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Last Updated: December 18, 2025

Claims for Patent: 8,574,869

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Summary for Patent: 8,574,869

Title:	Prevention of disulfide bond reduction during recombinant production of polypeptides
Abstract:	Provided herein are methods for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.
Inventor(s):	Kao Yung-Hsiang, Laird Michael W., Schmidt Melody Trexler, Wong Rita L., Hewitt Daniel P.
Assignee:	Genentech, Inc.
Application Number:	US13354223
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 8,574,869

Details for Patent 8,574,869

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Idec Pharmaceuticals Corp.	RITUXAN	rituximab	Injection	103737	February 19, 2002	8,574,869	2032-01-19
Genentech, Inc.	RAPTIVA	efalizumab	Injection	125075	October 27, 2003	8,574,869	2032-01-19
Genentech, Inc.	AVASTIN	bevacizumab	Injection	125085	February 26, 2004	8,574,869	2032-01-19
Genentech, Inc.	LUCENTIS	ranibizumab	Injection	125156	June 30, 2006	8,574,869	2032-01-19
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 8,574,869

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Country	Patent Number	Estimated Expiration
World Intellectual Property Organization (WIPO)	2009009523	⤷ Get Started Free
United States of America	2025243291	⤷ Get Started Free
United States of America	2024425610	⤷ Get Started Free
United States of America	2024301080	⤷ Get Started Free
>Country	>Patent Number	>Estimated Expiration

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