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Last Updated: December 31, 2025

Claims for Patent: 8,460,895

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Summary for Patent: 8,460,895

Title:	Method for producing recombinant proteins with a constant content of pCOin the medium
Abstract:	A method for the recombinant production of a polypeptide in a eukaryotic host cell modified in the citrate cycle is described, wherein the method comprises cultivating the eukaryotic host cell in a suitable medium under conditions which allow the expression of the polypeptide, wherein the content of dissolved CO(pCO) in the medium is maintained at a constant value in the range of 10% to 20%.
Inventor(s):	Eisenkraetzer Detlef, Gaetgens Jochen, Jockwer Alexander, Klinger Christian, Noll Thomas, Bezdek-Sueess Barbara
Assignee:	Hoffmann-La Roche Inc.
Application Number:	US12920915
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 8,460,895

Details for Patent 8,460,895

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Idec Pharmaceuticals Corp.	RITUXAN	rituximab	Injection	103737	February 19, 2002	⤷ Get Started Free	2029-03-11
Genentech, Inc.	AVASTIN	bevacizumab	Injection	125085	February 26, 2004	⤷ Get Started Free	2029-03-11
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 8,460,895

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Country	Patent Number	Estimated Expiration
World Intellectual Property Organization (WIPO)	2009112250	⤷ Get Started Free
United States of America	2011159539	⤷ Get Started Free
Japan	5487124	⤷ Get Started Free
>Country	>Patent Number	>Estimated Expiration

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