: halogen, hydroxy, cyano, nitro, C.sub.1-C.sub.6-alkyl, halo-C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-alkoxy, halo-C.sub.1-C.sub.6-alkoxy, C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl, halo-C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl, C.sub.3-C.sub.10-cycloalkyl, 3- to 10-membered heterocycloalkyl, --C(.dbd.O)OH, --C(.dbd.O)O--C.sub.1-C.sub.6-alkyl, --C(.dbd.O)O--C.sub.3-C.sub.10-cycloalkyl, --N(H)C(.dbd.O)R.sup.8, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)R.sup.8, --N(H)S(.dbd.O).sub.2R.sup.8, --N(C.sub.1-C.sub.6-alkyl)S(.dbd.O).sub.2R.sup.8, --C(.dbd.O)NR.sup.9R.sup.10, --OC(.dbd.O)NR.sup.9R.sup.10, --N(H)C(.dbd.O)OR.sup.8, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)OR.sup.8, --N(H)C(.dbd.O)NR.sup.9R.sup.10, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)NR.sup.9R.sup.10, --SR.sup.8, --S(.dbd.O)R.sup.8, --S(.dbd.O).sub.2R.sup.8, --S(.dbd.O).sub.2NR.sup.9R.sup.10, --NR.sup.9R.sup.10; R.sup.8, R.sup.9, R.sup.10: represent, independently from each other, a hydrogen atom, a C.sub.1-C.sub.6-alkyl, halo-C.sub.1-C.sub.6-alkyl, HO--C.sub.1-C.sub.6-alkyl-, cyano-C.sub.1-C.sub.6-alkyl-, C.sub.2-C.sub.10-alkynyl-C.sub.1-C.sub.6-alkyl-, C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl, halo-C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl, H.sub.2NC(.dbd.O)--C.sub.1-C.sub.6-alkyl-, C.sub.1-C.sub.6-alkyl-N(H)C(.dbd.O)--C.sub.1-C.sub.6-alkyl-, H.sub.2NS(.dbd.O).sub.2--C.sub.1-C.sub.6-alkyl-, C.sub.2-C.sub.6-alkenyl, C.sub.2-C.sub.6-alkynyl, C.sub.3-C.sub.10-cycloalkyl, 3- to 10-membered heterocycloalkyl, aryl, heteroaryl, C.sub.1-C.sub.6-alkylene-aryl, --C.sub.1-C.sub.6-alkylene-heteroaryl, --C.sub.1-C.sub.6-alkylene-C.sub.3-C.sub.10-cycloalkyl, --C.sub.1-C.sub.6-alkylene-3- to 10-membered heterocycloalkyl group; wherein said C.sub.3-C.sub.10-cycloalkyl group is optionally substituted one or more times with a halogen atom, cyano, C.sub.1-C.sub.6-alkyl, halo-C.sub.1-C.sub.6-alkyl, HO--C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-alkoxy, C.sub.3-C.sub.10-cycloalkyl, aryl, or a heteroaryl group; wherein said aryl group is optionally substituted one or more times, in the same way or differently, with a substituent selected from: halogen, hydroxy, cyano, nitro, C.sub.1-C.sub.6-alkyl, halo-C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-alkoxy, halo-C.sub.1-C.sub.6-alkoxy, C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl, halo-C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl, C.sub.3-C.sub.10-cycloalkyl, 3- to 10-membered heterocycloalkyl, --C.sub.1-C.sub.6-alkylene-3- to 10-membered heterocycloalkyl, --C(.dbd.O)OH, --C(.dbd.O)O--C.sub.1-C.sub.6-alkyl, --C(.dbd.O)O--C.sub.3-C.sub.10-cycloalkyl, --N(H)C(.dbd.O)--C.sub.1-C.sub.6-alkyl, --N(H)C(.dbd.O)-heteroaryl, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)--C.sub.1-C.sub.6-alkyl, --N(H)S(.dbd.O).sub.2--C.sub.1-C.sub.6-alkyl, --N(C.sub.1-C.sub.6-alkyl)S(.dbd.O).sub.2--C.sub.1-C.sub.6-alkyl, --C(.dbd.O)NH.sub.2, --C(.dbd.O)N(H)--C.sub.1-C.sub.6-alkyl, --C(.dbd.O)N(C.sub.1-C.sub.6-alkyl).sub.2, --OC(.dbd.O)NH.sub.2, --OC(.dbd.O)N(H)--C.sub.1-C.sub.6-alkyl, --OC(.dbd.O)N(C.sub.1-C.sub.6-alkyl).sub.2, --N(H)C(.dbd.O)O--C.sub.1-C.sub.6-alkyl, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)O--C.sub.1-C.sub.6-alkyl, --N(H)C(.dbd.O)NH.sub.2, --N(H)C(.dbd.O)N(H)--C.sub.1-C.sub.6-alkyl, --N(H)C(.dbd.O)N(C.sub.1-C.sub.6-alkyl).sub.2, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)NH.sub.2, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)N(H)--C.sub.1-C.sub.6-alkyl, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)N(C.sub.1-C.sub.6-alkyl).sub.2, --S--C.sub.1-C.sub.6-alkyl, --S(.dbd.O)--C.sub.1-C.sub.6-alkyl, --S(.dbd.O).sub.2--C.sub.1-C.sub.6-alkyl, --S(.dbd.O).sub.2NH.sub.2, --S(.dbd.O).sub.2N(H)--C.sub.1-C.sub.6-alkyl, --S(.dbd.O).sub.2N(C.sub.1-C.sub.6-alkyl), --NH.sub.2, --N(H)--C.sub.1-C.sub.6-alkyl, --N(C.sub.1-C.sub.6-alkyl).sub.2; or R.sup.9, R.sup.10, together with the nitrogen atom to which they are attached, represent a 3- to 10-membered heterocycloalkyl group; under the proviso that: R.sup.1 is not --CH.sub.2CH.sub.2CH.sub.2OH, --CH.sub.2CH.sub.2CH.sub.2O(C.dbd.O)--R.sub.a, --CH.sub.2CH.sub.2CH.sub.2O(C.dbd.O)--OR.sub.a, --CH.sub.2CH.sub.2CH.sub.2O(C.dbd.O)--CHR.sub.aNR.sub.bR.sub.c, in which R.sub.a, R.sub.b, R.sub.c, identical or different, are selected from the group consisting of H, C.sub.1-C.sub.10-alkyl, C.sub.2-C.sub.10-alkenyl, C.sub.2-C.sub.10-alkynyl, phenyl and heteroaryl; or a stereoisomer, a tautomer, an N-oxide, or a salt thereof, or a mixture of same. 2. The compound according to claim 1, wherein: R.sup.1 represents a C.sub.2-C.sub.10-alkyl-, halo-C.sub.1-C.sub.10-alkyl-, HO--C.sub.1-C.sub.10-alkyl-, C.sub.1-C.sub.10-alkoxy-C.sub.1-C.sub.10-alkyl-, aryloxy-C.sub.1-C.sub.10-alkyl-, halo-C.sub.1-C.sub.10-alkoxy-C.sub.1-C.sub.10-alkyl-, C.sub.2-C.sub.10-alkenyl-, C.sub.2-C.sub.10-alkynyl-, C.sub.3-C.sub.10-cycloalkyl-, 3- to 10-membered heterocycloalkyl-, aryl-, C.sub.1-C.sub.6-alkylene-aryl-, C.sub.1-C.sub.6-alkylene-heteroaryl-, --C.sub.1-C.sub.6-alkylene-C.sub.3-C.sub.10-cycloalkyl, --C.sub.1-C.sub.6-alkylene-(3- to 10-membered heterocycloalkyl), --C.sub.1-C.sub.6-alkylene-aryl, --C.sub.1-C.sub.6-alkylene-heteroaryl group; wherein said group is optionally substituted one or more times, in the same way or differently, with a substituent selected from: halo-, hydroxyl-, cyano-, nitro-, C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkyl-, C.sub.1-C.sub.6-alkoxy-, halo-C.sub.1-C.sub.6-alkoxy-, C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, C.sub.3-C.sub.10-cycloalkyl-, 3- to 10-membered heterocycloalkyl-, --C(.dbd.O)OH, --C(.dbd.O)O--C.sub.1-C.sub.6-alkyl, --C(.dbd.O)O--C.sub.3-C.sub.10-cycloalkyl, --OC(.dbd.O)--C.sub.1-C.sub.6-alkyl, --OC(.dbd.O)--C.sub.3-C.sub.10-cycloalkyl, --N(H)C(.dbd.O)R.sup.8, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)R.sup.8, --N(H)S(.dbd.O).sub.2R.sup.8, --N(C.sub.1-C.sub.6-alkyl)S(.dbd.O).sub.2R.sup.8, --C(.dbd.O)NR.sup.9R.sup.10, --OC(.dbd.O)NR.sup.9R.sup.10, --N(H)C(.dbd.O)OR.sup.8, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)OR.sup.8, --N(H)C(.dbd.O)NR.sup.9R.sup.10, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)NR.sup.9R.sup.10, --SR.sup.8, --S(.dbd.O)R.sup.8, --S(.dbd.O).sub.2R.sup.8, --S(.dbd.O).sub.2NR.sup.9R.sup.10, --NR.sup.9R.sup.10; R.sup.2 represents an aryl- or heteroaryl-group; wherein said group is optionally substituted one or more times, in the same way or differently, with a substituent selected from: halo-, hydroxy-, cyano-, nitro-, C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkyl-, HO--C.sub.1-C.sub.6-alkyl-, C.sub.1-C.sub.6-alkoxy-, halo-C.sub.1-C.sub.6-alkoxy-, C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, C.sub.1-C.sub.6-alkyl-C(.dbd.O)N(H)--C.sub.1-C.sub.6-alkyl-, C.sub.3-C.sub.10-cycloalkyl-, 3- to 10-membered heterocycloalkyl-, --C(.dbd.O)--C.sub.1-C.sub.6-alkyl, --C(.dbd.O)OH, --C(.dbd.O)O--C.sub.1-C.sub.6-alkyl, --C(.dbd.O)O--C.sub.3-C.sub.10-cycloalkyl, --OC(.dbd.O)--C.sub.1-C.sub.6-alkyl, --OC(.dbd.O)--C.sub.3-C.sub.10-cycloalkyl, --N(H)C(.dbd.O)R.sup.8, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)R.sup.8, --N(H)S(.dbd.O).sub.2R.sup.8, --N(C.sub.1-C.sub.6-alkyl)S(.dbd.O).sub.2R.sup.8, --C(.dbd.O)NR.sup.9R.sup.10, --OC(.dbd.O)NR.sup.9R.sup.10, --N(H)C(.dbd.O)OR.sup.8, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)OR.sup.8, --N(H)C(.dbd.O)NR.sup.9R.sup.10, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)NR.sup.9R.sup.10, --SR.sup.8, --S(.dbd.O)R.sup.8, --S(.dbd.O).sub.2R.sup.8, --S(.dbd.O).sub.2NR.sup.9R.sup.10, --NR.sup.9R.sup.10; R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7: represent, independently from each other, a hydrogen atom, a halogen atom, a hydroxy, cyano, nitro, or a group selected from: a C.sub.1-C.sub.6-alkyl, halo-C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-alkoxy, halo-C.sub.1-C.sub.6-alkoxy, C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl, halo-C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl, C.sub.3-C.sub.10-cycloalkyl, 3- to 10-membered heterocycloalkyl, --C(.dbd.O)OH, --C(.dbd.O)O--C.sub.1-C.sub.6-alkyl, --C(.dbd.O)O--C.sub.3-C.sub.10-cycloalkyl, --N(H)C(.dbd.O)R.sup.8, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)R.sup.8, --N(H)S(.dbd.O).sub.2R.sup.8, --N(C.sub.1-C.sub.6-alkyl)S(.dbd.O).sub.2R.sup.8, --C(.dbd.O)NR.sup.9R.sup.10, --OC(.dbd.O)NR.sup.9R.sup.10, --N(H)C(.dbd.O)OR.sup.8, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)OR.sup.8, --N(H)C(.dbd.O)NR.sup.9R.sup.10, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)NR.sup.9R.sup.10, --SR.sup.8, --S(.dbd.O)R.sup.8, --S(.dbd.O).sub.2R.sup.8, --S(.dbd.O).sub.2NR.sup.9R.sup.10, --NR.sup.9R.sup.10, C.sub.2-C.sub.6-alkenyl, C.sub.2-C.sub.6-alkynyl, aryl, heteroaryl, C.sub.1-C.sub.6-alkylene-aryl, C.sub.1-C.sub.6-alkylene-heteroaryl, --C.sub.1-C.sub.6-alkylene-C.sub.3-C.sub.10-cycloalkyl, or C.sub.1-C.sub.6-alkylene-3- to 10-membered heterocycloalkyl group; wherein said group is optionally substituted one or more times, in the same way or differently, with a substituent selected from: halogen, hydroxy, cyano, nitro, C.sub.1-C.sub.6-alkyl, halo-C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-alkoxy, halo-C.sub.1-C.sub.6-alkoxy, C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl, halo-C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl, C.sub.3-C.sub.10-cycloalkyl, 3- to 10-membered heterocycloalkyl, --C(.dbd.O)OH, --C(.dbd.O)O--C.sub.1-C.sub.6-alkyl, --C(.dbd.O)O--C.sub.3-C.sub.10-cycloalkyl, --N(H)C(.dbd.O)R.sup.8, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)R.sup.8, --N(H)S(.dbd.O).sub.2R.sup.8, --N(C.sub.1-C.sub.6-alkyl)S(.dbd.O).sub.2R.sup.8, --C(.dbd.O)NR.sup.9R.sup.10, --OC(.dbd.O)NR.sup.9R.sup.10, --N(H)C(.dbd.O)OR.sup.8, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)OR.sup.8, --N(H)C(.dbd.O)NR.sup.9R.sup.10, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)NR.sup.9R.sup.10, --SR.sup.8, --S(.dbd.O)R.sup.8, --S(.dbd.O).sub.2R.sup.8, --S(.dbd.O).sub.2NR.sup.9R.sup.10, --NR.sup.9R.sup.10; R.sup.8, R.sup.9, R.sup.10: represent, independently from each other, a hydrogen atom, a C.sub.1-C.sub.6-alkyl, halo-C.sub.1-C.sub.6-alkyl, HO--C.sub.1-C.sub.6-alkyl-, cyano-C.sub.1-C.sub.6-alkyl-, C.sub.2-C.sub.10-alkynyl-C.sub.1-C.sub.6-alkyl-, C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl, halo-C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl, H.sub.2NC(.dbd.O)--C.sub.1-C.sub.6-alkyl-, C.sub.1-C.sub.6-alkyl-N(H)C(.dbd.O)--C.sub.1-C.sub.6-alkyl-, H.sub.2NS(.dbd.O).sub.2--C.sub.1-C.sub.6-alkyl-, C.sub.2-C.sub.6-alkenyl, C.sub.2-C.sub.6-alkynyl, C.sub.3-C.sub.10-cycloalkyl, 3- to 10-membered heterocycloalkyl, aryl, heteroaryl, C.sub.1-C.sub.6-alkylene-aryl, --C.sub.1-C.sub.6-alkylene-heteroaryl, --C.sub.1-C.sub.6-alkylene-C.sub.3-C.sub.10-cycloalkyl, --C.sub.1-C.sub.6-alkylene-3- to 10-membered heterocycloalkyl group; wherein said C.sub.3-C.sub.10-cycloalkyl group is optionally substituted one or more times with a halogen atom, cyano, C.sub.1-C.sub.6-alkyl, halo-C.sub.1-C.sub.6-alkyl, HO--C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-alkoxy, C.sub.3-C.sub.10-cycloalkyl, aryl, or a heteroaryl group; wherein said aryl group is optionally substituted one or more times, in the same way or differently, with a substituent selected from: halogen, hydroxy, cyano, nitro, C.sub.1-C.sub.6-alkyl, halo-C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-alkoxy, halo-C.sub.1-C.sub.6-alkoxy, C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl, halo-C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl, C.sub.3-C.sub.10-cycloalkyl, 3- to 10-membered heterocycloalkyl, --C.sub.1-C.sub.6-alkylene-3- to 10-membered heterocycloalkyl, --C(.dbd.O)OH, --C(.dbd.O)O--C.sub.1-C.sub.6-alkyl, --C(.dbd.O)O--C.sub.3-C.sub.10-cycloalkyl, --N(H)C(.dbd.O)--C.sub.1-C.sub.6-alkyl, --N(H)C(.dbd.O)-heteroaryl, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)--C.sub.1-C.sub.6-alkyl, --N(H)S(.dbd.O).sub.2--C.sub.1-C.sub.6-alkyl, --N(C.sub.1-C.sub.6-alkyl)S(.dbd.O).sub.2--C.sub.1-C.sub.6-alkyl, --C(.dbd.O)NH.sub.2, --C(.dbd.O)N(H)--C.sub.1-C.sub.6-alkyl, --C(.dbd.O)N(C.sub.1-C.sub.6-alkyl).sub.2, --OC(.dbd.O)NH.sub.2, --OC(.dbd.O)N(H)--C.sub.1-C.sub.6-alkyl, --OC(.dbd.O)N(C.sub.1-C.sub.6-alkyl).sub.2, --N(H)C(.dbd.O)O--C.sub.1-C.sub.6-alkyl, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)O--C.sub.1-C.sub.6-alkyl, --N(H)C(.dbd.O)NH.sub.2, --N(H)C(.dbd.O)N(H)--C.sub.1-C.sub.6-alkyl, --N(H)C(.dbd.O)N(C.sub.1-C.sub.6-alkyl).sub.2, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)NH.sub.2, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)N(H)--C.sub.1-C.sub.6-alkyl, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)N(C.sub.1-C.sub.6-alkyl).sub.2, --S--C.sub.1-C.sub.6-alkyl, --S(.dbd.O)--C.sub.1-C.sub.6-alkyl, --S(.dbd.O).sub.2--C.sub.1-C.sub.6-alkyl, --S(.dbd.O).sub.2NH.sub.2, --S(.dbd.O).sub.2N(H)--C.sub.1-C.sub.6-alkyl, --S(.dbd.O).sub.2N(C.sub.1-C.sub.6-alkyl).sub.2, --NH.sub.2, --N(H)--C.sub.1-C.sub.6-alkyl, --N(C.sub.1-C.sub.6-alkyl).sub.2; or R.sup.9, R.sup.10, together with the nitrogen atom to which they are attached, represent a 3- to 10-membered heterocycloalkyl group; under the proviso that: R.sup.1 is not --CH.sub.2CH.sub.2CH.sub.2OH, --CH.sub.2CH.sub.2CH.sub.2O(C.dbd.O)--R.sub.a, --CH.sub.2CH.sub.2CH.sub.2O(C.dbd.O)--OR.sub.a, --CH.sub.2CH.sub.2CH.sub.2O(C.dbd.O)--CHR.sub.aNR.sub.bR.sub.c, in which R.sub.a, R.sub.b, R.sub.c, identical or different, are selected from the group consisting of H, C.sub.1-C.sub.10-alkyl, C.sub.2-C.sub.10-alkenyl, C.sub.2-C.sub.10-alkynyl, phenyl and heteroaryl; or a stereoisomer, a tautomer, an N-oxide, or a salt thereof, or a mixture of same. 3. The compound according to claim 1, wherein: R.sup.1 represents a C.sub.2-C.sub.10-alkyl-, halo-C.sub.1-C.sub.10-alkyl-, HO--C.sub.1-C.sub.10-alkyl-, C.sub.1-C.sub.10-alkoxy-C.sub.1-C.sub.10-alkyl-, aryloxy-C.sub.1-C.sub.10-alkyl-, halo-C.sub.1-C.sub.10-alkoxy-C.sub.1-C.sub.10-alkyl-, C.sub.2-C.sub.10-alkenyl-, C.sub.2-C.sub.10-alkynyl-, C.sub.3-C.sub.10-cycloalkyl-, 3- to 10-membered heterocycloalkyl-, aryl-, C.sub.1-C.sub.6-alkylene-aryl-, C.sub.1-C.sub.6-alkylene-heteroaryl-, --C.sub.1-C.sub.6-alkylene-C.sub.3-C.sub.10-cycloalkyl, --C.sub.1-C.sub.6-alkylene-(3- to 10-membered heterocycloalkyl), --C.sub.1-C.sub.6-alkylene-aryl, --C.sub.1-C.sub.6-alkylene-heteroaryl group; wherein said group is optionally substituted one or more times, in the same way or differently, with a substituent selected from: halo-, hydroxyl-, cyano-, nitro-, C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkyl-, C.sub.1-C.sub.6-alkoxy-, halo-C.sub.1-C.sub.6-alkoxy-, C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, C.sub.3-C.sub.10-cycloalkyl-, 3- to 10-membered heterocycloalkyl-, --C(.dbd.O)OH, --C(.dbd.O)O--C.sub.1-C.sub.6-alkyl, --C(.dbd.O)O--C.sub.3-C.sub.10-cycloalkyl, --OC(.dbd.O)--C.sub.1-C.sub.6-alkyl, --OC(.dbd.O)--C.sub.3-C.sub.10-cycloalkyl, --N(H)C(.dbd.O)R.sup.8, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)R.sup.8, --N(H)S(.dbd.O).sub.2R.sup.8, --N(C.sub.1-C.sub.6-alkyl)S(.dbd.O).sub.2R.sup.8, --C(.dbd.O)NR.sup.9R.sup.10, --OC(.dbd.O)NR.sup.9R.sup.10, --N(H)C(.dbd.O)OR.sup.8, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)OR.sup.8, --N(H)C(.dbd.O)NR.sup.9R.sup.10, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)NR.sup.9R.sup.10, --SR.sup.8, --S(.dbd.O)R.sup.8, --S(.dbd.O).sub.2R.sup.8, --S(.dbd.O).sub.2NR.sup.9R.sup.10, --NR.sup.9R.sup.10; R.sup.2 represents an aryl- or heteroaryl-group; wherein said group is optionally substituted one or more times, in the same way or differently, with a substituent selected from: halo-, hydroxy-, cyano-, nitro-, C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkyl-, HO--C.sub.1-C.sub.6-alkyl-, C.sub.1-C.sub.6-alkoxy-, halo-C.sub.1-C.sub.6-alkoxy-, C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl-, C.sub.1-C.sub.6-alkyl-C(.dbd.O)N(H)--C.sub.1-C.sub.6-alkyl-, C.sub.3-C.sub.10-cycloalkyl-, 3- to 10-membered heterocycloalkyl-, --C(.dbd.O)--C.sub.1-C.sub.6-alkyl, --C(.dbd.O)OH, --C(.dbd.O)O--C.sub.1-C.sub.6-alkyl, --C(.dbd.O)O--C.sub.3-C.sub.10-cycloalkyl, --OC(.dbd.O)--C.sub.1-C.sub.6-alkyl, --OC(.dbd.O)--C.sub.3-C.sub.10-cycloalkyl, --N(H)C(.dbd.O)R.sup.8, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)R.sup.8, --N(H)S(.dbd.O).sub.2R.sup.8, --N(C.sub.1-C.sub.6-alkyl)S(.dbd.O).sub.2R.sup.8, --C(.dbd.O)NR.sup.9R.sup.10, --OC(.dbd.O)NR.sup.9R.sup.10, --N(H)C(.dbd.O)OR.sup.8, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)OR.sup.8, --N(H)C(.dbd.O)NR.sup.9R.sup.10, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)NR.sup.9R.sup.10, --SR.sup.8, --S(.dbd.O)R.sup.8, --S(.dbd.O).sub.2R.sup.8, --S(.dbd.O).sub.2NR.sup.9R.sup.10, --NR.sup.9R.sup.10; R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7: represent, independently from each other, a hydrogen atom, a halogen atom, a hydroxy, cyano, nitro, or a group selected from: a C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-alkoxy, --N(H)C(.dbd.O)R.sup.8, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)R.sup.8, --C(.dbd.O)NR.sup.9R.sup.10, --NR.sup.9R.sup.10; wherein said group is optionally substituted one or more times, in the same way or differently, with a substituent selected from: halogen, hydroxy, cyano, nitro, C.sub.1-C.sub.6-alkyl, halo-C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-alkoxy, halo-C.sub.1-C.sub.6-alkoxy, C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl, halo-C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl, C.sub.3-C.sub.10-cycloalkyl, 3- to 10-membered heterocycloalkyl, --C(.dbd.O)OH, --C(.dbd.O)O--C.sub.1-C.sub.6-alkyl, --C(.dbd.O)O--C.sub.3-C.sub.10-cycloalkyl, --N(H)C(.dbd.O)R.sup.8, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)R.sup.8, --N(H)S(.dbd.O).sub.2R.sup.8, --N(C.sub.1-C.sub.6-alkyl)S(.dbd.O).sub.2R.sup.8, --C(.dbd.O)NR.sup.9R.sup.10, --OC(.dbd.O)NR.sup.9R.sup.10, --N(H)C(.dbd.O)OR.sup.8, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)OR.sup.8, --N(H)C(.dbd.O)NR.sup.9R.sup.10, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)NR.sup.9R.sup.10, --SR.sup.8, --S(.dbd.O)R.sup.8, --S(.dbd.O).sub.2R.sup.8, --S(.dbd.O).sub.2NR.sup.9R.sup.10, --NR.sup.9R.sup.10; R.sup.8, R.sup.9, R.sup.10: represent, independently from each other, a hydrogen atom, a C.sub.1-C.sub.6-alkyl, halo-C.sub.1-C.sub.6-alkyl, HO--C.sub.1-C.sub.6-alkyl-, cyano-C.sub.1-C.sub.6-alkyl-, C.sub.2-C.sub.10-alkynyl-C.sub.1-C.sub.6-alkyl-, C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl, halo-C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl, H.sub.2NC(.dbd.O)--C.sub.1-C.sub.6-alkyl-, C.sub.1-C.sub.6-alkyl-N(H)C(.dbd.O)--C.sub.1-C.sub.6-alkyl-, H.sub.2NS(.dbd.O).sub.2--C.sub.1-C.sub.6-alkyl-, C.sub.2-C.sub.6-alkenyl, C.sub.2-C.sub.6-alkynyl, C.sub.3-C.sub.10-cycloalkyl, 3- to 10-membered heterocycloalkyl, aryl, heteroaryl, C.sub.1-C.sub.6-alkylene-aryl, --C.sub.1-C.sub.6-alkylene-heteroaryl, --C.sub.1-C.sub.6-alkylene-C.sub.3-C.sub.10-cycloalkyl, --C.sub.1-C.sub.6-alkylene-3- to 10-membered heterocycloalkyl group; wherein said C.sub.3-C.sub.10-cycloalkyl group is optionally substituted one or more times with a halogen atom, cyano, C.sub.1-C.sub.6-alkyl, halo-C.sub.1-C.sub.6-alkyl, HO--C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-alkoxy, C.sub.3-C.sub.10-cycloalkyl, aryl, or a heteroaryl group; wherein said aryl group is optionally substituted one or more times, in the same way or differently, with a substituent selected from: halogen, hydroxy, cyano, nitro, C.sub.1-C.sub.6-alkyl, halo-C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-alkoxy, halo-C.sub.1-C.sub.6-alkoxy, C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl, halo-C.sub.1-C.sub.6-alkoxy-C.sub.1-C.sub.6-alkyl, C.sub.3-C.sub.10-cycloalkyl, 3- to 10-membered heterocycloalkyl, --C.sub.1-C.sub.6-alkylene-3- to 10-membered heterocycloalkyl, --C(.dbd.O)OH, --C(.dbd.O)O--C.sub.1-C.sub.6-alkyl, --C(.dbd.O)O--C.sub.3-C.sub.10-cycloalkyl, --N(H)C(.dbd.O)--C.sub.1-C.sub.6-alkyl, --N(H)C(.dbd.O)-heteroaryl, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)--C.sub.1-C.sub.6-alkyl, --N(H)S(.dbd.O).sub.2--C.sub.1-C.sub.6-alkyl, --N(C.sub.1-C.sub.6-alkyl)S(.dbd.O).sub.2--C.sub.1-C.sub.6-alkyl, --C(.dbd.O)NH.sub.2, --C(.dbd.O)N(H)--C.sub.1-C.sub.6-alkyl, --C(.dbd.O)N(C.sub.1-C.sub.6-alkyl).sub.2, --OC(.dbd.O)NH.sub.2, --OC(.dbd.O)N(H)--C.sub.1-C.sub.6-alkyl, --OC(.dbd.O)N(C.sub.1-C.sub.6-alkyl).sub.2, --N(H)C(.dbd.O)O--C.sub.1-C.sub.6-alkyl, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)O--C.sub.1-C.sub.6-alkyl, --N(H)C(.dbd.O)NH.sub.2, --N(H)C(.dbd.O)N(H)--C.sub.1-C.sub.6-alkyl, --N(H)C(.dbd.O)N(C.sub.1-C.sub.6-alkyl).sub.2, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)NH.sub.2, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)N(H)--C.sub.1-C.sub.6-alkyl, --N(C.sub.1-C.sub.6-alkyl)C(.dbd.O)N(C.sub.1-C.sub.6-alkyl).sub.2, --S--C.sub.1-C.sub.6-alkyl, --S(.dbd.O)--C.sub.1-C.sub.6-alkyl, --S(.dbd.O).sub.2--C.sub.1-C.sub.6-alkyl, --S(.dbd.O).sub.2NH.sub.2, --S(.dbd.O).sub.2N(H)--C.sub.1-C.sub.6-alkyl, --S(.dbd.O).sub.2N(C.sub.1-C.sub.6-alkyl).sub.2, --NH.sub.2, --N(H)--C.sub.1-C.sub.6-alkyl, --N(C.sub.1-C.sub.6-alkyl).sub.2; or R.sup.9, R.sup.10, together with the nitrogen atom to which they are attached, represent a 3- to 10-membered heterocycloalkyl group; under the proviso that: R.sup.1 is not --CH.sub.2CH.sub.2CH.sub.2OH, --CH.sub.2CH.sub.2CH.sub.2O(C.dbd.O)--R.sub.a, --CH.sub.2CH.sub.2CH.sub.2O(C.dbd.O)--OR.sub.a, --CH.sub.2CH.sub.2CH.sub.2O(C.dbd.O)--CHR.sub.aNR.sub.bR.sub.c, in which R.sub.a, R.sub.b, R.sub.c, identical or different, are selected from the group consisting of H, C.sub.1-C.sub.10-alkyl, C.sub.2-C.sub.10-alkenyl, C.sub.2-C.sub.10-alkynyl, phenyl and heteroaryl; or a stereoisomer, a tautomer, an N-oxide, or a salt thereof, or a mixture of same. 4. The compound according to claim 1, which is selected from the group consisting of: 1-ethyl-3-[4-(4-isobutylamino-imidazo[1,2-a]quinoxalin-1-yl)-phenyl]-urea 1-(2-fluorophenyl)-N-(2-methylpropyl)imidazo[1,2-a]quinoxalin-4-amine 1-(4-methoxy-2-methylphenyl)-N-(2-methylpropyl)imidazo[1,2-a]quinoxalin-4- -amine 1-(2,5-difluorophenyl)-N-(2-methylpropyl)imidazo[1,2-a]quinoxalin-4- -amine N-cyclopropyl-4-{4-[(3-methylbutyl)amino]imidazo[1,2-a]quinoxalin-1- -yl}benzamide 4-[4-(benzylamino)imidazo[1,2-a]quinoxalin-1-yl]-N-cyclopropylbenzamide 4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-[2-(2-oxoimi- dazolidin-1-yl)ethyl]benzamide N-[2-(methylamino)-2-oxoethyl]-4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]- quinoxalin-1-yl}benzamide 4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-[2-(pyridin-- 3-yl)ethyl]benzamide N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-4-{4-[(2- -methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide N-(1-methylcyclopropyl)-4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxa- lin-1-yl}benzamide 4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzoic acid 1-(2-fluoropyridin-3-yl)-N-(2-methylpropyl)imidazo[1,2-a]quinoxalin-4-ami- ne 4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzamide 1-(2,3-difluorophenyl)-N-(2-methylpropyl)imidazo[1,2-a]quinoxalin-4-amine 1-(3-fluoro-4-methoxyphenyl)-N-(2-methylpropyl)imidazo[1,2-a]quinoxalin-4- -amine N-(2-methylpropyl)-1-(5-methylthiophen-2-yl)imidazo[1,2-a]quinoxali- n-4-amine N-(2-methylpropyl)-1-(6-methylpyridin-3-yl)imidazo[1,2-a]quinoxa- lin-4-amine 2-chloro-N-cyclopropyl-4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxal- in-1-yl}benzamide N-methyl-5-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}pyridi- ne-2-carboxamide N-cyclopropyl-4-{4-[(4-sulfamoylbenzyl)amino]imidazo[1,2-a]quinoxalin-1-y- l}benzamide N-cyclopropyl-4-(4-{[2-(pyridin-3-yl)ethyl]amino}imidazo[1,2-a]quinoxalin- -1-yl)benzamide N-cyclopropyl-4-{4-[(2-sulfamoylethyl)amino]imidazo[1,2-a]quinoxalin-1-yl- }benzamide 4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-pr- opylbenzamide N-(2-hydroxyethyl)-4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1- -yl}benzamide 4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-(4-sulfamoyl- phenyl)benzamide 4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-[1-(pyridin-- 2-yl)cyclopropyl]benzamide 1-[4-(4-isobutylamino-imidazo[1,2-a]quinoxalin-1-yl)-phenyl]-3-[4-(4-meth- yl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]-urea 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-(2-methylpropyl)imidazo[1,2-a]quin- oxalin-4-amine 1-(2-fluoro-3-methoxyphenyl)-N-(2-methylpropyl)imidazo[1,2-a]quinoxalin-4- -amine N-(2-methylpropyl)-1-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-a]quinox- alin-4-amine 1-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)imidazo[1,2-a]quinoxalin-4-ami- ne 3-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}phenol 1-(1H-indol-5-yl)-N-(2-methylpropyl)imidazo[1,2-a]quinoxalin-4-amine 2-chloro-N-methyl-4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-- yl}benzamide N-cyclopropyl-4-{4-[(3-fluorobenzyl)amino]imidazo[1,2-a]quinoxalin-1-yl}b- enzamide N-cyclopropyl-4-{4-[(2-methylbenzyl)amino]imidazo[1,2-a]quinoxali- n-1-yl}benzamide N-cyclopropyl-4-(4-{[2-(morpholin-4-yl)ethyl]amino}imidazo[1,2-a]quinoxal- in-1-yl)benzamide N-cyclopropyl-4-(4-{[2-(2-oxoimidazolidin-1-yl)ethyl]amino}imidazo[1,2-a]- quinoxalin-1-yl)benzamide 4-{4-[(4-cyanobenzyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-cyclopropylbe- nzamide N-cyclopropyl-4-{4-[(1-methyl-1H-pyrazol-3-yl)amino]imidazo[1,2-a]- quinoxalin-1-yl}benzamide 4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-[3-(2-oxopyr- rolidin-1-yl)propyl]benzamide N-(3-carbamoylphenyl)-4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxali- n-1-yl}benzamide 4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-(1-methyl-1H- -pyrazol-3-yl)benzamide N-{3-[(4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzoyl)- amino]phenyl}pyridine-3-carboxamide 1-(4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}phenyl)ethan- one 1-(1H-indazol-5-yl)-N-(2-methylpropyl)imidazo[1,2-a]quinoxalin-4-amine N-cyclopropyl-4-[4-(2-hydroxy-ethylamino)-imidazo[1,2-a]quinoxalin-1-yl]-- benzamide N-cyclopropyl-4-{4-[(3-methylbenzyl)amino]imidazo[1,2-a]quinoxal- in-1-yl}benzamide N-cyclopropyl-4-{4-[(2-methoxybenzyl)amino]imidazo[1,2-a]quinoxalin-1-yl}- benzamide N-cyclopropyl-4-[4-(ethylamino)imidazo[1,2-a]quinoxalin-1-yl]ben- zamide N-cyclopropyl-4-[4-({4-[(methylsulfonyl)amino]phenyl}amino)imidazo[- 1,2-a]quinoxalin-1-yl]benzamide N-(1-benzylpiperidin-4-yl)-4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quin- oxalin-1-yl}benzamide N-{3-[(4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzoyl)- amino]phenyl}pyridine-4-carboxamide N-(2-methylpropyl)-1-[4-(methylsulfonyl)phenyl]imidazo[1,2-a]quinoxalin-4- -amine 1-(1H-indazol-6-yl)-N-(2-methylpropyl)imidazo[1,2-a]quinoxalin-4-am- ine N-cyclopropyl-4-(4-{[3-(morpholin-4-yl)propyl]amino}imidazo[1,2-a]quin- oxalin-1-yl)benzamide N-cyclopropyl-4-{4-[(2-methoxyethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}b- enzamide N-cyclopropyl-4-(4-{[2-(4-methoxyphenyl)ethyl]amino}imidazo[1,2-a- ]quinoxalin-1-yl)benzamide N-cyclopropyl-4-{4-[(thiophen-2-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1- -yl}benzamide N-cyclopropyl-4-(4-{[2-(4-sulfamoylphenyl)ethyl]amino}imidazo[1,2-a]quino- xalin-1-yl)benzamide N-cyclopropyl-4-{4-[(2-phenoxyethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}b- enzamide N,N-diethyl-4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-- 1-yl}benzamide N-(1-hydroxypropan-2-yl)-4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinox- alin-1-yl}benzamide N-(2-methylcyclopropyl)-4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxa- lin-1-yl}benzamide N-[1-(hydroxymethyl)cyclopropyl]-4-{4-[(2-methylpropyl)amino]imidazo[1,2-- a]quinoxalin-1-yl}benzamide N-cyclopropyl-4-(4-isobutylamino-imidazo[1,2-a]quinoxalin-1-yl)-benzamide 1-(4-methylphenyl)-N-(2-methylpropyl)imidazo[1,2-a]quinoxalin-4-amine N-(2-methylpropyl)-1-[4-(methylsulfanyl)phenyl]imidazo[1,2-a]quinoxalin-4- -amine 1-(2-methylphenyl)-N-(2-methylpropyl)imidazo[1,2-a]quinoxalin-4-ami- ne 1-(1H-indol-6-yl)-N-(2-methylpropyl)imidazo[1,2-a]quinoxalin-4-amine 1-(isoquinolin-5-yl)-N-(2-methylpropyl)imidazo[1,2-a]quinoxalin-4-amine N-methyl-3-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzam- ide N-(2-methylpropyl)-1-[2-(trifluoromethyl)phenyl]imidazo[1,2-a]quinoxal- in-4-amine 4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}pheno- l 1-(2-fluoro-4-methylphenyl)-N-(2-methylpropyl)imidazo[1,2-a]quinoxalin-4- -amine 4-{4-[(3-chlorobenzyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-cyclop- ropylbenzamide N-cyclopropyl-4-{4-[(2-phenylethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}be- nzamide N-cyclopropyl-4-[4-(phenylamino)imidazo[1,2-a]quinoxalin-1-yl]benz- amide N-cyclopropyl-4-{4-[(cyclopropylmethyl)amino]imidazo[1,2-a]quinoxali- n-1-yl}benzamide N-cyclopropyl-4-{4-[(pyridin-3-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-- yl}benzamide N-cyclopropyl-4-(4-{[4-(pyrrolidin-1-yl)butyl]amino}imidazo[1,2-a]quinoxa- lin-1-yl)benzamide N-cyclopropyl-4-(4-{[2-(4-fluorophenyl)ethyl]amino}imidazo[1,2-a]quinoxal- in-1-yl)benzamide 4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-(1H-pyrazol-- 3-yl)benzamide 4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-(prop-2-yn-1- -yl)benzamide 4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-[2-(pyridin-- 4-yl)ethyl]benzamide 1-ethyl-N-{3-[(4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}- benzoyl)amino]phenyl}-1H-pyrazole-5-carboxamide N-(2-methylpropyl)-1-phenylimidazo[1,2-a]quinoxalin-4-amine N-methyl-4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzam- ide N-(2-methylpropyl)-1-(thiophen-2-yl)imidazo[1,2-a]quinoxalin-4-amine 1-(4-ethoxyphenyl)-N-(2-methylpropyl)imidazo[1,2-a]quinoxalin-4-amine N-(2-methylpropyl)-1-(pyridin-3-yl)imidazo[1,2-a]quinoxalin-4-amine N-(2-methylpropyl)-1-(pyridin-4-yl)imidazo[1,2-a]quinoxalin-4-amine N-(3-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzyl)aceta- mide N-cyclopropyl-4-[4-(pentylamino)imidazo[1,2-a]quinoxalin-1-yl]benzami- de N-cyclopropyl-4-(4-{[3-(2-oxopyrrolidin-1-yl)propyl]amino}imidazo[1,2-a- ]quinoxalin-1-yl)benzamide N-cyclopropyl-4-{4-[(2-fluorobenzyl)amino]imidazo[1,2-a]quinoxalin-1-yl}b- enzamide N-cyclopropyl-4-(4-{[2-(3-fluorophenyl)ethyl]amino}imidazo[1,2-a]- quinoxalin-1-yl)benzamide 4-{4-[(1,3-benzodioxol-5-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-- cyclopropylbenzamide N-ethyl-4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}benzami- de N-(2-carbamoylphenyl)-4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxa- lin-1-yl}benzamide N-[3-(acetylamino)phenyl]-4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quino- xalin-1-yl}benzamide N-(2-fluorocyclopropyl)-4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxa- lin-1-yl}benzamide N,N-dimethyl-4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}be- nzamide 1-(2-methoxypyrimidin-5-yl)-N-(2-methylpropyl)imidazo[1,2-a]quinox- alin-4-amine (4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}phenyl)(pyrrol- idin-1-yl)methanone N-(2-methylpropyl)-1-(thiophen-3-yl)imidazo[1,2-a]quinoxalin-4-amine 1-(3,4-dimethoxyphenyl)-N-(2-methylpropyl)imidazo[1,2-a]quinoxalin-4-amin- e (4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}phenyl)methan- ol 2-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}phenol N-(2-methylpropyl)-1-(1H-pyrazol-3-yl)imidazo[1,2-a]quinoxalin-4-amine N-cyclopropyl-4-{4-[(4-fluorobenzyl)amino]imidazo[1,2-a]quinoxalin-1-yl}b- enzamide N-cyclopropyl-4-(4-{[3-(dimethylamino)propyl]amino}imidazo[1,2-a]- quinoxalin-1-yl)benzamide N-cyclopropyl-4-{4-[(3-phenylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}b- enzamide N-cyclopropyl-4-(4-{[2-(pyridin-4-yl)ethyl]amino}imidazo[1,2-a]qu- inoxalin-1-yl)benzamide 4-({1-[4-(cyclopropylcarbamoyl)phenyl]imidazo[1,2-a]quinoxalin-4-yl}amino- )-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide N-(2-amino-2-oxoethyl)-4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxal- in-1-yl}benzamide N-(3-amino-3-oxopropyl)-4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxa- lin-1-yl}benzamide N-(1-cyanocyclopropyl)-4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxal- in-1-yl}benzamide 4-{4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-(2-sulfamoyl- ethyl)benzamide N-cyclopropyl-4-[8-fluoro-4-(propylamino)imidazo[1,2-a]quinoxalin-1-yl]be- nzamide N-cyclopropyl-4-{8-fluoro-4-[(pyridin-3-ylmethyl)amino]imidazo[1,2- -a]quinoxalin-1-yl}benzamide N-cyclopropyl-4-{8-fluoro-4-[(3-methoxypropyl)amino]imidazo[1,2-a]quinoxa- lin-1-yl}benzamide N-cyclopropyl-4-{7,8-difluoro-4-[(3-methylbutyl)amino]imidazo[1,2-a]quino- xalin-1-yl}benzamide N-cyclopropyl-4-(7,8-difluoro-4-{[(1-methyl-1H-pyrazol-4-yl)methyl]amino}- imidazo[1,2-a]quinoxalin-1-yl)benzamide 1-(4-{7,8-difluoro-4-[(3-hydroxypropyl)amino]imidazo[1,2-a]quinoxalin-1-y- l}phenyl)-3-methylurea N-{2-[(7,8-difluoro-1-{4-[(methylcarbamoyl)amino]phenyl}imidazo[1,2-a]qui- noxalin-4-yl)amino]ethyl}acetamide 2-chloro-N-cyclopropyl-4-{7,8-difluoro-4-[(2-fluorobenzyl)amino]imidazo[1- ,2-a]quinoxalin-1-yl}benzamide 2-chloro-N-cyclopropyl-4-{7,8-difluoro-4-[(3-hydroxypropyl)amino]imidazo[- 1,2-a]quinoxalin-1-yl}benzamide tert-butyl [3-({1-[3-chloro-4-(cyclopropylcarbamoyl)phenyl]-7,8-difluoroimidazo[1,2-- a]quinoxalin-4-yl}amino)propyl]carbamate N-cyclopropyl-4-[4-(ethylamino)-7,8-dimethylimidazo[1,2-a]quinoxalin-1-yl- ]benzamide N-cyclopropyl-4-{7,8-dimethyl-4-[(pyridin-2-ylmethyl)amino]imid- azo[1,2-a]quinoxalin-1-yl}benzamide N-cyclopropyl-4-{4-[(2,3-dihydroxypropyl)amino]-7,8-dimethylimidazo[1,2-a- ]quinoxalin-1-yl}benzamide 1-(4-{4-[(2-methoxyethyl)amino]-7,8-dimethylimidazo[1,2-a]quinoxalin-1-yl- }phenyl)-3-methylurea 2-chloro-N-cyclopropyl-4-{4-[(2-hydroxyethyl)amino]-7,8-dimethylimidazo[1- ,2-a]quinoxalin-1-yl}benzamide 2-chloro-N-cyclopropyl-4-(4-{[3-(1H-imidazol-1-yl)propyl]amino}-7,8-dimet- hylimidazo[1,2-a]quinoxalin-1-yl)benzamide 2-chloro-N-cyclopropyl-4-{4-[(cyclopropylmethyl)amino]-7,8-dimethylimidaz- o[1,2-a]quinoxalin-1-yl}benzamide 2-chloro-N-cyclopropyl-4-{7,8-dimethyl-4-[(pyridin-3-ylmethyl)amino]imida- zo[1,2-a]quinoxalin-1-yl}benzamide 4-{4-[(3-amino-3-oxopropyl)amino]-7,8-dimethylimidazo[1,2-a]quinoxalin-1-- yl}-2-chloro-N-cyclopropylbenzamide tert-butyl [3-({1-[3-chloro-4-(cyclopropylcarbamoyl)phenyl]-7-cyanoimidazo[1,2-a]qui- noxalin-4-yl}amino)propyl]carbamate N-cyclopropyl-4-{8-fluoro-4-[(thiophen-2-ylmethyl)amino]imidazo[1,2-a]qui- noxalin-1-yl}benzamide N-cyclopropyl-4-[4-(ethylamino)-8-fluoroimidazo[1,2-a]quinoxalin-1-yl]ben- zamide 4-[4-(butylamino)-8-fluoroimidazo[1,2-a]quinoxalin-1-yl]-N-cyclopro- pylbenzamide 1-(4-{8-fluoro-4-[(2-methoxyethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}phe- nyl)-3-methylurea 1-(4-{8-fluoro-4-[(4-hydroxybutyl)amino]imidazo[1,2-a]quinoxalin-1-yl}phe- nyl)-3-methylurea 1-[4-(8-fluoro-4-{[(1-methyl-1H-pyrazol-4-yl)methyl]amino}imidazo[1,2-a]q- uinoxalin-1-yl)phenyl]-3-methylurea 2-chloro-N-cyclopropyl-4-[8-fluoro-4-(propylamino)imidazo[1,2-a]quinoxali- n-1-yl]benzamide 2-chloro-N-cyclopropyl-4-{8-fluoro-4-[(pyridin-4-ylmethyl)amino]imidazo[1- ,2-a]quinoxalin-1-yl}benzamide N-cyclopropyl-4-{7,8-difluoro-4-[(2-methoxyethyl)amino]imidazo[1,2-a]quin- oxalin-1-yl}benzamide N-cyclopropyl-4-{7,8-difluoro-4-[(3-hydroxypropyl)amino]imidazo[1,2-a]qui- noxalin-1-yl}benzamide N-cyclopropyl-4-{7,8-difluoro-4-[(furan-2-ylmethyl)amino]imidazo[1,2-a]qu- inoxalin-1-yl}benzamide N-cyclopropyl-4-{7,8-difluoro-4-[(3-methoxypropyl)amino]imidazo[1,2-a]qui- noxalin-1-yl}benzamide 1-{4-[7,8-difluoro-4-(propylamino)imidazo[1,2-a]quinoxalin-1-yl]phenyl}-3- -methylurea 4-[4-(butylamino)-7,8-difluoroimidazo[1,2-a]quinoxalin-1-yl]-2-chloro-N-c- yclopropylbenzamide 2-chloro-N-cyclopropyl-4-{7,8-difluoro-4-[(2-sulfamoylethyl)amino]imidazo- [1,2-a]quinoxalin-1-yl}benzamide 1-{4-[4-(benzylamino)-7,8-dimethylimidazo[1,2-a]quinoxalin-1-yl]phenyl}-3- -methylurea 1-(4-{7,8-dimethyl-4-[(pyridin-4-ylmethyl)amino]imidazo[1,2-a]quinoxalin-- 1-yl}phenyl)-3-methylurea 1-(4-{7,8-dimethyl-4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl- }phenyl)-3-methylurea 4-(7-cyano-4-{[3-(morpholin-4-yl)propyl]amino}imidazo[1,2-a]quinoxalin-1-- yl)-N-cyclopropylbenzamide 4-(7-cyano-4-{[3-(2-oxopyrrolidin-1-yl)propyl]amino}imidazo[1,2-a]quinoxa- lin-1-yl)-N-cyclopropylbenzamide 1-[4-(7-cyano-4-{[3-(2-oxopyrrolidin-1-yl)propyl]amino}imidazo[1,2-a]quin- oxalin-1-yl)phenyl]-3-methylurea 2-chloro-4-{7-cyano-4-[(4-hydroxybutyl)amino]imidazo[1,2-a]quinoxalin-1-y- l}-N-cyclopropylbenzamide 2-chloro-4-{7-cyano-4-[(3-methoxypropyl)amino]imidazo[1,2-a]quinoxalin-1-- yl}-N-cyclopropylbenzamide N-cyclopropyl-4-{8-fluoro-4-[(2-methoxyethyl)amino]imidazo[1,2-a]quinoxal- in-1-yl}benzamide 1-(4-{8-fluoro-4-[(2,2,2-trifluoroethyl)amino]imidazo[1,2-a]quinoxalin-1-- yl}phenyl)-3-methylurea 1-[4-(8-fluoro-4-{[3-(1H-imidazol-1-yl)propyl]amino}imidazo[1,2-a]quinoxa- lin-1-yl)phenyl]-3-methylurea 2-chloro-N-cyclopropyl-4-{8-fluoro-4-[(3-hydroxypropyl)amino]imidazo[1,2-- a]quinoxalin-1-yl}benzamide 2-chloro-N-cyclopropyl-4-{8-fluoro-4-[(3-methoxypropyl)amino]imidazo[1,2-- a]quinoxalin-1-yl}benzamide N-cyclopropyl-4-(7,8-difluoro-4-{[3-(morpholin-4-yl)propyl]amino}imidazo[- 1,2-a]quinoxalin-1-yl)benzamide N-cyclopropyl-4-{7,8-difluoro-4-[(4-fluorobenzyl)amino]imidazo[1,2-a]quin- oxalin-1-yl}benzamide 1-(4-{7,8-difluoro-4-[(pyridin-3-ylmethyl)amino]imidazo[1,2-a]quinoxalin-- 1-yl}phenyl)-3-methylurea 2-chloro-N-cyclopropyl-4-(7,8-difluoro-4-{[3-(2-oxopyrrolidin-1-yl)propyl- ]amino}imidazo[1,2-a]quinoxalin-1-yl)benzamide 2-chloro-N-cyclopropyl-4-{7,8-difluoro-4-[(pyridin-4-ylmethyl)amino]imida- zo[1,2-a]quinoxalin-1-yl}benzamide 4-[4-(butylamino)-7,8-dimethylimidazo[1,2-a]quinoxalin-1-yl]-N-cyclopropy- lbenzamide N-cyclopropyl-4-{4-[(furan-2-ylmethyl)amino]-7,8-dimethylimidaz- o[1,2-a]quinoxalin-1-yl}benzamide 1-{4-[4-(ethylamino)-7,8-dimethylimidazo[1,2-a]quinoxalin-1-yl]phenyl}-3-- methylurea 2-chloro-N-cyclopropyl-4-(7,8-dimethyl-4-{[3-(morpholin-4-yl)pr- opyl]amino}imidazo[1,2-a]quinoxalin-1-yl)benzamide 2-chloro-N-cyclopropyl-4-(7,8-dimethyl-4-{[3-(2-oxopyrrolidin-1-yl)propyl- ]amino}imidazo[1,2-a]quinoxalin-1-yl)benzamide 4-[4-(butylamino)-7,8-dimethylimidazo[1,2-a]quinoxalin-1-yl]-2-chloro-N-c- yclopropylbenzamide 2-chloro-N-cyclopropyl-4-{7,8-dimethyl-4-[(pyridin-2-ylmethyl)amino]imida- zo[1,2-a]quinoxalin-1-yl}benzamide 2-chloro-N-cyclopropyl-4-(7,8-dimethyl-4-{[(1-methyl-1H-pyrazol-4-yl)meth- yl]amino}imidazo[1,2-a]quinoxalin-1-yl)benzamide 4-[7-cyano-4-(propylamino)imidazo[1,2-a]quinoxalin-1-yl]-N-cyclopropylben- zamide 4-{7-cyano-4-[(2-methoxyethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-- N-cyclopropylbenzamide 4-[7-cyano-4-(ethylamino)imidazo[1,2-a]quinoxalin-1-yl]-N-cyclopropylbenz- amide 4-{7-cyano-4-[(3-hydroxypropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-- N-cyclopropylbenzamide 4-[4-(butylamino)-7-cyanoimidazo[1,2-a]quinoxalin-1-yl]-N-cyclopropylbenz- amide 4-{7-cyano-4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N- -cyclopropylbenzamide 2-chloro-4-{7-cyano-4-[(3-hydroxypropyl)amino]imidazo[1,2-a]quinoxalin-1-- yl}-N-cyclopropylbenzamide 4-(4-{[2-(acetylamino)ethyl]amino}-7-cyanoimidazo[1,2-a]quinoxalin-1-yl)-- 2-chloro-N-cyclopropylbenzamide 2-chloro-4-{7-cyano-4-[(pyridin-4-ylmethyl)amino]imidazo[1,2-a]quinoxalin- -1-yl}-N-cyclopropylbenzamide 1-(4-{8-fluoro-4-[(2-fluorobenzyl)amino]imidazo[1,2-a]quinoxalin-1-yl}phe- nyl)-3-methylurea 1-(4-{8-fluoro-4-[(3-methoxypropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}ph- enyl)-3-methylurea 2-chloro-N-cyclopropyl-4-(8-fluoro-4-{[(1-methyl-1H-pyrazol-4-yl)methyl]a- mino}imidazo[1,2-a]quinoxalin-1-yl)benzamide N-cyclopropyl-4-[4-(ethylamino)-7,8-difluoroimidazo[1,2-a]quinoxalin-1-yl- ]benzamide 4-(4-{[2-(acetylamino)ethyl]amino}-7,8-difluoroimidazo[1,2-a]qu- inoxalin-1-yl)-N-cyclopropylbenzamide 1-(4-{7,8-difluoro-4-[(pyridin-4-ylmethyl)amino]imidazo[1,2-a]quinoxalin-- 1-yl}phenyl)-3-methylurea 4-(4-{[2-(acetylamino)ethyl]amino}-7,8-difluoroimidazo[1,2-a]quinoxalin-1- -yl)-2-chloro-N-cyclopropylbenzamide 2-chloro-N-cyclopropyl-4-(7,8-difluoro-4-{[3-(1H-imidazol-1-yl)propyl]ami- no}imidazo[1,2-a]quinoxalin-1-yl)benzamide 2-chloro-N-cyclopropyl-4-{7,8-difluoro-4-[(2-methylpropyl)amino]imidazo[1- ,2-a]quinoxalin-1-yl}benzamide 2-chloro-N-cyclopropyl-4-(7,8-difluoro-4-{[(1-methyl-1H-pyrazol-4-yl)meth- yl]amino}imidazo[1,2-a]quinoxalin-1-yl)benzamide 1-{4-[7,8-dimethyl-4-(propylamino)imidazo[1,2-a]quinoxalin-1-yl]phenyl}-3- -methylurea 1-[4-(7,8-dimethyl-4-{[3-(morpholin-4-yl)propyl]amino}imidazo[1,2-a]quino- xalin-1-yl)phenyl]-3-methylurea 1-[4-(4-{[3-(1H-imidazol-1-yl)propyl]amino}-7,8-dimethylimidazo[1,2-a]qui- noxalin-1-yl)phenyl]-3-methylurea 2-chloro-N-cyclopropyl-4-{7,8-dimethyl-4-[(3-methylbutyl)amino]imidazo[1,- 2-a]quinoxalin-1-yl}benzamide 2-chloro-N-cyclopropyl-4-(7,8-dimethyl-4-{[(1-methyl-1H-pyrazol-5-yl)meth- yl]amino}imidazo[1,2-a]quinoxalin-1-yl)benzamide 2-chloro-N-cyclopropyl-4-{4-[(2,3-dihydroxypropyl)amino]-7,8-dimethylimid- azo[1,2-a]quinoxalin-1-yl}benzamide 4-{7-cyano-4-[(3-fluorobenzyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-cycl- opropylbenzamide 4-{4-[(3-amino-3-oxopropyl)amino]-7-cyanoimidazo[1,2-a]quinoxalin-1-yl}-N- -cyclopropylbenzamide 4-(7-cyano-4-{[(1-methyl-1H-pyrazol-5-yl)methyl]amino}imidazo[1,2-a]quino- xalin-1-yl)-N-cyclopropylbenzamide 1-(4-{7-cyano-4-[(pyridin-3-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}- phenyl)-3-methylurea 4-[4-(butylamino)-7-cyanoimidazo[1,2-a]quinoxalin-1-yl]-2-chloro-N-cyclop- ropylbenzamide 2-chloro-4-{7-cyano-4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxalin-1-y- l}-N-cyclopropylbenzamide N-cyclopropyl-4-{8-fluoro-4-[(2-hydroxyethyl)amino]imidazo[1,2-a]quinoxal- in-1-yl}benzamide N-cyclopropyl-4-{8-fluoro-4-[(3-methylbutyl)amino]imidazo[1,2-a]quinoxali- n-1-yl}benzamide N-cyclopropyl-4-(8-fluoro-4-{[3-(2-oxopyrrolidin-1-yl)propyl]amino}imidaz- o[1,2-a]quinoxalin-1-yl)benzamide N-cyclopropyl-4-{8-fluoro-4-[(2-methylpropyl)amino]imidazo[1,2-a]quinoxal- in-1-yl}benzamide 4-{4-[(3-amino-3-oxopropyl)amino]-8-fluoroimidazo[1,2-a]quinoxalin-1-yl}-- N-cyclopropylbenzamide N-cyclopropyl-4-[7,8-difluoro-4-(propylamino)imidazo[1,2-a]quinoxalin-1-y- l]benzamide 4-[4-(butylamino)-7,8-difluoroimidazo[1,2-a]quinoxalin-1-yl]-N-cyclopropy- lbenzamide N-cyclopropyl-4-(7,8-difluoro-4-{[3-(1H-imidazol-1-yl)propyl]am- ino}imidazo[1,2-a]quinoxalin-1-yl)benzamide N-cyclopropyl-4-{4-[(cyclopropylmethyl)amino]-7,8-difluoroimidazo[1,2-a]q- uinoxalin-1-yl}benzamide N-cyclopropyl-4-(7,8-difluoro-4-{[(1-methyl-1H-pyrazol-5-yl)methyl]amino}- imidazo[1,2-a]quinoxalin-1-yl)benzamide 1-[4-(7,8-difluoro-4-{[3-(2-oxopyrrolidin-1-yl)propyl]amino}imidazo[1,2-a- ]quinoxalin-1-yl)phenyl]-3-methylurea 1-(4-{7,8-difluoro-4-[(pyridin-2-ylmethyl)amino]imidazo[1,2-a]quinoxalin-- 1-yl}phenyl)-3-methylurea 2-chloro-N-cyclopropyl-4-{7,8-difluoro-4-[(pyridin-3-ylmethyl)amino]imida- zo[1,2-a]quinoxalin-1-yl}benzamide 4-{4-[(3-amino-3-oxopropyl)amino]-7,8-difluoroimidazo[1,2-a]quinoxalin-1-- yl}-2-chloro-N-cyclopropylbenzamide N-cyclopropyl-4-[7,8-dimethyl-4-(propylamino)imidazo[1,2-a]quinoxalin-1-y- l]benzamide N-cyclopropyl-4-{4-[(cyclopropylmethyl)amino]-7,8-dimethylimidazo[1,2-a]q- uinoxalin-1-yl}benzamide N-cyclopropyl-4-{7,8-dimethyl-4-[(2-methylpropyl)amino]imidazo[1,2-a]quin- oxalin-1-yl}benzamide N<sup>3</sup>-(7,8-dimethyl-1-{4-[(methylcarbamoyl)amino]phen- yl}imidazo[1,2-a]quinoxalin-4-yl)-beta-alaninamide 1-[4-(7,8-dimethyl-4-{[(1-methyl-1H-pyrazol-4-yl)methyl]amino}imidazo[1,2- -a]quinoxalin-1-yl)phenyl]-3-methylurea 2-chloro-N-cyclopropyl-4-{4-[(4-hydroxybutyl)amino]-7,8-dimethylimidazo[1- ,2-a]quinoxalin-1-yl}benzamide tert-butyl [3-({1-[3-chloro-4-(cyclopropylcarbamoyl)phenyl]-7,8-dimethylimidazo[1,2-- a]quinoxalin-4-yl}amino)propyl]carbamate 4-{7-cyano-4-[(2,2,2-trifluoroethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-- N-cyclopropylbenzamide 4-{7-cyano-4-[(pyridin-2-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-- cyclopropylbenzamide 1-(4-{7-cyano-4-[(3-hydroxypropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}phe- nyl)-3-methylurea 1-(4-{7-cyano-4-[(2,3-dihydroxypropyl)amino]imidazo[1,2-a]quinoxalin-1-yl- }phenyl)-3-methylurea 2-chloro-4-{7-cyano-4-[(3-methylbutyl)amino]imidazo[1,2-a]quinoxalin-1-yl- }-N-cyclopropylbenzamide 2-chloro-4-{7-cyano-4-[(2-fluorobenzyl)amino]imidazo[1,2-a]quinoxalin-1-y- l}-N-cyclopropylbenzamide 2-chloro-4-(7-cyano-4-{[(1-methyl-1H-pyrazol-4-yl)methyl]amino}imidazo[1,- 2-a]quinoxalin-1-yl)-N-cyclopropylbenzamide 1-(4-{4-[(2,3-dihydroxypropyl)amino]-8-fluoroimidazo[1,2-a]quinoxalin-1-y- l}phenyl)-3-methylurea 2-chloro-N-cyclopropyl-4-{8-fluoro-4-[(2-methoxyethyl)amino]imidazo[1,2-a- ]quinoxalin-1-yl}benzamide 2-chloro-N-cyclopropyl-4-{4-[(2,3-dihydroxypropyl)amino]-8-fluoroimidazo[- 1,2-a]quinoxalin-1-yl}benzamide N-cyclopropyl-4-{7,8-difluoro-4-[(thiophen-2-ylmethyl)amino]imidazo[1,2-a- ]quinoxalin-1-yl}benzamide N-cyclopropyl-4-(7,8-difluoro-4-{[(1-methyl-1H-pyrazol-3-yl)methyl]amino}- imidazo[1,2-a]quinoxalin-1-yl)benzamide 1-[4-(7,8-difluoro-4-{[3-(1H-imidazol-1-yl)propyl]amino}imidazo[1,2-a]qui- noxalin-1-yl)phenyl]-3-methylurea 1-(4-{4-[(cyclopropylmethyl)amino]-7,8-difluoroimidazo[1,2-a]quinoxalin-1- -yl}phenyl)-3-methylurea 2-chloro-N-cyclopropyl-4-{7,8-difluoro-4-[(3-methoxypropyl)amino]imidazo[- 1,2-a]quinoxalin-1-yl}benzamide N-cyclopropyl-4-(7,8-dimethyl-4-{[(1-methyl-1H-pyrazol-4-yl)methyl]amino}- imidazo[1,2-a]quinoxalin-1-yl)benzamide 1-(4-{4-[(3-fluorobenzyl)amino]-7,8-dimethylimidazo[1,2-a]quinoxalin-1-yl- }phenyl)-3-methylurea 1-(4-{4-[(2-fluorobenzyl)amino]-7,8-dimethylimidazo[1,2-a]quinoxalin-1-yl- }phenyl)-3-methylurea 2-[(7,8-dimethyl-1-{4-[(methylcarbamoyl)amino]phenyl}imidazo[1,2-a]quinox- alin-4-yl)amino]ethanesulfonamide 2-chloro-N-cyclopropyl-4-[7,8-dimethyl-4-(propylamino)imidazo[1,2-a]quino- xalin-1-yl]benzamide 2-chloro-N-cyclopropyl-4-{4-[(3-hydroxypropyl)amino]-7,8-dimethylimidazo[- 1,2-a]quinoxalin-1-yl}benzamide 4-(4-{[2-(acetylamino)ethyl]amino}-7,8-dimethylimidazo[1,2-a]quinoxalin-1- -yl)-2-chloro-N-cyclopropylbenzamide 2-chloro-N-cyclopropyl-4-{7,8-dimethyl-4-[(pyridin-4-ylmethyl)amino]imida- zo[1,2-a]quinoxalin-1-yl}benzamide 2-chloro-N-cyclopropyl-4-{7,8-dimethyl-4-[(2-methylpropyl)amino]imidazo[1- ,2-a]quinoxalin-1-yl}benzamide 2-chloro-N-cyclopropyl-4-(7,8-dimethyl-4-{[(1-methyl-1H-pyrazol-3-yl)meth- yl]amino}imidazo[1,2-a]quinoxalin-1-yl)benzamide 4-(7-cyano-4-{[(1-methyl-1H-pyrazol-4-yl)methyl]amino}imidazo[1,2-a]quino- xalin-1-yl)-N-cyclopropylbenzamide N-{2-[(7-cyano-1-{4-[(methylcarbamoyl)amino]phenyl}imidazo[1,2-a]quinoxal- in-4-yl)amino]ethyl}acetamide 2-chloro-4-{7-cyano-4-[(2-hydroxyethyl)amino]imidazo[1,2-a]quinoxalin-1-y- l}-N-cyclopropylbenzamide 2-chloro-4-{7-cyano-4-[(pyridin-3-ylmethyl)amino]imidazo[1,2-a]quinoxalin- -1-yl}-N-cyclopropylbenzamide 2-chloro-4-(7-cyano-4-{[(1-methyl-1H-pyrazol-3-yl)methyl]amino}imidazo[1,- 2-a]quinoxalin-1-yl)-N-cyclopropylbenzamide 2-chloro-4-{7-cyano-4-[(2,3-dihydroxypropyl)amino]imidazo[1,2-a]quinoxali- n-1-yl}-N-cyclopropylbenzamide N-cyclopropyl-4-{8-fluoro-4-[(4-fluorobenzyl)amino]imidazo[1,2-a]quinoxal- in-1-yl}benzamide N-cyclopropyl-4-{8-fluoro-4-[(3-hydroxypropyl)amino]imidazo[1,2-a]quinoxa- lin-1-yl}benzamide N-cyclopropyl-4-{8-fluoro-4-[(pyridin-2-ylmethyl)amino]imidazo[1,2-a]quin- oxalin-1-yl}benzamide N-cyclopropyl-4-{4-[(2,3-dihydroxypropyl)amino]-8-fluoroimidazo[1,2-a]qui- noxalin-1-yl}benzamide 1-(4-{8-fluoro-4-[(3-hydroxypropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}ph- enyl)-3-methylurea 1-(4-{8-fluoro-4-[(pyridin-3-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl- }phenyl)-3-methylurea 1-(4-{8-fluoro-4-[(furan-2-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}p- henyl)-3-methylurea 2-[(8-fluoro-1-{4-[(methylcarbamoyl)amino]phenyl}imidazo[1,2-a]quinoxalin- -4-yl)amino]ethanesulfonamide 2-chloro-N-cyclopropyl-4-(8-fluoro-4-{[3-(morpholin-4-yl)propyl]amino}imi- dazo[1,2-a]quinoxalin-1-yl)benzamide 2-chloro-N-cyclopropyl-4-(8-fluoro-4-{[3-(2-oxopyrrolidin-1-yl)propyl]ami- no}imidazo[1,2-a]quinoxalin-1-yl)benzamide 2-chloro-N-cyclopropyl-4-{8-fluoro-4-[(pyridin-3-ylmethyl)amino]imidazo[1- ,2-a]quinoxalin-1-yl}benzamide tert-butyl [3-({1-[3-chloro-4-(cyclopropylcarbamoyl)phenyl]-8-fluoroimidazo[1,2-a]qu- inoxalin-4-yl}amino)propyl]carbamate N-cyclopropyl-4-{7,8-difluoro-4-[(2-hydroxyethyl)amino]imidazo[1,2-a]quin- oxalin-1-yl}benzamide N-cyclopropyl-4-(7,8-difluoro-4-{[3-(2-oxopyrrolidin-1-yl)propyl]amino}im- idazo[1,2-a]quinoxalin-1-yl)benzamide N-cyclopropyl-4-{7,8-difluoro-4-[(4-hydroxybutyl)amino]imidazo[1,2-a]quin- oxalin-1-yl}benzamide N-cyclopropyl-4-{7,8-difluoro-4-[(2,2,2-trifluoroethyl)amino]imidazo[1,2-- a]quinoxalin-1-yl}benzamide 4-{4-[(3-amino-3-oxopropyl)amino]-7,8-difluoroimidazo[1,2-a]quinoxalin-1-- yl}-N-cyclopropylbenzamide N-cyclopropyl-4-{4-[(2,3-dihydroxypropyl)amino]-7,8-difluoroimidazo[1,2-a- ]quinoxalin-1-yl}benzamide 1-{4-[4-(butylamino)-7,8-difluoroimidazo[1,2-a]quinoxalin-1-yl]phenyl}-3-- methylurea 2-chloro-N-cyclopropyl-4-[7,8-difluoro-4-(propylamino)imidazo[1- ,2-a]quinoxalin-1-yl]benzamide 2-chloro-N-cyclopropyl-4-{7,8-difluoro-4-[(pyridin-2-ylmethyl)amino]imida- zo[1,2-a]quinoxalin-1-yl}benzamide N-cyclopropyl-4-{4-[(4-hydroxybutyl)amino]-7,8-dimethylimidazo[1,2-a]quin- oxalin-1-yl}benzamide N-cyclopropyl-4-{4-[(3-methoxypropyl)amino]-7,8-dimethylimidazo[1,2-a]qui- noxalin-1-yl}benzamide N-cyclopropyl-4-(7,8-dimethyl-4-{[(1-methyl-1H-pyrazol-3-yl)methyl]amino}- imidazo[1,2-a]quinoxalin-1-yl)benzamide 1-(4-{4-[(cyclopropylmethyl)amino]-7,8-dimethylimidazo[1,2-a]quinoxalin-1- -yl}phenyl)-3-methylurea 1-[4-(7,8-dimethyl-4-{[(1-methyl-1H-pyrazol-5-yl)methyl]amino}imidazo[1,2- -a]quinoxalin-1-yl)phenyl]-3-methylurea 2-chloro-N-cyclopropyl-4-{4-[(2-methoxyethyl)amino]-7,8-dimethylimidazo[1- ,2-a]quinoxalin-1-yl}benzamide 4-{7-cyano-4-[(2-hydroxyethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-cycl- opropylbenzamide 4-{7-cyano-4-[(3-methoxypropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-cyc- lopropylbenzamide 1-(4-{7-cyano-4-[(2-hydroxyethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}phen- yl)-3-methylurea 2-chloro-4-(7-cyano-4-{[3-(morpholin-4-yl)propyl]amino}imidazo[1,2-a]quin- oxalin-1-yl)-N-cyclopropylbenzamide 2-chloro-4-(7-cyano-4-{[(1-methyl-1H-pyrazol-5-yl)methyl]amino}imidazo[1,- 2-a]quinoxalin-1-yl)-N-cyclopropylbenzamide N-cyclopropyl-4-(8-fluoro-4-{[3-(morpholin-4-yl)propyl]amino}imidazo[1,2-- a]quinoxalin-1-yl)benzamide N-cyclopropyl-4-{8-fluoro-4-[(4-hydroxybutyl)amino]imidazo[1,2-a]quinoxal- in-1-yl}benzamide N-cyclopropyl-4-{4-[(cyclopropylmethyl)amino]-8-fluoroimidazo[1,2-a]quino- xalin-1-yl}benzamide N-cyclopropyl-4-(8-fluoro-4-{[(1-methyl-1H-pyrazol-4-yl)methyl]amino}imid- azo[1,2-a]quinoxalin-1-yl)benzamide 1-[4-(8-fluoro-4-{[3-(2-oxopyrrolidin-1-yl)propyl]amino}imidazo[1,2-a]qui- noxalin-1-yl)phenyl]-3-methylurea N-{2-[(8-fluoro-1-{4-[(methylcarbamoyl)amino]phenyl}imidazo[1,2-a]quinoxa- lin-4-yl)amino]ethyl}acetamide 1-(4-{8-fluoro-4-[(pyridin-4-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl- }phenyl)-3-methylurea 2-chloro-N-cyclopropyl-4-{8-fluoro-4-[(4-hydroxybutyl)amino]imidazo[1,2-a- ]quinoxalin-1-yl}benzamide 2-chloro-N-cyclopropyl-4-(8-fluoro-4-{[(1-methyl-1H-pyrazol-5-yl)methyl]a- mino}imidazo[1,2-a]quinoxalin-1-yl)benzamide N-cyclopropyl-4-{7,8-difluoro-4-[(3-fluorobenzyl)amino]imidazo[1,2-a]quin- oxalin-1-yl}benzamide N-cyclopropyl-4-{7,8-difluoro-4-[(2-methylpropyl)amino]imidazo[1,2-a]quin- oxalin-1-yl}benzamide N-cyclopropyl-4-{7,8-difluoro-4-[(2-sulfamoylethyl)amino]imidazo[1,2-a]qu- inoxalin-1-yl}benzamide 2-chloro-N-cyclopropyl-4-{7,8-difluoro-4-[(2-methoxyethyl)amino]imidazo[1- ,2-a]quinoxalin-1-yl}benzamide 2-chloro-N-cyclopropyl-4-{7,8-difluoro-4-[(4-fluorobenzyl)amino]imidazo[1- ,2-a]quinoxalin-1-yl}benzamide 2-chloro-N-cyclopropyl-4-{7,8-difluoro-4-[(4-hydroxybutyl)amino]imidazo[1- ,2-a]quinoxalin-1-yl}benzamide 2-chloro-N-cyclopropyl-4-(7,8-difluoro-4-{[(1-methyl-1H-pyrazol-3-yl)meth- yl]amino}imidazo[1,2-a]quinoxalin-1-yl)benzamide N-cyclopropyl-4-{7,8-dimethyl-4-[(3-methylbutyl)amino]imidazo[1,2-a]quino- xalin-1-yl}benzamide N-cyclopropyl-4-{4-[(3-hydroxypropyl)amino]-7,8-dimethylimidazo[1,2-a]qui- noxalin-1-yl}benzamide N-cyclopropyl-4-{7,8-dimethyl-4-[(pyridin-3-ylmethyl)amino]imidazo[1,2-a]- quinoxalin-1-yl}benzamide 1-(4-{4-[(4-fluorobenzyl)amino]-7,8-dimethylimidazo[1,2-a]quinoxalin-1-yl- }phenyl)-3-methylurea 1-(4-{4-[(4-hydroxybutyl)amino]-7,8-dimethylimidazo[1,2-a]quinoxalin-1-yl- }phenyl)-3-methylurea 1-(4-{7,8-dimethyl-4-[(thiophen-2-ylmethyl)amino]imidazo[1,2-a]quinoxalin- -1-yl}phenyl)-3-methylurea 1-(4-{7,8-dimethyl-4-[(pyridin-3-ylmethyl)amino]imidazo[1,2-a]quinoxalin-- 1-yl}phenyl)-3-methylurea 2-chloro-N-cyclopropyl-4-[4-(ethylamino)-7,8-dimethylimidazo[1,2-a]quinox- alin-1-yl]benzamide 2-chloro-N-cyclopropyl-4-{4-[(3-methoxypropyl)amino]-7,8-dimethylimidazo[- 1,2-a]quinoxalin-1-yl}benzamide 2-chloro-N-cyclopropyl-4-{7,8-dimethyl-4-[(2-sulfamoylethyl)amino]imidazo- [1,2-a]quinoxalin-1-yl}benzamide 4-{7-cyano-4-[(pyridin-3-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-- cyclopropylbenzamide 4-{7-cyano-4-[(furan-2-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N-cy- clopropylbenzamide 4-(7-cyano-4-{[(1-methyl-1H-pyrazol-3-yl)methyl]amino}imidazo[1,2-a]quino- xalin-1-yl)-N-cyclopropylbenzamide 4-{7-cyano-4-[(2,3-dihydroxypropyl)amino]imidazo[1,2-a]quinoxalin-1-yl}-N- -cyclopropylbenzamide 1-(4-{7-cyano-4-[(3-methylbutyl)amino]imidazo[1,2-a]quinoxalin-1-yl}pheny- l)-3-methylurea 1-(4-{7-cyano-4-[(thiophen-2-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl- }phenyl)-3-methylurea 1-[4-(7-cyano-4-{[3-(1H-imidazol-1-yl)propyl]amino}imidazo[1,2-a]quinoxal- in-1-yl)phenyl]-3-methylurea 1-(4-{7-cyano-4-[(furan-2-ylmethyl)amino]imidazo[1,2-a]quinoxalin-1-yl}ph- enyl)-3-methylurea 1-[4-(7-cyano-4-{[(1-methyl-1H-pyrazol-5-yl)methyl]amino}imidazo[1,2-a]qu- inoxalin-1-yl)phenyl]-3-methylurea 2-chloro-4-[7-cyano-4-(propylamino)imidazo[1,2-a]quinoxalin-1-yl]-N-cyclo- propylbenzamide 4-[4-(benzylamino)-7-cyanoimidazo[1,2-a]quinoxalin-1-yl]-2-chloro-N-cyclo- propylbenzamide 2-chloro-4-{7-cyano-4-[(thiophen-2-ylmethyl)amino]imidazo[1,2-a]quinoxali- n-1-yl}-N-cyclopropylbenzamide and 4-{4-[(3-amino-3-oxopropyl)amino]-7-cyanoimidazo[1,2-a]quinoxalin-1-yl}-2- -chloro-N-cyclopropylbenzamide. 5. A method of preparing a compound according to claim 1, in which method an intermediate compound of general formula (4): ##STR00372## wherein R.sup.1, R.sup.3, R.sup.4, R.sup.5, R.sup.6, and R.sup.7 are as defined in claim 1, and Y represents a halogen atom, is allowed to react with an intermediate compound of general formula: R.sup.2--Z in which R.sup.2 is as defined in claim 1, and Z is a suitable functional group via which the R.sup.2 of the R.sup.2--Z compound can be coupled onto the Y-bearing carbon atom of a compound (4), thereby replacing said Y with said R.sup.2 moiety, thus providing a compound of general formula (I): ##STR00373## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 are as defined in claim 1. 6. A pharmaceutical composition comprising a compound according to claim 1, and a pharmaceutically acceptable diluent or carrier. 7. A pharmaceutical combination comprising: one or more compounds according to claim 1; and one or more agents selected from: a taxane; an epothilone; Mitoxantrone; Prednisolone; Dexamethasone; Estramustine; Vinblastine; Vincristine; Doxorubicin; Idarubicin; Daunorubicin; Bleomycin; Etoposide; Cyclophosphamide; Ifosfamide; Procarbazine; Melphalan; 5-Fluorouracil; Capecitabine; Fludarabine; Cytarabine; 2-Chloro-2'-deoxyadenosine; Thioguanine; an anti-androgen; Bortezomib; a platinum derivative; Chlorambucil; Methotrexate; and Rituximab. 8. The pharmaceutical combination according to claim 7, wherein the taxane is selected from Docetaxel and Paclitaxel. 9. The pharmaceutical combination according to claim 7, wherein the epothilone is selected from Ixabepilone, Patupilone, and Sagopilone. 10. The pharmaceutical combination according to claim 7, wherein the anti-androgen is selected from Flutamide, Cyproterone acetate, and Bicalutamide. 11. The pharmaceutical combination according to claim 7, wherein the platinum derivative is selected from Cisplatin and Carboplatin. 12. The compound according to claim 1, wherein: R.sup.2 represents an aryl- or heteroaryl-group; wherein said group is substituted one time with --C(.dbd.O)NR.sup.9R.sup.10 and is optionally substituted with a substituent selected from: halo-, hydroxy-, cyano-, C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkyl-. 13. The compound according to claim 1, wherein: R.sup.2 represents an aryl- or heteroaryl-group; wherein said group is substituted one time with --C(.dbd.O)NH-cyclopropyl and is optionally substituted with a substituent selected from: halo-, hydroxy-, cyano-, C.sub.1-C.sub.6-alkyl-, halo-C.sub.1-C.sub.6-alkyl-.

Details for Patent 8,729,082

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Genentech, Inc.	RITUXAN	rituximab	Injection	103705	11/26/1997		2029-04-29
Idec Pharmaceuticals Corp.	RITUXAN	rituximab	Injection	103737	02/19/2002		2029-04-29
Genentech, Inc.	RITUXAN HYCELA	rituximab and hyaluronidase human	Injection	761064	06/22/2017		2029-04-29