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Last Updated: March 28, 2024

Claims for Patent: 8,669,266


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Summary for Patent: 8,669,266
Title:Quinoline-carboxamide derivatives as P2Y12 antagonists
Abstract: The present invention relates to compounds of the formula I, ##STR00001## in which R.sup.1; R.sup.2; R.sup.3; R.sup.4; R.sup.5; R.sup.6; Z; A; B; E; X; Q; J; V; G and M have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong anti-aggregating effect on platelets and thus an anti-thrombotic effect and are suitable e.g. for the therapy and prophylaxis of cardio-vascular disorders like thromboembolic diseases or restenoses. They are reversible antagonists of the platelet ADP receptor P2Y12, and can in general be applied in conditions in which an undesired activation of the platelet ADP receptor P2Y12 is present or for the cure or prevention of which an inhibition of the platelet ADP receptor P2Y12 is intended. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
Inventor(s): Nazare; Marc (Wiesbaden, DE), Zech; Gernot (Wiesbaden, DE), Just; Melitta (Langen, DE), Weiss; Tilo (Frankfurt am Main, DE), Hessler; Gerhard (Hofheim, DE), Czech; Joerg (Marburg, DE)
Assignee: Sanofi (Paris, FR)
Application Number:12/573,551
Patent Claims:1. A compound of formula I, ##STR00028## E is a heterocyclic residue selected from aza-bicycloheptane, aza-bicyclohexane, aza-bicyclooctane, aza-spiroheptane, aza-spirohexane, aza-spirooctane, aza-spiropentane, azepane, azepine, azetidine, aziridine, decahydro-quinoline, diaza-bicyclohexane, diaza-bicycloheptane, 2,5-Diaza-bicyclo[2.2.1]heptane, 1,2-diazapane, 2,7-diaza-spiro[4.5]decane, 2,8-diaza-spiro[4.5]decane, diaza-spirohexane, diaza-spirooctane, diaza-spiropentane, diaza-spiroheptane, 1,3-diazepane, 1,4-diazepane, 1,2-diazepine, 1,3-diazepine, 1,4-diazepine, dihydroazepine, 2,3-dihydro-1H-indole, 3,4-dihydro-1H-isoquinoline, 4,7-dihydro-5H-isoxazolo[5,4-c]pyridine, 6,7-dihydro-4H-isoxazolo[4,5-c]pyridine, dihydro-pyridazine, dihydro-oxazepine, 6,7-dihydro-4H-oxazolo[5,4-c]pyridine, 4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol, 4,6-dihydro-4H-pyrrolo[3,4-d]thiazole, 6,7-dihydro-4H-thiazolo[5,4-c]pyridine, 4,7-dihydro-5H-thieno[2,3-c]pyridine, 5,6-Dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin, dioxazole, hexahydro-cyclopenta[c]pyrroline, hexahydro-pyridazine, hexahydro-pyrrolo[1,2-a]pyrazin, hexahydro-pyrrolo[3,4-b]pyrrol, Hexahydro-pyrrolo[1,2-a]pyrazin, imidazoline, imidazolidine, indole, isoquinoline, isothiazolidine, isothiazoline, isoxazoline, isoxazolidine, ketopiperazine, morpholine, octahydro-cyclopenta[c]pyrrole, octahydro-indole, octahydro-pyrrolo[3,4-b]pyridine, octahydro-pyrrolo[3,4-c]pyridine, 1,4-oxazepane, oxazepine, 1,2-oxa-thiepane, 1,2-oxazine, 1,3-oxazine, 1,4-oxazine, oxazolidine, piperazine, piperidine, pyrazine, pyrazoline, pyrazolidine, pyridazine, pyrrolidine, pyrrolidinone, pyrroline, tetrahydropyridine, tetrahydro-azepine, 1,2,3,4-tetrahydro-isoquinoline, 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine, 1,2,3,4-tetrahydropyrazine, 1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine, 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine, tetrahydro-pyridazine, 3,5,7,8-tetrahydro-4H-pyrido[4,3-d]pyrimidine, 4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole, 1,2,3,4-tetrahydro-quinoline, 4,5,6,7-tetrahydro-thieno[2,3-c]pyridine, 1,4,6,7-tetrahydro-thiazolo[5,4-c]pyridine, 4,5,6,7-tetrahydro-thieno[3,2-c]pyridine, tetrazine, tetrazole, thiadiazine, 1,2-thiazine, 1,3-thiazine, 1,4-thiazine, 1,3-thiazole, thiazolidine, thiazoline, thietan, thiomorpholine, 1,3,8-triaza-spiro[4.5]decane, triaza-spirooctane, triazepane, 1,2,4-triazinane and 1,3,5-triazinane, wherein said heterocyclic residue is bond by its nitrogen atom to the carbonyl carbon atom and wherein said heterocyclic residue is unsubstituted or mono-, di- or trisubstituted independently of one another by R7, X is selected from nitrogen atom or C--R8, Q is selected from 1) a covalent bond, 2) --(C.sub.0-C.sub.4)-alkylene-CH(OH)--(C.sub.0-C.sub.4)-alkylene-, 3) --(C.sub.0-C.sub.4)-alkylene-O--(C.sub.0-C.sub.4)-alkylene-, 4) --(C.sub.0-C.sub.4)-alkylene-O--C(O)--N(R10)-(C.sub.0-C.sub.4)-alkylene-, 5) --(C.sub.0-C.sub.4)-alkylene-C(O)--(C.sub.0-C.sub.4)-alkylene-, 6) --(C.sub.0-C.sub.4)-alkylene-C(O)--O--(C.sub.0-C.sub.4)-alkylene-, 7) --(C.sub.0-C.sub.4)-alkylene-C(O)--NR10--, 8) --(C.sub.0-C.sub.4)-alkylene-N(R.sup.10)--(C.sub.0-C.sub.4)-alkylene-, 9) --(C.sub.0-C.sub.4)-alkylene-N(R10)-C(O)--(C.sub.0-C.sub.4)-alkylene-, 10) --(C.sub.0-C.sub.4)-alkylene-N(R10)-C(O)--O--(C.sub.0-C.sub.4)-alkyle- ne-, 11) --(C.sub.0-C.sub.4)-alkylene-N(R10)-C(O)--N(R10)-(C.sub.0-C.sub.4- )-alkylene-, 12) --(C.sub.0-C.sub.4)-alkylene-N(R10)-SO.sub.2--(C.sub.0-C.sub.4)-alkylene-- , 13) --(C.sub.0-C.sub.4)-alkylene-N(R10)-SO.sub.2--NR10-(C.sub.0-C.sub.4)- -alkylene-, 14) --(C.sub.0-C.sub.4)-alkylene-S--(C.sub.0-C.sub.4)-alkylene-, 15) --(C.sub.0-C.sub.4)-alkylene-SO.sub.2--(C.sub.0-C.sub.4)-alkylene-, 16) --(C.sub.0-C.sub.4)-alkylene-(C.sub.3-C.sub.8)-cycloalkyl-(C.sub.0-C.sub.- 4)-alkylene-, or 17) --(C.sub.0-C.sub.4)-alkylene-(C.sub.3-C.sub.15)-heterocyclyl-(C.sub.0-C.s- ub.4)-alkylene-, wherein heterocyclyl is selected from acridinyl, azabenzimidazolyl, aza-bicycloheptanyl, aza-bicyclohexanyl, aza-bicyclooctanyl, 8-aza-bicyclo[3.2.1]octanyl, azaspirodecanyl, aza-spiroheptanyl, aza-spirohexanyl, aza-spirooctanyl, aza-spiropentanyl, azepinyl, azetidinyl, aziridinyl, benzimidazolyl, benzofuranyl, benzothiofuranyl, benzothiophenyl, benzoxazolyl, benzthiazolyl, benztriazolyl, benztetrazolyl, benzisoxazolyl, benzisothiazolyl, carbazolyl, 4aH-carbazolyl, carbolinyl, chromanyl, chromenyl, cinnolinyl, decahydro-quinolinyl, diaza-bicyclohexanyl, diaza-bicycloheptanyl, 2,5-diaza-bicyclo[2.2.1]heptanyl, 1,2-diazapanyl, diaza-spirohexanyl, diaza-spirooctanyl, diaza-spiropentanyl, diaza-spiroheptanyl, 1,3-diazepanyl, 1,4-diazepanyl, 1,2-diazepinyl, 1,3-diazepinyl, 1,4-diazepinyl, dihydroazepinyl, 3,4-dihydro-2H-quinoline, dihydrofuro[2,3-b]-tetrahydrofuranyl, 2,3-dihydro-1H-indolyl, 3,4-dihydro-1H-isoquinolinyl, 6,7-dihydro-4H-isoxazolo[4,5-c]pyridinyl, dihydro-pyridazinyl, 4,5-dihydro-[1,3,4]oxadiazol, dihydro-oxazepinyl, 4,5-dihydrooxazolinyl, 4,6-dihydro-4H-pyrrolo[3,4-d]thiazolyl, 6,7-dihydro-4H-thiazolo[5,4-c]pyridinyl, 4,7-dihydro-5H-thieno[2,3-c]pyridinyl, 1,3-dioxanyl, dioxazolyl, dioxazinyl, 1,3-dioxolanyl, 1,3-dioxolenyl, 3,3-dioxo[1,3,4]oxathiazinyl, 6H-1,5,2-dithiazinyl, furanyl, furazanyl, hexahydro-pyridazine, hexahydro-cyclopenta[c]pyrroline, imidazolidinyl, imidazolinyl, imidazolyl, 1H-indazolyl, indolinyl, indolizinyl, indolyl, 3H-indolyl, isobenzofuranyl, isochromanyl, isoindazolyl, isoindolinyl, isoindolyl, isoquinolinyl (benzimidazolyl), isothiazolyl, isothiazolidinyl, isothiazolinyl, isoxazolyl, isoxazolinyl, isoxazolidinyl, 2-isoxazolinyl, ketopiperazinyl, morpholinyl, naphthyridinyl, octahydro-cyclopenta[c]pyrrolyl, octahydroisoquinolinyl, oxadiazolyl, 1,2,3-oxadiazolyl, 1,2,4-oxadiazolyl, 1,2,5-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2-oxa-thiepanyl, 1,2-oxathiolanyl, 1,4-oxazepanyl, oxazepinyl, 1,2-oxazinyl, 1,3-oxazinyl, 1,4-oxazinyl, oxazolidinyl, oxazolinyl, oxazolyl, oxetanyl, oxocanyl, phenanthridinyl, phenanthrolinyl, phenazinyl, phenothiazinyl, phenoxathiinyl, phenoxazinyl, phthalazinyl, piperazinyl, piperidinyl, pteridinyl, purinyl, pyranyl, pyrazinyl, pyrazolidinyl, pyrazolinyl, pyrazolyl, pyridazinyl, pyridooxazolyl, pyridoimidazolyl, pyridothiazolyl, pyridinyl, pyridyl, pyrimidinyl, pyrrolidinyl, pyrrolidinonyl, pyrrolinyl, 1H-pyrrolopyridinyl, 2H-pyrrolyl, pyrrolyl, quinazolinyl, quinolinyl, 4H-quinolizinyl, quinoxalinyl, quinuclidinyl, tetrahydrofuranyl, 1,2,3,4-tetrahydro-isoquinolinyl, 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridinyl, tetrahydropyranyl, 1,2,3,4-tetrahydropyrazinyl, 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridinyl, tetrahydro-pyridazinyl, tetrahydro-pyridinyl, 4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazolyl, 1,2,3,4-tetrahydro-quinolinyl, 4,5,6,7-tetrahydro-thieno[2,3-c]pyridinyl, 1,4,6,7-tetrahydro-thiazolo[5,4-c]pyridinyl, 4,5,6,7-tetrahydro-thieno[3,2-c]pyridinyl, tetrahydrothiophenyl, tetrazinyl, tetrazolyl, 6H-1,2,5-thiadiazinyl, 1,2,3-thiadiazolyl, 1,2,4-thiadiazolyl, 1,2,5-thiadiazolyl, 1,3,4-thiadiazolyl, thianthrenyl, 1,2-thiazinyl, 1,3-thiazinyl, 1,4-thiazinyl, 1,3-thiazolyl, thiazolyl, thiazolidinyl, thiazolinyl, thienyl, thietanyl, thienothiazolyl, thienooxazolyl, thienoimidazolyl, thietanyl, thiomorpholinyl, thiophenolyl, thiophenyl, thiopyranyl, triaza-spirooctanyl, 1,2,3-triazinyl, 1,2,4-triazinyl, 1,3,5-triazinyl, 1,2,3-triazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, 1,2,5-triazolyl, 1,3,4-triazolyl, and xanthenyl, and wherein said --(C.sub.3-C.sub.15)-heterocyclyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R14; and wherein the alkyl residues are unsubstituted or mono-, di- or trisubstituted independently of one another by halogen, --NH.sub.2, --OH; or --(C.sub.3-C.sub.6)-cycloalkyl, wherein cycloalkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by halogen, --NH.sub.2 or --OH; J is 1) a hydrogen atom, 2) --(C.sub.1-C.sub.6)-alkyl, wherein alkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, 3) --(C.sub.0-C.sub.4)-alkylene-C(O)--R11, 4) --(C.sub.0-C.sub.4)-alkylene-C(O)--O--R11, 5) --(C.sub.0-C.sub.4)-alkylene-C(O)--O--(C.sub.1-C.sub.4)-alkylene-O--C(O)-- -R17, wherein --(C.sub.1-C.sub.4)-alkylene is unsubstituted or mono-, di- or trisubstituted independently of one another by R15, 6) --(C.sub.0-C.sub.4)-alkylene-C(O)--O--(C.sub.1-C.sub.4)-alkylene-O--C(O)-- -O--R17, wherein --(C.sub.1-C.sub.4)-alkylene is unsubstituted or mono-, di- or trisubstituted independently of one another by R15, 7) --(C.sub.0-C.sub.4)-alkylene-C(O)--N(R11)-R13 8) --(C.sub.0-C.sub.4)-alkylene-N(R11)-R13, 9) --(C.sub.0-C.sub.4)-alkylene-N(R10)-SO.sub.2--R10, 10) --(C.sub.0-C.sub.4)-alkylene-SO.sub.s--R11, wherein s is 1 or 2, 11) --(C.sub.0-C.sub.4)-alkylene-SO.sub.t--N(R11)-R12, wherein t is 1 or 2, 12) --(C.sub.0-C.sub.4)-alkylene-SO.sub.w--N(R11)-R13, wherein w is 1 or 2, 13) --(C.sub.0-C.sub.4)-alkylene-R22, 14) --(C.sub.0-C.sub.4)-alkylene-(C.sub.3-C.sub.8)-cycloalkyl, wherein cycloalkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, 15) --(C.sub.0-C.sub.4)-alkylene-(C.sub.6-C.sub.14)-aryl, wherein aryl is selected from phenyl, naphthyl, biphenylyl, indanyl, anthryl and fluorenyl and aryl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, or 16) --(C.sub.0-C.sub.4)-alkylene-(C.sub.3-C.sub.15)-heterocyclyl, wherein --(C.sub.3-C.sub.15)-heterocyclyl is as defined above and is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, R1 is a hydrogen atom, --(C.sub.1-C.sub.4)-alkyl, wherein alkyl is unsubstituted or substituted one to three times by R13; --(C.sub.1-C.sub.3)-alkylene-C(O)--NH--R10 or --(C.sub.1-C.sub.3)-alkylene-C(O)--O--R10, Z is 1) --(C.sub.0-C.sub.8)-alkylene-, 2) --(C.sub.2-C.sub.10)-alkenyl-, 3) --(C.sub.2-C.sub.10)-alkynyl-, 4) --(C.sub.0-C.sub.4)-alkylene-O--(C.sub.0-C.sub.4)-alkylene-, 5) --(C.sub.0-C.sub.4)-alkylene-O--C(O)--N(R10)-(C.sub.0-C.sub.4)-alkylene-, 6) --(C.sub.0-C.sub.4)-alkylene-C(O)--(C.sub.0-C.sub.4)-alkylene-, 7) --(C.sub.0-C.sub.4)-alkylene-N(R10)-C(O)--(C.sub.0-C.sub.4)-alkylene-, 8) --(C.sub.0-C.sub.4)-alkylene-N(R10)-C(O)--O--(C.sub.0-C.sub.4)-alkylene-, 9) --(C.sub.0-C.sub.4)-alkylene-N(R10)-C(O)--N(R10)-(C.sub.0-C.sub.4)-alk- ylene-, 10) --(C.sub.0-C.sub.4)-alkylene-N(R10)-(C.sub.0-C.sub.4)-alkylene-, 11) --(C.sub.0-C.sub.4)-alkylene-S--(C.sub.0-C.sub.4)-alkylene-, 12) --(C.sub.0-C.sub.4)-alkylene-S(O)--(C.sub.0-C.sub.4)-alkylene-, 13) --(C.sub.0-C.sub.4)-alkylene-SO.sub.2--(C.sub.0-C.sub.4)-alkylene-, or 14) --(C.sub.0-C.sub.4)-alkylene-(C.sub.3-C.sub.8)-cycloalkyl-(C.sub.0-C.- sub.4)-alkylene-, A is a covalent bond, --(C.sub.3-C.sub.8)-alkylene, --(C.sub.3-C.sub.8)-cycloalkylene or --(C.sub.3-C.sub.15)-heterocyclyl, wherein --(C.sub.3-C.sub.15)-heterocyclyl is as defined above, B is 1) a covalent bond, 2) --(C.sub.2-C.sub.10)-alkenyl-, 3) --(C.sub.2-C.sub.10)-alkynyl-, 4) --(C.sub.0-C.sub.4)-alkylene-CH(OH)--(C.sub.0-C.sub.4)-alkylene-, 5) --(C.sub.0-C.sub.4)-alkylene-O--(C.sub.0-C.sub.4)-alkylene-, 6) --(C.sub.0-C.sub.4)-alkylene-O--C(O)--N(R10)-(C.sub.0-C.sub.4)-alkylene-, 7) --(C.sub.0-C.sub.4)-alkylene-C(O)--(C.sub.0-C.sub.4)-alkylene-, 8) --(C.sub.0-C.sub.4)-alkylene-C(O)--O--(C.sub.0-C.sub.4)-alkylene-, 9) --(C.sub.0-C.sub.4)-alkylene-C(O)--N(R10)-, 10) --(C.sub.0-C.sub.4)-alkylene-N(R10)-(C.sub.0-C.sub.4)-alkylene-, 11) --(C.sub.0-C.sub.4)-alkylene-N(R10)-C(O)--(C.sub.0-C.sub.4)-alkylene-, 12) --(C.sub.0-C.sub.4)-alkylene-N(R10)-C(O)--O--(C.sub.0-C.sub.4)-alkyle- ne-, 13) --(C.sub.0-C.sub.4)-alkylene-N(R10)-C(O)--N(R10)-(C.sub.0-C.sub.4- )-alkylene-, 14) --(C.sub.0-C.sub.4)-alkylene-N(R10)-SO.sub.2--(C.sub.0-C.sub.4)-alkylene-- , 15) --(C.sub.0-C.sub.4)-alkylene-N(R10)-SO.sub.2--N(R10)-(C.sub.0-C.sub.- 4)-alkylene-, 16) --(C.sub.0-C.sub.4)-alkylene-S--(C.sub.0-C.sub.4)-alkylene-, 17) --(C.sub.0-C.sub.4)-alkylene-S(O)--(C.sub.0-C.sub.4)-alkylene-, 18) --(C.sub.0-C.sub.4)-alkylene-SO.sub.2--(C.sub.0-C.sub.4)-alkylene-, 19) --(C.sub.0-C.sub.4)-alkylene-SO.sub.2--N(R10)-(C.sub.0-C.sub.4)-alkylene-- , 20) --(C.sub.0-C.sub.4)-alkylene-(C.sub.3-C.sub.8)-cycloalkyl-(C.sub.0-C- .sub.4)-alkylene-, or 21) --(C.sub.0-C.sub.4)-alkylene-(C.sub.3-C.sub.15)-heterocyclyl-(C.sub.0-C.s- ub.4)-alkylene-, wherein --(C.sub.3-C.sub.15)-heterocyclyl is as defined above, wherein said heterocyclyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R14, and wherein the alkyl residues are unsubstituted or mono-, di- or trisubstituted independently of one another by halogen, --NH.sub.2, --OH; or --(C.sub.3-C.sub.6)-cycloalkyl, wherein cycloalkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by halogen, --NH.sub.2 or --OH; R14 is halogen, --OH, .dbd.O, --(C.sub.1-C.sub.8)-alkyl, --(C.sub.1-C.sub.4)-alkoxy, --NO.sub.2, --CN, --NH.sub.2, --S--R18, --(C.sub.1-C.sub.4)-alkylene-C(O)--OH, --C(O)--O--(C.sub.1-C.sub.4)-alkyl, --(C.sub.1-C.sub.4)-alkylene-C(O)--NH.sub.2, --(C.sub.0-C.sub.8)-alkylene-SO.sub.2--(C.sub.1-C.sub.4)-alkyl, --(C.sub.0-C.sub.8)-alkylene-SO.sub.2--(C.sub.1-C.sub.3)-fluoroalkyl, --(C.sub.0-C.sub.8)-alkylene-SO.sub.2--N(R18)-R21, --(C.sub.1-C.sub.4)-alkylene-C(O)--NH--(C.sub.1-C.sub.8)-alkyl, --(C.sub.1-C.sub.4)-alkylene-C(O)--N--[(C.sub.1-C.sub.8)-alkyl].sub.2, --N(R18)-C(O)--NH--(C.sub.1-C.sub.8)-alkyl, --N(R18)-C(O)--NH--[(C.sub.1-C.sub.8)-alkyl].sub.2, --(C.sub.2-C.sub.10)-alkenyl, or --(C.sub.2-C.sub.10)-alkynyl, wherein R18 and R21 are independently from each other hydrogen atom, --(C.sub.1-C.sub.3)-fluoroalkyl or --(C.sub.1-C.sub.6)-alkyl, V is --(C.sub.3-C.sub.15)-heterocyclyl or --N(R1)-(C.sub.3-C.sub.15)-heterocyclyl, wherein --(C.sub.3-C.sub.15)-heterocyclyl is as defined above and is unsubstituted or mono-, di- or trisubstituted independently of one another by R14, G is 1) a covalent bond, 2) --(C.sub.0-C.sub.4)-alkylene-CH(OH)--(C.sub.0-C.sub.4)-alkylene-, 3) --(C.sub.0-C.sub.4)-alkylene-O--(C.sub.0-C.sub.4)-alkylene-, 4) --(C.sub.0-C.sub.4)-alkylene-O--C(O)--N(R10)-(C.sub.0-C.sub.4)-alkylene-, 5) --(C.sub.0-C.sub.4)-alkylene-C(O)--(C.sub.0-C.sub.4)-alkylene-, 6) --(C.sub.0-C.sub.4)-alkylene-C(O)--O--(C.sub.0-C.sub.4)-alkylene-, 7) --(C.sub.0-C.sub.4)-alkylene-C(O)--N(R10)-, 8) --(C.sub.0-C.sub.4)-alkylene-N(R10)-(C.sub.0-C.sub.4)-alkylene-, 9) --(C.sub.0-C.sub.4)-alkylene-N(R10)-C(O)--(C.sub.0-C.sub.4)-alkylene-, 10) --(C.sub.0-C.sub.4)-alkylene-N(R10)-C(O)--O--(C.sub.0-C.sub.4)-alkyle- ne-, 11) --(C.sub.0-C.sub.4)-alkylene-N(R10)-C(O)--N(R10)-(C.sub.0-C.sub.4- )-alkylene-, 12) --(C.sub.0-C.sub.4)-alkylene-N(R10)-SO.sub.2--(C.sub.0-C.sub.4)-alkylene-- , 13) --(C.sub.0-C.sub.4)-alkylene-N(R10)-SO.sub.2--N(R10)-(C.sub.0-C.sub.- 4)-alkylene-, 14) --(C.sub.0-C.sub.4)-alkylene-S--(C.sub.0-C.sub.4)-alkylene-, 15) --(C.sub.0-C.sub.4)-alkylene-S(O)--(C.sub.0-C.sub.4)-alkylene-, 16) --(C.sub.0-C.sub.4)-alkylene-SO.sub.2--(C.sub.0-C.sub.4)-alkylene-, 17) --(C.sub.0-C.sub.4)-alkylene-SO.sub.2--N(R10)-(C.sub.0-C.sub.4)-alkylene-- , or 18) --(C.sub.0-C.sub.4)-alkylene-(C.sub.3-C.sub.8)-cycloalkyl-(C.sub.- 0-C.sub.4)-alkylene-, and wherein the alkyl residues are unsubstituted or mono-, di- or trisubstituted independently of one another by halogen, --NH.sub.2, --OH; or --(C.sub.3-C.sub.6)-cycloalkyl, wherein cycloalkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by halogen, --NH.sub.2 or --OH; M is 1) a hydrogen atom, 2) --(C.sub.1-C.sub.8)-alkyl, wherein alkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R14, 3) --C(O)--N(R11)-R12, 4) --C(O)--O--R12, 5)

--(C.sub.1-C.sub.8)-alkylen-N(R10).sub.2, 6)--(C.sub.6-C.sub.14)-aryl, wherein aryl is as defined above and is unsubstituted or mono-, di- or trisubstituted independently of one another by R14, 7) --(C.sub.3-C.sub.8)-cycloalkyl, wherein said cycloalkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R14, or 8) a 3- to 7-membered heterocyclyl, containing 1, 2, 3 or 4 heteroatoms chosen from nitrogen, sulfur or oxygen, selected from azepine, azetidine, aziridine, azirine, 1,4-diazepane, 1,2-diazepine, 1,3-diazepine, 1,4-diazepine, diaziridine, diazirine, dihydroimidazolone, dioxazole, dioxazine, dioxole, 1,3-dioxolene, 1,3-dioxolane, furan, imidazole, imidazoline, imidazolidine, imidazolidinone, isothiazole, isothiazolidine, isothiazoline, isoxazole, isoxazoline, isoxazolidine, morpholine, 1,2-oxa-thiepane, 1,2-oxathiolane, 1,4-oxazepane, 1,2-oxazine, 1,3-oxazine, 1,4-oxazine, oxazolone, oxazole, [1,3,4]oxathiazinane 3,3-dioxide, oxaziridine, oxazolidinone, oxetan, oxirane, piperazine, piperidine, pyran, pyrazine, pyrazole, pyrazoline, pyrazolidine, pyridazine, pyridine, pyridinone, pyrimidine, pyrimidine-2,4-dione, pyrrole, pyrrolidine, pyrrolidinone, pyrroline, tetrahydrofuran, tetrahydropyran, tetrahydropyridine, tetrazine, tetrazole, thiadiazine thiadiazole, 1,2-thiazine, 1,3-thiazine, 1,4-thiazine, 1,3-thiazole, thiazole, thiazolidine, thiazoline, thienyl, thietan, thiomorpholine, thiomorpholine 1,1-dioxide thiopyran, 1,2,3-triazine, 1,2,4-triazine, 1,3,5-triazine, 1,2,3-triazole and 1,2,4-triazole, wherein said cyclic residue is unsubstituted or mono-, di- or trisubstituted independently of one another by R14, R2, R3, R4, R5, R6 and R8 are independently of one another selected from 1) a hydrogen atom, 2) --(C.sub.1-C.sub.6)-alkyl, wherein alkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, 3) --(C.sub.0-C.sub.4)-alkylene-O--R10, 4) halogen, 5) --(C.sub.1-C.sub.3)-fluoroalkyl, 6) --CN or 7) phenyl, wherein phenyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, or R3 and R4, R4 and R5 or R5 and R6 are each time both --O--R10 and form together with the atoms which they are attached to a 1,3-dioxole ring or 2,3-dihydro-[1,4]dioxine ring, which is unsubstituted or substituted one, two, three or four times by R13, R3 and R4, R4 and R5 or R5 and R6 form together with the atoms which they are attached to a cyclopentyl or cyclohexyl, which is unsubstituted or substituted one, two, three or four times by R13, R7 is 1) a hydrogen atom, 2) halogen, 3) --(C.sub.1-C.sub.6)-alkyl, wherein alkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, 4) .dbd.O, 5) --(C.sub.1-C.sub.3)-fluoroalkyl, 6) --(C.sub.0-C.sub.4)-alkylene-O--R19, wherein R19 is a) hydrogen atom, b) --(C.sub.1-C.sub.4)-alkyl, wherein alkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, c) --(C.sub.3-C.sub.8)-cycloalkyl, wherein alkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, d) phenyl, wherein phenyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, e) --CF.sub.3, or f) --CHF.sub.2, 7) --NO.sub.2, 8) --CN, 9) --(C.sub.0-C.sub.4)-alkylene-O--CH.sub.2--(C.sub.1-C.sub.3)-fluoroalkylen- e-CH.sub.2--O--(C.sub.1-C.sub.4)-alkyl, 10) --(C.sub.0-C.sub.4)-alkylene-C(O)--R11, 11) --(C.sub.0-C.sub.4)-alkylene-C(O)--O--R11, 12) --(C.sub.0-C.sub.4)-alkylene-C(O)--O--(C.sub.1-C.sub.4)-alkylene-O--C(O)-- -R17, wherein --(C.sub.1-C.sub.4)-alkylene is unsubstituted or mono-, di- or trisubstituted independently of one another by R15, 13) --(C.sub.0-C.sub.4)-alkylene-C(O)--O--(C.sub.1-C.sub.4)-alkylene-O--C(O)-- -O--R17, wherein --(C.sub.1-C.sub.4)-alkylene is unsubstituted or mono-, di- or trisubstituted independently of one another by R15, 14) --(C.sub.0-C.sub.4)-alkylene-C(O)--N(R11)-R12, 15) --(C.sub.0-C.sub.4)-alkylene-C(O)--N(R11)-R13, 16) --(C.sub.0-C.sub.4)-alkylene-C(O)--N[(C.sub.0-C.sub.4)-alkylene]-R13, wherein alkyl and cycloalkyl are unsubstituted or mono-, di- or trisubstituted independently of one another by R13, 17) --(C.sub.0-C.sub.4)-alkylene-C(O)--N[(C.sub.0-C.sub.4)-alkylene-(C.sub.3-- C.sub.8)-cycloalkyl]-R13, wherein alkyl and cycloalkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, 18) --(C.sub.0-C.sub.4)-alkylene-N(R11)-R12, 19) --(C.sub.0-C.sub.4)-alkylene-N(R11)-R13, 20) --(C.sub.0-C.sub.4)-alkylene-N(R10)-SO.sub.2--R10, 21) --(C.sub.0-C.sub.4)-alkylene-S--R10, 22) --(C.sub.0-C.sub.4)-alkylene-SO.sub.s--R11, wherein s is 1 or 2, 23) --(C.sub.0-C.sub.4)-alkylene-SO.sub.t--N(R11)-R12, wherein t is 1 or 2, 24) --(C.sub.0-C.sub.4)-alkylene-SO.sub.w--N(R11)-R13, wherein w is 1 or 2, 25) --(C.sub.0-C.sub.4)-alkylene-SO.sub.u--(C.sub.0-C.sub.4)-alkylene-- C(O)--O--R10, wherein u is 1 or 2, 26) --(C.sub.0-C.sub.4)-alkylene-(C.sub.3-C.sub.8)-cycloalkyl, wherein cycloalkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, 27) --(C.sub.0-C.sub.4)-alkylene-(C.sub.6-C.sub.14)-aryl, wherein aryl is selected from phenyl, naphthyl, biphenylyl, indanyl, anthryl or fluorenyl; and wherein aryl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, or 28) --(C.sub.0-C.sub.4)-alkylene-(C.sub.3-C.sub.15)-heterocyclyl, wherein --(C.sub.3-C.sub.15)-heterocyclyl is as defined above and is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, 29) --(C.sub.0-C.sub.4)-alkylene-O--(C.sub.0-C.sub.4)-alkylene-(C.sub.6-C.sub- .14)-aryl, wherein aryl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, 30) --(C.sub.0-C.sub.4)-alkylene-O--(C.sub.0-C.sub.4)-alkylene-(C.sub.3-C.sub- .15)-heterocyclyl, wherein --(C.sub.3-C.sub.15)-heterocyclyl is un-substituted or mono-, di- or trisubstituted independently of one another by R13, 31) --(C.sub.0-C.sub.4)-alkylene-N(R13)-(C.sub.0-C.sub.4)-alkylene-(C.sub.6-C- .sub.14)-aryl, wherein aryl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, or 32) --(C.sub.0-C.sub.4)-alkylene-N(R13)-(C.sub.0-C.sub.4)-alkylene-(C.sub.3-C- .sub.15)-heterocyclyl, wherein --(C.sub.3-C.sub.15)-heterocyclyl is un-substituted or mono-, di- or trisubstituted independently of one another by R13, R11 and R12 are independently of one another identical or different and are 1) a hydrogen atom, 2) --(C.sub.1-C.sub.6)-alkyl, wherein alkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, 3) --(C.sub.0-C.sub.6)-alkylene-(C.sub.3-C.sub.8)-cycloalkyl, wherein alkylene and cycloalkyl independently from one another are unsubstituted or mono-, di- or trisubstituted independently of one another by R13, 4) --SO.sub.t--R10, wherein t is 1 or 2, 5) --(C.sub.0-C.sub.6)-alkylene-(C.sub.6-C.sub.14)-aryl, wherein aryl is as defined above and alkylene and aryl independently from one another are unsubstituted or mono-, di- or trisubstituted by R13, 6) --(C.sub.1-C.sub.3)-fluoroalkyl, 7) --O--R17, or 8) --(C.sub.0-C.sub.6)-alkylene-(C.sub.3-C.sub.15)-heterocyclyl, wherein --(C.sub.3-C.sub.15)-heterocyclyl is as defined above and alkylene and heterocyclyl independently from one another are unsubstituted or mono-, di- or trisubstituted by R13, or R11 and R12 together with the nitrogen atom to which they are bonded form a 4- to 8-membered monocyclic heterocyclic ring, which is selected from aza-bicycloheptane, aza-bicyclohexane, aza-spiroheptane, aza-spirohexane, aza-spirooctane, aza-spiropentane, azepane, azepine, azetidine, diaza-bicycloheptane, diaza-bicyclohexane, diaza-spiroheptane, diaza-spirohexane, diaza-spiropentane, diaza-spirooctane 1,2-diazapane, 1,3-diazepane, 1,4-diazepane, 1,2-diazepine, 1,3-diazepine, 1,4-diazepine, dihydroazepine, dihydro-oxazepine, dihydro-pyridazine, dioxazole, hexahydro-pyridazine, imidazoline, imidazolidine, isothiazolidine, isothiazoline, isoxazoline, isoxazolidine, ketopiperazine, morpholine, 1,4-oxazepane, 1,2-oxa-thiepane, oxazepine, 1,2-oxazine, 1,3-oxazine, 1,4-oxazine, piperazine, piperidine, pyrazine, pyrazoline, pyrazolidine, pyridazine, pyrrolidine, pyrrolidinone, pyrroline, tetrahydro-azepine, 1,2,3,4-tetrahydropyrazine, tetrahydropyridine, tetrazine, tetrazole, thiadiazine, 1,2-thiazine, 1,3-thiazine, 1,4-thiazine, 1,3-thiazole, thiazolidine, thiazoline, thietan, thiomorpholine, triazepane, 1,2,4-triazinane and 1,3,5-triazinane; wherein said heterocyclic ring is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, R13 is halogen, --NO.sub.2, --CN, .dbd.O, --OH, --CF.sub.3, --C(O)--O--R10, --C(O)--N(R10)-R20, --N(R10)-R20, --(C.sub.3-C.sub.8)-cycloalkyl, --(C.sub.2-C.sub.10)-alkenyl-, --(C.sub.2-C.sub.10)-alkynyl-, --O--CF.sub.3, --Si--(CH.sub.3).sub.3, --(C.sub.0-C.sub.4)-alkylene-O--R10, --N(R10)-S(O).sub.u--R10, wherein u is 1 or 2, --SO.sub.r--R10, wherein r is 1 or 2, --S(O).sub.v--N(R10)-R20, wherein v is 1 or 2, --S--R10, --C(O)--R10, --(C.sub.1-C.sub.8)-alkyl, --(C.sub.1-C.sub.8)-alkoxy, phenyl, phenyloxy-, --(C.sub.1-C.sub.8)-alkoxy-phenyl, --(C.sub.0-C.sub.4)-alkylene-C(O)--O--C(R15,R16)-O--C(O)--R17, --O--R15, --NH--C(O)--NH--R10, --(C.sub.0-C.sub.4)-alkylene-C(O)--O--C(R15,R16)-O--C(O)--O--R17, --(C.sub.1-C.sub.3)-fluoroalkyl, --NH--C(O)--O--R10 or --(C.sub.0-C.sub.4)-alkylene-R22, R10 and R20 are independently of one another hydrogen, --(C.sub.1-C.sub.4)-alkyl, --(C.sub.1-C.sub.4)-alkyl-OH, --(C.sub.0-C.sub.4)-alkylene-O--(C.sub.1-C.sub.4)-alkyl or --(C.sub.1-C.sub.3)-fluoroalkyl, R15 and R16 are independently of one another hydrogen atom, --(C.sub.1-C.sub.6)-alkyl, or together with the carbon atom to which they are bonded form a --(C.sub.3-C.sub.6)-cycloalkyl, which is unsubstituted or mono, di- or trisubstituted by R10, R17 is hydrogen atom, --(C.sub.1-C.sub.6)-alkyl, --(C.sub.1-C.sub.6)-alkyl-OH, --(C.sub.1-C.sub.6)-alkylene-O--(C.sub.1-C.sub.6)-alkyl, --(C.sub.0-C.sub.6)-alkylene-(C.sub.3-C.sub.8)-cycloalkyl or --(C.sub.1-C.sub.6)-alkylene-O--(C.sub.1-C.sub.6)-alkylene-(C.sub.3-C.sub- .8)-cycloalkyl, wherein said cycloalkyl ring is unsubstituted or substituted one, two or three times by --OH, --O--(C.sub.1-C.sub.4)-alkyl or R10, and R22 is a residue from the following list: ##STR00029## wherein Me is methyl, in all its stereoisomeric forms and mixtures thereof in any ratio, and its physiologically tolerable salts.

2. A compound as claimed in claim 1, wherein E is a heterocyclic residue selected from aza-bicycloheptane, aza-bicyclohexane, aza-bicyclooctane, aza-spiroheptane, aza-spirohexane, aza-spirooctane, aza-spiropentane, azepane, azepine, azetidine, aziridine, decahydro-quinoline, diaza-bicyclohexane, diaza-bicycloheptane, 2,5-Diaza-bicyclo[2.2.1]heptane, 1,2-diazapane, 2,7-diaza-spiro[4.5]decane, 2,8-diaza-spiro[4.5]decane, diaza-spirohexane, diaza-spirooctane, diaza-spiropentane, diaza-spiroheptane, 1,3-diazepane, 1,4-diazepane, 1,2-diazepine, 1,3-diazepine, 1,4-diazepine, dihydroazepine, 2,3-dihydro-1H-indole, 3,4-dihydro-1H-isoquinoline, 4,7-dihydro-5H-isoxazolo[5,4-c]pyridine, 6,7-dihydro-4H-isoxazolo[4,5-c]pyridine, dihydro-pyridazine, dihydro-oxazepine, 6,7-dihydro-4H-oxazolo[5,4-c]pyridine, 4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol, 4,6-dihydro-4H-pyrrolo[3,4-d]thiazole, 6,7-dihydro-4H-thiazolo[5,4-c]pyridine, 4,7-dihydro-5H-thieno[2,3-c]pyridine, 5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin, dioxazole, hexahydro-cyclopenta[c]pyrroline, hexahydro-pyridazine, hexahydro-pyrrolo[1,2-a]pyrazin, hexahydro-pyrrolo[3,4-b]pyrrol, Hexahydro-pyrrolo[1,2-a]pyrazin, imidazoline, imidazolidine, indole, isoquinoline, isothiazolidine, isothiazoline, isoxazoline, isoxazolidine, ketopiperazine, morpholine, octahydro-cyclopenta[c]pyrrole, octahydro-indole, octahydro-pyrrolo[3,4-b]pyridine, octahydro-pyrrolo[3,4-c]pyridine, 1,4-oxazepane, oxazepine, 1,2-oxa-thiepane, 1,2-oxazine, 1,3-oxazine, 1,4-oxazine, oxazolidine, piperazine, piperidine, pyrazine, pyrazoline, pyrazolidine, pyridazine, pyrrolidine, pyrrolidinone, pyrroline, tetrahydropyridine, tetrahydro-azepine, 1,2,3,4-tetrahydro-isoquinoline, 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine, 1,2,3,4-tetrahydropyrazine, 1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine, 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine, tetrahydro-pyridazine, 3,5,7,8-tetrahydro-4H-pyrido[4,3-d]pyrimidine, 4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole, 1,2,3,4-tetrahydro-quinoline, 4,5,6,7-tetrahydro-thieno[2,3-c]pyridine, 1,4,6,7-tetrahydro-thiazolo[5,4-c]pyridine, 4,5,6,7-tetrahydro-thieno[3,2-c]pyridine, tetrazine, tetrazole, thiadiazine, 1,2-thiazine, 1,3-thiazine, 1,4-thiazine, 1,3-thiazole, thiazolidine, thiazoline, thietan, thiomorpholine, 1,3,8-triaza-spiro[4.5]decane, triaza-spirooctane, triazepane, 1,2,4-triazinane and 1,3,5-triazinane, wherein said heterocyclic residue is bond by its nitrogen atom to the carbonyl carbon atom and wherein said heterocyclic residue is unsubstituted or mono-, di- or trisubstituted independently of one another by R7, X is a nitrogen atom, Q is 1) a covalent bond, 2) --(C.sub.0-C.sub.4)-alkylene-CH(OH)--(C.sub.0-C.sub.4)-alkylene-, 3) --(C.sub.0-C.sub.4)-alkylene-O--(C.sub.0-C.sub.4)-alkylene-, 4) --(C.sub.0-C.sub.4)-alkylene-C(O)--(C.sub.0-C.sub.4)-alkylene-, 5) --(C.sub.0-C.sub.4)-alkylene-C(O)--O--(C.sub.0-C.sub.4)-alkylene-, 6) --(C.sub.0-C.sub.4)-alkylene-C(O)--N(R10)-, 7) --(C.sub.0-C.sub.4)-alkylene-N(R10)-(C.sub.0-C.sub.4)-alkylene-, 8) --(C.sub.0-C.sub.4)-alkylene-N(R10)-C(O)--(C.sub.0-C.sub.4)-alkylene-, 9) --(C.sub.0-C.sub.4)-alkylene-N(R10)-C(O)--O--(C.sub.0-C.sub.4)-alkylene-, 10) --(C.sub.0-C.sub.4)-alkylene-N(R10)-C(O)--N(R10)-(C.sub.0-C.sub.4)-al- kylene-, 11) --(C.sub.0-C.sub.4)-alkylene-S--(C.sub.0-C.sub.4)-alkylene-, 12) --(C.sub.0-C.sub.4)-alkylene-SO.sub.2--(C.sub.0-C.sub.4)-alkylene-, 13) --(C.sub.0-C.sub.4)-alkylene-(C.sub.3-C.sub.6)-cycloalkyl-(C.sub.0-C.- sub.4)-alkylene-, or 14) --(C.sub.0-C.sub.4)-alkylene-(C.sub.3-C.sub.15)-heterocyclyl-(C.sub.0-C.s- ub.4)-alkylene-, wherein --(C.sub.3-C.sub.15)-heterocyclyl is selected from acridinyl, azabenzimidazolyl, aza-bicycloheptanyl, aza-bicyclohexanyl, aza-bicyclooctanyl, 8-aza-bicyclo[3.2.1]octanyl, azaspirodecanyl, aza-spiroheptanyl, aza-spirohexanyl, aza-spirooctanyl, aza-spiropentanyl, azepinyl, azetidinyl, aziridinyl, benzimidazolyl, benzofuranyl, benzothiofuranyl, benzothiophenyl, benzoxazolyl, benzthiazolyl, benztriazolyl, benztetrazolyl, benzisoxazolyl, benzisothiazolyl, carbazolyl, 4aH-carbazolyl, carbolinyl, chromanyl, chromenyl, cinnolinyl, decahydro-quinolinyl, diaza-bicyclohexanyl, diaza-bicycloheptanyl, 2,5-diaza-bicyclo[2.2.1]heptanyl, 1,2-diazapanyl, diaza-spirohexanyl, diaza-spirooctanyl, diaza-spiropentanyl, diaza-spiroheptanyl, 1,3-diazepanyl, 1,4-diazepanyl, 1,2-diazepinyl, 1,3-diazepinyl, 1,4-diazepinyl, dihydroazepinyl, 3,4-dihydro-2H-quinoline, dihydrofuro[2,3-b]-tetrahydrofuranyl, 2,3-dihydro-1H-indolyl, 3,4-dihydro-1H-isoquinolinyl, 6,7-dihydro-4H-isoxazolo[4,5-c]pyridinyl, dihydro-pyridazinyl, 4,5-dihydro-[1,3,4]oxadiazol, dihydro-oxazepinyl, 4,5-dihydrooxazolinyl, 4,6-dihydro-4H-pyrrolo[3,4-d]thiazolyl, 6,7-dihydro-4H-thiazolo[5,4-c]pyridinyl, 4,7-dihydro-5H-thieno[2,3-c]pyridinyl, 1,3-dioxanyl, dioxazolyl, dioxazinyl, 1,3-dioxolanyl, 1,3-dioxolenyl, 3,3-dioxo[1,3,4]oxathiazinyl, 6H-1,5,2-dithiazinyl, furanyl, furazanyl, hexahydro-pyridazine, hexahydro-cyclopenta[c]pyrroline, imidazolidinyl, imidazolinyl, imidazolyl, 1H-indazolyl, indolinyl, indolizinyl, indolyl, 3H-indolyl, isobenzofuranyl, isochromanyl, isoindazolyl, isoindolinyl, isoindolyl, isoquinolinyl (benzimidazolyl), isothiazolyl, isothiazolidinyl, isothiazolinyl, isoxazolyl, isoxazolinyl, isoxazolidinyl, 2-isoxazolinyl, ketopiperazinyl, morpholinyl, naphthyridinyl, octahydro-cyclopenta[c]pyrrolyl, octahydroisoquinolinyl, oxadiazolyl, 1,2,3-oxadiazolyl, 1,2,4-oxadiazolyl, 1,2,5-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2-oxa-thiepanyl, 1,2-oxathiolanyl, 1,4-oxazepanyl, oxazepinyl, 1,2-oxazinyl, 1,3-oxazinyl, 1,4-oxazinyl, oxazolidinyl, oxazolinyl, oxazolyl, oxetanyl, oxocanyl, phenanthridinyl, phenanthrolinyl, phenazinyl, phenothiazinyl, phenoxathiinyl, phenoxazinyl, phthalazinyl, piperazinyl, piperidinyl, pteridinyl, purinyl, pyranyl, pyrazinyl, pyrazolidinyl, pyrazolinyl, pyrazolyl, pyridazinyl, pyridooxazolyl, pyridoimidazolyl, pyridothiazolyl, pyridinyl, pyridyl, pyrimidinyl, pyrrolidinyl, pyrrolidinonyl, pyrrolinyl, 1H-pyrrolopyridinyl, 2H-pyrrolyl, pyrrolyl, quinazolinyl, quinolinyl, 4H-quinolizinyl, quinoxalinyl, quinuclidinyl, tetrahydrofuranyl, 1,2,3,4-tetrahydro-isoquinolinyl, 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridinyl, tetrahydropyranyl, 1,2,3,4-tetrahydropyrazinyl, 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridinyl, tetrahydro-pyridazinyl, tetrahydro-pyridinyl, 4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazolyl, 1,2,3,4-tetrahydro-quinolinyl, 4,5,6,7-tetrahydro-thieno[2,3-c]pyridinyl, 1,4,6,7-tetrahydro-thiazolo[5,4-c]pyridinyl, 4,5,6,7-tetrahydro-thieno[3,2-c]pyridinyl, tetrahydrothiophenyl, tetrazinyl, tetrazolyl, 6H-1,2,5-thiadiazinyl, 1,2,3-thiadiazolyl, 1,2,4-thiadiazolyl, 1,2,5-thiadiazolyl, 1,3,4-thiadiazolyl, thianthrenyl, 1,2-thiazinyl, 1,3-thiazinyl, 1,4-thiazinyl, 1,3-thiazolyl, thiazolyl, thiazolidinyl, thiazolinyl, thienyl, thietanyl, thienothiazolyl, thienooxazolyl, thienoimidazolyl, thietanyl, thiomorpholinyl, thiophenolyl, thiophenyl, thiopyranyl, triaza-spirooctanyl, 1,2,3-triazinyl, 1,2,4-triazinyl, 1,3,5-triazinyl, 1,2,3-triazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, 1,2,5-triazolyl, 1,3,4-triazolyl, and xanthenyl, and wherein --(C.sub.3-C.sub.15)-heterocyclyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R14; and wherein the alkyl residues are unsubstituted or mono-, di- or trisubstituted independently of one another by halogen, --NH.sub.2, --OH; or --(C.sub.3-C.sub.6)-cycloalkyl, wherein cycloalkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by halogen, --NH.sub.2 or --OH; J is 1) a hydrogen atom, 2) --(C.sub.1-C.sub.6)-alkyl, wherein alkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, 3) --(C.sub.0-C.sub.4)-alkylene-C(O)--R11, 4) --(C.sub.0-C.sub.4)-alkylene-C(O)--O--R11, 5) --(C.sub.0-C.sub.4)-alkylene-C(O)--O--(C.sub.1-C.sub.4)-alkylene-O--C(O)-- -R17, wherein --(C.sub.1-C.sub.4)-alkylene is unsubstituted or mono-, di- or trisubstituted independently of one another by R15, 6) --(C.sub.0-C.sub.4)-alkylene-C(O)--O--(C.sub.1-C.sub.4)-alkyl ene-O--C(O)--O--R17, wherein --(C.sub.1-C.sub.4)-alkylene is unsubstituted or mono-, di- or trisubstituted independently of one another by R15, 7) --(C.sub.0-C.sub.4)-alkylene-C(O)--N(R11)-R13, 8) --(C.sub.0-C.sub.4)-alkylene-N(R11)-R13, 9) --(C.sub.0-C.sub.4)-alkylene-N(R10)-SO.sub.2--R10, 10) --(C.sub.0-C.sub.4)-alkylene-SO.sub.s--R11, wherein s is 1 or 2, 11) --(C.sub.0-C.sub.4)-alkylene-SO.sub.t--N(R11)-R12, wherein t is 1 or 2, 12) --(C.sub.0-C.sub.4)-alkylene-SO.sub.w--N(R11)-R13, wherein w is 1 or 2, 13) --(C.sub.0-C.sub.4)-alkylene-R22, 14) --(C.sub.0-C.sub.4)-alkylene-(C.sub.3-C.sub.6)-cycloalkyl, wherein cycloalkyl is unsubstituted or 5 mono-, di- or trisubstituted independently of one another by R13, 15) --(C.sub.0-C.sub.4)-alkylene-(C.sub.6-C.sub.14)-aryl, wherein aryl is selected from phenyl or indanyl, and aryl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, or 16) --(C.sub.0-C.sub.4)-alkylene-(C.sub.3-C.sub.15)-heterocyclyl, wherein heterocyclyl is as defined above and is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, R1 is a hydrogen atom, --(C.sub.1-C.sub.4)-alkyl, wherein alkyl is unsubstituted or substituted one to three times by R13; --(C.sub.1-C.sub.3)-alkylene-C(O)--NH--R10 or --(C.sub.1-C.sub.3)-alkylene-C(O)--O--R10, Z is 1) --(C.sub.0-C.sub.8)-alkylene-, 2) --(C.sub.2-C.sub.10)-alkenyl-, 3) --(C.sub.2-C.sub.10)-alkynyl-, 4) --(C.sub.0-C.sub.4)-alkylene-O--(C.sub.0-C.sub.4)-alkylene-, 5) --(C.sub.0-C.sub.4)-alkylene-O--C(O)--N(R10)-(C.sub.0-C.sub.4)-alkylene-, 6) --(C.sub.0-C.sub.4)-alkylene-C(O)--(C.sub.0-C.sub.4)-alkylene-, 7) --(C.sub.0-C.sub.4)-alkylene-N(R10)-C(O)--(C.sub.0-C.sub.4)-alkylene-, 8) --(C.sub.0-C.sub.4)-alkylene-N(R10)-C(O)--O--(C.sub.0-C.sub.4)-alkylene-, 9) --(C.sub.0-C.sub.4)-alkylene-N(R10)-C(O)--N(R10)-(C.sub.0-C.sub.4)-alk- ylene-, 10) --(C.sub.0-C.sub.4)-alkylene-N(R10)-(C.sub.0-C.sub.4)-alkylene-, 11) --(C.sub.0-C.sub.4)-alkylene-S--(C.sub.0-C.sub.4)-alkylene-, 12) --(C.sub.0-C.sub.4)-alkylene-S(O)--(C.sub.0-C.sub.4)-alkylene-, 13) --(C.sub.0-C.sub.4)-alkylene-SO.sub.2--(C.sub.0-C.sub.4)-alkylene-, or 14) --(C.sub.0-C.sub.4)-alkylene-(C.sub.3-C.sub.8)-cycloalkyl-(C.sub.0-C.- sub.4)-alkylene-, A is selected from a covalent bond, --(C.sub.3-C.sub.8)-alkylene, --(C.sub.3-C.sub.8)-cycloalkylene or --(C.sub.3-C.sub.15)-heterocyclyl, wherein --(C.sub.3-C.sub.15)-heterocyclyl is as defined above, B is 1) a covalent bond, 2) --(C.sub.2-C.sub.10)-alkenyl-, 3) --(C.sub.2-C.sub.10)-alkynyl-, 4) --(C.sub.0-C.sub.4)-alkylene-CH(OH)--(C.sub.0-C.sub.4)-alkylene-, 5) --(C.sub.0-C.sub.4)-alkylene-O--(C.sub.0-C.sub.4)-alkylene-, 6) --(C.sub.0-C.sub.4)-alkylene-O--C(O)--N(R10)-(C.sub.0-C.sub.4)-alkylene-, 7) --(C.sub.0-C.sub.4)-alkylene-C(O)--(C.sub.0-C.sub.4)-alkylene-, 8) --(C.sub.0-C.sub.4)-alkylene-C(O)--O--(C.sub.0-C.sub.4)-alkylene-, 9) --(C.sub.0-C.sub.4)-alkylene-C(O)--N(R10)-, 10) --(C.sub.0-C.sub.4)-alkylene-N(R10)-(C.sub.0-C.sub.4)-alkylene-, 11) --(C.sub.0-C.sub.4)-alkylene-N(R10)-C(O)--(C.sub.0-C.sub.4)-alkylene-, 12) --(C.sub.0-C.sub.4)-alkylene-N(R10)-C(O)--O--(C.sub.0-C.sub.4)-alkyle- ne-, 13) --(C.sub.0-C.sub.4)-alkylene-N(R10)-C(O)--N(R10)-(C.sub.0-C.sub.4- )-alkylene-, 14) --(C.sub.0-C.sub.4)-alkylene-N(R10)-SO.sub.2--(C.sub.0-C.sub.4)-alkylene-- , 15) --(C.sub.0-C.sub.4)-alkylene-N(R10)-SO.sub.2--N(R10)-(C.sub.0-C.sub.- 4)-alkylene-, 16) --(C.sub.0-C.sub.4)-alkylene-S--(C.sub.0-C.sub.4)-alkylene-, 17) --(C.sub.0-C.sub.4)-alkylene-S(O)--(C.sub.0-C.sub.4)-alkylene-, 18) --(C.sub.0-C.sub.4)-alkylene-SO.sub.2--(C.sub.0-C.sub.4)-alkylene-, 19) --(C.sub.0-C.sub.4)-alkylene-SO.sub.2--N(R10)-(C.sub.0-C.sub.4)-alkylene-- , 20) --(C.sub.0-C.sub.4)-alkylene-(C.sub.3-C.sub.8)-cycloalkyl-(C.sub.0-C- .sub.4)-alkylene-, or 21) --(C.sub.0-C.sub.4)-alkylene-(C.sub.3-C.sub.15)-heterocyclyl-(C.sub.0-C.s- ub.4)-alkylene-, wherein heterocyclyl is as defined above, wherein --(C.sub.3-C.sub.15)-heterocyclyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R14, and wherein the alkyl residues are unsubstituted or mono-, di- or trisubstituted independently of one another by halogen, --NH.sub.2, --OH; or --(C.sub.3-C.sub.6)-cycloalkyl, wherein cycloalkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by halogen, --NH.sub.2 or --OH; R14 is halogen, --OH, .dbd.O, --(C.sub.1-C.sub.8)-alkyl, --(C.sub.1-C.sub.4)-alkoxy, --NO.sub.2, --CN, --NH.sub.2, --S--R18, --(C.sub.1-C.sub.4)-alkylene-C(O)--OH, --C(O)--O--(C.sub.1-C.sub.4)-alkyl, --(C.sub.1-C.sub.4)-alkylene-C(O)--NH.sub.2, --(C.sub.0-C.sub.8)-alkylene-SO.sub.2--(C.sub.1-C.sub.4)-alkyl, --(C.sub.0-C.sub.8)-alkylene-SO.sub.2--(C.sub.1-C.sub.3)-fluoroalkyl, --(C.sub.0-C.sub.8)-alkylene-SO.sub.2--N(R18)-R21, --(C.sub.1-C.sub.4)-alkylene-C(O)--NH--(C.sub.1-C.sub.8)-alkyl, --(C.sub.1-C.sub.4)-alkylene-C(O)--N--[(C.sub.1-C.sub.8)-alkyl].sub.2, --N(R18)-C(O)--NH--(C.sub.1-C.sub.8)-alkyl, --N(R18)-C(O)--NH--[(C.sub.1-C.sub.8)-alkyl].sub.2, --(C.sub.2-C.sub.10)-alkenyl, or --(C.sub.2-C.sub.10)-alkynyl, wherein R18 and R21 are independently from each other hydrogen atom, --(C.sub.1-C.sub.3)-fluoroalkyl or --(C.sub.1-C.sub.6)-alkyl, V is --(C.sub.3-C.sub.15)-heterocyclyl or --N(R1)-(C.sub.3-C.sub.15)-heterocyclyl, wherein --(C.sub.3-C.sub.15)-heterocyclyl is as defined above and is unsubstituted or mono-, di- or trisubstituted independently of one another by R14, G is 1) a covalent bond, 2) --(C.sub.0-C.sub.4)-alkylene-O--(C.sub.0-C.sub.4)-alkylene-, 3) --(C.sub.0-C.sub.4)-alkylene-O--C(O)--N(R10)-(C.sub.0-C.sub.4)-alkylene-, 4) --(C.sub.0-C.sub.4)-alkylene-C(O)--(C.sub.0-C.sub.4)-alkylene-, 5) --(C.sub.0-C.sub.4)-alkylene-C(O)--O--(C.sub.0-C.sub.4)-alkylene-, 6) --(C.sub.0-C.sub.4)-alkylene-C(O)--N(R10)-, 7) --(C.sub.0-C.sub.4)-alkylene-N(R10)-(C.sub.0-C.sub.4)-alkylene-, 8) --(C.sub.0-C.sub.4)-alkylene-N(R10)-C(O)--(C.sub.0-C.sub.4)-alkylene-, 9) --(C.sub.0-C.sub.4)-alkylene-N(R10)-C(O)--O--(C.sub.0-C.sub.4)-alkylene-, 10) --(C.sub.0-C.sub.4)-alkylene-N(R10)-C(O)--N(R10)-(C.sub.0-C.sub.4)-al- kylene-, 11) --(C.sub.0-C.sub.4)-alkylene-N(R10)-SO.sub.2--(C.sub.0-C.sub.4)-alkylene-- , 12) --(C.sub.0-C.sub.4)-alkylene-N(R10)-SO.sub.2--N(R10)-(C.sub.0-C.sub.- 4)-alkylene-, 13) --(C.sub.0-C.sub.4)-alkylene-SO.sub.2--(C.sub.0-C.sub.4)-alkylene-, or 14) --(C.sub.0-C.sub.4)-alkylene-SO.sub.2--N(R10)-(C.sub.0-C.sub.4)-alkyl- ene-, and wherein the alkyl residues are unsubstituted or mono-, di- or trisubstituted independently of one another by halogen, --NH.sub.2, --OH; or --(C.sub.3-C.sub.6)-cycloalkyl, wherein cycloalkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by halogen, --NH.sub.2 or --OH; M is 1) a hydrogen atom, 2) --(C.sub.1-C.sub.8)-alkyl, wherein alkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R14, 3) --C(O)--N(R11)-R12, 4) --C(O)--O--R12, 5) --(C.sub.1-C.sub.8)-alkylene-N(R10).sub.2, 6)--(C.sub.6-C.sub.14)-aryl, wherein aryl is selected from phenyl, naphthyl, biphenylyl, indanyl, anthryl and fluorenyl and aryl is unsubstituted or mono-, di- or trisubstituted independently of one another by R14, 7) --(C.sub.3-C.sub.8)-cycloalkyl, wherein said cycloalkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R14, or 8) a 3- to 7-membered heterocyclyl, containing 1, 2, 3 or 4 heteroatoms chosen from nitrogen, sulfur or oxygen, selected from azepine, azetidine, aziridine, azirine, 1,4-diazepane, 1,2-diazepine, 1,3-diazepine,

1,4-diazepine, diaziridine, diazirine, dihydroimidazolone, dioxazole, dioxazine, dioxole, 1,3-dioxolene, 1,3-dioxolane, furan, imidazole, imidazoline, imidazolidine, imidazolidinone, isothiazole, isothiazolidine, isothiazoline, isoxazole, isoxazoline, isoxazolidine, morpholine, 1,2-oxa-thiepane, 1,2-oxathiolane, 1,4-oxazepane, 1,2-oxazine, 1,3-oxazine, 1,4-oxazine, oxazolone, oxazole, [1,3,4]oxathiazinane 3,3-dioxide, oxaziridine, oxazolidinone, oxetan, oxirane, piperazine, piperidine, pyran, pyrazine, pyrazole, pyrazoline, pyrazolidine, pyridazine, pyridine, pyridinone, pyrimidine, pyrimidine-2,4-dione, pyrrole, pyrrolidine, pyrrolidinone, pyrroline, tetrahydrofuran, tetrahydropyran, tetrahydropyridine, tetrazine, tetrazole, thiadiazine thiadiazole, 1,2-thiazine, 1,3-thiazine, 1,4-thiazine, 1,3-thiazole, thiazole, thiazolidine, thiazoline, thienyl, thietan, thiomorpholine, thiomorpholine-1,1-dioxide, thiopyran, 1,2,3-triazine, 1,2,4-triazine, 1,3,5-triazine, 1,2,3-triazole and 1,2,4-triazole, wherein said cyclic residue is unsubstituted or mono-, di- or trisubstituted independently of one another by R14, R2, R3, R4, R5 and R6 are independently of one another selected from 1) a hydrogen atom, 2) --(C.sub.1-C.sub.6)-alkyl, wherein alkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, 3) --(C.sub.0-C.sub.4)-alkylene-O--R10, 4) halogen, 5) --(C.sub.1-C.sub.3)-fluoroalkyl, 6) --CN or 7) phenyl, wherein phenyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, or R3 and R4, R4 and R5 or R5 and R6 are each time both --O--R10 and form together with the atoms which they are attached to a 1,3-dioxole ring or 2,3-dihydro-[1,4]dioxine ring, which is unsubstituted or substituted one, two, three or four times by R13, R3 and R4, R4 and R5 or R5 and R6 form together with the atoms which they are attached to a cyclopentyl or cyclohexyl, which is unsubstituted or substituted one, two, three or four times by R13, R7 is 1) a hydrogen atom, 2) halogen, 3) --(C.sub.1-C.sub.6)-alkyl, wherein alkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, 4) .dbd.O, 5) --(C.sub.1-C.sub.3)-fluoroalkyl, 6) --(C.sub.0-C.sub.4)-alkylene-O--R19, wherein R19 is a) a hydrogen atom, b) --(C.sub.1-C.sub.4)-alkyl, wherein alkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, c) --(C.sub.3-C.sub.8)-cycloalkyl, wherein alkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, d) phenyl, wherein phenyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, e) --CF.sub.3, or f) --CHF.sub.2, 7) --NO.sub.2, 8) --CN, 9) --(C.sub.0-C.sub.4)-alkylene-O--CH.sub.2--(C.sub.1-C.sub.3)-fluoroalkylen- e-CH.sub.2--O--(C.sub.1-C.sub.4)-alkyl, 10) --(C.sub.0-C.sub.4)-alkylene-C(O)--R11, 11) --(C.sub.0-C.sub.4)-alkylene-C(O)--O--R11, 12) --(C.sub.0-C.sub.4)-alkylene-C(O)--O--(C.sub.1-C.sub.4)-alkylene-O--C(O)-- -R17, wherein --(C.sub.1-C.sub.4)-alkylene is unsubstituted or mono-, di- or trisubstituted independently of one another by R15, 13) --(C.sub.0-C.sub.4)-alkylene-C(O)--O--(C.sub.1-C.sub.4)-alkylene-O--C(O)-- -O--R17, wherein --(C.sub.1-C.sub.4)-alkylene is unsubstituted or mono-, di- or trisubstituted independently of one another by R15, 14) --(C.sub.0-C.sub.4)-alkylene-C(O)--N(R11)-R12, 15) --(C.sub.0-C.sub.4)-alkylene-C(O)--N(R11)-R13, 16) --(C.sub.0-C.sub.4)-alkylene-C(O)--N[(C.sub.0-C.sub.4)-alkylene]-R13, wherein alkyl and cycloalkyl are unsubstituted or mono-, di- or trisubstituted independently of one another by R13, 17) --(C.sub.0-C.sub.4)-alkylene-C(O)--N[(C.sub.0-C.sub.4)-alkylene-(C.sub.3-- C.sub.8)-cycloalkyl]-R13, wherein alkyl and cycloalkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, 18) --(C.sub.0-C.sub.4)-alkylene-N(R11)-R12, 19) --(C.sub.0-C.sub.4)-alkylene-N(R11)-R13, 20) --(C.sub.0-C.sub.4)-alkylene-N(R10)-SO.sub.2--R10, 21) --(C.sub.0-C.sub.4)-alkylene-S--R10, 22) --(C.sub.0-C.sub.4)-alkylene-SO.sub.s--R11, wherein s is 1 or 2, 23) --(C.sub.0-C.sub.4)-alkylene-SO.sub.t--N(R11)-R12, wherein t is 1 or 2, 24) --(C.sub.0-C.sub.4)-alkylene-SO.sub.w--N(R11)-R13, wherein w is 1 or 2, 25) --(C.sub.0-C.sub.4)-alkylene-SO.sub.u--(C.sub.0-C.sub.4)-alkylene-- C(O)--O--R10, wherein u is 1 or 2, 26) --(C.sub.0-C.sub.4)-alkylene-(C.sub.3-C.sub.8)-cycloalkyl, wherein cycloalkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, 27) --(C.sub.0-C.sub.4)-alkylene-(C.sub.6-C.sub.14)-aryl, wherein aryl is selected from phenyl, naphthyl, biphenylyl, indanyl, anthryl or fluorenyl; and wherein aryl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, or 28) --(C.sub.0-C.sub.4)-alkylene-(C.sub.3-C.sub.15)-heterocyclyl, wherein heterocyclyl is as defined above and is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, 29) --(C.sub.0-C.sub.4)-alkylene-O--(C.sub.0-C.sub.4)-alkylene-(C.sub.6-C.sub- .14)-aryl, wherein aryl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, 30) --(C.sub.0-C.sub.4)-alkylene-O--(C.sub.0-C.sub.4)-alkylene-(C.sub.3-C.sub- .15)-heterocyclyl, wherein heterocyclyl is un-substituted or mono-, di- or trisubstituted independently of one another by R13, 31) --(C.sub.0-C.sub.4)-alkylene-N(R13)-(C.sub.0-C.sub.4)-alkylene-(C.sub.6-C- .sub.14)-aryl, wherein aryl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, or 32) --(C.sub.0-C.sub.4)-alkylene-N(R13)-(C.sub.0-C.sub.4)-alkylene-(C.sub.3-C- .sub.15)-heterocyclyl, wherein heterocyclyl is un-substituted or mono-, di- or trisubstituted independently of one another by R13, R11 and R12 are independently of one another identical or different and are 1) a hydrogen atom, 2) --(C.sub.1-C.sub.6)-alkyl, wherein alkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, 3) --(C.sub.0-C.sub.6)-alkylene-(C.sub.3-C.sub.8)-cycloalkyl, wherein alkylene and cycloalkyl independently from one another are unsubstituted or mono-, di- or trisubstituted independently of one another by R13, 4) --SO.sub.t--R10, wherein t is 1 or 2, 5) --(C.sub.0-C.sub.6)-alkylene-(C.sub.6-C.sub.14)-aryl, wherein aryl is as defined above and alkylene and aryl independently from one another are unsubstituted or mono-, di- or trisubstituted by R13, 6) --(C.sub.1-C.sub.3)-fluoroalkyl, 7) --O--R17, or 8) --(C.sub.0-C.sub.6)-alkylene-(C.sub.3-C.sub.15)-heterocyclyl, wherein heterocyclyl is as defined above and alkylene and heterocyclyl independently from one another are unsubstituted or mono-, di- or trisubstituted by R13, or R11 and R12 together with the nitrogen atom to which they are bonded form a 4- to 8-membered monocyclic heterocyclic ring, which is selected from aza-bicycloheptane, aza-bicyclohexane, aza-spiroheptane, aza-spirohexane, aza-spirooctane, aza-spiropentane, azepane, azepine, azetidine, diaza-bicycloheptane, diaza-bicyclohexane, diaza-spiroheptane, diaza-spirohexane, diaza-spiropentane, diaza-spirooctane 1,2-diazapane, 1,3-diazepane, 1,4-diazepane, 1,2-diazepine, 1,3-diazepine, 1,4-diazepine, dihydroazepine, dihydro-oxazepine, dihydro-pyridazine, dioxazole, hexahydro-pyridazine, imidazoline, imidazolidine, isothiazolidine, isothiazoline, isoxazoline, isoxazolidine, ketopiperazine, morpholine, 1,4-oxazepane, 1,2-oxa-thiepane, oxazepine, 1,2-oxazine, 1,3-oxazine, 1,4-oxazine, piperazine, piperidine, pyrazine, pyrazoline, pyrazolidine, pyridazine, pyrrolidine, pyrrolidinone, pyrroline, tetrahydro-azepine, 1,2,3,4-tetrahydropyrazine, tetrahydropyridine, tetrazine, tetrazole, thiadiazine, 1,2-thiazine, 1,3-thiazine, 1,4-thiazine, 1,3-thiazole, thiazolidine, thiazoline, thietan, thiomorpholine, triazepane, 1,2,4-triazinane and 1,3,5-triazinane; wherein said heterocyclic ring is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, R13 is halogen, --NO.sub.2, --CN, .dbd.O, --OH, --CF.sub.3, --C(O)--O--R10, --C(O)--N(R10)-R20, --N(R10)-R20, --(C.sub.3-C.sub.8)-cycloalkyl, --(C.sub.2-C.sub.10)-alkenyl-, --(C.sub.2-C.sub.10)-alkynyl-, --O--CF.sub.3, --Si--(CH.sub.3).sub.3, --(C.sub.0-C.sub.4)-alkylene-O--R10, --N(R10)-S(O).sub.u--R10, wherein u is 1 or 2, --SO.sub.r--R10, wherein r is 1 or 2, --S(O).sub.v--N(R10)-R20, wherein v is 1 or 2, --S--R10, --C(O)--R10, --(C.sub.1-C.sub.8)-alkyl, --(C.sub.1-C.sub.8)-alkoxy, phenyl, phenyloxy-, --(C.sub.1-C.sub.8)-alkoxy-phenyl, --(C.sub.0-C.sub.4)-alkylene-C(O)--O--C(R15, R16)-O--C(O)--R17, O--R15, --NH--C(O)--NH--R10, --(C.sub.0-C.sub.4)-alkylene-C(O)--O--C(R15,R16)-O--C(O)--O--R17, --(C.sub.1-C.sub.3)-fluoroalkyl, --NH--C(O)--O--R10, or --(C.sub.0-C.sub.4)-alkylene-R22, R10 and R20 are independently of one another hydrogen, --(C.sub.1-C.sub.4)-alkyl, --(C.sub.1-C.sub.4)-alkyl-OH, --(C.sub.0-C.sub.4)-alkylene-O--(C.sub.1-C.sub.4)-alkyl or --(C.sub.1-C.sub.3)-fluoroalkyl, R15 and R16 are independently of one another hydrogen atom or --(C.sub.1-C.sub.6)-alkyl, or together with the carbon atom to which they are bonded form a --(C.sub.3-C.sub.6)-cycloalkyl, which is unsubstituted or mono, di- or trisubstituted by R10, R17 is hydrogen atom, --(C.sub.1-C.sub.6)-alkyl, --(C.sub.1-C.sub.6)-alkyl-OH, --(C.sub.1-C.sub.6)-alkylene-O--(C.sub.1-C.sub.6)-alkyl, --(C.sub.10-C.sub.16)-alkylene-(C.sub.3-C.sub.8)-cycloalkyl or --(C.sub.1-C.sub.6)-alkylene-O--(C.sub.1-C.sub.6)-alkylene-(C.sub.3-C.sub- .8)-cycloalkyl, wherein said cycloalkyl ring is unsubstituted or substituted one, two or three times by --OH, --O--(C.sub.1-C.sub.4)-alkyl or R10, and R22 is a residue from the following list: ##STR00030## wherein Me is methyl, in all its stereoisomeric forms and mixtures thereof in any ratio, and its physiologically tolerable salts.

3. A compound as claimed in claim 1, of formula Ia ##STR00031## E is a heterocyclic residue selected from aza-bicycloheptane, aza-bicyclohexane, aza-bicyclooctane, aza-spiroheptane, aza-spirohexane, aza-spirooctane, aza-spiropentane, azepane, azepine, azetidine, aziridine, decahydro-quinoline, diaza-bicyclohexane, diaza-bicycloheptane, 2,5-Diaza-bicyclo[2.2.1]heptane, 1,2-diazapane, 2,7-diaza-spiro[4.5]decane, 2,8-diaza-spiro[4.5]decane, diaza-spirohexane, diaza-spirooctane, diaza-spiropentane, diaza-spiroheptane, 1,3-diazepane, 1,4-diazepane, 1,2-diazepine, 1,3-diazepine, 1,4-diazepine, dihydroazepine, 2,3-dihydro-1H-indole, 3,4-dihydro-1H-isoquinoline, 4,7-dihydro-5H-isoxazolo[5,4-c]pyridine, 6,7-dihydro-4H-isoxazolo[4,5-c]pyridine, dihydro-pyridazine, dihydro-oxazepine, 6,7-dihydro-4H-oxazolo[5,4-c]pyridine, 4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol, 4,6-dihydro-4H-pyrrolo[3,4-d]thiazole, 6,7-dihydro-4H-thiazolo[5,4-c]pyridine, 4,7-dihydro-5H-thieno[2,3-c]pyridine, 5,6-Dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin, dioxazole, hexahydro-cyclopenta[c]pyrroline, hexahydro-pyridazine, hexahydro-pyrrolo[1,2-a]pyrazin, hexahydro-pyrrolo[3,4-b]pyrrol, Hexahydro-pyrrolo[1,2-a]pyrazin, imidazoline, imidazolidine, indole, isoquinoline, isothiazolidine, isothiazoline, isoxazoline, isoxazolidine, ketopiperazine, morpholine, octahydro-cyclopenta[c]pyrrole, octahydro-indole, octahydro-pyrrolo[3,4-b]pyridine, octahydro-pyrrolo[3,4-c]pyridine, 1,4-oxazepane, oxazepine, 1,2-oxa-thiepane, 1,2-oxazine, 1,3-oxazine, 1,4-oxazine, oxazolidine, piperazine, piperidine, pyrazine, pyrazoline, pyrazolidine, pyridazine, pyrrolidine, pyrrolidinone, pyrroline, tetrahydropyridine, tetrahydro-azepine, 1,2,3,4-tetrahydro-isoquinoline, 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine, 1,2,3,4-tetrahydropyrazine, 1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine, 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine, tetrahydro-pyridazine, 3,5,7,8-tetrahydro-4H-pyrido[4,3-d]pyrimidine, 4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole, 1,2,3,4-tetrahydro-quinoline, 4,5,6,7-tetrahydro-thieno[2,3-c]pyridine, 1,4,6,7-tetrahydro-thiazolo[5,4-c]pyridine, 4,5,6,7-tetrahydro-thieno[3,2-c]pyridine, tetrazine, tetrazole, thiadiazine, 1,2-thiazine, 1,3-thiazine, 1,4-thiazine, 1,3-thiazole, thiazolidine, thiazoline, thietan, thiomorpholine, 1,3,8-triaza-spiro[4.5]decane, triaza-spirooctane, triazepane, 1,2,4-triazinane and 1,3,5-triazinane, wherein said heterocyclic residue is bond by its nitrogen atom to the carbonyl carbon atom and wherein said heterocyclic residue is mono-, di- or trisubstituted independently of one another by R7, Q is 1) a covalent bond, 2) --(C.sub.0-C.sub.4)-alkylene-CH(OH)--(C.sub.0-C.sub.4)-alkylene-, 3) --(C.sub.0-C.sub.4)-alkylene-O--(C.sub.0-C.sub.4)-alkylene-, 4) --(C.sub.0-C.sub.4)-alkylene-C(O)--(C.sub.0-C.sub.4)-alkylene-, 5) --(C.sub.0-C.sub.4)-alkylene-C(O)--O--(C.sub.0-C.sub.4)-alkylene-, 6) --(C.sub.0-C.sub.4)-alkylene-C(O)--N(R10)-, 7) --(C.sub.0-C.sub.4)-alkylene-N(R10)-(C.sub.0-C.sub.4)-alkylene-, 8) --(C.sub.0-C.sub.4)-alkylene-N(R10)-C(O)--(C.sub.0-C.sub.4)-alkylene-, 9) --(C.sub.0-C.sub.4)-alkylene-N(R10)-C(O)--O--(C.sub.0-C.sub.4)-alkylene-, 10) --(C.sub.0-C.sub.4)-alkylene-N(R10)-C(O)--N(R10)-(C.sub.0-C.sub.4)-al- kylene-, 11) --(C.sub.0-C.sub.4)-alkylene-S--(C.sub.0-C.sub.4)-alkylene-, 12) --(C.sub.0-C.sub.4)-alkylene-SO.sub.2--(C.sub.0-C.sub.4)-alkylene-, 13) --(C.sub.0-C.sub.4)-alkylene-(C.sub.3-C.sub.6)-cycloalkyl-(C.sub.0-C.- sub.4)-alkylene-, or 14) --(C.sub.0-C.sub.4)-alkylene-(C.sub.3-C.sub.15)-heterocyclyl-(C.sub.0-C.s- ub.4)-alkylene-, wherein --(C.sub.3-C.sub.15)-heterocyclyl is selected from acridinyl, azabenzimidazolyl, aza-bicycloheptanyl, aza-bicyclohexanyl, aza-bicyclooctanyl, 8-aza-bicyclo[3.2.1]octanyl, azaspirodecanyl, aza-spiroheptanyl, aza-spirohexanyl, aza-spirooctanyl, aza-spiropentanyl, azepinyl, azetidinyl, aziridinyl, benzimidazolyl, benzofuranyl, benzothiofuranyl, benzothiophenyl, benzoxazolyl, benzthiazolyl, benztriazolyl, benztetrazolyl, benzisoxazolyl, benziso-thiazolyl, carbazolyl, 4aH-carbazolyl, carbolinyl, chromanyl, chromenyl, cinnolinyl, decahydro-quinolinyl, diaza-bicyclohexanyl, diaza-bicycloheptanyl, 2,5-Diaza-bicyclo[2.2.1]heptanyl, 1,2-diazapanyl, diaza-spirohexanyl, diaza-spirooctanyl, diaza-spiropentanyl, diaza-spiroheptanyl, 1,3-diazepanyl, 1,4-diazepanyl, 1,2-diazepinyl, 1,3-diazepinyl, 1,4-diazepinyl, dihydroazepinyl, 3,4-dihydro-2H-quinoline, dihydrofuro[2,3-b]-tetrahydrofuranyl, 2,3-dihydro-1H-indolyl, 3,4-dihydro-1H-isoquinolinyl, 6,7-dihydro-4H-isoxazolo[4,5-c]pyridinyl, dihydro-pyridazinyl, 4,5-dihydro-[1,3,4]oxadiazol, dihydro-oxazepinyl, 4,5-dihydrooxazolinyl, 4,6-dihydro-4H-pyrrolo[3,4-d]thiazolyl, 6,7-dihydro-4H-thiazolo[5,4-c]pyridinyl, 4,7-dihydro-5H-thieno[2,3-c]pyridinyl, 1,3-dioxanyl, dioxazolyl, dioxazinyl, 1,3-dioxolanyl, 1,3-dioxolenyl, 3,3-dioxo[1,3,4]oxathiazinyl, furanyl, furazanyl, hexahydro-pyridazine, hexahydro-cyclopenta[c]pyrroline, imidazolidinyl, imidazolinyl, imidazolyl, 1H-indazolyl, indolinyl, indolizinyl, indolyl, 3H-indolyl, isobenzofuranyl, isochromanyl, isoindazolyl, isoindolinyl, isoindolyl, isoquinolinyl (benzimidazolyl), isothiazolyl, isothiazolidinyl, isothiazolinyl, isoxazolyl, isoxazolinyl, isoxazolidinyl, 2-isoxazolinyl, ketopiperazinyl, morpholinyl, naphthyridinyl, octahydro-cyclopenta[c]pyrrolyl, octahydroisoquinolinyl, oxadiazolyl, 1,2,3-oxadiazolyl, 1,2,4-oxadiazolyl, 1,2,5-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2-oxa-thiepanyl, 1,2-oxathiolanyl, 1,4-oxazepanyl, oxazepinyl, 1,2-oxazinyl, 1,3-oxazinyl, 1,4-oxazinyl, oxazolidinyl, oxazolinyl, oxazolyl, oxetanyl, oxocanyl, phenanthridinyl, phenanthrolinyl, phenazinyl, phenothiazinyl, phenoxathiinyl, phenoxazinyl, phthalazinyl, piperazinyl, piperidinyl, pteridinyl, purinyl, pyranyl, pyrazinyl, pyrazolidinyl, pyrazolinyl, pyrazolyl, pyridazinyl, pyridooxazolyl, pyridoimidazolyl, pyridothiazolyl, pyridinyl, pyridyl, pyrimidinyl, pyrrolidinyl, pyrrolidinonyl, pyrrolinyl, 1H-pyrrolopyridinyl, 2H-pyrrolyl, pyrrolyl, quinazolinyl, quinolinyl, 4H-quinolizinyl, quinoxalinyl, quinuclidinyl, tetrahydrofuranyl, 1,2,3,4-tetrahydro-isoquinolinyl, 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridinyl, tetrahydropyranyl, 1,2,3,4-tetrahydropyrazinyl, 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridinyl, tetrahydro-pyridazinyl, tetrahydro-pyridinyl, 4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazolyl, 1,2,3,4-tetrahydro-quinolinyl, 4,5,6,7-tetrahydro-thieno[2,3-c]pyridinyl, 1,4,6,7-tetrahydro-thiazolo[5,4-c]pyridinyl, 4,5,6,7-tetrahydro-thieno[3,2-c]pyridinyl, tetrahydrothiophenyl, tetrazinyl, tetrazolyl, 6H-1,2,5-thiadiazinyl, 1,2,3-thiadiazolyl, 1,2,4-thiadiazolyl, 1,2,5-thiadiazolyl, 1,3,4-thiadiazolyl, thianthrenyl, 1,2-thiazinyl, 1,3-thiazinyl, 1,4-thiazinyl, 1,3-thiazolyl, thiazolyl, thiazolidinyl, thiazolinyl, thienyl, thietanyl, thienothiazolyl, thienooxazolyl, thienoimidazolyl, thietanyl, thiomorpholinyl, thiophenolyl, thiophenyl, thiopyranyl, triaza-spirooctanyl, 1,2,3-triazinyl, 1,2,4-triazinyl, 1,3,5-triazinyl, 1,2,3-triazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, 1,2,5-triazolyl, 1,3,4-triazolyl, and xanthenyl, and wherein --(C.sub.3-C.sub.15)-heterocyclyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R14; and wherein the alkyl residues are unsubstituted or mono-, di- or trisubstituted independently of one another by halogen, --NH.sub.2, --OH; or --(C.sub.3-C.sub.6)-cycloalkyl, wherein cycloalkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by halogen, --NH.sub.2 or --OH; J is 1) a hydrogen atom, 2) --(C.sub.1-C.sub.6)-alkyl, wherein alkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, 3) --(C.sub.0-C.sub.4)-alkylene-C(O)--R11, 4) --(C.sub.0-C.sub.4)-alkylene-C(O)--O--R11, 5) --(C.sub.0-C.sub.4)-alkylene-C(O)--O--(C.sub.1-C.sub.4)-alkylene-O--C(O)-- -R17, wherein --(C.sub.1-C.sub.4)-alkylene is unsubstituted or mono-, di- or trisubstituted independently of one another by R15, 6) --(C.sub.0-C.sub.4)-alkylene-C(O)--O--(C.sub.1-C.sub.4)-alkylene-O--C(O)-- -O--R17, wherein --(C.sub.1-C.sub.4)-alkylene is unsubstituted or mono-, di- or trisubstituted independently of one another by R15, 7) --(C.sub.0-C.sub.4)-alkylene-C(O)--N(R11)-R13 8) --(C.sub.0-C.sub.4)-alkylene-N(R11)-R13, 9) --(C.sub.0-C.sub.4)-alkylene-N(R10)-SO.sub.2--R10, 10) --(C.sub.0-C.sub.4)-alkylene-SO.sub.s--R11, wherein s is 1 or 2, 11) --(C.sub.0-C.sub.4)-alkylene-SO.sub.t--N(R11)-R12, wherein t is 1 or 2, 12) --(C.sub.0-C.sub.4)-alkylene-SO.sub.w--N(R11)-R13, wherein w is 1 or 2, 13) --(C.sub.0-C.sub.4)-alkylene-R22, 14) --(C.sub.0-C.sub.4)-alkylene-(C.sub.3-C.sub.6)-cycloalkyl, wherein cycloalkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, 15) --(C.sub.0-C.sub.4)-alkylene-(C.sub.6-C.sub.14)-aryl, wherein aryl is selected from phenyl or indanyl, and aryl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, or 16) --(C.sub.0-C.sub.4)-alkylene-(C.sub.3-C.sub.15)-heterocyclyl, wherein --(C.sub.3-C.sub.15)-heterocyclyl is as defined above and is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, V is --(C.sub.3-C.sub.15)-heterocyclyl or --N(R1)-(C.sub.3-C.sub.15)-heterocyclyl, wherein --(C.sub.3-C.sub.15)-heterocyclyl is as defined above and is unsubstituted or mono-, di- or trisubstituted independently of one another by R14, G is 1) a covalent bond, 2) --(C.sub.0-C.sub.4)-alkylene-O--(C.sub.0-C.sub.4)-alkylene-, 3) --(C.sub.0-C.sub.4)-alkylene-O--C(O)--N(R10)-(C.sub.0-C.sub.4)-alkylene-, 4) --(C.sub.0-C.sub.4)-alkylene-C(O)--(C.sub.0-C.sub.4)-alkylene-, 5) --(C.sub.0-C.sub.4)-alkylene-C(O)--O--(C.sub.0-C.sub.4)-alkylene-, 6) --(C.sub.0-C.sub.4)-alkylene-C(O)--N(R10)-, 7) --(C.sub.0-C.sub.4)-alkylene-N(R10)-(C.sub.0-C.sub.4)-alkylene-, 8) --(C.sub.0-C.sub.4)-alkylene-N(R10)-C(O)--(C.sub.0-C.sub.4)-alkylene-, 9) --(C.sub.0-C.sub.4)-alkylene-N(R10)-C(O)--O--(C.sub.0-C.sub.4)-alkylene-, 10) --(C.sub.0-C.sub.4)-alkylene-N(R10)-C(O)--N(R10)-(C.sub.0-C.sub.4)-al- kylene-, 11) --(C.sub.0-C.sub.4)-alkylene-N(R10)-SO.sub.2--(C.sub.0-C.sub.4)-alkylene-- , 12) --(C.sub.0-C.sub.4)-alkylene-N(R10)-SO.sub.2--N(R10)-(C.sub.0-C.sub.- 4)-alkylene-, 13) --(C.sub.0-C.sub.4)-alkylene-SO.sub.2--(C.sub.0-C.sub.4)-alkylene-, or 14) --(C.sub.0-C.sub.4)-alkylene-SO.sub.2--N(R10)-(C.sub.0-C.sub.4)-alkyl- ene-, and wherein the alkyl residues are unsubstituted or mono-, di- or trisubstituted independently of one another by halogen, --NH.sub.2, --OH; or --(C.sub.3-C.sub.6)-cycloalkyl, wherein cycloalkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by halogen, --NH.sub.2 or --OH; M is 1) a hydrogen atom, 2) --(C.sub.1-C.sub.8)-alkyl, wherein alkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R14, 3) --C(O)--N(R11)-R12, 4) --C(O)--O--R12, 5) --(C.sub.1-C.sub.8)-alkylene-N(R10).sub.2, 6) --(C.sub.6-C.sub.14)-aryl, wherein aryl is selected from phenyl, naphthyl, biphenylyl, indanyl, anthryl and fluorenyl and aryl is unsubstituted or mono-, di- or trisubstituted independently of one another by R14, 7) --(C.sub.3-C.sub.6)-cycloalkyl, wherein said cycloalkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R14, or 8) a 3- to 7-membered heterocyclyl, containing 1, 2, 3 or 4 heteroatoms chosen from nitrogen, sulfur or oxygen, selected from azepine, azetidine, aziridine, azirine, 1,4-diazepane, 1,2-diazepine, 1,3-diazepine, 1,4-diazepine, diaziridine, diazirine, dihydroimidazolone, dioxazole, dioxazine, dioxole, 1,3-dioxolene, 1,3-dioxolane, furan, imidazole, imidazoline, imidazolidine, imidazolidinone, isothiazole, isothiazolidine, isothiazoline, isoxazole, isoxazoline, isoxazolidine, morpholine, 1,2-oxa-thiepane, 1,2-oxathiolane, 1,4-oxazepane, 1,2-oxazine, 1,3-oxazine, 1,4-oxazine, oxazolone, oxazole, [1,3,4]oxathiazinane 3,3-dioxide, oxaziridine, oxazolidinone, oxetan, oxirane, piperazine, piperidine, pyran, pyrazine, pyrazole, pyrazoline, pyrazolidine, pyridazine, pyridine, pyridinone, pyrimidine, pyrimidine-2,4-dione, pyrrole, pyrrolidine, pyrrolidinone, pyrroline, tetrahydrofuran, tetrahydropyran, tetrahydropyridine, tetrazine, tetrazole, thiadiazine thiadiazole, 1,2-thiazine, 1,3-thiazine, 1,4-thiazine, 1,3-thiazole, thiazole, thiazolidine, thiazoline, thienyl, thietan, thiomorpholine, thiomorpholine 1,1-dioxide thiopyran, 1,2,3-triazine, 1,2,4-triazine, 1,3,5-triazine, 1,2,3-triazole and 1,2,4-triazole, wherein said cyclic residue is unsubstituted or mono-, di- or trisubstituted independently of one another by R14, R1 is a hydrogen atom, --(C.sub.1-C.sub.4)-alkyl, wherein alkyl is unsubstituted or substituted one to three times by R13; --(C.sub.1-C.sub.3)-alkylene-C(O)--NH--R10 or --(C.sub.1-C.sub.3)-alkylene-C(O)--O--R10, R2, R3, R4, R5 and R6 are independently of one another selected from 1) a hydrogen atom, 2) --(C.sub.1-C.sub.6)-alkyl, wherein alkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, 3) --(C.sub.0-C.sub.4)-alkylene-O--R10, 4) halogen, 5) --(C.sub.1-C.sub.3)-fluoroalkyl, 6) --CN or 7) phenyl, wherein phenyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, or R3 and R4, R4 and R5 or R5 and R6 are each time both --O--R10 and form together with the atoms which they are attached to a 1,3-dioxole ring or 2,3-dihydro-[1,4]dioxine ring, which is unsubstituted or substituted one, two, three or four times by R13, R3 and R4, R4 and R5 or R5 and R6 form together with the atoms which they are attached to a cyclopentyl or cyclohexyl, which is unsubstituted or substituted one, two, three or four times by R13, R7 is 1) a hydrogen atom, 2)halogen, 3) --(C.sub.1-C.sub.6)-alkyl, wherein alkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, 4) .dbd.O, 5) --(C.sub.1-C.sub.3)-fluoroalkyl, 6) --(C.sub.0-C.sub.4)-alkylene-O--R19, wherein R19 is a) hydrogen atom, b) --(C.sub.1-C.sub.4)-alkyl, wherein alkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, c) --(C.sub.3-C.sub.8)-cycloalkyl, wherein alkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, d) phenyl, wherein phenyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, e) --CF.sub.3, or f) --CHF.sub.2, 7) --NO.sub.2, 8) --CN, 9) --(C.sub.0-C.sub.4)-alkylene-O--CH.sub.2--(C.sub.1-C.sub.3)-fluoroalkylen- e-CH.sub.2--O--(C.sub.1-C.sub.4)-alkyl, 10) --(C.sub.0-C.sub.4)-alkylene-C(O)--R11, 11) --(C.sub.0-C.sub.4)-alkylene-C(O)--O--R11, 12) --(C.sub.0-C.sub.4)-alkylene-C(O)--O--(C.sub.1-C.sub.4)-alkylene-O--C(O)-- -R17, wherein --(C.sub.1-C.sub.4)-alkylene is unsubstituted or mono-, di- or trisubstituted independently of one another by R15, 13) --(C.sub.0-C.sub.4)-alkylene-C(O)--O--(C.sub.1-C.sub.4)-alkylene-O--C(O)-- -O--R17, wherein --(C.sub.1-C.sub.4)-alkylene is unsubstituted or mono-, di- or trisubstituted independently of one another by R15, 14) --(C.sub.0-C.sub.4)-alkylene-C(O)--N(R11)-R12, 15) --(C.sub.0-C.sub.4)-alkylene-C(O)--N(R11)-R13, 16) --(C.sub.0-C.sub.4)-alkylene-C(O)--N[(C.sub.0-C.sub.4)-alkylene]-R13, wherein alkyl and cycloalkyl are unsubstituted or mono-, di- or trisubstituted independently of one another by R13, 17) --(C.sub.0-C.sub.4)-alkylene-C(O)--N[(C.sub.0-C.sub.4)-alkylene-(C.sub.3-- C.sub.8)-cycloalkyl]-R13, wherein alkyl and cycloalkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, 18) --(C.sub.0-C.sub.4)-alkylene-N(R11)-R12, 19) --(C.sub.0-C.sub.4)-alkylene-N(R11)-R13, 20) --(C.sub.0-C.sub.4)-alkylene-N(R10)-SO.sub.2--R10, 21) --(C.sub.0-C.sub.4)-alkylene-S--R10, 22) --(C.sub.0-C.sub.4)-alkylene-SO.sub.s--R11, wherein s is 1 or 2, 23)

--(C.sub.0-C.sub.4)-alkylene-SO.sub.t--N(R11)-R12, wherein t is 1 or 2, 24) --(C.sub.0-C.sub.4)-alkylene-SO.sub.w--N(R11)-R13, wherein w is 1 or 2, 25) --(C.sub.0-C.sub.4)-alkylene-SO.sub.u--(C.sub.0-C.sub.4)-alkylene-- C(O)--O--R10, wherein u is 1 or 2, 26) --(C.sub.0-C.sub.4)-alkylene-(C.sub.3-C.sub.6)-cycloalkyl, wherein cycloalkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, 27) --(C.sub.0-C.sub.4)-alkylene-(C.sub.6-C.sub.14)-aryl, wherein aryl is selected from phenyl, naphthyl, biphenylyl, indanyl, anthryl or fluorenyl; and wherein aryl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, 28) --(C.sub.0-C.sub.4)-alkylene-(C.sub.3-C.sub.15)-heterocyclyl, wherein heterocyclyl is as defined above and is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, 29) --(C.sub.0-C.sub.4)-alkylene-O--(C.sub.0-C.sub.4)-alkylene-(C.sub.6-C.sub- .14)-aryl, wherein aryl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, 30) --(C.sub.0-C.sub.4)-alkylene-O--(C.sub.0-C.sub.4)-alkylene-(C.sub.3-C.sub- .15)-heterocyclyl, wherein heterocyclyl is un-substituted or mono-, di- or trisubstituted independently of one another by R13, 31) --(C.sub.0-C.sub.4)-alkylene-N(R13)-(C.sub.0-C.sub.4)-alkylene-(C.sub.6-C- .sub.14)-aryl, wherein aryl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, or 32) --(C.sub.0-C.sub.4)-alkylene-N(R13)-(C.sub.0-C.sub.4)-alkylene-(C.sub.3-C- .sub.15)-heterocyclyl, wherein heterocyclyl is un-substituted or mono-, di- or trisubstituted independently of one another by R13, R11 and R12 are independently of one another identical or different and are 1) a hydrogen atom, 2) --(C.sub.1-C.sub.6)-alkyl, wherein alkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, 3) --(C.sub.0-C.sub.6)-alkylene-(C.sub.3-C.sub.8)-cycloalkyl, wherein alkylene and cycloalkyl independently from one another are unsubstituted or mono-, di- or trisubstituted independently of one another by R13, 4) --SO.sub.t--R10, wherein t is 1 or 2, 5) --(C.sub.0-C.sub.6)-alkylene-(C.sub.6-C.sub.14)-aryl, wherein aryl is as defined above and alkylene and aryl independently from one another are unsubstituted or mono-, di- or trisubstituted by R13, 6) --(C.sub.1-C.sub.3)-fluoroalkyl, 7) --O--R17, or 8) --(C.sub.0-C.sub.6)-alkylene-(C.sub.3-C.sub.15)-heterocyclyl, wherein --(C.sub.3-C.sub.15)-heterocyclyl is as defined above and alkylene and heterocyclyl independently from one another are unsubstituted or mono-, di- or trisubstituted by R13, or R11 and R12 together with the nitrogen atom to which they are bonded form a 4- to 8-membered monocyclic heterocyclic ring, which is selected from aza-bicycloheptane, aza-bicyclohexane, aza-spiroheptane, aza-spirohexane, aza-spirooctane, aza-spiropentane, azepane, azepine, azetidine, diaza-bicycloheptane, diaza-bicyclohexane, diaza-spiroheptane, diaza-spirohexane, diaza-spiropentane, diaza-spirooctane 1,2-diazapane, 1,3-diazepane, 1,4-diazepane, 1,2-diazepine, 1,3-diazepine, 1,4-diazepine, dihydroazepine, dihydro-oxazepine, dihydro-pyridazine, dioxazole, hexahydro-pyridazine, imidazoline, imidazolidine, isothiazolidine, isothiazoline, isoxazoline, isoxazolidine, ketopiperazine, morpholine, 1,4-oxazepane, 1,2-oxa-thiepane, oxazepine, 1,2-oxazine, 1,3-oxazine, 1,4-oxazine, piperazine, piperidine, pyrazine, pyrazoline, pyrazolidine, pyridazine, pyrrolidine, pyrrolidinone, pyrroline, tetrahydro-azepine, 1,2,3,4-tetrahydropyrazine, tetrahydropyridine, tetrazine, tetrazole, thiadiazine, 1,2-thiazine, 1,3-thiazine, 1,4-thiazine, 1,3-thiazole, thiazolidine, thiazoline, thietan, thiomorpholine, triazepane, 1,2,4-triazinane and 1,3,5-triazinane; wherein said heterocyclic ring is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, R13 is halogen, --NO.sub.2, --CN, .dbd.O, --OH, --CF.sub.3, --C(O)--O--R10, --C(O)--N(R10)-R20, --N(R10)-R20, --(C.sub.3-C.sub.8)-cycloalkyl, --(C.sub.2-C.sub.10)-alkenyl-, --(C.sub.2-C.sub.10)-alkynyl-, --O--CF.sub.3, --Si--(CH.sub.3).sub.3, --(C.sub.0-C.sub.4)-alkylene-O--R10, --N(R10)-S(O).sub.u--R10, wherein u is 1 or 2, --SO.sub.r--R10, wherein r is 1 or 2, --S(O).sub.v--N(R10)-R20, wherein v is 1 or 2, --S--R10, --C(O)--R10, --(C.sub.1-C.sub.8)-alkyl, --(C.sub.1-C.sub.8)-alkoxy, phenyl, phenyloxy-, --(C.sub.1-C.sub.8)-alkoxy-phenyl, --(C.sub.0-C.sub.4)-alkylene-C(O)--O--C(R15,R16)-O--C(O)--R17, --O--R15, --NH--C(O)--NH--R10, --(C.sub.0-C.sub.4)-alkylene-C(O)--O--C(R15,R16)-O--C(O)--O--R17, --(C.sub.1-C.sub.3)-fluoroalkyl, hydrogen, --NH--C(O)--O--R10, or --(C.sub.0-C.sub.4)-alkylene-R22, R10 and R20 are independently of one another hydrogen, --(C.sub.1-C.sub.4)-alkyl, --(C.sub.1-C.sub.4)-alkyl-OH, --(C.sub.0-C.sub.4)-alkylene-O--(C.sub.1-C.sub.4)-alkyl or --(C.sub.1-C.sub.3)-fluoroalkyl, R14 is halogen, --OH, .dbd.O, --(C.sub.1-C.sub.8)-alkyl, --(C.sub.1-C.sub.4)-alkoxy, --NO.sub.2, --CN, --NH.sub.2, --S--R18, --(C.sub.1-C.sub.4)-alkylene-C(O)--OH, --C(O)--O--(C.sub.1-C.sub.4)-alkyl, --(C.sub.1-C.sub.4)-alkylene-C(O)--NH.sub.2, --(C.sub.0-C.sub.8)-alkylene-SO.sub.2--(C.sub.1-C.sub.4)-alkyl, --(C.sub.0-C.sub.8)-alkylene-SO.sub.2--(C.sub.1-C.sub.3)-fluoro alkyl, --(C.sub.0-C.sub.8)-alkylene-SO.sub.2--N(R18)-R21, --(C.sub.1-C.sub.4)-alkylene-C(O)--NH--(C.sub.1-C.sub.8)-alkyl, --(C.sub.1-C.sub.4)-alkylene-C(O)--N--[(C.sub.1-C.sub.8)-alkyl].sub.2, --N(R18)-C(O)--NH--(C.sub.1-C.sub.8)-alkyl, hydrogen, --N(R18)-C(O)--NH--[(C.sub.1-C.sub.8)-alkyl].sub.2, --(C.sub.2-C.sub.10)-alkenyl, or --(C.sub.2-C.sub.10)-alkynyl, wherein R18 and R21 are independently from each other hydrogen atom, --(C.sub.1-C.sub.3)-fluoroalkyl or --(C.sub.1-C.sub.6)-alkyl, R15 and R16 are independently of one another hydrogen atom or --(C.sub.1-C.sub.6)-alkyl, or together with the carbon atom to which they are bonded form a --(C.sub.3-C.sub.6)-cycloalkyl, which is unsubstituted or mono, di- or trisubstituted by R10, R17 is hydrogen atom, --(C.sub.1-C.sub.6)-alkyl, --(C.sub.1-C.sub.6)-alkyl-OH, --(C.sub.1-C.sub.6)-alkylene-O--(C.sub.1-C.sub.6)-alkyl, --(C.sub.0-C.sub.6)-alkylene-(C.sub.3-C.sub.8)-cycloalkyl or --(C.sub.1-C.sub.6)-alkylene-O--(C.sub.1-C.sub.6)-alkylene-(C.sub.3-C.sub- .8)-cycloalkyl, wherein each cycloalkyl ring is unsubstituted or substituted one, two or three times by --OH, --O--(C.sub.1-C.sub.4)-alkyl or R10, and R22 is a residue from the following list: ##STR00032## wherein Me is methyl, R23 and R24 are independently of one another selected from hydrogen atom or methyl, in all its stereoisomeric forms and mixtures thereof in any ratio, and its physiologically tolerable salts.

4. A compound as claimed in claim 3, wherein E is a heterocyclic residue selected from aza-bicyclohexane, aza-bicyclooctane, azetidine, aziridine, decahydro-quinoline, 2,5-diaza-bicyclo[2.2.1]heptane, 1,4-diazepane, 2,7-diaza-spiro[4.5]decane, 2,8-diaza-spiro[4.5]decane, 2,3-dihydro-1H-indole, 4,7-dihydro-5H-isoxazolo[5,4-c]pyridine, 6,7-dihydro-4H-oxazolo[5,4-c]pyridine, 4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol, 4,6-dihydro-4H-pyrrolo[3,4-d]thiazole, 5,6-Dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin, hexahydro-pyrrolo[1,2-a]pyrazin, hexahydro-pyrrolo[3,4-b]pyrrol, Hexahydro-pyrrolo[1,2-a]pyrazin, imidazolidine, morpholine, indole, octahydro-cyclopenta[c]pyrrole, octahydro-indole, octahydro-pyrrolo[3,4-b]pyridine, octahydro-pyrrolo[3,4-c]pyridine, oxazolidine, piperazine, piperidine, pyrazolidine, pyrrolidine, 1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine, 1,2,3,4-tetrahydro-isoquinoline, 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine, 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine, 3,5,7,8-tetrahydro-4H-pyrido[4,3-d]pyrimidine, 4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole, 1,2,3,4-tetrahydro-quinoline, 4,5,6,7-tetrahydro-thieno[2,3-c]pyridine, 4,5,6,7-tetrahydro-thieno[3,2-c]pyridine, 4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridine, 1,3,8-triaza-spiro[4.5]decane or triaza-spirooctane, wherein said heterocyclic residue is mono-, di- or trisubstituted independently of one another by R7, Q is 1) a covalent bond, 2) --(C.sub.0-C.sub.4)-alkylene-CH(OH)--, 3) --(C.sub.0-C.sub.4)-alkylene-C(O)--N(R10)-, 4) --(C.sub.1-C.sub.3)-alkylene-C(O)--O--, 5) --(C.sub.1-C.sub.3)-alkylene-O-- or 6) --(C.sub.1-C.sub.3)-alkylene-S(O).sub.2--, J is 1) a hydrogen atom, 2) --(C.sub.1-C.sub.6)-alkyl, 3) --(C.sub.0-C.sub.4)-alkylene-C(O)--R11, 4) --(C.sub.0-C.sub.4)-alkylene-C(O)--O--R11, 5) --(C.sub.0-C.sub.4)-alkylene-N(R11)-R13, 6) --(C.sub.0-C.sub.2)-alkylene-(C.sub.3-C.sub.6)-cycloalkyl, 7) --(C.sub.0-C.sub.2)-alkylene-(C.sub.6-C.sub.14)-aryl, wherein aryl is selected from phenyl or indanyl, or 8) --(C.sub.0-C.sub.4)-alkylene-(C.sub.3-C.sub.15)-heterocyclyl, wherein --(C.sub.3-C.sub.15)-heterocyclyl is azetidinyl, benzimidazolyl, 2,3-dihydro-1H-indolyl, 4,5-dihydro-[1,3,4]oxadiazolyl, 3,4-dihydro-2H-quinolinyl, 1,3-dioxanyl, 1,3-dioxolanyl, isoxazolyl, furanyl, morpholinyl, oxadiazolyl, oxazolidinyl, oxetanyl, piperidinyl, pyridyl, pyrimidinyl, pyrrolidinyl, tetrahydrofuranyl, tetrahydropyranyl, tetrazolyl, thiazolyl or thiophenyl, wherein heterocyclyl is unsubstituted or mono- or di-substituted independently of one another by R13, V is azetidinyl, aminoazetidinyl, piperazinyl, piperidinyl or pyrrolidinyl, G and M together form a --C(O)--(C.sub.0-C.sub.4)-alkyl, --C(O)--O--(C.sub.2-C.sub.6)-alkyl or --N(R10)-C(O)--O--(C.sub.2-C.sub.6)-alkyl, or G is a direct bond and M is a phenyl residue, which is unsubstituted or substituted by Cl, F or Br, R1 is a hydrogen atom, methyl or ethyl, R2, R3, R4, R5 and R6 are independently of one another selected from hydrogen atom, Cl, F, Br, --CN, --O--CH.sub.3, --O--CH.sub.2--CH.sub.3, methyl, ethyl, propyl or butyl, or R3 and R4, R4 and R5 or R5 and R6 form together with the atoms which they are attached to a cyclohexyl ring, R7 is 1) a hydrogen atom, 2) halogen, 3) --(C.sub.1-C.sub.6)-alkyl, wherein alkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, 4) .dbd.O, 5) --(C.sub.1-C.sub.3)-fluoroalkyl, 6) --(C.sub.0-C.sub.4)-alkylene-O--R19, wherein R19 is a) hydrogen atom, b) --(C.sub.1-C.sub.4)-alkyl, wherein alkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, c) phenyl, wherein phenyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, d) --CF.sub.3, or e) --CHF.sub.2, 7) --NO.sub.2, 8) --CN, 9) --(C.sub.0-C.sub.4)-alkylene-O--CH.sub.2--(C.sub.1-C.sub.3)-fluo- roalkylene-CH.sub.2--O--(C.sub.1-C.sub.4)-alkyl, 10) --(C.sub.0-C.sub.4)-alkylene-C(O)--R11, 11) --(C.sub.0-C.sub.4)-alkylene-C(O)--O--R11, 12) --(C.sub.0-C.sub.4)-alkylene-C(O)--O--(C.sub.1-C.sub.4)-alkylene-O--C(O)-- -R17, wherein --(C.sub.1-C.sub.4)-alkylene is unsubstituted or mono-, di- or trisubstituted independently of one another by R15, 13) --(C.sub.0-C.sub.4)-alkylene-C(O)--O--(C.sub.1-C.sub.4)-alkylene-O--C(O)-- -O--R17, wherein --(C.sub.1-C.sub.4)-alkylene is unsubstituted or mono-, di- or trisubstituted independently of one another by R15, 14) --(C.sub.0-C.sub.4)-alkylene-C(O)--N(R11)-R12, 15) --(C.sub.0-C.sub.4)-alkylene-C(O)--N(R11)-R13, 16) --(C.sub.0-C.sub.4)-alkylene-C(O)--N[(C.sub.0-C.sub.4)-alkylene]-R13, wherein alkyl and cycloalkyl are unsubstituted or mono-, di- or trisubstituted independently of one another by R13, 17) --(C.sub.0-C.sub.4)-alkylene-C(O)--N[(C.sub.0-C.sub.4)-alkylene-(C.sub.3-- C.sub.8)-cycloalkyl]-R13, wherein alkyl and cycloalkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13 18) --(C.sub.0-C.sub.4)-alkylene-N(R11)-R12, 19) --(C.sub.0-C.sub.4)-alkylene-N(R11)-R13, 20) --(C.sub.0-C.sub.4)-alkylene-N(R10)-SO.sub.2--R10, 21) --(C.sub.0-C.sub.4)-alkylene-S--R10, 22) --(C.sub.0-C.sub.4)-alkylene-SO.sub.s--R11, wherein s is 1 or 2, 23) --(C.sub.0-C.sub.4)-alkylene-SO.sub.t--N(R11)-R12, wherein t is 1 or 2, 24) --(C.sub.0-C.sub.4)-alkylene-SO.sub.s, --N(R11)-R13, wherein w is 1 or 2, 25) --(C.sub.0-C.sub.4)-alkylene-SO.sub.u--(C.sub.0-C.sub.4)-alkyle- ne-C(O)--O--R10, wherein u is 1 or 2, 26) --(C.sub.0-C.sub.4)-alkylene-(C.sub.3-C.sub.6)-cycloalkyl, wherein cycloalkyl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, 27) --(C.sub.0-C.sub.4)-alkylene-(C.sub.6-C.sub.14)-aryl, wherein aryl is selected from phenyl, naphthyl, biphenylyl, indanyl, anthryl or fluorenyl; and wherein aryl is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, 28) --(C.sub.0-C.sub.4)-alkylene-(C.sub.3-C.sub.15)-heterocyclyl, wherein --(C.sub.3-C.sub.15)-heterocyclyl is selected from the group consisting of azetidinyl, benzimidazolyl, 2,3-dihydro-1H-indolyl, 4,5-dihydro-[1,3,4]oxadiazolyl, 3,4-dihydro-2H-quinolinyl, 1,3-dioxanyl, 1,3-dioxolanyl, furanyl, morpholinyl, oxadiazolyl, oxazolidinyl, oxetanyl, piperidinyl, pyridyl, pyrimidinyl, pyrrolidinyl, tetrahydrofuranyl, tetrahydropyranyl, tetrazolyl, thiazolyl or thiophenyl, and is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, 29) --(C.sub.0-C.sub.4)-alkylene-O--(C.sub.0-C.sub.4)-alkylene-(C.sub.6-C.sub- .14)-aryl, wherein aryl is as defined above and is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, 30) --(C.sub.0-C.sub.4)-alkylene-O--(C.sub.0-C.sub.4)-alkylene-(C.sub.3-C.sub- .15)-heterocyclyl, wherein --(C.sub.3-C.sub.15)-heterocyclyl is as defined above and is un-substituted or mono-, di- or trisubstituted independently of one another by R13, 31) --(C.sub.0-C.sub.4)-alkylene-N(R13)-(C.sub.0-C.sub.4)-alkylene-(C.sub.6-C- .sub.14)-aryl, wherein aryl is as defined above and is unsubstituted or mono-, di- or trisubstituted independently of one another by R13, or 32) --(C.sub.0-C.sub.4)-alkylene-N(R13)-(C.sub.0-C.sub.4)-alkylene-(C.sub.3-C- .sub.15)-heterocyclyl, wherein --(C.sub.3-C.sub.15)-heterocyclyl is as defined above and is un-substituted or mono-, di- or trisubstituted independently of one another by R13, R10 is hydrogen atom or --(C.sub.1-C.sub.4)-alkyl, R11 and R12 are independently of one another identical or different and are 1) a hydrogen atom, 2) --(C.sub.1-C.sub.4)-alkyl, wherein alkyl is unsubstituted or mono- or di-substituted independently of one another by R13, 3) --(C.sub.1-C.sub.3)-fluoroalkyl, 4) --(C.sub.0-C.sub.4)-alkylene-(C.sub.3-C.sub.6)-cycloalkyl, wherein cycloalkyl is unsubstituted or mono- or di-substituted independently of one another by R13, 5) --(C.sub.0-C.sub.4)-alkylene-(C.sub.3-C.sub.15)-heterocyclyl, wherein --(C.sub.3-C.sub.15)-heterocyclyl is azetidinyl, benzimidazolyl, 2,3-dihydro-1H-indolyl, 4,5-dihydro-[1,3,4]oxadiazolyl, 3,4-dihydro-2H-quinolinyl, 1,3-dioxanyl, 1,3-dioxolanyl, furanyl, morpholinyl, oxadiazolyl, oxazolidinyl, oxetanyl, piperidinyl, pyridyl, pyrimidinyl, pyrrolidinyl, tetrahydrofuranyl, tetrahydropyranyl, tetrazolyl, thiazolyl or thiophenyl, or R11 and R12 together with the nitrogen atom to which they are bonded form a 4- to 8-membered monocyclic heterocyclic ring selected from azetidine, piperidine, pyrrolidine or morpholine, R13 is F, Cl, Br, --CN, .dbd.O, --OH, --CF.sub.3, --C(O)--O--R10, --(C.sub.3-C.sub.6)-cycloalkyl, --(C.sub.0-C.sub.4)-alkylene-O--R10, --C(O)--R10, --(C.sub.1-C.sub.4)-alkyl or phenyl, R15 is hydrogen atom or --(C.sub.1-C.sub.6)-alkyl, R17 is hydrogen atom or --(C.sub.1-C.sub.6)-alkyl, R23 and R24 are independently of one another selected from hydrogen atom or methyl, in all its stereoisomeric forms and mixtures thereof in any ratio, and its physiologically tolerable salts.

5. A compound as claimed in claim 3, wherein E is a heterocyclic residue selected from aza-bicyclohexane, aza-bicyclooctane, azetidine, aziridine, decahydro-quinoline, 2,5-diaza-bicyclo[2.2.1]heptane, 1,4-diazepane, 2,7-diaza-spiro[4.5]decane, 2,8-diaza-spiro[4.5]decane, 2,3-dihydro-1H-indole, 4,7-dihydro-5H-isoxazolo[5,4-c]pyridine, 6,7-dihydro-4H-oxazolo[5,4-c]pyridine, 4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol, 4,6-dihydro-4H-pyrrolo[3,4-d]thiazole, 5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin, hexahydro-pyrrolo[1,2-a]pyrazin, hexahydro-pyrrolo[3,4-b]pyrrol, Hexahydro-pyrrolo[1,2-a]pyrazin, imidazolidine, morpholine, indole, octahydro-cyclopenta[c]pyrrole, octahydro-indole, octahydro-pyrrolo[3,4-b]pyridine, octahydro-pyrrolo[3,4-c]pyridine, oxazolidine, piperazine, piperidine, pyrazolidine, pyrrolidine, 1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine, 1,2,3,4-tetrahydro-isoquinoline, 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine, 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine, 3,5,7,8-tetrahydro-4H-pyrido[4,3-d]pyrimidine, 4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole, 1,2,3,4-tetrahydro-quinoline, 4,5,6,7-tetrahydro-thieno[2,3-c]pyridine, 4,5,6,7-tetrahydro-thieno[3,2-c]pyridine, 4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridine, 1,3,8-triaza-spiro[4.5]decane or triaza-spirooctane, wherein said heterocyclic residue is mono-, di- or trisubstituted independently of one another by R7, Q is 1) a covalent bond, 2) --(C.sub.0-C.sub.4)-alkylene-CH(OH)--, 3) --(C.sub.0-C.sub.4)-alkylene-C(O)--N(R10)-, 4) --(C.sub.1-C.sub.3)-alkylene-C(O)--O--, 5) --(C.sub.1-C.sub.3)-alkylene-O-- or 6) --(C.sub.1-C.sub.3)-alkylene-S(O).sub.2--, J is 1) a hydrogen atom, 2) --(C.sub.1-C.sub.6)-alkyl, 3) --(C.sub.0-C.sub.4)-alkylene-C(O)--R11, 4) --(C.sub.0-C.sub.4)-alkylene-C(O)--O--R11, 5) --(C.sub.0-C.sub.4)-alkylene-N(R11)-R13, 6) --(C.sub.0-C.sub.2)-alkylene-(C.sub.3-C.sub.6)-cycloalkyl, 7) --(C.sub.0-C.sub.2)-alkylene-phenyl or 8) --(C.sub.0-C.sub.4)-alkylene-(C.sub.3-C.sub.15)-heterocyclyl, wherein --(C.sub.3-C.sub.15)-heterocyclyl is azetidinyl, benzimidazolyl, 2,3-dihydro-1H-indolyl, 4,5-dihydro-[1,3,4]oxadiazolyl, 3,4-dihydro-2H-quinolinyl, 1,3-dioxanyl, 1,3-dioxolanyl, indanyl, isoxazolyl, furanyl, morpholinyl, oxadiazolyl, oxazolidinyl, oxetanyl, piperidinyl, pyridyl, pyrimidinyl, pyrrolidinyl, tetrahydrofuranyl, tetrahydropyranyl, tetrazolyl, thiazolyl or thiophenyl, wherein heterocyclyl is unsubstituted or mono- or di-substituted independently of one another by R13, V is a piperazinyl, piperidinyl, azetidinyl or aminoazetidinyl, G and M together form a --C(O)--(C.sub.0-C.sub.4)-alkyl, --C(O)--O--(C.sub.2-C.sub.4)-alkyl or --N(R10)-C(O)--O--(C.sub.2-C.sub.4)-alkyl, or G is a direct bond and M is a phenyl residue, which is unsubstituted or substituted by Cl, F or Br, R1 is a hydrogen atom, methyl or ethyl, R2, R3, R4, R5 and R6 are independently of one another selected from hydrogen atom, Cl, F, Br, --CN, --O--CH.sub.3, --O--CH.sub.2--CH.sub.3, methyl, ethyl, propyl or butyl, or R3 and R4, R4 and R5 or R5 and R6 form together with the atoms which they are attached to a cyclohexyl ring, R7 is 1) hydrogen atom, 2) Cl, F or Br, 3) --(C.sub.1-C.sub.4)-alkyl, 4) .dbd.O, 5) --(C.sub.1-C.sub.3)-fluoroalkyl, 6) --(C.sub.0-C.sub.2)-alkylene-OH, 7) --(C.sub.0-C.sub.2)-alkylene-O--(C.sub.1-C.sub.4)-alkyl, 8) --(C.sub.0-C.sub.2)-alkylene-O--CF.sub.3, 9) --CN, 10) --C(O)--R11, 11) --(C.sub.0-C.sub.2)-alkylene-C(O)--O--R11, 12) --(C.sub.0-C.sub.2)-alkylene-C(O)--N(R11)-R12, 13) --N(R11)-R12, 14) --N(R11)-R13, 15) --SO.sub.2--(C.sub.1-C.sub.4)-alkyl, 16) --(C.sub.0-C.sub.4)-alkyl-(C.sub.3-C.sub.6)-cycloalkyl, 17) phenyl, 18) --(C.sub.0-C.sub.4)-alkylene-(C.sub.3-C.sub.15)-heterocyclyl, wherein --(C.sub.3-C.sub.15)-heterocyclyl is azetidinyl, benzimidazolyl, 2,3-dihydro-1H-indolyl, 4,5-dihydro-[1,3,4]oxadiazolyl, 3,4-dihydro-2H-quinolinyl, 1,3-dioxanyl, 1,3-dioxolanyl, furanyl, morpholinyl, oxadiazolyl, oxazolidinyl, oxetanyl, piperidinyl, pyridyl, pyrimidinyl, pyrrolidinyl, tetrahydrofuranyl, tetrahydropyranyl, tetrazolyl, thiazolyl or thiophenyl, or 19) --O-phenyl, wherein phenyl is unsubstituted or mono- or di-substituted independently of one another by R13, R10 is hydrogen atom or --(C.sub.1-C.sub.4)-alkyl, R11 and R12 are independently of one another identical or different and are 1) a hydrogen atom, 2) --(C.sub.1-C.sub.4)-alkyl, wherein alkyl is unsubstituted or mono- or di-substituted independently of one another by R13, 3) --(C.sub.1-C.sub.3)-fluoroalkyl, 4) --(C.sub.0-C.sub.4)-alkylene-(C.sub.3-C.sub.6)-cycloalkyl, wherein cycloalkyl is unsubstituted or mono- or di-substituted independently of one another by R13, 5) phenyl or 6) --(C.sub.0-C.sub.4)-alkylene-(C.sub.3-C.sub.15)-heterocyclyl, wherein --(C.sub.3-C.sub.15)-heterocyclyl is azetidinyl, benzimidazolyl, 2,3-dihydro-1H-indolyl, 4,5-dihydro-[1,3,4]oxadiazolyl, 3,4-dihydro-2H-quinolinyl, 1,3-dioxanyl, 1,3-dioxolanyl, furanyl, morpholinyl, oxadiazolyl, oxazolidinyl, oxetanyl, piperidinyl, pyridyl, pyrimidinyl, pyrrolidinyl, tetrahydrofuranyl, tetrahydropyranyl, tetrazolyl, thiazolyl or thiophenyl, R13 is F, Cl, Br, --CN, .dbd.O, --OH, --CF.sub.3, --C(O)--O--R10, --(C.sub.3-C.sub.6)-cycloalkyl, --(C.sub.0-C.sub.4)-alkylene-O--R10, --C(O)--R10, --(C.sub.1-C.sub.4)-alkyl or phenyl, R23 and R24 are independently of one another selected from hydrogen atom or methyl, in all its stereoisomeric forms and mixtures thereof in any ratio, and its physiologically tolerable salts.

6. A compound as claimed in claim 1, wherein the compound is 4-[(S)-4-Carboxy-2-({4-[2-(4-hydroxy-2-methoxycarbonyl-pyrrolidin-1-yl)-2- -oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-c- arboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({7-methyl-4-[2-oxo-2-(2-oxo-pyrrolidin-1-yl)-ethoxy]-- quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-cyclopropylcarbamoyl-pyrrolidin-1- -yl)-2-oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazi- ne-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({7-methyl-4-[2-oxo-2-(3-oxo-piperazin-1-yl)-ethoxy]-q- uinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(3-carboxy-azetidin-1-yl)-2-oxo-ethoxy]-- 7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((2S,3S)-2-carboxy-3-hydroxy-pyrrolidin-1-yl)-2- -oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-c- arboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((2S,4R)-2-ethoxycarbonyl-4-hydroxy-pyrrolidin-- 1-yl)-2-oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperaz- ine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((R)-3-hydroxy-pyrrolidin-1-yl)-2-oxo-ethoxy]-7- -methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-3-hydroxy-pyrrolidin-1-yl)-2-oxo-ethoxy]-7- -methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(4-hydroxy-piperidin-1-yl)-2-oxo-ethoxy]-7-meth- yl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-ethoxycarbonyl-pyrrolidin-1-yl)-2-oxo-et- hoxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxyl- ic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((2R,4R)-2-carboxy-4-hydroxy-pyrrolidin-1-yl)-2- -oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-c- arboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(3-hydroxy-azetidin-1-yl)-2-oxo-ethoxy]-7-methy- l-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-methoxycarbonyl-pyrrolidin-1-yl)-- 2-oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-- carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-carboxy-azetidin-1-yl)-2-oxo-ethoxy]-7-m- ethyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Ethoxycarbonyl-2-({7-methyl-4-[2-oxo-2-(2-oxo-pyrrolidin-1-yl)-e- thoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-carboxy-pyrrolidin-1-yl)-2-oxo-ethoxy]-7- -methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(3-methanesulfonyl-pyrrolidin-1-yl)-2-oxo-ethox- y]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(3-carboxy-pyrrolidin-1-yl)-2-oxo-ethoxy]-7-met- hyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((3S,4S)-3,4-dihydroxy-pyrrolidin-1-yl)-2-oxo-e- thoxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxy- lic acid ethyl ester, 4-[(S)-4-Carboxy-2-({7-methyl-4-[2-oxo-2-(2-oxo-oxazolidin-3-yl)-ethoxy]-- quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(3-cyclopropylcarbamoyl-azetidin-1-yl)-2- -oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-c- arboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((R)-2-cyclopropylcarbamoyl-azetidin-1-yl)-2-ox- o-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carb- oxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclopropylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy- ]-7-methyl-quinoline-2-carbonyl}-amino)-4-ethoxycarbonyl-butyryl]-piperazi- ne-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-ethylcarbamoyl-pyrrolidin-1-yl)-2-oxo-et- hoxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxyl- ic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-cyclopropylcarbamoyl-pyrrolidin-1-yl)-1,- 1-dimethyl-2-oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-pi- perazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-dimethylcarbamoyl-pyrrolidin-1-yl)-2-oxo- -ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carbo- xylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Carbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]-7-methyl-- quinoline-2-carbonyl}-amino)-4-carboxy-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-3-cyclopropylcarbamoyl-pyrrolidin-1-yl)-2-- oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-ca- rboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((R)-3-cyclopropylcarbamoyl-pyrrolidin-1-yl)-2-- oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-ca- rboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-hydroxymethyl-pyrrolidin-1-yl)-2-oxo-eth- oxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxyli- c acid ethyl ester, 4-{(S)-4-Carboxy-2-[(7-methyl-4-{2-oxo-2-[(S)-2-(2,2,2-trifluoro-ethylcar- bamoyl)-pyrrolidin-1-yl]-ethoxy}-quinoline-2-carbonyl)-amino]-butyryl}-pip- erazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(4-methoxy-piperidin-1-yl)-2-oxo-ethoxy]-7-meth- yl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({7-methyl-4-[2-oxo-2-(3-oxo-pyrazolidin-1-yl)-ethoxy]- -quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(2-hydroxymethyl-morpholin-4-yl)-2-oxo-e- thoxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxy- lic acid ethyl ester, 4-[(S)-4-Carboxy-2-({7-methyl-4-[2-oxo-2-((1S,5R)-3-oxo-8-aza-bicyclo[3.2- .1]oct-8-yl)-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-ca- rboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({7-methyl-4-[2-oxo-2-(5-oxo-[1,4]diazepan-1-yl)-ethox- y]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(4-ethoxycarbonyl-piperidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(4-ethoxy-piperidin-1-yl)-2-oxo-ethoxy]-7-methy- l-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-((S)-4-Carboxy-2-{[7-methyl-4-(2-morpholin-4-yl-2-oxo-ethoxy)-qu- inoline-2-carbonyl]-amino}-butyryl)-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(3-hydroxy-piperidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(4-carboxy-piperidin-1-yl)-2-oxo-ethoxy]-7-meth- yl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((R)-3-hydroxy-piperidin-1-yl)-2-oxo-ethoxy]-7-- methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(2,2-dimethyl-3-oxo-piperazin-1-yl)-2-oxo-ethox- y]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-carboxy-piperidin-1-yl)-2-oxo-ethoxy]-7-- methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((R)-2-carboxy-piperidin-1-yl)-2-oxo-ethoxy]-7-- methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-methoxymethyl-pyrrolidin-1-yl)-2-oxo-eth- oxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxyli- c acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(4-cyclopropylcarbamoyl-piperidin-1-yl)-2-oxo-e- thoxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxy- lic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((R)-2-cyclopropylcarbamoyl-piperidin-1-yl)-2-o- xo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-car- boxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-3-hydroxymethyl-pyrrolidin-1-yl)-2-oxo-eth- oxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxyli- c acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((R)-3-hydroxymethyl-pyrrolidin-1-yl)-2-oxo-eth- oxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxyli- c acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(2-carboxy-4,4-difluoro-pyrrolidin-1-yl)-2-oxo-- ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carbox- ylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({7-methyl-4-[2-oxo-2-(3-oxo-pyrrolidin-1-yl)-ethoxy]-- quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-cyclopropylcarbamoyl-piperidin-1-- yl)-2-oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazin- e-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(3-cyclopropylcarbamoyl-piperidin-1-yl)-2-oxo-e- thoxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxy- lic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-cyclopropylcarbamoyl-pyrrolidin-1-yl)-2-- oxo-ethoxy]-5,7-dimethyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-- 1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-o- xo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-car- boxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-ethoxycarbonyl-butyryl]-piperazin- e-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-cyclopropylcarbamoyl-pyrrolidin-1-yl)-2-- oxo-ethoxy]-6-fluoro-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-pipera- zine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((R)-2-ethoxycarbonyl-pyrrolidin-1-yl)-2-oxo-et- hoxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxyl- ic acid ethyl ester, 4-[(S)-2-({4-[2-((R)-2-Carbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]-7-methyl-- quinoline-2-carbonyl}-amino)-4-carboxy-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-carboxy-2-methyl-pyrrolidin-1-yl)-2-oxo-- ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carbox- ylic acid ethyl ester, 4-{(S)-4-Carboxy-2-[(4-{2-[(S)-2-(cyclopropylmethyl-carbamoyl)-pyrrolidin- -1-yl]-2-oxo-ethoxy}-7-methyl-quinoline-2-carbonyl)-amino]-butyryl}-pipera- zine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-isopropylcarbamoyl-pyrrolidin-1-yl)-2-ox- o-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carb- oxylic acid ethyl ester, 4-{(S)-4-Carboxy-2-[(4-{2-[(S)-2-(2,2-difluoro-ethylcarbamoyl)-pyrrolidin- -1-yl]-2-oxo-ethoxy}-7-methyl-quinoline-2-carbonyl)-amino]-butyryl}-pipera- zine-1-carboxylic acid ethyl ester, 4-{(S)-4-Carboxy-2-[(4-{2-[(S)-2-(2-fluoro-ethylcarbamoyl)-pyrrolidin-1-y- l]-2-oxo-ethoxy}-7-methyl-quinoline-2-carbonyl)-amino]-butyryl}-piperazine- -1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((R)-2-cyclopropylcarbamoyl-pyrrolidin-1-yl)-2-- oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-ca- rboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(4,4-dimethyl-oxazolidin-3-yl)-2-oxo-ethoxy]-7-- methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Ethoxycarbonyl-2-({4-[2-(4-hydroxy-piperidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({7-methyl-4-[2-oxo-2-((S)-2-propylcarbamoyl-pyrrolidi- n-1-yl)-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxy- lic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(4-hydroxy-2-methoxycarbonyl-pyrrolidin-1-yl)-2- -oxo-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-oxo-2-(2-oxo-pyrrolidin-1-yl)-ethoxy]-quinoline- -2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-cyclopropylcarbamoyl-pyrrolidin-1-yl)-2-- oxo-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((R)-3-hydroxy-pyrrolidin-1-yl)-2-oxo-ethoxy]-q- uinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((2S,4R)-2-ethoxycarbonyl-4-hydroxy-pyrr- olidin-1-yl)-2-oxo-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazin- e-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-carboxy-pyrrolidin-1-yl)-2-oxo-ethoxy]-q- uinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({-[2-((2S,4R)-2-carboxy-4-hydroxy-pyrrolidin-1- -yl)-2-oxo-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carb- oxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((2S,3S)-2-carboxy-3-hydroxy-pyrrolidin-1-yl)-2- -oxo-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-carboxy-azetidin-1-yl)-2-oxo-ethoxy]-qui- noline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(2,4-dioxo-1,3,8-triaza-spiro[4.5]dec-8-- yl)-2-oxo-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carbo- xylic acid ethyl ester, 4-[(S)-2-({4-[2-(3-Acetylamino-pyrrolidin-1-yl)-2-oxo-ethoxy]-quinoline-2- -carbonyl}-amino)-4-carboxy-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-(2-{2-[(S)-3-Carboxy-1-(4-ethoxycarbonyl-piperazine-1-carbonyl)-- propylcarbamoyl]-quinolin-4-yloxy}-acetyl)-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(4-ethyl-piperazin-1-yl)-2-oxo-ethoxy]-quinolin- e-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((2S,4S)-2-carboxy-4-hydroxy-pyrrolidin-1-yl)-2- -oxo-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(3-methanesulfonyl-pyrrolidin-1-yl)-2-oxo-ethox- y]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-oxo-2-(3-oxo-piperazin-1-yl)-ethoxy]-quinoline-- 2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-{(S)-4-Carboxy-2-[(4-{2-[4-(2-hydroxy-ethyl)-piperazin-1-yl]-2-oxo-etho- xy}-quinoline-2-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-(4-Acetyl-piperazin-1-yl)-2-oxo-ethoxy]-quinoline-2-carbo- nyl}-amino)-4-carboxy-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((2R,4R)-2-carboxy-4-hydroxy-pyrrolidin-1-yl)-2- -oxo-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic

acid ethyl ester, 4-[(S)-2-({4-[2-(3-Amino-azetidin-1-yl)-2-oxo-ethoxy]-quinoline-2-carbony- l}-amino)-4-carboxy-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(3-hydroxy-azetidin-1-yl)-2-oxo-ethoxy]-quinoli- ne-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((2S,4R)-4-hydroxy-2-methoxycarbonyl-pyrrolidin- -1-yl)-2-oxo-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-ca- rboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(3-carboxy-azetidin-1-yl)-2-oxo-ethoxy]-quinoli- ne-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 3-(2-{2-[(S)-3-Carboxy-1-(4-ethoxycarbonyl-piperazine-1-carbonyl)-propylc- arbamoyl]-quinolin-4-yloxy}-acetyl)-3-aza-bicyclo[3.1.0]hexane-6-carboxyli- c acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-ethoxycarbonyl-pyrrolidin-1-yl)-2-oxo-et- hoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(4-carboxymethyl-piperazin-1-yl)-2-oxo-ethoxy]-- quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-methoxycarbonyl-pyrrolidin-1-yl)-- 2-oxo-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxyli- c acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(3-methoxycarbonylmethanesulfonyl-azetidin-1-yl- )-2-oxo-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxy- lic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((3R,4R)-3,4-dihydroxy-pyrrolidin-1-yl)-2-oxo-e- thoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((3S,4S)-3,4-dihydroxy-pyrrolidin-1-yl)-2-oxo-e- thoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-3-hydroxy-2-oxo-pyrrolidin-1-yl)-2-oxo-eth- oxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(4-hydroxy-piperidin-1-yl)-2-oxo-ethoxy]-quinol- ine-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(3-carboxy-pyrrolidin-1-yl)-2-oxo-ethoxy]-quino- line-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-3-hydroxy-pyrrolidin-1-yl)-2-oxo-ethoxy]-q- uinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((2S,4S)-4-hydroxy-2-methoxycarbonyl-pyr- rolidin-1-yl)-2-oxo-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazi- ne-1-carboxylic acid ethyl ester, 4-[(S)-4-Ethoxycarbonyl-2-({4-[2-oxo-2-(2-oxo-pyrrolidin-1-yl)-ethoxy]-qu- inoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclopropylcarbamoyl-pyrrolidin-1-yl)-2-oxo- -ethoxy]-quinoline-2-carbonyl}-amino)-4-ethoxycarbonyl-butyryl]-piperazine- -1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-dimethylcarbamoyl-pyrrolidin-1-yl)-2-oxo- -ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-ethylcarbamoyl-pyrrolidin-1-yl)-2-oxo-et- hoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Carbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]-quinoline- -2-carbonyl}-amino)-4-carboxy-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(3-cyclopropylcarbamoyl-azetidin-1-yl)-2- -oxo-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-3-cyclopropylcarbamoyl-pyrrolidin-1-yl)-2-- oxo-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((R)-3-cyclopropylcarbamoyl-pyrrolidin-1-yl)-2-- oxo-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-{(S)-4-Carboxy-2-[(4-{2-[(S)-2-(2,2-difluoro-ethylcarbamoyl)-pyrrolidin- -1-yl]-2-oxo-ethoxy}-quinoline-2-carbonyl)-amino]-butyryl}-piperazine-1-ca- rboxylic acid ethyl ester, 4-{(S)-4-Carboxy-2-[(4-{2-[(S)-2-(2-fluoro-ethylcarbamoyl)-pyrrolidin-1-y- l]-2-oxo-ethoxy}-quinoline-2-carbonyl)-amino]-butyryl}-piperazine-1-carbox- ylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-oxo-2-((1S,5R)-3-oxo-8-aza-bicyclo[3.2.1]oct-8-- yl)-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(2-hydroxymethyl-morpholin-4-yl)-2-oxo-ethoxy]-- quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((R)-3-hydroxy-piperidin-1-yl)-2-oxo-eth- oxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-oxo-2-(3-oxo-pyrazolidin-1-yl)-ethoxy]-quinolin- e-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(4-methoxy-piperidin-1-yl)-2-oxo-ethoxy]-quinol- ine-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-{(S)-4-Carboxy-2-[(4-{2-oxo-2-[(S)-2-(2,2,2-trifluoro-ethylcarbamoyl)-p- yrrolidin-1-yl]-ethoxy}-quinoline-2-carbonyl)-amino]-butyryl}-piperazine-1- -carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-hydroxymethyl-pyrrolidin-1-yl)-2-oxo-eth- oxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(4-cyclopropylcarbamoyl-piperidin-1-yl)-2-oxo-e- thoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-cyclopropylcarbamoyl-piperidin-1-yl)-2-o- xo-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-3-hydroxymethyl-pyrrolidin-1-yl)-2-oxo-eth- oxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((R)-3-hydroxymethyl-pyrrolidin-1-yl)-2-oxo-eth- oxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-((S)-4-Carboxy-2-{[4-(2-morpholin-4-yl-2-oxo-ethoxy)-quinoline-2-carbon- yl]-amino}-butyryl)-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(4-ethoxy-piperidin-1-yl)-2-oxo-ethoxy]-quinoli- ne-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(4-carboxy-piperidin-1-yl)-2-oxo-ethoxy]-quinol- ine-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(4-ethoxycarbonyl-piperidin-1-yl)-2-oxo-ethoxy]- -quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-oxo-2-(5-oxo-[1,4]diazepan-1-yl)-ethoxy]- -quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(3-cyclopropylcarbamoyl-piperidin-1-yl)-- 2-oxo-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxyli- c acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((R)-2-cyclopropylcarbamoyl-piperidin-1-yl)-2-o- xo-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-oxo-2-(3-oxo-pyrrolidin-1-yl)-ethoxy]-quinoline- -2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(2-carboxy-4,4-difluoro-pyrrolidin-1-yl)-2-oxo-- ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(3-hydroxy-piperidin-1-yl)-2-oxo-ethoxy]-quinol- ine-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-carboxy-piperidin-1-yl)-2-oxo-ethoxy]-qu- inoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((R)-2-carboxy-piperidin-1-yl)-2-oxo-eth- oxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-methoxymethyl-pyrrolidin-1-yl)-2-oxo-eth- oxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({6-chloro-4-[2-((S)-2-cyclopropylcarbamoyl-pyrrolidin- -1-yl)-2-oxo-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-ca- rboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-cyclopropylcarbamoyl-pyrrolidin-1-yl)-2-- oxo-ethoxy]-6-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-ca- rboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-cyclopropylcarbamoyl-pyrrolidin-1-yl)-2-- oxo-ethoxy]-5-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-ca- rboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-o- xo-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((R)-2-ethoxycarbonyl-pyrrolidin-1-yl)-2-oxo-et- hoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((R)-2-Carbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]-quinoline- -2-carbonyl}-amino)-4-carboxy-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-carboxy-2-methyl-pyrrolidin-1-yl)- -2-oxo-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxyl- ic acid ethyl ester, 4-{(S)-4-Carboxy-2-[(4-{2-[(S)-2-(cyclopropylmethyl-carbamoyl-pyrrolidin-- 1-yl]-2-oxo-ethoxy}-quinoline-2-carbonyl)-amino]-butyryl}-piperazine-1-car- boxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-isopropylcarbamoyl-pyrrolidin-1-yl)-2-ox- o-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((R)-2-cyclopropylcarbamoyl-pyrrolidin-1-yl)-2-- oxo-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(4,4-dimethyl-oxazolidin-3-yl)-2-oxo-ethoxy]-qu- inoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-oxo-2-((S)-2-propylcarbamoyl-pyrrolidin-- 1-yl)-ethoxyl]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxyl- ic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((R)-2-hydroxymethyl-pyrrolidin-1-yl)-2-oxo-eth- oxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-((S)-4-Carboxy-2-{[4-(3-carboxy-azetidine-1-carbonyl)-quinoline-2-carbo- nyl]-amino}-butyryl)-piperazine-1-carboxylic acid ethyl ester, 4-((S)-2-{[4-(Azetidine-1-carbonyl)-quinoline-2-carbonyl]-amino}-4-carbox- y-butyryl)-piperazine-1-carboxylic acid ethyl ester, 4-((S)-4-Carboxy-2-{[4-(morpholine-4-carbonyl)-quinoline-2-carbonyl]-amin- o}-butyryl)-piperazine-1-carboxylic acid ethyl ester, 4-((S)-4-Carboxy-2-{[4-((S)-2-carboxy-azetidine-1-carbonyl)-quinoline-2-c- arbonyl]-amino}-butyryl)-piperazine-1-carboxylic acid ethyl ester, 4-((S)-4-Carboxy-2-{[4-(2-carboxy-pyrrolidine-1-carbonyl)-quinoline-2-car- bonyl]-amino}-butyryl)-piperazine-1-carboxylic acid ethyl ester, 4-((S)-4-Carboxy-2-{[4-(3-hydroxy-azetidine-1-carbonyl)-quinoline-2-carbo- nyl]-amino}-butyryl)-piperazine-1-carboxylic acid ethyl ester, 4-((S)-4-Carboxy-2-{[4-(2-methoxycarbonyl-aziridine-1-carbonyl)-quinoline- -2-carbonyl]-amino}-butyryl)-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(2-carboxy-4-hydroxy-pyrrolidin-1-yl)-2-oxo-eth- oxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({7-fluoro-4-[2-(4-hydroxy-piperidin-1-yl)-2-oxo-ethox- y]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-o- xo-ethoxy]-8-fluoro-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-car- boxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-o- xo-ethoxy]-7-fluoro-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-car- boxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-ethylcarbamoyl-pyrrolidin-1-yl)-2-oxo-et- hoxy]-7-fluoro-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxyl- ic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-cyclobutylcarbamoyl-azetidin-1-yl)-2-oxo- -ethoxy]-7-fluoro-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carbo- xylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-cyclopropylcarbamoyl-pyrrolidin-1-yl)-2-- oxo-ethoxy]-7-fluoro-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-ca- rboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-cyclobutylcarbamoyl-azetidin-1-yl)-2-oxo- -ethoxy]-8-fluoro-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carbo- xylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-ethylcarbamoyl-pyrrolidin-1-yl)-2-oxo-et- hoxy]-8-fluoro-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxyl- ic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-cyclopropylcarbamoyl-pyrrolidin-1-yl)-2-- oxo-ethoxy]-8-fluoro-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-ca- rboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({8-fluoro-4-[2-(4-hydroxy-piperidin-1-yl)-2-oxo-ethox- y]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({6-fluoro-4-[2-(4-hydroxy-piperidin-1-yl)-2-oxo-ethox- y]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-ethylcarbamoyl-pyrrolidin-1-yl)-2-oxo-et- hoxy]-6-fluoro-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxyl- ic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-cyclopropylcarbamoyl-pyrrolidin-1-yl)-2-- oxo-ethoxy]-5-fluoro-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-ca- rboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-o- xo-ethoxy]-5-fluoro-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-car- boxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-cyclopropylcarbamoyl-pyrrolidin-1-yl)-2-- oxo-ethoxy]-6-fluoro-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-ca- rboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-o- xo-ethoxy]-6-fluoro-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-car- boxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-cyclobutylcarbamoyl-azetidin-1-yl)-2-oxo- -ethoxy]-6-fluoro-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carbo- xylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({5-fluoro-4-[2-(4-hydroxy-piperidin-1-yl)-2-oxo-ethox- y]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-ethylcarbamoyl-pyrrolidin-1-yl)-2-oxo-et- hoxy]-5-fluoro-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxyl- ic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-cyclobutylcarbamoyl-azetidin-1-yl)-2-oxo- -ethoxy]-5-fluoro-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carbo- xylic acid ethyl ester, 4-{(S)-2-[(4-{2-[(S)-2-(Azetidine-1-carbonyl}-pyrrolidin-1-yl)-2-oxo-etho- xy]-7-methyl-quinoline-2-carbonyl)-amino]-4-carboxy-butyryl}-piperazine-1-- carboxylic acid ethyl ester, 4-{(S)-4-Carboxy-2-[(7-methyl-4-{2-oxo-2-[(S)-2-(pyrrolidine-1-carbonyl)-- pyrrolidin-1-yl]-ethoxy}-quinoline-2-carbonyl)-amino]-butyryl}-piperazine-- 1-carboxylic acid ethyl ester,

4-{(S)-4-Carboxy-2-[(7-methyl-4-{2-oxo-2-[(S)-2-(piperidine-1-carbonyl)-p- yrrolidin-1-yl]-ethoxy}-quinoline-2-carbonyl)-amino]-butyryl}-piperazine-1- -carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-cyclopentylcarbamoyl-pyrrolidin-1-yl)-2-- oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-ca- rboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-cyclopropylcarbamoyl-pyrrolidin-1-yl)-2-- oxo-ethoxy]-7,8,9,10-tetrahydro-benzo[h]quinoline-2-carbonyl}-amino)-butyr- yl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-3-Carboxy-2-({4-[(S)-2-((S)-2-cyclopentylcarbamoyl-pyrrolidin-1-yl- )-1-methyl-2-oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-propionyl]-- piperazine-1-carboxylic acid ethyl ester, 4-[(S)-3-Carboxy-2-({4-[(S)-2-((S)-2-cyclopentylcarbamoyl-azetidin-1-yl)-- 1-methyl-2-oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-propionyl]-pi- perazine-1-carboxylic acid ethyl ester, 4-[(S)-3-Carboxy-2-({4-[(S)-2-((S)-2-cyclopropylcarbamoyl-pyrrolidin-1-yl- )-1-methyl-2-oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-propionyl]-- piperazine-1-carboxylic acid ethyl ester, 4-[(S)-3-Carboxy-2-({4-[(S)-2-((S)-2-ethylcarbamoyl-pyrrolidin-1-yl)-1-me- thyl-2-oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-propionyl]-pipera- zine-1-carboxylic acid ethyl ester, 4-[(S)-3-Carboxy-2-({4-[(S)-2-(4-hydroxy-piperidin-1-yl)-1-methyl-2-oxo-e- thoxy]-7-methyl-quinoline-2-carbonyl}-amino)-propionyl]-piperazine-1-carbo- xylic acid ethyl ester, 4-[(S)-3-Carboxy-2-({4-[(S)-2-((S)-2-hydroxymethyl-pyrrolidin-1-yl)-1-met- hyl-2-oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-propionyl]-piperaz- ine-1-carboxylic acid ethyl ester, 4-[(S)-3-Carboxy-2-({4-[(S)-2-((S)-3-hydroxymethyl-pyrrolidin-1-yl)-1-met- hyl-2-oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-propionyl]-piperaz- ine-1-carboxylic acid ethyl ester, 4-[(S)-3-Carboxy-2-({4-[(S)-2-((S)-2-cyclobutylcarbamoyl-azetidin-1-yl)-1- -methyl-2-oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-propionyl]-pip- erazine-1-carboxylic acid ethyl ester, 4-[(S)-3-Carboxy-2-({4-[(S)-2-((S)-2-isopropylcarbamoyl-pyrrolidin-1-yl)-- 1-methyl-2-oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-propionyl]-pi- perazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-cyclopentylcarbamoyl-azetidin-1-yl)-2-ox- o-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carb- oxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-ethylcarbamoyl-pyrrolidin-1-yl)-2-oxo-et- hoxy]-6,7-difluoro-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carb- oxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-o- xo-ethoxy]-6,7-difluoro-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1- -carboxylic acid ethyl ester, 4-[(S)-3-Carboxy-2-({4-[2-((S)-2-ethylcarbamoyl-pyrrolidin-1-yl)-2-oxo-et- hoxy]-7-methyl-quinoline-2-carbonyl}-amino)-propionyl]-piperazine-1-carbox- ylic acid ethyl ester, 4-[(S)-3-Carboxy-2-({4-[2-((S)-2-isopropylcarbamoyl-pyrrolidin-1-yl)-2-ox- o-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-propionyl]-piperazine-1-ca- rboxylic acid ethyl ester, 4-[(S)-3-Carboxy-2-({4-[2-((S)-2-cyclopentylcarbamoyl-pyrrolidin-1-yl)-2-- oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-propionyl]-piperazine-1-- carboxylic acid ethyl ester, 4-{(S)-3-Carboxy-2-[(4-{2-[(S)-2-(cyclopropylmethyl-carbamoyl)-pyrrolidin- -1-yl]-2-oxo-ethoxy}-7-methyl-quinoline-2-carbonyl)-amino]-propionyl}-pipe- razine-1-carboxylic acid ethyl ester, 4-[(S)-3-Carboxy-2-({4-[2-((S)-2-cyclopentylcarbamoyl-azetidin-1-yl)-2-ox- o-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-propionyl]-piperazine-1-ca- rboxylic acid ethyl ester, 4-[(S)-3-Carboxy-2-({4-[2-((S)-2-cyclopentylcarbamoyl-azetidin-1-yl)-2-ox- o-ethoxy]-quinoline-2-carbonyl}-amino)-propionyl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-3-Carboxy-2-({4-[2-((S)-2-cyclopropylcarbamoyl-pyrrolidin-1-yl)-2-- oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-propionyl]-piperazine-1-- carboxylic acid ethyl ester, 4-[(S)-3-Carboxy-2-({7-methyl-4-[2-oxo-2-((S)-2-propylcarbamoyl-pyrrolidi- n-1-yl)-ethoxy]-quinoline-2-carbonyl}-amino)-propionyl]-piperazine-1-carbo- xylic acid ethyl ester, 4-[(S)-3-Carboxy-2-({4-[2-((S)-2-cyclopentylcarbamoyl-pyrrolidin-1-yl)-2-- oxo-ethoxy]-quinoline-2-carbonyl}-amino)-propionyl]-piperazine-1-carboxyli- c acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-ethylcarbamoyl-pyrrolidin-1-yl)-2-oxo-et- hoxy]-7-methoxy-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxy- lic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-o- xo-ethoxy]-7-methoxy-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-ca- rboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({7-ethyl-4-[2-((S)-2-ethylcarbamoyl-pyrrolidin-1-yl)-- 2-oxo-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxyli- c acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-o- xo-ethoxy]-7-ethyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carb- oxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-cyclopropylcarbamoyl-pyrrolidin-1-yl)-2-- oxo-ethoxy]-7-ethyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-car- boxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-ethylcarbamoyl-pyrrolidin-1-yl)-2-oxo-et- hoxy]-6-fluoro-5-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1- -carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-o- xo-ethoxy]-6-fluoro-5-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperaz- ine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-cyclopropylcarbamoyl-pyrrolidin-1-yl)-2-- oxo-ethoxy]-6-ethoxy-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-ca- rboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({6-ethoxy-4-[2-((S)-2-ethylcarbamoyl-pyrrolidin-1-yl)- -2-oxo-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxyl- ic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-o- xo-ethoxy]-6-ethoxy-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-car- boxylic acid ethyl ester, 4-[(S)-4-Carbamoyl-2-({4-[2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2- -oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-c- arboxylic acid ethyl ester, 4-{(S)-4-Carboxy-2-[(6-fluoro-7-methyl-4-{2-oxo-2-[((S)-2-(pyrrolidine-1-- carbonyl)-pyrrolidin-1-yl]-ethoxy}-quinoline-2-carbonyl)-amino]-butyryl}-p- iperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-ethylcarbamoyl-pyrrolidin-1-yl)-2-oxo-et- hoxy]-6-fluoro-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1- -carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-o- xo-ethoxy]-6-fluoro-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperaz- ine-1-carboxylic acid ethyl ester, 4-{(S)-4-Carboxy-2-[(7-fluoro-4-{2-oxo-2-[(S)-2-(pyrrolidine-1-carbonyl)-- pyrrolidin-1-yl]-ethoxy}-quinoline-2-carbonyl)-amino]-butyryl}-piperazine-- 1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({7-fluoro-4-[2-oxo-2-((S)-2-propylcarbamoyl-pyrrolidi- n-1-yl)-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxy- lic acid ethyl ester, 4-[(S)-4-Ethoxycarbonyl-2-({7-fluoro-4-[2-oxo-2-((S)-2-propylcarbamoyl-py- rrolidin-1-yl)-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-- carboxylic acid ethyl ester, 4-[(S)-4-Ethoxycarbonyl-2-({4-[2-((S)-2-ethylcarbamoyl-pyrrolidin-1-yl)-2- -oxo-ethoxy]-7-fluoro-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-c- arboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-fluoro-quinoline-2-carbonyl}-amino)-4-ethoxycarbonyl-butyryl]-piperazin- e-1-carboxylic acid ethyl ester, 4-{(S)-4-Carboxy-2-[(4-{2-[(S)-2-(ethyl-methyl-carbamoyl)-pyrrolidin-1-yl- ]-2-oxo-ethoxy}-7-methyl-quinoline-2-carbonyl)-amino]-butyryl}-piperazine-- 1-carboxylic acid ethyl ester, 4-[(S)-3-Carboxy-2-({4-[(R)-2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)- -1-methyl-2-oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-propionyl]-p- iperazine-1-carboxylic acid ethyl ester, 4-{(S)-3-Carboxy-2-[(7-methyl-4-(R)-1-methyl-2-oxo-2-[(S)-2-(pyrrolidine-- 1-carbonyl)-pyrrolidin-1-yl)-ethoxy]-quinoline-2-carbonyl)-amino]-propiony- l}-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-3-Carboxy-2-({7-methyl-4-[(R)-1-methyl-2-oxo-2-((S)-2-propylcarbam- oyl-pyrrolidin-1-yl)-ethoxy]-quinoline-2-carbonyl}-amino)-propionyl]-piper- azine-1-carboxylic acid ethyl ester, 4-[(S)-3-Carboxy-2-({4-[(R)-2-((S)-2-cyclopropylcarbamoyl-pyrrolidin-1-yl- )-1-methyl-2-oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-propionyl]-- piperazine-1-carboxylic acid ethyl ester, 4-[(S)-3-Carboxy-2-({4-[(R)-2-((S)-2-cyclobutylcarbamoyl-azetidin-1-yl)-1- -methyl-2-oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-propionyl]-pip- erazine-1-carboxylic acid ethyl ester, 4-[(S)-3-Carboxy-2-({4-[(R)-2-((S)-3-hydroxymethyl-pyrrolidin-1-yl)-1-met- hyl-2-oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-propionyl]-piperaz- ine-1-carboxylic acid ethyl ester, 4-[(S)-4-Ethoxycarbonyl-2-({4-[2-((S)-2-ethylcarbamoyl-pyrrolidin-1-yl)-2- -oxo-ethoxy]-6-fluoro-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piper- azine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-ethylcarbamoyl-butyryl]-piperazin- e-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-dimethylcarbamoyl-butyryl]-pipera- zine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-methylcarbamoyl-butyryl]-piperazi- ne-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-cyclopropylcarbamoyl-butyryl]-pip- erazine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-methoxycarbonyl-butyryl]-piperazi- ne-1-carboxylic acid ethyl ester, 4-[(S)-4-Butoxycarbonyl-2-({4-[2-((S)-2-cyclobutyl carbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-a- mino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-pentyloxycarbonyl-butyryl]-pipera- zine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-isopropoxycarbonyl-butyryl]-piper- azine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-(1-ethyl-propoxycarbonyl)-butyryl- ]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Cyclobutoxycarbonyl-2-({4-[2-((S)-2-cyclobutylcarbamoyl-pyrrolid- in-1-yl)-2-oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-pipe- razine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-cyclopentyloxycarbonyl-butyryl]-p- iperazine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-cyclopropylmethoxycarbonyl-butyry- l]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-(indan-5-yloxycarbonyl)-butyryl]-- piperazine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-cyclopentylmethoxycarbonyl-butyry- l]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclopropylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy- ]-7-fluoro-quinoline-2-carbonyl}-amino)-4-ethoxycarbonyl-butyryl]-piperazi- ne-1-carboxylic acid ethyl ester, 4-{(S)-4-Ethoxycarbonyl-2-[(7-fluoro-4-{2-oxo-2-[(S)-2-(pyrrolidine-1-car- bonyl)-pyrrolidin-1-yl]-ethoxy}-quinoline-2-carbonyl)-amino]-butyryl}-pipe- razine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-(2-morpholin-4-yl-ethoxycarbonyl)- -butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-(1-morpholin-4-ylmethyl-propoxyca- rbonyl)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-cyclohexyloxycarbonyl-butyryl]-pi- perazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Benzyloxycarbonyl-2-({4-[2-((S)-2-cyclobutylcarbamoyl-pyrrolidin- -1-yl)-2-oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-pipera- zine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-isobutoxycarbonyl-butyryl]-pipera- zine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclopropylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy- ]-6-fluoro-7-methyl-quinoline-2-carbonyl}-amino)-4-ethoxycarbonyl-butyryl]- -piperazine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -6-fluoro-7-methyl-quinoline-2-carbonyl}-amino)-4-ethoxycarbonyl-butyryl]-- piperazine-1-carboxylic acid ethyl ester, 4-{(S)-4-Ethoxycarbonyl-2-[(6-fluoro-7-methyl-4-{2-oxo-2-[(S)-2-(pyrrolid- ine-1-carbonyl)-pyrrolidin-1-yl]-ethoxy}-quinoline-2-carbonyl)-amino]-buty- ryl}-piperazine-1-carboxylic acid ethyl ester, 4-{(S)-4-Ethoxycarbonyl-2-[(7-methyl-4-{2-oxo-2-[(S)-2-(pyrrolidine-1-car- bonyl)-pyrrolidin-1-yl]-ethoxy}-quinoline-2-carbonyl)-amino]-butyryl}-pipe- razine-1-carboxylic acid ethyl ester, 4-[(S)-3-Carboxy-2-({4-[2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-o- xo-ethoxy]-5-fluoro-quinoline-2-carbonyl}-amino)-propionyl]-piperazine-1-c- arboxylic acid ethyl ester, 4-[(S)-3-Carboxy-2-({5-fluoro-4-[2-oxo-2-((S)-2-propylcarbamoyl-pyrrolidi- n-1-yl)-ethoxy]-quinoline-2-carbonyl}-amino)-propionyl]-piperazine-1-carbo- xylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({5-fluoro-7-methyl-4-[2-oxo-2-((S)-2-propylcarbamoyl-- pyrrolidin-1-yl)-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-- 1-carboxylic acid ethyl ester, 4-{(S)-4-Carboxy-2-[(5-fluoro-7-methyl-4-{2-oxo-2-[(S)-2-(pyrrolidine-1-c- arbonyl)-pyrrolidin-1-yl]-ethoxy}-quinoline-2-carbonyl)-amino]-butyryl}-pi- perazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-o- xo-ethoxy]-5-fluoro-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperaz- ine-1-carboxylic acid ethyl ester, 4-{(S)-3-Carboxy-2-[(7-methyl-4-{2-oxo-2-[(S)-2-(pyrrolidine-1-carbonyl)-- pyrrolidin-1-yl]-ethoxy}-quinoline-2-carbonyl)-amino]-propionyl}-piperazin- e-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclopentylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy- ]-7-methyl-quinoline-2-carbonyl}-amino)-4-ethoxycarbonyl-butyryl]-piperazi- ne-1-carboxylic acid ethyl ester, 4-[(S)-3-Carboxy-2-({4-[2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-o- xo-ethoxy]-7-fluoro-quinoline-2-carbonyl}-amino)-propionyl]-piperazine-1-c-

arboxylic acid ethyl ester, 4-[(S)-3-Carboxy-2-({5-fluoro-7-methyl-4-[2-oxo-2-((S)-2-propylcarbamoyl-- pyrrolidin-1-yl)-ethoxy]-quinoline-2-carbonyl}-amino)-propionyl]-piperazin- e-1-carboxylic acid ethyl ester, 4-{(S)-3-Carboxy-2-[(5-fluoro-7-methyl-4-{2-oxo-2-[(S)-2-(pyrrolidine-1-c- arbonyl)-pyrrolidin-1-yl]-ethoxy}-quinoline-2-carbonyl)-amino]-propionyl}-- piperazine-1-carboxylic acid ethyl ester, 4-[(S)-3-Carboxy-2-({4-[2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-o- xo-ethoxy]-5-fluoro-7-methyl-quinoline-2-carbonyl}-amino)-propionyl]-piper- azine-1-carboxylic acid ethyl ester, 4-{(S)-3-Carboxy-2-[(5-fluoro-4-{2-oxo-2-[(S)-2-(pyrrolidine-1-carbonyl)-- pyrrolidin-1-yl]-ethoxy}-quinoline-2-carbonyl)-amino]-propionyl}-piperazin- e-1-carboxylic acid ethyl ester, 4-[(S)-3-Carboxy-2-({4-[2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-o- xo-ethoxy]-6-fluoro-7-methyl-quinoline-2-carbonyl}-amino)-propionyl]-piper- azine-1-carboxylic acid ethyl ester, 4-{(S)-4-Ethoxycarbonyl-2-[(5-fluoro-7-methyl-4-{2-oxo-2-[(S)-2-(pyrrolid- ine-1-carbonyl)-pyrrolidin-1-yl]-ethoxy}-quinoline-2-carbonyl)-amino]-buty- ryl}-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -5-fluoro-7-methyl-quinoline-2-carbonyl}-amino)-4-ethoxycarbonyl-butyryl]-- piperazine-1-carboxylic acid ethyl ester, 4-{(S)-3-Carboxy-2-[(4-{2-[(S)-2-(ethyl-methyl-carbamoyl)-pyrrolidin-1-yl- ]-2-oxo-ethoxy}-7-methyl-quinoline-2-carbonyl)-amino]-propionyl}-piperazin- e-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[(R)-2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)- -1-methyl-2-oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-pip- erazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Ethoxycarbonyl-2-({5-fluoro-7-methyl-4-[2-oxo-2-((S)-2-propylcar- bamoyl-pyrrolidin-1-yl)-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-pipe- razine-1-carboxylic acid ethyl ester, 4-{(S)-3-Carboxy-2-[(6-fluoro-7-methyl-4-{2-oxo-2-[(S)-2-(pyrrolidine-1-c- arbonyl)-pyrrolidin-1-yl]-ethoxy}-quinoline-2-carbonyl)-amino]-propionyl}-- piperazine-1-carboxylic acid ethyl ester, 4-[(S)-3-Carboxy-2-({4-[2-((S)-2-ethylcarbamoyl-pyrrolidin-1-yl)-2-oxo-et- hoxy]-7-fluoro-quinoline-2-carbonyl}-amino)-propionyl]-piperazine-1-carbox- ylic acid ethyl ester, 4-[(S)-3-Carboxy-2-({7-fluoro-4-[2-oxo-2-((S)-2-propylcarbamoyl-pyrrolidi- n-1-yl)-ethoxy]-quinoline-2-carbonyl}-amino)-propionyl]-piperazine-1-carbo- xylic acid ethyl ester, 4-[(S)-3-Carboxy-2-({4-[2-((S)-2-cyclopropylcarbamoyl-pyrrolidin-1-yl)-2-- oxo-ethoxy]-7-fluoro-quinoline-2-carbonyl}-amino)-propionyl]-piperazine-1-- carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-cyclopropylcarbamoyl-pyrrolidin-1-yl)-2-- oxo-ethoxy]-naphthalene-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxyli- c acid ethyl ester, 4-{(S)-4-Carboxy-2-[(6,7-dimethyl-4-{2-oxo-2-[(S)-2-(pyrrolidine-1-carbon- yl)-pyrrolidin-1-yl]-ethoxy}-quinoline-2-carbonyl)-amino]-butyryl}-piperaz- ine-1-carboxylic acid ethyl ester, 4-{(S)-4-Ethoxycarbonyl-2-[(7-methyl-4-{2-oxo-2-[(S)-2-(2,2,2-trifluoro-e- thylcarbamoyl)-pyrrolidin-1-yl]-ethoxy}-quinoline-2-carbonyl)-amino]-butyr- yl}-piperazine-1-carboxylic acid ethyl ester, 4-{(S)-2-[(4-{2-[(S)-2-(Cyclopropylmethyl-carbamoyl)-pyrrolidin-1-yl]-2-o- xo-ethoxy}-7-methyl-quinoline-2-carbonyl)-amino]-4-ethoxycarbonyl-butyryl}- -piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Ethoxycarbonyl-2-({7-methyl-4-[2-oxo-2-((S)-2-propylcarbamoyl-py- rrolidin-1-yl)-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-- carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({6,7-dimethyl-4-[2-oxo-2-((S)-2-propylcarbamoyl-pyrro- lidin-1-yl)-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-car- boxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -5-fluoro-quinoline-2-carbonyl}-amino)-4-ethoxycarbonyl-butyryl]-piperazin- e-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -6-fluoro-quinoline-2-carbonyl}-amino)-4-ethoxycarbonyl-butyryl]-piperazin- e-1-carboxylic acid ethyl ester, 4-{(S)-4-Carboxy-2-[(5,6-difluoro-4-[2-oxo-2-[(S)-2-(pyrrolidine-1-carbon- yl)-pyrrolidin-1-yl]-ethoxy]-quinoline-2-carbonyl)-amino]-butyryl}-piperaz- ine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-o- xo-ethoxy]-5,6-difluoro-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1- -carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({5,6-difluoro-4-[2-oxo-2-((S)-2-propylcarbamoyl-pyrro- lidin-1-yl)-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-car- boxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-o- xo-ethoxy]-6,7-dimethyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1- -carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -6-fluoro-5-methyl-quinoline-2-carbonyl}-amino)-4-ethoxycarbonyl-butyryl]-- piperazine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[(R)-2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-1-methyl-- 2-oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-4-ethoxycarbonyl-butyr- yl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[(R)-2-((S)-2-cyclopentylcarbamoyl-pyrrolidin-1-yl- )-1-methyl-2-oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-pi- perazine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[(R)-2-((S)-2-Cyclopentylcarbamoyl-pyrrolidin-1-yl)-1-methyl- -2-oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-4-ethoxycarbonyl-buty- ryl]-piperazine-1-carboxylic acid ethyl ester, 4-{(S)-4-Carboxy-2-[(7-methyl-4-{(R)-1-methyl-2-oxo-2-[(S)-2-(piperidine-- 1-carbonyl)-pyrrolidin-1-yl]-ethoxy}-quinoline-2-carbonyl)-amino]-butyryl}- -piperazine-1-carboxylic acid ethyl ester, 4-{(S)-4-Ethoxycarbonyl-2-[(7-methyl-4-{(R)-1-methyl-2-oxo-2-[(S)-2-(pipe- ridine-1-carbonyl)-pyrrolidin-1-yl]-ethoxy}-quinoline-2-carbonyl)-amino]-b- utyryl}-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({7-methyl-4-[(R)-1-methyl-2-oxo-2-((S)-2-propylcarbam- oyl-pyrrolidin-1-yl)-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperaz- ine-1-carboxylic acid ethyl ester, 4-[(S)-4-Ethoxycarbonyl-2-({7-methyl-4-[(R)-1-methyl-2-oxo-2-((S)-2-propy- lcarbamoyl-pyrrolidin-1-yl)-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-- piperazine-1-carboxylic acid ethyl ester, 4-{(S)-4-Carboxy-2-[(4-{(R)-2-[(S)-2-(cyclopropylmethyl-carbamoyl)-pyrrol- idin-1-yl]-1-methyl-2-oxo-ethoxy}-7-methyl-quinoline-2-carbonyl)-amino]-bu- tyryl}-piperazine-1-carboxylic acid ethyl ester, 4-{(S)-2-[(4-{(R)-2-[(S)-2-(Cyclopropylmethyl-carbamoyl)-pyrrolidin-1-yl]- -1-methyl-2-oxo-ethoxy}-7-methyl-quinoline-2-carbonyl)-amino]-4-ethoxycarb- onyl-butyryl}-piperazine-1-carboxylic acid ethyl ester, 4-{(S)-4-Carboxy-2-[(4-{2-[(S)-2-(4,4-difluoro-piperidine-1-carbonyl)-pyr- rolidin-1-yl]-2-oxo-ethoxy}-7-methyl-quinoline-2-carbonyl)-amino]-butyryl}- -piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-o- xo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-car- boxylic acid butyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -quinoline-2-carbonyl}-amino)-4-hydroxy-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -quinoline-2-carbonyl}-amino)-4-hydroxy-butyryl]-piperazine-1-carboxylic acid butyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-hydroxy-butyryl]-piperazine-1-car- boxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-fluoro-quinoline-2-carbonyl}-amino)-4-ethoxycarbonyl-butyryl]-piperazin- e-1-carboxylic acid ethyl ester, 4-{(S)-4-Carboxy-2-[(4-{2-[(S)-2-(cyclobutylmethyl-carbamoyl)-pyrrolidin-- 1-yl]-2-oxo-ethoxy}-7-methyl-quinoline-2-carbonyl)-amino]-butyryl}-piperaz- ine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(3,3-difluoro-pyrrolidin-1-yl)-2-oxo-ethoxy]-qu- inoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-(2-Butyl-pyrrolidin-1-yl)-2-oxo-ethoxy]-quinoline-- 2-carbonyl}-amino)-4-carboxy-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(4-cyclohexyl-3-oxo-piperazin-1-yl)-2-ox- o-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(2-methyl-3-oxo-piperazin-1-yl)-2-oxo-ethoxy]-q- uinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-{(S)-4-Carboxy-2-[(4-{2-oxo-2-[4-(2-oxo-pyrrolidin-1-yl)-piperid- in-1-yl]-ethoxy}-quinoline-2-carbonyl)-amino]-butyryl}-piperazine-1-carbox- ylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-oxo-2-(3-oxo-4-phenyl-piperazin-1-yl)-ethoxy]-q- uinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(4-isobutoxy-piperidin-1-yl)-2-oxo-ethox- y]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(4-isopropoxy-piperidin-1-yl)-2-oxo-ethoxy]-qui- noline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(2-furan-2-yl-pyrrolidin-1-yl)-2-oxo-eth- oxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((R)-2-cyano-pyrrolidin-1-yl)-2-oxo-ethoxy]-qui- noline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-{(S)-4-Carboxy-2-[(4-{2-[4-(2-morpholin-4-yl-2-oxo-ethyl)-pipera- zin-1-yl]-2-oxo-ethoxy}-quinoline-2-carbonyl)-amino]-butyryl}-piperazine-1- -carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((2S,4R)-4-hydroxy-2-methoxycarbonyl-piperidin-- 1-yl)-2-oxo-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-car- boxylic acid ethyl ester, 4-{(S)-4-Carboxy-2-[(4-{2-[2-(5-methyl-furan-2-yl)-pyrrolidin-1-yl]-2-oxo- -ethoxy}-quinoline-2-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(2-methoxymethyl-piperidin-1-yl)-2-oxo-ethoxy]-- quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(4-morpholin-4-yl-piperidin-1-yl)-2-oxo-- ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(4-isopropyl-piperazin-1-yl)-2-oxo-ethoxy]-quin- oline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(2-ethoxymethyl-pyrrolidin-1-yl)-2-oxo-e- thoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(4-cyclopropanecarbonyl-piperazin-1-yl)-2-oxo-e- thoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-((S)-4-Carboxy-2-{[4-(2-oxo-2-piperazin-1-yl-ethoxy)-quinoline-2-carbon- yl]-amino}-butyryl)-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(4-ethanesulfonyl-piperazin-1-yl)-2-oxo-ethoxy]- -quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-oxo-2-((S)-2-trifluoromethyl-pyrrolidin-- 1-yl)-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxyli- c acid ethyl ester, 4-{(S)-4-Carboxy-2-[(4-[2-oxo-2-[2-(tetrahydro-furan-2-yl)-piperidin-1-yl- ]-ethoxy}-quinoline-2-carbonyl)-amino]1-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(2-morpholin-4-ylmethyl-pyrrolidin-1-yl)-2-oxo-- ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(2,2-dimethyl-3-oxo-piperazin-1-yl)-2-oxo-ethox- y]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(2-methylsulfanylmethyl-pyrrolidin-1-yl)-2-oxo-- ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-oxo-2-(2-phenyl-pyrrolidin-1-yl)-ethoxy]-quinol- ine-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-oxo-2-(2-thiazol-2-yl-pyrrolidin-1-yl)-ethoxy]-- quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(2-cyclopentyl-pyrrolidin-1-yl)-2-oxo-et- hoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(3-methoxy-3a,4,6,6a-tetrahydro-pyrrolo[3,4-d]i- soxazol-5-yl)-2-oxo-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazi- ne-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(4,4-difluoro-piperidin-1-yl)-2-oxo-ethoxy]-qui- noline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-cyano-pyrrolidin-1-yl)-2-oxo-etho- xy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-oxo-2-(3-trifluoromethyl-pyrrolidin-1-yl)-ethox- y]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-oxo-2-(4-oxo-hexahydro-cyclopenta[c]pyrrol-2-yl- )-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-oxo-2-(4-oxo-imidazolidin-1-yl)-ethoxy]-quinoli- ne-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, (S)-4-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]-qu- inoline-2-carbonyl}-amino)-5-[4-(3-methoxy-phenyl)-piperazin-1-yl]-5-oxo-p- entanoic acid, 4-[(S)-5-Carboxy-2-({4-[2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-o- xo-ethoxy]-quinoline-2-carbonyl}-amino)-pentanoyl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -quinoline-2-carbonyl}-amino)-4-methanesulfonyl-butyryl]-piperazine-1-carb- oxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-methyl-3-oxo-piperazin-1-yl)-2-oxo-ethox- y]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-oxo-2-(2-pyridin-3-yl-pyrrolidin-1-yl)-ethoxy]-- quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-((S)-4-Carboxy-2-{[4-((1S,4S)-2-2,5-diaza-bicyclo[2.2.1]hept-2-y- l-2-oxo-ethoxy)-quinoline-2-carbonyl]-amino}-butyryl)-piperazine-1-carboxy- lic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-3-Amino-pyrrolidin-1-yl)-2-oxo-ethoxy]-quinoline-2-c- arbonyl}-amino)-4-carboxy-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-{(S)-4-Carboxy-2-[(4-{2-[2-(1-methyl-piperidin-2-yl)-pyrrolidin-- 1-yl]-2-oxo-ethoxy}-quinoline-2-carbonyl)-amino]-butyryl}-piperazine-1-car- boxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-oxo-2-(3-pyridin-4-yl-pyrrolidin-1-yl)-ethoxy]-- quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-- ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-4-ethoxycarbonyl-butyryl]-pi- perazine-1-carboxylic acid butyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((R)-2-methoxymethyl-pyrrolidin-1-yl)-2-oxo-eth- oxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-hydroxy-butyryl]-piperazine-1-car- boxylic acid butyl ester,

4-[(S)-4-Carboxy-2-({4-[(R)-2-((S)-2-carboxy-pyrrolidin-1-yl)-1-methyl-2-- oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-ca- rboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({7-methyl-4-[(R)-1-methyl-2-oxo-2-(2-phenyl-pyrrolidi- n-1-yl)-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxy- lic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-oxo-2-(2-o-tolyl-pyrrolidin-1-yl)-ethoxy]-quino- line-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-oxo-2-(3-phenyl-pyrrolidin-1-yl)-ethoxy]-quinol- ine-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(2-hydroxymethyl-2,3-dihydro-indol-1-yl)-2-oxo-- ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-(5-Acetyl-2,3-dihydro-indol-1-yl)-2-oxo-ethoxy]-quinoline- -2-carbonyl}-amino)-4-carboxy-butyryl]-piperazine-1-carboxylic acid ethyl ester, (S)-1-(2-{2-[(S)-3-Carboxy-1-(4-ethoxycarbonyl-piperazine-1-carbon- yl)-propylcarbamoyl]-quinolin-4-yloxy}-acetyl)-2,3-dihydro-1H-indole-2-car- boxylic acid, 4-[(S)-4-Carboxy-2-({4-[2-(2-methyl-2,3-dihydro-indol-1-yl)-2-oxo-ethoxy]- -quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(2,3-dihydro-indol-1-yl)-2-oxo-ethoxy]-q- uinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-3-hydroxymethyl-3,4-dihydro-1H-isoq- uinolin-2-yl)-2-oxo-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazi- ne-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(3,4-dihydro-1H-isoquinolin-2-yl)-2-oxo-ethoxy]- -quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(6-methoxy-3,4-dihydro-2H-quinolin-1-yl)- -2-oxo-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxyl- ic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(3,4-dihydro-2H-quinolin-1-yl)-2-oxo-ethoxy]-qu- inoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-{(S)-4-Carboxy-2-[(4-{2-[2-(4-fluoro-phenyl)-pyrrolidin-1-yl]-2-- oxo-ethoxy}-quinoline-2-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester, 4-{(S)-4-Carboxy-2-[(4-{2-[2-(2-chloro-phenyl)-pyrrolidin-1-yl)-2-oxo-eth- oxy]-quinoline-2-carbonyl}-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(4-methyl-3-oxo-piperazin-1-yl)-2-oxo-ethoxy]-q- uinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(5-methyl-3-oxo-pyrazolidin-1-yl)-2-oxo-- ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-oxo-2-(2-pyridin-4-yl-pyrrolidin-1-yl)-ethoxy]-- quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(2-methyl-4,6-dihydro-pyrrolo[3,4-d]thia- zol-5-yl)-2-oxo-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1- -carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-oxo-2-(3-pyridin-2-yl-pyrrolidin-1-yl)-ethoxy]-- quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-oxo-2-((R)-2-phenylaminomethyl-pyrrolidi- n-1-yl)-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxy- lic acid ethyl ester, 4-[(S)-2-({4-[2-(2-Benzyloxymethyl-pyrrolidin-1-yl)-2-oxo-ethoxy]-quinoli- ne-2-carbonyl}-amino)-4-carboxy-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(4,7-dihydro-5H-thieno[2,3-c]pyridin-6-yl)-2-ox- o-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(4-methyl-6,7-dihydro-4H-thieno[3,2-c]pyridin-5- -yl)-2-oxo-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carb- oxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-oxo-2-(3-phenyl-6,7-dihydro-4H-isoxazolo[4,5-c]- pyridin-5-yl)-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-c- arboxylic acid ethyl ester, 4-[(S)-2-({4-[2-(3-Benzyloxy-pyrrolidin-1-yl)-2-oxo-ethoxy]-quinoline-2-c- arbonyl}-amino)-4-carboxy-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-oxo-2-(3-trifluoromethyl-1,4,6,7-tetrahy- dro-pyrazolo[4,3-c]pyridin-5-yl)-ethoxy]-quinoline-2-carbonyl}-amino)-buty- ryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(2-isopropyl-pyrrolidin-1-yl)-2-oxo-ethoxy]-qui- noline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-oxo-2-(2-m-tolyl-pyrrolidin-1-yl)-ethoxy- ]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-oxo-2-((R)-3-phenyl-pyrrolidin-1-yl)-eth- oxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(2-isopropyl-4-methyl-3-oxo-piperazin-1-yl)-2-o- xo-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(2-ethyl-pyrrolidin-1-yl)-2-oxo-ethoxy]-quinoli- ne-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-oxo-2-(2-pyridin-2-yl-pyrrolidin-1-yl)-ethoxy]-- quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-(2-tert-Butyl-pyrrolidin-1-yl)-2-oxo-ethoxy]-quino- line-2-carbonyl}-amino)-4-carboxy-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-{(S)-2-[(4-{2-[2-(1H-Benzoimidazol-2-yl)-pyrrolidin-1-yl]-2-oxo-ethoxy}- -quinoline-2-carbonyl)-amino]-4-carboxy-butyryl}-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-oxo-2-(3-phenylamino-pyrrolidin-1-yl)-ethoxy]-q- uinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-((S)-2-{[4-(2-[1,3']Bipyrrolidinyl-1'-yl-2-oxo-ethoxy)-quinoline- -2-carbonyl]-amino}-4-carboxy-butyryl)-piperazine-1-carboxylic acid ethyl ester, 4-{(S)-4-Carboxy-2-[(4-{2-oxo-2-[(S)-2-(1H-tetrazol-5-ylmethyl)-py- rrolidin-1-yl]-ethoxy}-quinoline-2-carbonyl)-amino]-butyryl}-piperazine-1-- carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-oxo-2-(3-o-tolyloxy-pyrrolidin-1-yl)-ethoxy]-qu- inoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(2-methyl-6,7-dihydro-4H-thiazolo[5,4-c]- pyridin-5-yl)-2-oxo-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazi- ne-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-(2-Butyl-4-methyl-3-oxo-piperazin-1-yl)-2-oxo-ethoxy]-qui- noline-2-carbonyl}-amino)-4-carboxy-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-{(S)-4-Carboxy-2-[(4-{2-[2-(3-methoxy-phenyl)-pyrrolidin-1-yl]-2-oxo-et- hoxy}-quinoline-2-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(6-methyl-octahydro-pyrrolo[3,4-b]pyridin-1-yl)- -2-oxo-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxyl- ic acid ethyl ester, 4-{(S)-4-Carboxy-2-[(4-{2-[2-(2-methoxy-phenyl)-pyrrolidin-1-yl]-2-oxo-et- hoxy}-quinoline-2-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(3-diethylamino-pyrrolidin-1-yl)-2-oxo-ethoxy]-- quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-oxo-2-(3-o-tolyloxy-pyrrolidin-1-yl)-eth- oxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-{(S)-4-Carboxy-2-[(4-{2-[(S)-2-(cyclobutyl-methyl-carbamoyl)-pyrrolidin- -1-yl]-2-oxo-ethoxy}-7-methyl-quinoline-2-carbonyl)-amino]-butyryl}-pipera- zine-1-carboxylic acid ethyl ester, 4-{(S)-2-[(4-{2-[(S)-2-(Cyclobutyl-methyl-carbamoyl)-pyrrolidin-1-yl]-2-o- xo-ethoxy}-7-methyl-quinoline-2-carbonyl)-amino]-4-ethoxycarbonyl-butyryl}- -piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-oxo-2-((R)-2-phenyl-pyrrolidin-1-yl)-ethoxy]-qu- inoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-oxo-2-((S)-2-phenyl-pyrrolidin-1-yl)-eth- oxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-{(S)-4-Carboxy-2-[(4-{2-[2-(2-fluoro-phenyl)-pyrrolidin-1-yl]-2-oxo-eth- oxy}-quinoline-2-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester, 4-{(S)-4-Carboxy-2-[(4-{2-[3-(2-fluoro-phenyl)-pyrrolidin-1-yl]-2-oxo-eth- oxy}-quinoline-2-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester, 4-{(S)-4-Carboxy-2-[(4-{2-[2-(2,4-dimethoxy-phenyl)-pyrrolidin-1-yl]-2-ox- o-ethoxy}-quinoline-2-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((2S,5R)-2-carboxy-5-phenyl-pyrrolidin-1-yl)-2-- oxo-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-oxo-2-(2-p-tolyl-pyrrolidin-1-yl)-ethoxy]-quino- line-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-{(S)-4-Carboxy-2-[(4-{2-[2-(3,4-difluoro-phenyl)-pyrrolidin-1-yl]-2-oxo- -ethoxy}-quinoline-2-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester, 4-{(S)-4-Carboxy-2-[(4-{2-[2-(3,4-dimethoxy-phenyl)-pyrrolidin-1-yl]-2-ox- o-ethoxy}-quinoline-2-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(2-ethyl-3-oxo-piperazin-1-yl)-2-oxo-ethoxy]-qu- inoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-{(S)-4-Carboxy-2-[(4-{2-oxo-2-[3-(2-oxo-pyrrolidin-1-ylmethyl)-p- iperidin-1-yl]-ethoxy}-quinoline-2-carbonyl)-amino]-butyryl}-piperazine-1-- carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-oxo-2-(2-thiophen-2-yl-pyrrolidin-1-yl)-ethoxy]- -quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-oxo-2-(2-pyrimidin-4-yl-pyrrolidin-1-yl)- -ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-cyclohexylmethoxycarbonyl-butyryl- ]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-cyclobutylmethoxycarbonyl-butyryl- ]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-propoxycarbonyl-butyryl]-piperazi- ne-1-carboxylic acid ethyl ester, 4-[(S)-4-Cyclobutoxycarbonyl-2-({4-[2-((S)-2-cyclobutylcarbamoyl-pyrrolid- in-1-yl)-2-oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-pipe- razine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-cyclopentylmethoxycarbonyl-butyry- l]-piperazine-1-carboxylic acid butyl ester, 4-[(S)-4-Carboxy-2-({4-[2-oxo-2-(4-oxo-3,5,7,8-tetrahydro-4H-pyrido[4,3-d- ]pyrimidin-6-yl)-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-- 1-carboxylic acid ethyl ester, 4-{(S)-4-Carboxy-2-[(4-{2-[2-(3-chloro-phenyl)-pyrrolidin-1-yl]-2-oxo-eth- oxy}-quinoline-2-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester, 4-{(S)-4-Carboxy-2-[(4-{2-[2-(2,4-difluoro-phenyl)-pyrrolidin-1-yl]-2-oxo- -ethoxy}-quinoline-2-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester, 3-[(S)-4-Carboxy-2-({4-[2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-o- xo-ethoxy]-quinoline-2-carbonyl}-amino)-butyrylamino]-azetidine-1-carboxyl- ic acid butyl ester, (S)-5-(4-Benzoyl-piperidin-1-yl)-4-({4-[2-((S)-2-cyclobutylcarbamoyl-pyrr- olidin-1-yl)-2-oxo-ethoxy]-quinoline-2-carbonyl}-amino)-5-oxo-pentanoic acid, (S)-5-[4-(3-Chloro-benzoyl)-piperidin-1-yl]-4-({4-[2-((S)-2-cyclobu- tylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]-quinoline-2-carbonyl}-amino)-5- -oxo-pentanoic acid, (S)-5-(4-Benzoyl-piperazin-1-yl)-4-({4-[2-((S)-2-cyclobutylcarbamoyl-pyrr- olidin-1-yl)-2-oxo-ethoxy]-quinoline-2-carbonyl}-amino)-5-oxo-pentanoic acid, 4-[(S)-4-Carboxy-2-({4-[2-((2S,4R)-4-fluoro-2-methoxycarbonyl-pyrro- lidin-1-yl)-2-oxo-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine- -1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(hexahydro-pyrrolo[3,4-b]pyrrol-5-yl)-2-oxo-eth- oxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-{(S)-2-[(4-{2-[2-(5-Bromo-pyridin-3-yl)-pyrrolidin-1-yl]-2-oxo-ethoxy}-- quinoline-2-carbonyl)-amino]-4-carboxy-butyryl}-piperazine-1-carboxylic acid ethyl ester, (S)-5-(3-Butoxycarbonylamino-azetidin-1-yl)-4-({4-[2-((S)-2-cyclobutylcar- bamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]-quinoline-2-carbonyl}-amino)-5-oxo-p- entanoic acid, 4-{(S)-4-Carboxy-2-[(4-{2-[2-(3,4-dimethyl-phenyl)-pyrrolidin-1-yl]-2-oxo- -ethoxy}-quinoline-2-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester, 4-{(S)-4-Carboxy-2-[(4-{2-[2-(3,5-dimethyl-phenyl)-pyrrolidin-1-yl]-2-oxo- -ethoxy}-quinoline-2-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester, 4-{(S)-4-Carboxy-2-[(4-{2-[2-(2,4-dimethyl-phenyl)-pyrrolidin-1-yl]-2-oxo- -ethoxy}-quinoline-2-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester, 4-[2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]-7-m- ethyl-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-{(S)-4-Carboxy-2-[(4-{2-[2-(2,5-dimethyl-phenyl)-pyrrolidin-1-yl]-2-oxo- -ethoxy}-quinoline-2-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(3-hydroxy-4,7-dihydro-5H-isoxazolo[5,4-c]pyrid- in-6-yl)-2-oxo-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-- carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-oxo-2-(2-trifluoromethoxymethyl-pyrrolidin-1-yl- )-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(3-methoxy-pyrrolidin-1-yl)-2-oxo-ethoxy]-quino- line-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((2S,4S)-4-fluoro-2-methoxycarbonyl-pyrrolidin-- 1-yl)-2-oxo-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-car- boxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)-2-o- xo-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-{(S)-4-Carboxy-2-[(4-{2-[(S)-2-(5-methyl-pyridin-3-yl)-pyrrolidin-1-yl]- -2-oxo-ethoxy}-quinoline-2-carbonyl)-amino]-butyryl}-piperazine-1-carboxyl- ic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-5-hydroxy-pentanoyl]-piperazine-1-c- arboxylic acid butyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-(2-cyclopentyl-ethoxycarbonyl)-bu- tyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-(tetrahydro-furan-3-ylmethoxycarb- onyl)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-(3-methyl-oxetan-3-ylmethoxycarbo- nyl)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-((1R,4S)-1-Bicyclo[2.2.1]hept-2-ylmethoxycarbonyl)-2-({4-[2-((S)-

-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]-7-methyl-quinoline-2- -carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-(3-ethyl-oxetan-3-ylmethoxycarbon- yl)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-(tetrahydro-pyran-2-ylmethoxycarb- onyl)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-(5-ethyl-[1,3]dioxan-5-ylmethoxyc- arbonyl)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-(2-oxo-[1,3]dioxolan-4-ylmethoxyc- arbonyl)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-{(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-[2-(2-hydroxy-ethylamino)-ethoxyc- arbonyl]-butyryl}-piperazine-1-carboxylic acid ethyl, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-(3-methoxy-butoxycarbonyl)-butyry- l]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-(tetrahydro-furan-2-ylmethoxycarb- onyl)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-(3-dimethylamino-2,2-dimethyl-pro- poxycarbonyl)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-(2-dimethylamino-2-methyl-propoxy- carbonyl)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-(2-morpholin-4-yl-ethoxycarbonyl)- -butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)-2-o- xo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-car- boxylic acid butyl ester, 4-{(S)-4-Carboxy-2-[(4-{2-[2-(3,4-difluoro-phenyl)-pyrrolidin-1-yl]-2-oxo- -ethoxy}-7-methyl-quinoline-2-carbonyl)-amino]-butyryl}-piperazine-1-carbo- xylic acid butyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-cyano-pyrrolidin-1-yl)-2-oxo-ethoxy]-7-m- ethyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid butyl ester, 4-{(S)-4-Carboxy-2-[(4-{2-[2-(2,4-difluoro-phenyl)-pyrrolidin-1-yl]-2-oxo- -ethoxy}-7-methyl-quinoline-2-carbonyl)-amino]-butyryl}-piperazine-1-carbo- xylic acid butyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(2-furan-2-yl-pyrrolidin-1-yl)-2-oxo-ethoxy]-7-- methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid butyl ester, 4-[(S)-4-Carboxy-2-({7-methyl-4-[2-oxo-2-(4-oxo-3,5,7,8-tetrahydro-4H-pyr- ido[4,3-d]pyrimidin-6-yl)-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-pi- perazine-1-carboxylic acid butyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-(1-methyl-2-morpholin-4-yl-ethoxy- carbonyl)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[(R)-2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-1-methyl-- 2-oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-4-cyclopentylmethoxyca- rbonyl-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({7-methyl-4-[2-oxo-2-(2-oxo-oxazolidin-3-yl)-ethoxy]-- quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid butyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-- ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-4-(3-methoxy-propoxycarbonyl- )-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-(2-ethoxy-ethoxycarbonyl)-butyryl- ]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({7-methyl-4-[2-oxo-2-(2-o-tolyl-pyrrolidin-1-yl)-etho- xy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid butyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-hydroxymethyl-pyrrolidin-1-yl)-2-oxo-eth- oxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxyli- c acid butyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(3,3-difluoro-pyrrolidin-1-yl)-2-oxo-ethoxy]-7-- methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid butyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(3-hydroxy-azetidin-1-yl)-2-oxo-ethoxy]-7-methy- l-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid butyl ester, 4-[(S)-4-Carboxy-2-({7-methyl-4-[2-(4-methyl-3-oxo-piperazin-1-yl)- -2-oxo-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxyl- ic acid butyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(4-hydroxy-piperidin-1-yl)-2-oxo-ethoxy]-7-meth- yl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid butyl ester, 4-[(S)-4-Carboxy-2-({7-methyl-4-[2-(5-methyl-3-oxo-pyrazolidin-1-yl)-2-ox- o-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid butyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-(2-dimethylamino-ethoxycarbonyl)-- butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-(2-isopropoxy-ethoxycarbonyl)-but- yryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((R)-3-hydroxy-pyrrolidin-1-yl)-2-oxo-ethoxy]-7- -methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid butyl ester, 4-{(S)-4-Carboxy-2-[(7-methyl-4-{2-[(S)-2-(5-methyl-pyridin-3-yl)-pyrroli- din-1-yl]-2-oxo-ethoxy}-quinoline-2-carbonyl)-amino]-butyryl}-piperazine-1- -carboxylic acid butyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-3-hydroxy-pyrrolidin-1-yl)-2-oxo-ethoxy]-7- -methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid butyl ester, 4-[(S)-4-Carboxy-2-({7-methyl-4-[2-oxo-2-((S)-2-phenyl-pyrrolidin-1-yl)-e- thoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid butyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-methoxymethyl-pyrrolidin-1-yl)-2-oxo-eth- oxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxyli- c acid butyl ester, 4-((S)-4-Carboxy-2-{[7-methyl-4-(2-oxo-2-piperazin-1-yl-ethoxy)-quinoline- -2-carbonyl]-amino}-butyryl)-piperazine-1-carboxylic acid butyl ester, 4-{(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-[2-(2-oxo-oxazolidin-3-yl)-ethoxy- carbonyl]-butyryl}-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-(5-methyl-[1,3]dioxan-5-ylmethoxy- carbonyl)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(3-methoxy-pyrrolidin-1-yl)-2-oxo-ethoxy]-7-met- hyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid butyl ester, 4-[(S)-4-Carboxy-2-({7-methyl-4-[2-oxo-2-(3-oxo-pyrazolidin-1-yl)-ethoxy]- -quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid butyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-- ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-4-methoxycarbonyl-butyryl]-p- iperazine-1-carboxylic acid butyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-o- xo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-car- boxylic acid propyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-o- xo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-car- boxylic acid cyclobutyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-methoxycarbonyl-butyryl]-piperazi- ne-1-carboxylic acid propyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-methoxycarbonyl-butyryl]-piperazi- ne-1-carboxylic acid cyclobutyl ester, 4-{(S)-4-Carboxy-2-[(4-{2-[2-(3-fluoro-phenyl)-pyrrolidin-1-yl]-2-oxo-eth- oxy}-quinoline-2-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-oxo-2-(2-oxo-[1,4']bipiperidinyl-1'-yl)-ethoxy]- -quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(2-methyl-6,7-dihydro-4H-oxazolo[5,4-c]p- yridin-5-yl)-2-oxo-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazin- e-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-oxo-2-((S)-2-phenylcarbamoyl-pyrrolidin-1-yl)-e- thoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({4-[2-(1-methyl-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-- 5-yl)-2-oxo-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-car- boxylic acid ethyl ester, 4-{(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-[2-(tetrahydro-pyran-4-yl)-ethoxy- carbonyl]-butyryl}-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-(3-hydroxy-3-methyl-butoxycarbony- l)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-(tetrahydro-pyran-3-ylmethoxycarb- onyl)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-4-Carboxy-2-({7-methyl-4-[2-oxo-2-(3-oxo-piperazin-1-yl)-ethoxy]-q- uinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid butyl ester, 4-{(S)-4-Carboxy-2-[(4-{2-[2-(4-fluoro-phenyl)-pyrrolidin-1-yl]-2-- oxo-ethoxy}-7-methyl-quinoline-2-carbonyl)-amino]-butyryl}-piperazine-1-ca- rboxylic acid butyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-(tetrahydro-pyran-4-ylmethoxycarb- onyl)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-(2-hydroxy-2-methyl-butoxycarbony- l)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-(2-methyl-oxetan-2-ylmethoxycarbo- nyl)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-(3-ethyl-oxetan-3-ylmethoxycarbon- yl)-butyryl]-piperazine-1-carboxylic acid butyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-(tetrahydro-pyran-2-ylmethoxycarb- onyl)-butyryl]-piperazine-1-carboxylic acid butyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-(tetrahydro-furan-3-ylmethoxycarb- onyl)-butyryl]-piperazine-1-carboxylic acid butyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-(tetrahydro-furan-2-ylmethoxycarb- onyl)-butyryl]-piperazine-1-carboxylic acid butyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-(2-ethoxy-ethoxycarbonyl)-butyryl- ]-piperazine-1-carboxylic acid butyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-o- xo-ethoxy]-7-methyl-naphthalene-2-carbonyl}-amino)-butyryl]-piperazine-1-c- arboxylic acid butyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-naphthalene-2-carbonyl}-amino)-4-methoxycarbonyl-butyryl]-pipera- zine-1-carboxylic acid butyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-naphthalene-2-carbonyl}-amino)-4-ethoxycarbonyl-butyryl]-piperaz- ine-1-carboxylic acid butyl ester, 4-[(S)-3-Cyclobutyl-2-({4-[2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-- 2-oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-propionyl]-piperazine-- 1-carboxylic acid butyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid butyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-3-cyclopropyl-propionyl]-piperazine- -1-carboxylic acid butyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-3-methoxy-propionyl]-piperazine-1-c- arboxylic acid butyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-naphthalene-2-carbonyl}-amino)-4-cyclopentylmethoxycarbonyl-buty- ryl]-piperazine-1-carboxylic acid butyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-cyclopentylmethoxycarbonyl-butyry- l]-piperazine-1-carboxylic acid cyclopropylmethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-cyclopentylmethoxycarbonyl-butyry- l]-piperazine-1-carboxylic acid cyclobutyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-methoxy-butyryl]-piperazine-1-car- boxylic acid butyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-2-cyclopropyl-acetyl]-piperazine-1-- carboxylic acid butyl ester, 4-[(2S,3R)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-eth- oxy]-7-methyl-quinoline-2-carbonyl}-amino)-3-methyl-pentanoyl]-piperazine-- 1-carboxylic acid butyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-3-hydroxy-3-methyl-butyryl]-piperaz- ine-1-carboxylic acid butyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-3-ethoxy-propionyl]-piperazine-1-ca- rboxylic acid butyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-hydroxy-butyryl]-piperazine-1-car- boxylic acid cyclopropylmethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-hydroxy-butyryl]-piperazine-1-car- boxylic acid cyclobutyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-3-hydroxy-propionyl]-piperazine-1-c- arboxylic acid butyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-propionyl]-piperazine-1-carboxylic acid butyl ester, 4-[(2S,3R)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-eth- oxy]-7-methyl-quinoline-2-carbonyl}-amino)-3-methoxy-butyryl]-piperazine-1- -carboxylic acid butyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -quinoline-2-carbonyl}-amino)-4-cyclopentylmethoxycarbonyl-butyryl]-pipera- zine-1-carboxylic acid butyl ester, 4-[2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]-7-m- ethyl-quinoline-2-carbonyl}-amino)-2-(tetrahydro-furan-3-yl)-acetyl]-piper- azine-1-carboxylic acid butyl ester,

4-[2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]-7-m- ethyl-quinoline-2-carbonyl}-amino)-2-(tetrahydro-pyran-4-yl)-acetyl]-piper- azine-1-carboxylic acid butyl ester, 4-[(S)-2-({4-[(R)-2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-1-methyl-- 2-oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-4-hydroxy-butyryl]-pip- erazine-1-carboxylic acid butyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-5-cyclopentylmethoxycarbonyl-pentan- oyl]-piperazine-1-carboxylic acid ethyl ester, 4-{(S)-2-[(4-[2-[(S)-2-(Cyclobutyl-methyl-carbamoyl)-pyrrolidin-1-yl]-2-o- xo-ethoxy}-7-methyl-quinoline-2-carbonyl)-amino]-4-(2-ethoxy-ethoxycarbony- l)-butyryl]-piperazine-1-carboxylic acid butyl ester, 4-[(S)-4-Cyclopentylmethoxycarbonyl-2-({4-[2-((S)-2-cyclopropylcarbamoyl-- pyrrolidin-1-yl)-2-oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyr- yl]-piperazine-1-carboxylic acid butyl ester, 4-[(S)-2-[(4-{2-[(S)-2-(Cyclobutylmethyl-carbamoyl)-pyrrolidin-1-yl]-2-ox- o-ethoxy}-7-methyl-quinoline-2-carbonyl)-amino]-4-(2-ethoxy-ethoxycarbonyl- )-butyryl]-piperazine-1-carboxylic acid butyl ester, 4-{(S)-2-[(4-{2-[(S)-2-(Cyclobutylmethyl-carbamoyl)-pyrrolidin-1-yl]-2-ox- o-ethoxy}-7-methyl-quinoline-2-carbonyl)-amino]-4-cyclopentylmethoxycarbon- yl-butyryl}-piperazine-1-carboxylic acid butyl ester, 4-[(S)-4-(2-Ethoxy-ethoxycarbonyl)-2-({4-[2-((S)-2-methoxymethyl-pyrrolid- in-1-yl)-2-oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-pipe- razine-1-carboxylic acid butyl ester, 4-[(S)-4-Cyclopentylmethoxycarbonyl-2-({4-[2-((R)-3-hydroxy-pyrrolidin-1-- yl)-2-oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazin- e-1-carboxylic acid butyl ester, 4-[(S)-4-(2-Ethoxy-ethoxycarbonyl)-2-({4-[2-((R)-3-hydroxy-pyrrolidin-1-y- l)-2-oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine- -1-carboxylic acid butyl ester, 4-[(S)-4-Cyclopentylmethoxycarbonyl-2-({4-[2-(3,3-difluoro-pyrrolidin-1-y- l)-2-oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine- -1-carboxylic acid butyl ester, 4-[(S)-2-({4-[2-(3,3-Difluoro-pyrrolidin-1-yl)-2-oxo-ethoxy]-7-methyl-qui- noline-2-carbonyl}-amino)-4-(2-ethoxy-ethoxycarbonyl)-butyryl]-piperazine-- 1-carboxylic acid butyl ester, 4-[(2S,3S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-eth- oxy]-7-methyl-quinoline-2-carbonyl}-amino)-3-methyl-pentanoyl]-piperazine-- 1-carboxylic acid butyl ester, 4-[(S)-2-({6-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -2,3-dihydro-1H-9-aza-cyclopenta[a]naphthalene-8-carbonyl}-amino)-4-cyclop- entylmethoxycarbonyl-butyryl]-piperazine-1-carboxylic ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclopropylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy- ]-7-methyl-quinoline-2-carbonyl}-amino)-4-(2-ethoxy-ethoxycarbonyl)-butyry- l]-piperazine-1-carboxylic acid butyl ester, 4-[(S)-4-Cyclopentylmethoxycarbonyl-2-({4-[2-((S)-2-methoxymethyl-pyrroli- din-1-yl)-2-oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-pip- erazine-1-carboxylic acid butyl ester, 4-[(S)-4-Cyclopentylmethoxycarbonyl-2-({7-methyl-4-[2-oxo-2-((S)-2-phenyl- -pyrrolidin-1-yl)-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine- -1-carboxylic acid butyl ester, 4-[(S)-4-(2-Ethoxy-ethoxycarbonyl)-2-({7-methyl-4-[2-oxo-2-((S)-2-phenyl-- pyrrolidin-1-yl)-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-- 1-carboxylic acid butyl ester, 4-{(S)-2-[(4-{2-[(S)-2-(Cyclobutyl-methyl-carbamoyl)-pyrrolidin-1-yl]-2-o- xo-ethoxy}-7-methyl-quinoline-2-carbonyl)-amino]-4-cyclopentylmethoxycarbo- nyl-butyryl}-piperazine-1-carboxylic acid butyl ester, 4-[2-({7-Methyl-4-[2-oxo-2-(3-oxo-piperazin-1-yl)-ethoxy]-quinoline-2-car- bonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-(4,4-Difluoro-piperidin-1-yl)-2-oxo-ethoxy]-7-methyl-quinolin- e-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-(3,3-Difluoro-pyrrolidin-1-yl)-2-oxo-ethoxy]-7-methyl-quinoli- ne-2-carbonyl]-amino)-acetyl}-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-(4-Cyclopropylmethyl-piperazin-1-yl)-2-oxo-ethoxy]-7-methyl-q- uinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-((R)-3-Hydroxy-pyrrolidin-1-yl)-2-oxo-ethoxy]-7-methyl- -quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-(4-Isobutyl-piperazin-1-yl)-2-oxo-ethoxy]-7-methyl-qui- noline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-{2-[(7-Methyl-4-{2-[(S)-2-(5-methyl-pyridin-3-yl)-pyrrolidin-1-y- l]-2-oxo-ethoxy}-quinoline-2-carbonyl)-amino]-acetyl}-piperazine-1-carboxy- lic acid butyl ester, 4-{2-[(4-{2-[2-(4-Fluoro-phenyl)-pyrrolidin-1-yl]-2-oxo-ethoxy}-7-methyl-- quinoline-2-carbonyl)-amino]-acetyl}-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-(3-Hydroxy-azetidin-1-yl)-2-oxo-ethoxy]-7-methyl-quino- line-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-{2-[(4-{2-[2-(3,4-Difluoro-phenyl)-pyrrolidin-1-yl]-2-oxo-ethoxy}-7-met- hyl-quinoline-2-carbonyl)-amino]-acetyl}-piperazine-1-carboxylic acid butyl ester, 4-{2-[(4-{2-[2-(2,4-Difluoro-phenyl)-pyrrolidin-1-yl]-2-oxo-ethoxy}-7-met- hyl-quinoline-2-carbonyl)-amino]-acetyl}-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-((S)-2-Ethoxycarbonyl-pyrrolidin-1-yl)-2-oxo-ethoxy]-7-methyl- -quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-(3,3-Difluoro-piperidin-1-yl)-2-oxo-ethoxy]-7-methyl-q- uinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-((S)-2-Cyano-pyrrolidin-1-yl)-2-oxo-ethoxy]-7-methyl-q- uinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-(Hexahydro-pyrrolo[1,2-a]pyrazin-2-yl)-2-oxo-ethoxy]-7- -methyl-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({7-Methyl-4-[2-oxo-2-(4-oxo-3,5,7,8-tetrahydro-4H-pyrido[4,3-d]pyri- midin-6-yl)-ethoxy]-quinoline-2-carbonyl}-amino)-acetyl]piperazine-1-carbo- xylic acid butyl ester, 4-[2-({7-Methyl-4-[2-(4-methyl-piperazin-1-yl)-2-oxo-ethoxy]-quinoline-2-- carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-((R)-2-Hydroxymethyl-pyrrolidin-1-yl)-2-oxo-ethoxy]-7-methyl-- quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({7-Methyl-4-[2-(4-methoxycarbonyl-piperazin-1-yl)-2-oxo-etho- xy]-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-((S)-3-Hydroxy-pyrrolidin-1-yl)-2-oxo-ethoxy]-7-methyl-quinol- ine-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-{2-[(4-{2-[4-(2-Methoxy-ethyl)-piperazin-1-yl]-2-oxo-ethoxy}-7-methyl-q- uinoline-2-carbonyl)-amino]-acetyl}-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-(4,6-Dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)-2-oxo-etho- xy]-7-methyl-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({7-Methyl-4-[2-oxo-2-(3-oxo-pyrazolidin-1-yl)-ethoxy]-quinoline-2-c- arbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({7-Methyl-4-[2-(4-methyl-3-oxo-piperazin-1-yl)-2-oxo-ethoxy]-quinol- ine-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-4,4-difluoro-pyrrolidin-1-yl)-- 2-oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-4-(2-ethoxy-ethoxycarb- onyl)-butyryl]-piperazine-1-carboxylic acid butyl ester, 4-{2-[(7-Methyl-4-{2-oxo-2-[(S)-2-(pyrrolidine-1-carbonyl)-pyrrolidin-1-y- l]-ethoxy}-quinoline-2-carbonyl)-amino]-acetyl}-piperazine-1-carboxylic acid butyl ester, 4-{2-[(7-Methyl-4-{2-oxo-2-[4-(2,2,2-trifluoro-ethyl)-piperazin-1-yl]-eth- oxy}-quinoline-2-carbonyl)-amino]-acetyl}-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-((S)-2-Carboxy-pyrrolidin-1-yl)-2-oxo-ethoxy]-7-methyl-quinol- ine-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-(4-Cyclopropyl-piperazin-1-yl)-2-oxo-ethoxy]-7-methyl-quinoli- ne-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-{2-[(4-{2-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-2-oxo-ethoxy}-7-methyl-q- uinoline-2-carbonyl)-amino]-acetyl}-piperazine-1-carboxylic acid butyl ester, 4-[2-({7-Methyl-4-[2-oxo-2-((S)-2-phenylcarbamoyl-pyrrolidin-1-yl)- -ethoxy]-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-((S)-2-Cyclopropylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]-7-- methyl-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-(3-Methoxy-pyrrolidin-1-yl)-2-oxo-ethoxy]-7-methyl-quinoline-- 2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-((S)-3-tert-Butoxycarbonylamino-pyrrolidin-1-yl)-2-oxo-ethoxy- ]-7-methyl-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-{2-([7-Methyl-4-[2-(4-ethoxycarbonyl-piperazin-1-yl)-2-oxo-ethoxy]-quin- oline-2-carbonyl]-amino)-acetyl}-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-(4-Hydroxy-piperidin-1-yl)-2-oxo-ethoxy]-7-methyl-quinoline-2- -carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-(4-Ethyl-piperazin-1-yl)-2-oxo-ethoxy]-7-methyl-quinoline-2-c- arbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-(2-{[7-Methyl-4-(2-oxo-2-piperazin-1-yl-ethoxy)-quinoline-2-carbonyl]-a- mino}-acetyl)-piperazine-1-carboxylic acid butyl ester, 4-[2-({7-Methyl-4-[2-oxo-2-((S)-2-propylcarbamoyl-pyrrolidin-1-yl)-ethoxy- ]-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-{2-[(4-{2-[(S)-2-(Cyclopropylmethyl-carbamoyl)-pyrrolidin-1-yl]-- 2-oxo-ethoxy}-7-methyl-quinoline-2-carbonyl)-amino]-acetyl}-piperazine-1-c- arboxylic acid butyl ester, 4-{2-[(7-Methyl-4-{2-oxo-2-[(S)-2-(piperidine-1-carbonyl)-pyrrolidin-1-yl- ]-ethoxy}-quinoline-2-carbonyl)-amino]-acetyl}-piperazine-1-carboxylic acid butyl ester, 4-{2-((4-{2-[(S)-2-(4,4-Difluoro-piperidine-1-carbonyl)-pyrrolidin-1-yl)-- 2-oxo-ethoxy}-7-methyl-quinoline-2-carbonyl)-amino]-acetyl}-piperazine-1-c- arboxylic acid butyl ester, 4-[2-({4-[2-((S)-2-Cyclopentylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]-7-- methyl-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-(2-Furan-2-yl-pyrrolidin-1-yl)-2-oxo-ethoxy]-7-methyl-quinoli- ne-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({7-Methyl-4-[2-oxo-2-(3-oxo-pyrrolidin-1-yl)-ethoxy]-quinoline-2-ca- rbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({7-Methyl-4-[2-oxo-2-((S)-2-phenyl-pyrrolidin-1-yl)-ethoxy]-quinoli- ne-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-((S)-2-Methoxymethyl-pyrrolidin-1-yl)-2-oxo-ethoxy]-7-methyl-- quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-{2-[(7-Methyl-4-{2-oxo-2-[(S)-2-(pyridin-2-ylcarbamoyl)-pyrrolid- in-1-yl]-ethoxy}-quinoline-2-carbonyl)-amino]-acetyl}-piperazine-1-carboxy- lic acid butyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-(2H-tetrazol-5-yl)-butyryl]-piper- azine-1-carboxylic acid butyl ester, 4-[2-({4-[2-((2S,5S)-2,5-Bis-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-e- thoxy]-7-methyl-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxyl- ic acid butyl ester, 4-{(S)-4-Carboxy-2-[(4-{2-[(S)-2-(2,2-difluoro-cyclopropylcarbamoyl)-pyrr- olidin-1-yl]-2-oxo-ethoxy}-7-methyl-quinoline-2-carbonyl)-amino]-butyryl}-- piperazine-1-carboxylic acid butyl ester, 4-{2-[(4-{2-[(S)-2-(2,2-Difluoro-cyclopropylcarbamoyl)-pyrrolidin-1-yl]-2- -oxo-ethoxy}-7-methyl-quinoline-2-carbonyl)-amino]-acetyl}-piperazine-1-ca- rboxylic acid butyl ester, 4-[2-({4-[2-(5,6-Dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)-2-oxo-eth- oxy]-7-methyl-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({7-Methyl-4-[2-oxo-2-(2-o-tolyl-pyrrolidin-1-yl)-ethoxy]-quinoline-- 2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-{2-[(4-{2-[(S)-2-(Ethyl-methyl-carbamoyl)-pyrrolidin-1-yl]-2-oxo-ethoxy- }-7-methyl-quinoline-2-carbonyl)-amino]-acetyl}-piperazine-1-carboxylic acid butyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-4,4-difluoro-pyrrolidin-1-yl)-- 2-oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-4-cyclopentylmethoxyca- rbonyl-butyryl]piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-((S)-3-Amino-pyrrolidin-1-yl)-2-oxo-ethoxy]-7-methyl-quinolin- e-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]-7-m- ethyl-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid cyclobutyl ester, 4-[2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]-7-m- ethyl-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid cyclopropylmethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methoxy-quinoline-2-carbonyl}-amino)-4-cyclopentylmethoxycarbonyl-butyr- yl]-piperazine-1-carboxylic acid butyl ester, 4-[(R)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-3-fluoro-propionyl]-piperazine-1-ca- rboxylic acid ethyl ester, 4-[(R)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-3-fluoro-propionyl]-piperazine-1-ca- rboxylic acid butyl ester, 4-[2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]-7-m- ethoxy-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 3-(2-{2-[2-(4-Butoxycarbonyl-piperazin-1-yl)-2-oxo-ethylcarbamoyl]-7-meth- yl-quinolin-4-yloxy}-acetyl)-3-aza-bicyclo[3.1.0]hexane-6-carboxylic acid ethyl ester, 4-[2-({7-Methyl-4-[2-oxo-2-(2-trifluoromethoxymethyl-pyrrolidin-1-yl)-eth- oxy]-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-(2,4-Dioxo-1,3,8-triaza-spiro[4.5]dec-8-yl)-2-oxo-ethoxy]-7-m- ethyl-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-(5-oxo-4,5-dihydro-[1,3,4]oxadiaz- ol-2-yl)-butyryl]-piperazine-1-carboxylic acid ethyl ester, 4-[2-({4-[2-(3-Hydroxy-4,7-dihydro-5H-isoxazolo[5,4-c]pyridin-6-yl)-2-oxo- -ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carbox- ylic acid butyl ester, 4-{2-[(4-{2-[2-(1H-Benzoimidazol-2-yl)-pyrrolidin-1-yl]-2-oxo-ethoxy}-7-m- ethyl-quinoline-2-carbonyl)-amino]-acetyl}-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[(R)-2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-1-methyl-2-ox- o-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carbo- xylic acid butyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4,4-difluoro-butyryl]-piperazine-1-- carboxylic acid ethyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4,4-difluoro-butyryl]-piperazine-1-- carboxylic acid butyl ester, 4-{2-[(7-Methyl-4-{2-[(S)-2-(morpholine-4-carbonyl)-pyrrolidin-1-yl]-2-ox- o-ethoxy}-quinoline-2-carbonyl)-amino]-acetyl}-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]-7-m- ethyl-quinoline-2-carbonyl}-methyl-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({7-Methyl-4-[2-oxo-2-(6-oxo-hexahydro-pyrrolo[1,2-a]pyrazin-2-yl)-e- thoxy]-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-(2,4-Dioxo-1,3,7-triaza-spiro[4.5]dec-7-yl)-2-oxo-ethoxy]-7-m-

ethyl-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({7-Methyl-4-[2-oxo-2-(3-trifluoromethyl-4,6-dihydro-1H-pyrrolo[3,4-- c]pyrazol-5-yl)-ethoxy]-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-- carboxylic acid butyl ester, 4-[2-({4-[2-((R)-3-Dimethylamino-pyrrolidin-1-yl)-2-oxo-ethoxy]-7-methyl-- quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({7-Methyl-4-[2-oxo-2-((S)-2-trifluoromethyl-pyrrolidin-1-yl)- -ethoxy]-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-((R)-3-Acetylamino-pyrrolidin-1-yl)-2-oxo-ethoxy]-7-methyl-qu- inoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({7-Methyl-4-[2-oxo-2-(2-trifluoromethyl-pyrrolidin-1-yl)-eth- oxy]-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-((S)-3-Dimethylamino-pyrrolidin-1-yl)-2-oxo-ethoxy]-7-methyl-- quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-(2-{[4-((R)-2-Hexahydro-pyrrolo[1,2-a]pyrazin-2-yl-2-oxo-ethoxy)- -7-methyl-quinoline-2-carbonyl}-amino]-acetyl)-piperazine-1-carboxylic acid butyl ester, 4-{2-[(4-{2-[2-(1H-Indol-2-yl)-pyrrolidin-1-yl]-2-oxo-ethoxy}-7-methyl-qu- inoline-2-carbonyl)-amino]-acetyl}-piperazine-1-carboxylic acid butyl ester, 4-{2-[(7-Methyl-4-{2-[2-(3-methyl-[1,2,4]oxadiazol-5-yl)-pyrrolidi- n-1-yl]-2-oxo-ethoxy}-quinoline-2-carbonyl)-amino]-acetyl}-piperazine-1-ca- rboxylic acid butyl ester, 4-[2-({4-[2-((2S,4S)-2-Cyano-4-fluoro-pyrrolidin-1-yl)-2-oxo-ethoxy]-7-me- thyl-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, (2S,3aR,7aR)-1-(2-{2-[2-(4-Butoxycarbonyl-piperazin-1-yl)-2-oxo-ethylcarb- amoyl]-7-methyl-quinolin-4-yloxy}-acetyl)-octahydro-indole-2-carboxylic acid, 4-[2-({7-Methyl-4-[2-oxo-2-(3-trifluoromethyl-pyrrolidin-1-yl)-etho- xy]-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({7-Methyl-4-[2-oxo-2-((R)-2-trifluoromethyl-pyrrolidin-1-yl)-ethoxy- ]-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-((2S,5R)-2-Carboxy-5-phenyl-pyrrolidin-1-yl)-2-oxo-eth- oxy]-7-methyl-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({7-Methyl-4-[2-(2-methyl-6,7-dihydro-4H-oxazolo[5,4-c]pyridin-5-yl)- -2-oxo-ethoxy]-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxyli- c acid butyl ester, 4-[2-({4-[2-(3-Methanesulfonyl-pyrrolidin-1-yl)-2-oxo-ethoxy]-7-methyl-qu- inoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-(3-Ethoxy-piperidin-1-yl)-2-oxo-ethoxy]-7-methyl-quino- line-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({7-Methyl-4-[2-oxo-2-(1-oxo-2,8-diaza-spiro[4.5]dec-8-yl)-ethoxy]-q- uinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[(S)-2-({4-[(R)-2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-1-- methyl-2-oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-4-hydroxy-butyr- yl]-piperazine-1-carboxylic acid ethyl ester, 4-[2-({7-Methyl-4-[2-(1-methyl-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)- -2-oxo-ethoxy]-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxyli- c acid butyl ester, 4-[2-({4-[2-((1R,4R)-5-Ethyl-2,5-diaza-bicyclo[2.2.1]hept-2-yl)-2-oxo-eth- oxy]-7-methyl-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-((R)-3-tert-Butoxycarbonylamino-pyrrolidin-1-yl)-2-oxo-ethoxy- ]-7-methyl-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-(4-Cyanomethyl-piperazin-1-yl)-2-oxo-ethoxy]-7-methyl-quinoli- ne-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-{2-[(4-{2-[3-(Acetyl-methyl-amino)-pyrrolidin-1-yl]-2-oxo-ethoxy}-7-met- hyl-quinoline-2-carbonyl)-amino]-acetyl}-piperazine-1-carboxylic acid butyl ester, 4-{2-[(7-Methyl-4-{2-[2-(6-methyl-pyridin-2-yl)-pyrrolidin-1-yl]-2-oxo-et- hoxy}-quinoline-2-carbonyl)-amino]-acetyl}-piperazine-1-carboxylic acid butyl ester, 4-{2-[(7-Methyl-4-{2-oxo-2-[4-(pyrrolidine-1-carbonyl)-piperazin-1-yl]-et- hoxy}-quinoline-2-carbonyl)-amino]-acetyl}-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-(3-Methoxy-piperidin-1-yl)-2-oxo-ethoxy]-7-methyl-quinoline-2- -carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-(4-Methoxy-piperidin-1-yl)-2-oxo-ethoxy]-7-methyl-quinoline-2- -carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-(4-Acetylamino-piperidin-1-yl)-2-oxo-ethoxy]-7-methyl-quinoli- ne-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-((S)-3-Acetylamino-pyrrolidin-1-yl)-2-oxo-ethoxy]-7-methyl-qu- inoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({7-Methyl-4-[2-(1-methyl-3-trifluoromethyl-1,4,6,7-tetrahydr- o-pyrazolo[4,3-c]pyridin-5-yl)-2-oxo-ethoxy]-quinoline-2-carbonyl}-amino)-- acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]-6,7- -dimethyl-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({7-Methyl-4-[2-(2-methyl-octahydro-pyrrolo[3,4-c]pyridin-5-yl)-2-ox- o-ethoxy]-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-{2-[(7-Methyl-4-{2-oxo-2-[4-(pyrrolidine-1-carbonyl)-piperidin-1-yl]-et- hoxy}-quinoline-2-carbonyl)-amino]-acetyl}-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-((2S,4R)-2-Ethoxycarbonyl-4-hydroxy-pyrrolidin-1-yl)-2-oxo-et- hoxy]-7-methyl-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxyli- c acid butyl ester, 4-{2-[(7-Methyl-4-{2-[(S)-2-(4-methyl-piperidine-1-carbonyl)-pyrrolidin-1- -yl]-2-oxo-ethoxy}-quinoline-2-carbonyl)-amino]-acetyl}-piperazine-1-carbo- xylic acid butyl ester, 4-[2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]-7-m- ethyl-quinoline-2-carbonyl}-methyl-amino)-acetyl]-piperazine-1-carboxylic acid ethyl ester, 4-{2-[(4-{2-[(S)-2-(3,4-Dihydro-2H-quinoline-1-carbonyl)-pyrrolidin-1-yl]- -2-oxo-ethoxy}-7-methyl-quinoline-2-carbonyl)-amino]-acetyl}-piperazine-1-- carboxylic acid butyl ester, 4-{2-[(4-{2-[(S)-2-(2,3-Dihydro-indole-1-carbonyl)-pyrrolidin-1-yl]-2-oxo- -ethoxy}-7-methyl-quinoline-2-carbonyl)-amino]-acetyl}-piperazine-1-carbox- ylic acid butyl ester, 4-[2-({4-[2-((S)-4-Cyclobutylcarbamoyl-oxazolidin-3-yl)-2-oxo-ethoxy]-7-m- ethyl-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-(3-Dimethylamino-pyrrolidin-1-yl)-2-oxo-ethoxy]-7-methyl-quin- oline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-{2-[(7-Methyl-4-{2-oxo-2-[(S)-2-(1H-tetrazol-5-ylmethyl)-pyrrolidin-1-y- l]-ethoxy}-quinoline-2-carbonyl)-amino]-acetyl}-piperazine-1-carboxylic acid butyl ester, 4-[2-({7-Methyl-4-[2-oxo-2-(1-oxo-2,7-diaza-spiro[4.5]dec-7-yl)-ethoxy]-q- uinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-(3-Dimethylamino-piperidin-1-yl)-2-oxo-ethoxy]-7-methy- l-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-(4-Cyclobutyl-piperazin-1-yl)-2-oxo-ethoxy]-7-methyl-q- uinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-etho- xy]-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({7-Chloro-4-[2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-et- hoxy]-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[(S)-2-({4-[(R)-2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-1-methyl-- 2-oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-4-methoxycarbonyl-buty- ryl]-piperazine-1-carboxylic acid ethyl ester, 4-[(S)-2-({4-[(R)-2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-1-methyl-- 2-oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-4-hydroxy-butyryl]-pip- erazine-1-carboxylic acid cyclobutyl ester, 4-[2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]-6-f- luoro-5-methyl-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxyli- c acid butyl ester, 4-[(S)-2-({4-[(R)-2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-1-methyl-- 2-oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-4-hydroxy-butyryl]-pip- erazine-1-carboxylic acid cyclopropylmethyl ester, 4-[2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]-7-m- ethyl-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid 3,3,3-trifluoro-propyl ester, 4-[2-({6-Chloro-4-[2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-et- hoxy]-7-methyl-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxyli- c acid butyl ester, 4-[(S)-2-({4-[(R)-2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-1-methyl-- 2-oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-4-(1H-tetrazol-5-yl)-b- utyryl]-piperazine-1-carboxylic acid butyl ester, 4-[(S)-2-({4-[(S)-2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-1-methyl-- 2-oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-4-(1H-tetrazol-5-yl)-b- utyryl]-piperazine-1-carboxylic acid butyl ester, 4-[(S)-4-Hydroxy-2-({7-methyl-4-[2-oxo-2-((S)-2-phenyl-pyrrolidin-1-yl)-e- thoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]-6,7- -difluoro-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({7-Cyano-4-[2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-eth- oxy]-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-{(S)-4-Carboxy-2-[(4-{2-[(S)-2-(4-fluoro-phenyl)-pyrrolidin-1-yl]-2-oxo- -ethoxy}-7-methyl-quinoline-2-carbonyl)-amino]-butyryl}-piperazine-1-carbo- xylic acid butyl ester, 4-{(S)-4-Carboxy-2-[(4-{2-[(S)-2-(4-fluoro-phenyl)-pyrrolidin-1-yl]-2-oxo- -ethoxy}-6,7-dimethyl-quinoline-2-carbonyl)-amino]-butyryl}-piperazine-1-c- arboxylic acid butyl ester, 4-[2-({4-[2-((2S,4R)-4-Cyano-2-cyclopropylcarbamoyl-pyrrolidin-1-yl)-2-ox- o-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carbo- xylic acid butyl ester, 4-[2-({4-[2-((2S,4R)-2-Cyclobutylcarbamoyl-4-hydroxy-pyrrolidin-1-yl)-2-o- xo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carb- oxylic acid butyl ester, 4-{2-[(7-Methyl-4-{2-oxo-2-[(S)-2-(1H-tetrazol-5-yl)-pyrrolidin-1-yl]-eth- oxy}-quinoline-2-carbonyl)-amino]-acetyl}-piperazine-1-carboxylic acid butyl ester, 4-{(S)-4-Carboxy-2-[(4-{(R)-2-[(S)-2-(4-fluoro-phenyl)-pyrrolidin-1-yl]-1- -methyl-2-oxo-ethoxy}-7-methyl-quinoline-2-carbonyl)-amino]-butyryl}-piper- azine-1-carboxylic acid butyl ester, 4-[2-({4-[2-((2S,4R)-4-Cyano-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo- -ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carbox- ylic acid butyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-(2-methyl-2H-tetrazol-5-yl)-butyr- yl]-piperazine-1-carboxylic acid butyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-4-(1-methyl-1H-tetrazol-5-yl)-butyr- yl]-piperazine-1-carboxylic acid butyl ester, 4-{2-[(7-Methyl-4-{2-[(S)-2-(1-methyl-azetidin-3-ylcarbamoyl)-pyrrolidin-- 1-yl]-2-oxo-ethoxy}-quinoline-2-carbonyl)-amino]-acetyl}-piperazine-1-carb- oxylic acid butyl ester, 4-{2-[(7-Methyl-4-{2-[(S)-2-(4-methyl-piperazine-1-carbonyl)-pyrrolidin-1- -yl]-2-oxo-ethoxy}-quinoline-2-carbonyl)-amino]-acetyl}-piperazine-1-carbo- xylic acid butyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-3-(1H-[1,2,3]triazol-4-yl)-propiony- l]-piperazine-1-carboxylic acid butyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]- -7-methyl-quinoline-2-carbonyl}-amino)-3-(3-hydroxy-5-methyl-isoxazol-4-yl- )-propionyl]-piperazine-1-carboxylic acid butyl ester, 4-[(S)-4-Ethoxycarbonyl-2-({7-methyl-4-[2-oxo-2-((S)-2-phenyl-pyrrolidin-- 1-yl)-ethoxy]-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxyli- c acid butyl ester, 4-{2-[(7-Methyl-4-{2-oxo-2-[(S)-2-(2,2,2-trifluoro-ethylcarbamoyl)-pyrrol- idin-1-yl]-ethoxy}-quinoline-2-carbonyl)-amino]-acetyl}-piperazine-1-carbo- xylic acid butyl ester, 4-[(S)-2-({4-[2-(3,3-Difluoro-pyrrolidin-1-yl)-2-oxo-ethoxy]-7-methyl-qui- noline-2-carbonyl}-amino)-4-(2H-tetrazol-5-yl)-butyryl]-piperazine-1-carbo- xylic acid butyl ester, 4-[(S)-2-({4-[2-((R)-3-Hydroxy-pyrrolidin-1-yl)-2-oxo-ethoxy]-7-methyl-qu- inoline-2-carbonyl}-amino)-4-(2H-tetrazol-5-yl)-butyryl]-piperazine-1-carb- oxylic acid butyl ester, 4-[(S)-2-({4-[2-(4-Methoxy-piperidin-1-yl)-2-oxo-ethoxy]-7-methyl-quinoli- ne-2-carbonyl}-amino)-4-(2H-tetrazol-5-yl)-butyryl]-piperazine-1-carboxyli- c acid butyl ester, 4-[(S)-2-({4-[2-((S)-2-Cyano-pyrrolidin-1-yl)-2-oxo-ethoxy]-7-methyl-quin- oline-2-carbonyl}-amino)-4-(2H-tetrazol-5-yl)-butyryl]-piperazine-1-carbox- ylic acid butyl ester, 4-[(R)-2-({4-[2-((2S,4S)-2-Cyclobutylcarbamoyl-4-hydroxy-pyrrolidin-1-yl)- -2-oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-3-fluoro-propionyl]-p- iperazine-1-carboxylic acid butyl ester, 4-((R)-3-Fluoro-2-{[7-methyl-4-(2-oxo-2-piperazin-1-yl-ethoxy)-quinoline-- 2-carbonyl]-amino}-propionyl)-piperazine-1-carboxylic acid butyl ester, 4-[(S)-4-Carboxy-2-({4-[2-((R)-2-hydroxymethyl-pyrrolidin-1-yl)-2-oxo-eth- oxy]-7-methyl-quinoline-2-carbonyl}-amino)-butyryl]-piperazine-1-carboxyli- c acid ethyl ester, 4-[2-({4-[2-((S)-2-tert-Butylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]-qui- noline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-((S)-2-Methylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]-- quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-((S)-2-Ethylcarbamoyl-pyrrolidin-1-yl)-2-oxo-ethoxy]-q- uinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-Oxo-2-(1-oxo-2,7-diaza-spiro[4.5]dec-7-yl)-ethoxy]-qui- noline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-oxo-2-(3-oxo-piperazin-1-yl)-ethoxy]-quinoline-2-carbo- nyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-{2-[(4-{2-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-2-oxo-ethoxy}-quinoline-- 2-carbonyl)-amino]-acetyl}-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-((S)-2-Cyano-pyrrolidin-1-yl)-2-oxo-ethoxy]-quinoline-2-carbo- nyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-(5,6-Dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)-2-oxo-eth- oxy]-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-((2S,4S)-2-Cyano-4-fluoro-pyrrolidin-1-yl)-2-oxo-ethoxy]-quin- oline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[2-(2-Methyl-octahydro-pyrrolo[3,4-c]pyridin-5-yl)-2-oxo-ethoxy]- -quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[(R)-2-((S)-2-Cyano-pyrrolidin-1-yl)-1-methyl-2-oxo-ethox- y]-7-methyl-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[(R)-2-(3-Hydroxy-azetidin-1-yl)-1-methyl-2-oxo-ethoxy]-7-methyl- -quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic acid butyl ester, 4-[2-({4-[(R)-2-(3,3-Difluoro-pyrrolidin-1-yl)-1-methyl-2-oxo-etho- xy]-7-methyl-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carboxylic

acid butyl ester, 4-[2-({7-Methyl-4-[(R)-1-methyl-2-(2-methyl-octahydro-pyrrolo[3,4-c]pyrid- in-5-yl)-2-oxo-ethoxy]-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-c- arboxylic acid butyl ester, 4-[2-({4-[(R)-2-((2S,4R)-4-Cyano-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-1- -methyl-2-oxo-ethoxy]-7-methyl-quinoline-2-carbonyl}-amino)-acetyl]-pipera- zine-1-carboxylic acid butyl ester, 4-[2-({4-[2-((2S,4R)-4-Cyano-2-cyclobutylcarbamoyl-pyrrolidin-1-yl)-2-oxo- -ethoxy]-6,7-dimethyl-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-ca- rboxylic acid butyl ester, or 4-[2-({7-Chloro-4-[2-((2S,4R)-4-cyano-2-cyclobutylcarbamoyl-pyrrolidin-1-- yl)-2-oxo-ethoxy]-quinoline-2-carbonyl}-amino)-acetyl]-piperazine-1-carbox- ylic acid butyl ester.

7. A process for the preparation of a compound of formula I as claimed in claim 1, which comprises reacting a compound of formula XI with a compound of formula VII to give a compound of formula II, ##STR00033## wherein the residues R2, R3, R4, R5, R6, X, A, B and E are as defined in formula I, R33 is oxygen, sulfur or nitrogen atom, LG is Cl, Br, J, tosyloxy, mesyloxy or trifluormethyl-sulfonyloxy, R44 is --OH or --(C.sub.1-C.sub.4)-alkoxy and R43 is a compound of the formula VI or a precursor of a compound of the formula VI ##STR00034## and reacting a compound of formula II with a compound of formula IV ##STR00035## wherein R1, Q, J, V, G and M are as defined in claim 1, to give a compound of formula I.

8. A process for the preparation of a compound of formula I as claimed in claim 1, which comprises reacting a compound of formula XI with a compound of formula H-R45 to give a compound of formula XII, followed by a reaction of compound XII with LG-R43 to give a compound of formula III, ##STR00036## wherein the residues R2, R3, R4, R5, R6, X, A, B and E are as defined in claim 1, R33 is oxygen, sulfur or nitrogen atom, LG is Cl, Br, J, tosyloxy, mesyloxy or trifluormethyl-sulfonyloxy, R44 is --OH or --(C.sub.1-C.sub.4)-alkoxy and R45 is a compound of the formula V or a precursor of a compound of the formula V ##STR00037## and R43 is a compound of formula VI or a precursor of a compound of the formula VI ##STR00038## wherein R1, Q, J, V, G and M are as defined in claim 1, to give a compound of formula I.

9. A pharmaceutical composition, comprising at least one compound of as claimed in claim 1 in all its stereoisomeric forms and mixtures thereof in any ratio, and its physiologically tolerable salts, and a pharmaceutically acceptable carrier.

10. A pharmaceutical composition comprising a compound as claimed in claim 1 and a pharmaceutically acceptable carrier, in combination with an anti-arrhythmic agent; a K+ channel opener, an antihypertensive agent; a calcium channel blockers; a diruetic; a renin inhibitor; an angiotensin-converting enzyme (ACE) inhibitor; an angiotensin AT-I receptor antagonist such; an ET-A receptor antagonist; a dual ET-A/AT-I antagonist; a neutral endopeptidase inhibitor (NEP); a vasopepsidase inhibitor; a dual NEP-ACE inhibitor; a .beta.-blocker; a non-steroidal anti-inflammatory drug (NSAID); a glycoprotein IIb/IIIa blocker; a thromboxane-A2-receptor antagonist; a thromboxane-A2-synthetase inhibitor; a phosphodiesterase-III (PDE-III) inhibitor; a PDE V inhibitors; a protease-activated receptor 1 (PAR-I) antagonist; an anticoagulant; a direct acting thrombin inhibitor; a factor VIIa inhibitor; a factor Xa inhibitor; a factor XIa inhibitor; an inhibitor of activated procarboxypeptidase U (TAFIa); an inhibitor of plasminogen activator inhibitor 1 (PAI-1); a thrombin inhibitor; a thrombolytic agent; an anisoylated plasminogen streptokinase activator complex; a urokinase; a cardiac glycoside; a mineralocorticoid receptor antagonist; a cholesterol/lipid lowering agent; a squalene synthetase inhibitor; a fibrate; a bile acid sequestrant such as questran; an ACAT inhibitor; an MTP inhibitors; a lipooxygenase inhibitor; nicotonic acid; a fenofibric acid derivative; probucol; a choesterol absorption inhibitor; a cholesterol ester transfer protein inhibitor; an anti-diabetic agent; an anti-depressant agent; an anti-inflammatory agent; an anti-osteoporosis agent; an estrogen or estradiol; an anti-obesity agent; an anti-proliferative agent; or an anti-ulcer and gastroesophageal reflux disease agent.

11. The pharmaceutical composition claimed in claim 10 wherein the anti-arrhythmic agent is propafenone, carvadiol, propranolol, sotalol, dofetilide, amiodarone, azimilide, ibutilide, ditiazem or verapamil; the K+ channel opener is an lAch inhibitor or an I.kappa.ur inhibitor; the antihypertensive agent is an alpha adrenergic blocker or a beta adrenergic blocker; the calcium channel blocker is diltiazem, verapamil, nifedipine, amlodipine or mybefradil; the diruetic is chlorothiazide, hydrochlorothiazide, flumethiazide, hydroflumethiazide, bendroflumethiazide, methylchlorothiazide, trichloromethiazide, polythiazide, benzthiazide, ethacrynic acid tricrynafen, chlorthalidone, furosemide, musolimine, bumetanide, triamtrenene, amiloride or spironolactone; the angiotensin-converting enzyme (ACE) inhibitor is captopril, zofenopril, fosinopril, enalapril, ceranopril, cilazopril, delapril, pentopril, quinapril, ramipril or lisinopril; the angiotensin AT-I receptor antagonist is losartan, irbesartan or valsartan; the ET-A receptor antagonist is sitaxsentan or atrsentan; the dual NEP-ACE inhibitor is omapatrilat, gemopatrilat or nitrates; the .beta.-blocker is propanolol, nadolol, or carvedilol; the non-steroidal anti-inflammatory drug (NSAID) is acetaminophen, aspirin, codeine, diclofenac, droxicam, fentaynl, ibuprofen, indomethacin, ketorolac-, mefenamate, morphine, naproxen, phenacetin, piroxicam, sufentanyl, sulfinpyrazone, or sulindac, or a pharmaceutically acceptable salt thereof; the glycoprotein IIb/IIIa blocker is abciximab, eptifibatide, tirofiban, or integrelin; the thromboxane-A2-receptor antagonist is ifetroban; the phosphodiesterase-III (PDE-III) inhibitor is dipyridamole or cilostazol, the PDE V inhibitor is sildenafil; the protease-activated receptor 1 (PAR-I) antagonist is SCH-530348, SCH-203099, SCH-529153, or SCH-205831, or a pharmaceutically acceptable salt thereof; the anticoagulant is warfarin, unfractionated heparin or a low molecular weight heparin, or a synthetic pentasaccharide; the direct acting thrombin inhibitor is hirudin or argatroban; the factor Xa inhibitor is Arixtra.TM., apixaban, rivaroxaban, LY-517717, DU-176b, DX-9065a, or otamixaban; the thrombin inhibitor is a boroarginine derivative, a boropeptide, a heparin, hirudin, argatroban, dabigatran or AZD-0837; the thrombolytic agent is tissue plasminogen activator (TPA), anistreplase, urokinase, streptokinase, tenecteplase (TNK), or lanoteplase (nPA); the urokinase is dual or single chain urokinase; the cardiac glycoside is digitalis or ouabain; the mineralocorticoid receptor antagonist is sprionolactone or eplirinone; the cholesterol/lipid lowering agent is an HMG-CoA reductase inhibitor selected from pravastatin, lovastatin, atorvastatin, simvastatin, NK-104, itavastatin, nisvastatin, nisbastatin, ZD-4522, rosuvastatin, atavastatin or visastatin; the bile acid sequestrants is questran; the fenofibric acid derivative is gemfibrozil, clofibrat, fenofibrate or benzafibrate; the cholesterol ester transfer protein inhibitors is CP-529414; the anti-diabetic agent is metformin, a glucosidase inhibitor; insulin; a meglitinide; a sulfonylurea; a biguanide/glyburide combination, a thiozolidinedione, a PPAR-alpha agonist, a PPAR-gamma agonist, a PPAR alpha/gamma dual agonist, an SGLT2 inhibitor, an inhibitor of fatty acid binding protein (aP2), a glucagon-like peptide-1 (GLP-I), or a dipeptidyl peptidase IV (DPP4) inhibitor; the anti-depressant agent is nefazodone or sertraline; the anti-inflammatory agent is prednisone, dexamethasone, enbrel, a protein tyrosine kinase (PTK) inhibitor; a cyclooxygenase inhibitor, aspirin, indomethacin, ibuprofen, prioxicam, naproxen, celecoxib or rofecoxib; the anti-osteoporosis agent is alendronate or raloxifene; the anti-obesity agent is orlistat, a P2 inhibitor, a cannabinoid receptor CBl antagonist, AVE-1625, SR-147778, or CP-945598; the anti-anxiety agent is diazepam, lorazepam, buspirone, or hydroxyzine pamoate; the anti-proliferative agent is cyclosporin A, paclitaxel, adriamycin; epithilones, cisplatin, or carboplatin; and the anti-ulcer and gastroesophageal reflux disease agent is famotidine, ranitidine, or omeprazole.

12. A method for treating abnormal thrombus formation, acute myocardial infarction, unstable angina, thromboembolism, acute vessel closure associated with thrombolytic therapy or percutaneous transluminal coronary angioplasty, transient ischemic attacks, stroke, intermittent claudication or bypass grafting of the coronary or peripheral arteries, vessel luminal narrowing, restenosis post coronary or venous angioplasty, maintenance of vascular access patency in long-term hemodialysis patients, pathologic thrombus formation occurring in the veins of the lower extremities following abdominal, knee or hip surgery, pathologic thrombus formation occurring in the veins of the lower extremities following abdominal, knee and hip surgery, a risk of pulmonary thromboembolism, or disseminated systemic intravascular coagulatopathy occurring in vascular systems during septic shock; or treatment or prophylaxis of coronary heart disease, myocardial infarction, angina pectoris, vascular restenosis, restenosis following angioplasty, adult respiratory distress syndrome, and disseminated intravascular clotting disorder, or treatment or prophylaxis of deep vein and proximal vein thrombosis, the method comprising administering to a patient in need thereof an effective dose of a compound as claimed in claim 1, in all its stereoisomeric forms and mixtures thereof in any ratio, or a physiologically tolerable salt thereof.

Details for Patent 8,669,266

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Microbix Biosystems Inc. KINLYTIC urokinase For Injection 021846 01/16/1978 ⤷  Try a Trial 2027-04-23
Janssen Biotech, Inc. REOPRO abciximab Injection 103575 12/22/1994 ⤷  Try a Trial 2027-04-23
Immunex Corporation ENBREL etanercept For Injection 103795 11/02/1998 ⤷  Try a Trial 2027-04-23
Immunex Corporation ENBREL etanercept For Injection 103795 05/27/1999 ⤷  Try a Trial 2027-04-23
Immunex Corporation ENBREL etanercept Injection 103795 09/27/2004 ⤷  Try a Trial 2027-04-23
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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