Claims for Patent: 8,541,607

Summary for Patent: 8,541,607

Title:	Disulfide, sulfide, sulfoxide, and sulfone derivatives of cyclic sugars and uses thereof
Abstract:	In the present invention there are disclosed new derivatives of dianhydrohexite mononitrate corresponding to formula (I), tautomers, pharmaceutically acceptable salts, prodrugs and solvates thereof: ##STR00001## as well as pharmaceutical compositions comprising these compounds and uses thereof.
Inventor(s):	Moliner; Jose Repolles (Barcelona, ES), Perez-Rasilla; Eduardo Salas (Barcelona, ES), Coy; Francisco Pubill (Barcelona, ES)
Assignee:	Lacer, S.A. (Barcelona, ES)
Application Number:	12/755,103
Patent Claims:	1. A method for the treatment of a condition selected from atherosclerosis, endothelial dysfunctions, cardiac allograft vasculopathy, platelet activation, thrombosis, stroke, and/or tissue damage resulting from ischemia or ischemia reperfusion, or symptoms of the above-mentioned conditions, said method comprising administering to a patient a therapeutically effective amount of at least one compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR00037## wherein: n is an integer of 0, 1, or 2, X represents --S(O).sub.m--, --(C.dbd.O)-- or a single bond, wherein m is an integer of 0, 1, or 2, with the proviso that when X represents --(C.dbd.O)-- then n is 0, R represents hydrogen or is a residue R.sup.a, which residue R.sup.a is selected from the group consisting of: C.sub.1-6 alkyl; C.sub.2-6 alkenyl; C.sub.3-8 cycloalkyl; C.sub.3-8 cycloalkyl, wherein one CH.sub.2 group is replaced by O, S, NH or NCH.sub.3; C.sub.4-8 cycloalkenyl; phenyl; pyridyl; thiophenyl; nitrosyl; S-cysteinyl; S-glutathionyl; and ##STR00038## wherein R* is selected from the group consisting of hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.3-8 cycloalkyl, C.sub.4-8 cycloalkenyl, acetyloxy, hydroxyl, ONO.sub.2 and halogen; and wherein R.sup.a optionally is substituted by one to three groups independently selected from C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.3-8 cycloalkyl, C.sub.4-8 cycloalkenyl, acetyloxy, hydroxyl, ONO.sub.2 and halogen, provided that when RXS(O).sub.n -- and --ONO.sub.2 are trans to each other with respect to the ring plane as depicted in formulae (Ia) and (Ib): ##STR00039## then RXS(O).sub.n-- does not represent ##STR00040## wherein Z is an C.sub.1-C.sub.4 alkyl group, aryl group, or an aralkyl group. 2. The method according to claim 1 wherein either one or both of m and n is 0. 3. The method according to claim 1 wherein X represents a single bond or --S--. 4. The method according to claim 1 wherein R represents hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.3-8 cycloalkyl, C.sub.4-8 cycloalkenyl, (C.sub.1-6 alkyl) C.sub.3-8 cycloalkyl, (C.sub.1-6 alkyl) C.sub.4-8 cycloalkenyl, phenyl or (C.sub.l-6 alkyl) phenyl. 5. The method according to claim 1 wherein R is C.sub.1-6 alkyl. 6. The method according to claim 1 wherein the compound according to formula (I) is a compound according to formula (Ic) or (Id): ##STR00041## 7. The method according to claim 1 wherein the compound of formula (I) is selected from: 2-thioisosorbide 5-mononitrate, 5, 5' -dinitrate-2, 2' -dithiodiisosorbide, 2-methylthioisosorbide 5-mononitrate, 2- [(R) -methylsulfinyl]isosorbide 5-mononitrate, 2- [(S) -methylsulfinyl]isosorbide 5-mononitrate, 2-methylsulfinylisosorbide 5-mononitrate, 2-methylsulfonylisosorbide 5-mononitrate, S-nitroso-2-thioisosorbide 5-mononitrate, 2- (tetrahydropyran-2-yl-thio) isosorbide 5-mononitrate, 2- (isosorbidyl-2' -dithio) isosorbide 5-mononitrate, and 2- (5' -acetyloxyisosorbidyl-2' -dithio) isosorbide 5-mononitrate. 8. The method according to claim 1 wherein the compound is 2-acetylthioisosorbide 5-mononitrate, which is represented by the following formula: ##STR00042## 9. The method according to claim 1 which additionally comprises a thrombolytic agent. 10. The method according to claim 9 wherein the thrombolytic agent is a plasminogen activator. 11. The method according to claim 9 wherein the thrombolytic agent is urokinase, streptokinase, alteplase or anistreplase. 12. The method according to claim 1 in which an anticoagulant agent is additionally present. 13. The method according to claim 1 wherein the anticoagulant agent is heparin, dicoumarol, acenocoumarol, enoxaparine or pentosan polysulfate. 14. The method according to claim 1 in which an antithrombotic agent is additionally present. 15. The method according to claim 14 wherein the antithrombotic agents is acetylsalicylic acid, dipyridamole, ticlopidine, clopidrogel, triflusal, pentosan polysulfate or abciximab. 16. The method according to claim 1 in which an immunoglobulin or a fragment thereof having a specificity for glycoprotein IIb/IIIa is additionally present. 17. The method according to claim 1 which additionally comprises an hypolipemiant agent. 18. The method according to claim 17 wherein the hypolipemiant agent is selected from the group consisting of simvastatin, lovastatin, atorvastatin, pravastatin, fluvastatin, eptastatin, lifibrol, acifran, acitemate, flunicate and rosuvastatin. 19. The method according to claim 1 in which an antioxidant/free radical scavenger agent is additionally present. 20. The method according to claim 19 wherein the antioxidant/free radical scavenger agent is selected from the group consisting of nicaraven, ranolazine, emoxipin, glutathione, edaravone, raxofelast, lycopene, N-acetyl-L-cysteine, N-acetyl-D-cysteine, a racemic mixture of N-acetyl-L-cysteine and N-acetyl-D-cysteine, and carvedilol. 21. The method according to claim 1 wherein the pathological conditions where oxidative stress causes or results in pathogenesis is selected from the group consisting of allergies, stroke, Alzheimer's disease, and ischemic cardiovascular disease.

Details for Patent 8,541,607

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Microbix Biosystems Inc.	KINLYTIC	urokinase	For Injection	021846	01/16/1978		2023-10-03
Genentech, Inc.	ACTIVASE	alteplase	For Injection	103172	11/13/1987		2023-10-03
Genentech, Inc.	CATHFLO ACTIVASE	alteplase	For Injection	103172	09/04/2001		2023-10-03
Janssen Biotech, Inc.	REOPRO	abciximab	Injection	103575	12/22/1994		2023-10-03