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Last Updated: May 10, 2024

Claims for Patent: 8,673,631

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Summary for Patent: 8,673,631

Title:	Chimeric regulatory sequences comprising introns for plant gene expression
Abstract:	The present invention relates to a method of using a dicot intron or elements thereof to enhance transgene expression in plants. The present invention also provides constructs, transgenic plants and seeds containing the polynucleotide useful for expressing transgene in plants.
Inventor(s):	Flasinski; Stanislaw (Chesterfield, MO), Hubmeier; Christopher (Ballwin, MO), Lu; Maolong (St. Louis, MO), Malven; Marianne (Ellisville, MO), Wu; Wei (St. Louis, MO)
Assignee:	Monsanto Technology LLC (St. Louis, MO)
Application Number:	13/280,227
Patent Claims:	1. A chimeric DNA regulatory sequence comprising a monocot promoter operably linked to a dicot intron, wherein said chimeric DNA regulatory sequence provides enhanced transgene expression in dicot plants relative to a regulatory sequence comprising a monocot promoter without a dicot intron, wherein said dicot intron is the first intron of At-Act7 and said monocot promoter is the rice TPI promoter. 2. The chimeric DNA regulatory sequence of claim 1, further comprising a sequence encoding a glyphosate tolerance protein. 3. The chimeric DNA regulatory sequence of claim 2, wherein said glyphosate tolerance protein is selected from the group consisting of glyphosate oxidoreductase, glyphosate acetyltransferase, and 5-enolpyruvyl-3-phosphoshikimate synthase.

Details for Patent 8,673,631

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132	06/04/1986	⤷ Try a Trial	2026-02-17
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132		⤷ Try a Trial	2026-02-17
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	Injection	103132		⤷ Try a Trial	2026-02-17
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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