Claims for Patent: 8,663,656

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Summary for Patent: 8,663,656

Title:	Polypeptide-vaccines for broad protection against hypervirulent meningococcal lineages
Abstract:	A small number of defined antigens can provide broad protection against meningococcal infection, and the invention provides a composition which, after administration to a subject, is able to induce an antibody response in that subject, wherein the antibody response is bactericidal against two or three of hypervirulent lineages A4, ET 5 and lineage 3 of N. meningitidis serogroup B. Rather than consisting of a single antigen, the composition comprises a mixture of 10 or fewer purified antigens, and should not include complex or undefined mixtures of antigens such as outer membrane vesicles. Five protein antigens are used in particular: (1) a ‘NadA’ protein; (2) a ‘741’ protein; (3) a ‘936’ protein; (4) a ‘953’ protein; and (5) a ‘287’ protein.
Inventor(s):	Mariagrazia Pizza
Assignee:	GlaxoSmithKline Biologicals SA
Application Number:	US10/530,753

Details for Patent 8,663,656

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Glaxosmithkline Biologicals	BEXSERO	meningococcal group b vaccine	Injection	125546	January 23, 2015	8,663,656	2023-10-02
Valeant Pharmaceuticals Luxembourg S.à.r.l.	SILIQ	brodalumab	Injection	761032	February 15, 2017	8,663,656	2023-10-02
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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