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Last Updated: March 29, 2024

Claims for Patent: 8,691,321


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Summary for Patent: 8,691,321
Title:Bioabsorbable polymeric composition and medical device background
Abstract: A method for fabricating an embodiment of a medical device comprising the steps of: preparing a biodegradable polymeric structure; coating the biodegradable polymeric structure with a polymeric coat including a pharmacological or biological agent; cutting the structure into patterns configured to allow for crimping of the cut structure and expansion of the cut structure after crimping into a deployed configuration.
Inventor(s): Cottone; Robert J. (Davie, FL)
Assignee: Orbusneich Medical, Inc. (Fort Lauderdale, FL)
Application Number:11/875,892
Patent Claims:1. A method for fabricating a cardiovascular expandable scaffold comprising: blending a polymer composition comprising a crystallizable composition comprising a base polymer of poly L-lactide, and/or poly D-lactide, and/or poly L-lactide-co-PEG, and/or poly D-lactide-co-PEG, linked with modifying copolymers comprising poly L (or D)-lactide-co-Tri-methylene-carbonate or poly L (or D)-lactide-co-.epsilon.-caprolactone in the form of block copolymers or as blocky random copolymers; molding said polymer composition to structurally configure said scaffold; coating said polymer scaffold with a pharmaceutical composition comprising a ligand; and cutting said scaffold to form desired patterns; wherein the polymer scaffold is configured in the form of a continuously interconnected scaffold of struts which is crystallizable when stretched by expansion and wherein the polymer of poly L-lactide and poly D-lactide form a racemate-type cross-moiety crystallization.

2. The method of claim 1, wherein the blending further comprises blending a pharmacological and/or biological agent and/or radioopaque or radio-detectable material into the polymer composition.

3. The method of claim 2, wherein the pharmacological agent is selected from the group consisting of: cyclosporin A, mycophenolic acid, mycophenolate mofetil acid, rapamycin, rapamycin derivatives, biolimus A9, CCI-779, RAD 001, AP23573, azathioprene, tacrolimus (FK506), tranilast, dexamethasone, corticosteroid, everolimus, pimecrolimus, retinoic acid, vitamin E, rosglitazone, simvastatins, fluvastatin, estrogen, 17.beta.-estradiol, hydrocortisone, acetaminophen, ibuprofen, naproxen, fluticasone, clobetasol, adalimumab, sulindac, dihydroepiandrosterone, testosterone, puerarin, platelet factor 4, basic fibroblast growth factor, fibronectin, butyric acid, butyric acid derivatives, paclitaxel, paclitaxel derivatives, LBM-642, deforolimus, and probucol.

4. The method of claim 2, wherein the biological agent is selected from the group consisting of: antibiotics/antimicrobials, antiproliferative agents, antineoplastic agents, antioxidants, endothelial cell growth factors, smooth muscle cell growth and/or migration inhibitors, thrombin inhibitors, immunosuppressive agents, anti-platelet aggregation agents, collagen synthesis inhibitors, therapeutic antibodies, nitric oxide donors, antisense oligonucleotides, wound healing agents, therapeutic gene transfer constructs, peptides, proteins, extracellular matrix components, vasodialators, thrombolytics, anti-metabolites, growth factor agonists, antimitotics, steroids, steroidal antiinflammatory agents, chemokines, proliferator-activated receptor-gamma agonists, proliferator-activated receptor-alpha agonists proliferator-activated receptor-beta agonists, proliferator-activated receptor-alpha/beta agonists, proliferator-activated receptor-delta agonists, NF.kappa..beta., proliferator-activated receptor-alpha-gamma agonists, nonsteroidal antiinflammatory agents, angiotensin converting enzyme (ACE) inhibitors, free radical scavengers, inhibitors of the CX3CR1 receptor and anti-cancer chemotherapeutic agents.

5. The method of claim 1, wherein the ligand comprises a small molecule, a peptide, an antibody, an antibody fragment, or combinations thereof.

6. The method of claim 5, wherein the antibody or antibody fragment is specific for a progenitor endothelial cell surface antigen.

7. The method of claim 6, wherein the progenitor endothelial cell surface antigen is selected from the group consisting of CD34, CD45, CD133, CD14, CDw90, CD117, HLA-DR, VEGFR-1, VEGFR-2, CD146, CD130, CD131, stem cell antigen, stem cell factor 1, Tie-2, MCH-H-2Kk and MCH-HLA-DR.

Details for Patent 8,691,321

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Abbvie Inc. HUMIRA adalimumab Injection 125057 12/31/2002 ⤷  Try a Trial 2039-03-29
Abbvie Inc. HUMIRA adalimumab Injection 125057 02/21/2008 ⤷  Try a Trial 2039-03-29
Abbvie Inc. HUMIRA adalimumab Injection 125057 04/24/2013 ⤷  Try a Trial 2039-03-29
Abbvie Inc. HUMIRA adalimumab Injection 125057 09/23/2014 ⤷  Try a Trial 2039-03-29
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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