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Last Updated: September 27, 2020

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Claims for Patent: 8,540,684

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Summary for Patent: 8,540,684
Title:Back pain relief and immuno protection of donor cells
Abstract: The intervertebral disc is avascular. With aging, endplates become occluded by calcified layers, and diffusion of nutrients and oxygen into the disc diminishes. The disc degenerates, and pain ensues. Conduits are delivered and deployed into the intervertebral disc to re-establish the exchange of nutrients and waste between the disc and bodily circulation to stop or reverse disc degeneration and relieve pain. The intervertebral disc installed with semi-permeable conduits may be used as an immuno-isolated capsule to encapsulate donor cells capable of biosynthesizing therapeutic molecules. The semi-permeable conduits establish the exchange of nutrients and therapeutic molecules between disc and bodily circulation to treat a disease without using immuno-suppressive drugs.
Inventor(s): Yeung; Jeffrey E. (San Jose, CA), Yeung; Teresa T. (San Jose, CA)
Assignee: Aleeva Medical Inc. (San Jose, CA)
Application Number:12/930,632
Patent Claims:1. An elongated conduit for re-establishing exchange of nutrients and waste between an intervertebral disc and bodily circulation comprising: capillary action channels within said elongated conduit, a first portion, a middle portion and a second portion, and wherein said first portion is locatable within a patient's nucleus of the intervertebral disc, and said second portion is locatable within the patient's bodily circulation, thereby fluid is drawn through said capillary action channels to re-establish exchange of nutrients and waste between the intervertebral disc and bodily circulation.

2. The elongated conduit of claim 1, wherein said second portion is extended through an endplate and into a vertebra.

3. The elongated conduit of claim 1, wherein said second portion is extended outside the intervertebral disc.

4. The elongated conduit of claim 1, wherein said second portion is extended into a muscle.

5. The elongated conduit of claim 1, wherein said elongated conduit is a tube formed of a biocompatible material.

6. The elongated conduit of claim 1, wherein said elongated conduit is a multi-filament formed of a biocompatible material.

7. The elongated conduit of claim 6, wherein said multi-filament is braided.

8. The elongated conduit of claim 1, wherein said elongated conduit is a sponge formed of a biocompatible material.

9. The elongated conduit of claim 1, wherein said elongated conduit further comprises a plurality of protrusions extending therefrom.

10. The elongated conduit of claim 1, wherein said elongated conduit is formed of a multi-filament portion and a mono-filament portion.

11. The elongated conduit of claim 1, wherein said elongated conduit is formed of a biodegradable material.

12. The elongated conduit of claim 1, wherein said elongated conduit is formed of a non-degradable material.

13. The elongated conduit of claim 1, wherein said elongated conduit further comprises at least one indentation.

14. The elongated conduit of claim 1, wherein said capillary action channels having diameters ranging between 200 microns and 10 nanometers.

15. The elongated conduit of claim 1, further comprising a tube located around said middle portion of said conduit.

16. The elongated conduit of claim 15, wherein said tube is formed of a material chosen from the group of materials consisting of polytetrafluoroethylene, polypropylene, polyethylene, polyamide, polyester, polyurethane, silicon, poly-ether-ether-ketone, acetal resin, polysulfone, polycarbonate and polyethylene glycol.

17. The elongated conduit of claim 1, wherein at least a portion of said elongated conduit is coated with fibrous tissue inhibitor.

18. A treatment kit used to provide immunoisolated retention of donor cells within a patient's intervertebral disc: the elongated conduit of claim 1, and donor cells injectable into the intervertebral disc.

19. The treatment kit of claim 18, wherein the donor cells are from a gland.

20. The treatment kit of claim 18, wherein the donor cells are from tissue.

21. The treatment kit of claim 18, wherein the donor cells have an origin chosen from the group of origins consisting of the pituitary gland, hypothalamus, adrenal gland, adrenal medulla, fat cells, thyroid, parathyroid, pancreas, testes, ovary, pineal gland, adrenal cortex, liver, renal cortex, kidney, thalamus, parathyroid gland, ovary, corpus luteum, placenta, small intestine, skin cells, stem cells, gene therapy, tissue engineering and cell culture.

22. The treatment kit of claim 18, further comprising growth factor injectable into the intervertebral disc.

23. The treatment kit of claim 18, wherein the donor cells are capable of creating a therapeutic product.

24. The treatment kit of claim 18, wherein the donor cells are capable of creating a product chosen from the group of biosynthesized products consisting of adrenaline, adrenocorticotropic hormone, aldosterone, androgens, angiotensinogen (angiotensin I and II), antidiuretic hormone, atrial-natriuretic peptide, calcitonin, calciferol, cholecalciferol, calcitriol, cholecystokinin, corticotropin-releasing hormone, cortisol, dehydroepiandrosterone, dopamine, endorphin, enkephalin, ergocalciferol, erythropoietin, follicle stimulating hormone, gamma aminobutyrate, gastrin, ghrelin, glucagon, glucocorticoids, gonadotropin-releasing hormone, growth hormone-releasing hormone, human chorionic gonadotrophin, human growth hormone, insulin, insulin-like growth factor, leptin, lipotropin, luteinizing hormone, melanocyte-stimulating hormone, melatonin, mineralocorticoids, neuropeptide Y, neurotransmitter, noradrenaline, oestrogens, oxytocin, parathyroid hormone, peptide, pregnenolone, progesterone, prolactin, pro-opiomelanocortin, PYY-336, renin, secretin, somatostatin, testosterone, thrombopoietin, thyroid-stimulating hormone, thyrotropin-releasing hormone, thyroxine, triiodothyronine, trophic hormone, serotonin, and vasopressin.

Details for Patent 8,540,684

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 001 2015-01-23   Start Trial Aleeva Medical Inc. (San Jose, CA) 2024-05-07 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 002 2015-01-23   Start Trial Aleeva Medical Inc. (San Jose, CA) 2024-05-07 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 003 2015-01-23   Start Trial Aleeva Medical Inc. (San Jose, CA) 2024-05-07 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 004 2015-01-23   Start Trial Aleeva Medical Inc. (San Jose, CA) 2024-05-07 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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