Claims for Patent: 8,455,489

Summary for Patent: 8,455,489

Title:	Substituted pyrimidine compositions and methods of use
Abstract:	Novel compositions and methods of using substituted pyrimidines which have the general formula: (I). ##STR00001##
Inventor(s):	Martin; Richard (San Diego, CA), Mohan; Raju (Encinitas, CA), Ordentlich; Peter (San Diego, CA)
Assignee:	Exelixis, Inc. (South San Francisco, CA)
Application Number:	10/595,734
Patent Claims:	1. A pharmaceutical composition comprising a compound of formula (I) ##STR00009## or a pharmaceutical acceptable salt thereof, wherein n is 0 to 5; R.sup.1 is each independently selected from the group consisting of halo, cyanato, thiocyanato, selenocyanato, trifluoromethoxy, azido, cyano, nitro, hydroxyl, formyl, mercapto, hydroxycarbonyl, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, alkoxy, aminoalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted cycloalkyl, and optionally substituted heterocyclyl; R.sup.2 is selected from the group consisting of optionally substituted cycloalkyl, optionally substituted aralkyl, --OR.sup.6, --S(O)R.sup.6, --S(O).sub.2R.sup.6, --N(R.sup.9)S(O).sub.tR.sup.10, --C(O)R.sup.6, --C(O)OR.sup.6, and --C(O)N(R.sup.7)R.sup.8; R.sup.3 is independently selected from the group consisting of hydrogen, halo, cyanato, thiocyanato, selenocyanato, trifluoromethoxy, azido, nitro, hydroxyl, mercapto, alkyl, optionally substituted alkenyl, optionally substituted alkynyl, alkoxy, aminoalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted cycloalkyl, and optionally substituted heterocyclyl; and R.sup.4 selected from the group consisting of cyanato, thiocyanato, selenocyanato, trifluoromethoxy, azido, cyano, nitro, hydroxyl, formyl, mercapto, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclyl, optionally substituted heteroaryl, optionally substituted heteroaralkyl, optionally substituted heterocyclylalkyl, --R.sup.12--N(R.sup.14)R.sup.15, --R.sup.12--C(O)R.sup.13, --R.sup.12--C(O)OR.sup.15, --R.sup.12--N(R.sup.14)C(O)R.sup.15, --R.sup.12--N(R.sup.14)C(O)OR.sup.15, --R.sup.12--S(O).sub.tR.sup.15 and --R.sup.12--S(O).sub.tN(R.sup.14)R.sup.15; R.sup.6 represents substituted alkyl, optionally substituted aryl, optionally substituted aralkyl or optionally substituted heterocyclyl; R.sup.7 represents H or optionally substituted alkyl; R.sup.8 represents optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl or optionally substituted heterocyclyl; R.sup.9 represents H or optionally substituted alkyl; R.sup.10 represents optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl or optionally substituted heterocyclyl; R.sup.12 represents a C.sub.1-C.sub.6 alkylene, C.sub.2-C.sub.6 alkenylene, C.sub.2-C.sub.6 alkynylene or C.sub.1-C.sub.6 alkyleneoxy; R.sup.13 represents optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl or optionally substituted heterocyclyl; R.sup.14 represents H or optionally substituted alkyl; R.sup.15 represents optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl or optionally substituted heterocyclyl, and where each t is independently 0 to 2, wherein the optional substituents are independently Q.sup.1, where Q.sup.1 represents alkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, heterocyclylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, cyano, halo, hydroxyl, hydroxycarbonyl, cyanato, thiocyanato, selenocyanato trifluoromethox azido, --R.sup.30--OR.sup.31, --R.sup.30--SR.sup.16, --R.sup.30--N(R.sup.32)(R.sup.33), --R.sup.30--C(J)R.sup.34, --R.sup.30--C(J)OR.sup.31, --R.sup.30--C(J)N(R.sup.31)N(R.sup.32)(R.sup.33), --R.sup.30--N(R.sup.31)C(J)R.sup.34, --R.sup.30--N(R.sup.31)C(J)OR.sup.31, --R.sup.30--N(R.sup.31)C(J)N(R.sup.32)(R.sup.33), --R.sup.30--OC(J)R.sup.34, --R.sup.30--OC(J)OR.sup.31, --R.sup.30--OC(J)N(R.sup.32)(R.sup.33), --Si(R.sup.35).sub.3, --N(R.sup.31)S(O).sub.yR.sup.36 or --R.sup.30--S(O).sub.yR.sup.36; where each R.sup.30 is independently a direct bond or a straight or branched alkylene chain; R.sup.31 and R.sup.34 are each independently hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, cycloalkylalkyl, heterocyclylalkyl, aryl, aralkyl, heteroaryl or heteroaralkyl; R.sup.32 and R.sup.33 are each independently hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, aryl, aralkyl, heteroaryl or heteroaralkyl; or R.sup.32 and R.sup.33 together with the nitrogen atom to which they are attached, form a heterocyclylalkenyl, or heteroaryl; R.sup.35 R.sup.36 and R.sup.16 are each independently alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, aralkyl, heteroaryl or heteroaralkyl; each J is independently O or S; and each y is independently 0 to 2; and a pharmaceutically acceptable excipient. 2. A pharmaceutical composition comprising the compound of formula (II) ##STR00010## wherein n is 0 to 2; p is 0 to 2; X is O, or S(O), where r is 0 to 2; R.sup.1 is each independently selected from the group consisting of halo, cyanato, thiocyanato, selenocyanato, trifluoromethoxy, azido, cyano, nitro, hydroxyl, formyl, mercapto, hydroxycarbonyl, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, alkoxy, aminoalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted cycloalkyl, and optionally substituted heterocyclyl; R.sup.3 is independently selected from the group consisting of hydrogen, halo, cyanato, thiocyanato, selenocyanato, trifluoromethoxy, azido, nitro, hydroxyl, formyl, mercapto, alkyl, optionally substituted alkenyl, optionally substituted alkynyl, alkoxy, aminoalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted cycloalkyl, and optionally substituted heterocyclyl; R.sup.4 selected from the group consisting of cyanato, thiocyanato, selenocyanato, trifluoromethoxy, azido, cyano, nitro, hydroxyl, formyl, mercapto, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclyl, optionally substituted heteroaryl, optionally substituted heteroaralkyl, optionally substituted heterocyclylalkyl, --R.sup.12--OR.sup.13, --R.sup.12--N(R.sup.14)R.sup.15, --R.sup.12--C(O)R.sup.13, --R.sup.12--C(O)OR.sup.15, --R.sup.12--N(R.sup.14)C(O)R.sup.15, --R.sup.12--N(R.sup.14)C(O)OR.sup.15, --R.sup.12--S(O).sub.tR.sup.15 and --R.sup.12--S(O).sub.tN(R.sup.14)R.sup.15; and each R.sup.5 independently selected from the group consisting of halo, cyanato, thiocyanato, selenocyanato, trifluoromethoxy, azido, cyano, hydroxyl, formyl, mercapto, hydroxycarbonyl, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, --OR.sup.20, --S(O).sub.tR.sup.20, --N(R.sup.7)R.sup.20, --N(R.sup.9)S(O).sub.tR.sup.20, --C(O)R.sup.20, and --C(O)OR.sup.20; R.sup.7 and R.sup.9 are each independently H or optionally substituted alkyl; R.sup.12 represents a C.sub.1-C.sub.6 alkylene, C.sub.2-C.sub.6 alkenylene, C.sub.2-C.sub.6 alkynylene or C.sub.1-C.sub.6 alkyleneoxy; R.sup.13 represents optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl or optionally substituted heterocyclyl; R.sup.14 represents H or optionally substituted alkyl; R.sup.15 represents optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl or optionally substituted heterocyclyl; R.sup.20 represents optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl or optionally substituted heterocyclyl and where each t is independently 0 to 2 wherein the optional substituents are independently Q.sup.1, where Q.sup.1 represents alkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, cyano, halo, hydroxyl, hydroxycarbonyl, cyanato, thiocyanato, selenocyanato, trifluoromethoxy, azido, --R.sup.30--OR.sup.31, --R.sup.30--SR.sup.16, --R.sup.30--N(R.sup.32)(R.sup.33), --R.sup.30--C(J)R.sup.34, --R.sup.30--C(J)OR.sup.31, --R.sup.30--C(J)N(R.sup.31)N(R.sup.32)(R.sup.33), --R.sup.30--N(R.sup.31)C(J)R.sup.34, --R.sup.30--N(R.sup.31)C(J)OR.sup.31, --R.sup.30--N(R.sup.31)C(J)N(R.sup.32)(R.sup.33), --R.sup.30--OC(J)R.sup.34, --R.sup.30--OC(J)OR.sup.31, --R.sup.30--OC(J)N(R.sup.32)(R.sup.33), --Si(R.sup.35).sub.3, --N(R.sup.31)S(O).sub.yR.sup.36 or --R.sup.30--S(O).sub.yR.sup.36; where each R.sup.30 is independently a direct bond or a straight or branched alkylene chain; R.sup.31 and R.sup.34 are each independently hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, cycloalkylalkyl, heterocyclylalkyl, aryl, aralkyl, heteroaryl or heteroaralkyl; R.sup.32 and R.sup.33 are each independently hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, aryl, aralkyl, heteroaryl or heteroaralkyl; or R.sup.32 and R.sup.33 together with the nitrogen atom to which they are attached, form a heterocyclylalkenyl, or heteroaryl; R.sup.35 R.sup.36 and R.sup.16 are each independently alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, aralkyl, heteroaryl or heteroaralkyl; each J is independently O or S; and each y is independently 0 to 2; and a pharmaceutically acceptable excipient. 3. The pharmaceutical composition of claim 2 wherein n is 0; p is 0 to 2; X is O, or S(O).sub.r where r is 0 to 2; R.sup.3 is independently selected from the group consisting of hydrogen, halo, cyanato, thiocyanato, selenocyanato, trifluoromethoxy, azido, nitro, hydroxyl, formyl, mercapto, alkyl, optionally substituted alkenyl, optionally substituted alkynyl, alkoxy, aminoalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted cycloalkyl, and optionally substituted heterocyclyl; R.sup.4 selected from the group consisting of cyanato, thiocyanato, selenocyanato, trifluoromethoxy, azido, cyano, nitro, hydroxyl, formyl, mercapto, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclyl, optionally substituted heteroaryl, optionally substituted heteroaralkyl, optionally substituted heterocyclylalkyl, --R.sup.12--OR.sup.13, --R.sup.12--N(R.sup.14)R.sup.15, --R.sup.12--C(O)R.sup.13, --R.sup.12--C(O)OR.sup.15, --R.sup.12--N(R.sup.14)C(O)R.sup.15--R.sup.12--N(R.sup.14)C(O)OR.sup.15, --R.sup.12--S(O).sub.tR.sup.15 and --R.sup.12--S(O).sub.tN(R.sup.14)R.sup.15; each R.sup.5 independently selected from the group consisting of halo, cyanato, thiocyanato, selenocyanato, trifluoromethoxy, azido, cyano, hydroxyl, formyl, mercapto, hydroxycarbonyl, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, --OR.sup.20, --S(O).sub.tR.sup.20, --N(R.sup.7)R.sup.20, --N(R.sup.9)S(O).sub.tR.sup.20, --C(O)R.sup.20, and --C(O)OR.sup.20; R.sup.7 and R.sup.9 are each independently H or optionally substituted alkyl; R.sup.12 represents a C.sub.1-C.sub.6 alkylene, C.sub.2-C.sub.6 alkenylene, C.sub.2-C.sub.6 alkynylene or C.sub.1-C.sub.6 alkyleneoxy; R.sup.13 represents optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl or optionally substituted heterocyclyl; R.sup.14 represents H or optionally substituted alkyl; R.sup.15 represents optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl or optionally substituted heterocyclyl; and R.sup.20 represents optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl or optionally substituted heterocyclyl, and where each t is independently 0 to 2. 4. The pharmaceutical composition of claim 2 wherein n is 0 to 2; p is 0 to 2; X is O, or S(O).sub.r, where r is 0 to 2; R.sup.1 is each independently selected from the group consisting of halo, cyanato, thiocyanato, selenocyanato, trifluoromethoxy, azido, cyano, nitro, hydroxyl, formyl, mercapto, hydroxycarbonyl, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, alkoxy, aminoalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted cycloalkyl, and optionally substituted heterocyclyl; R.sup.3 is independently selected from the group consisting of hydrogen, halo, cyanato, thiocyanato, selenocyanato, trifluoromethoxy, azido, nitro, hydroxyl, formyl, mercapto, lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, lower alkoxy, and lower aminoalkyl; R.sup.4 selected from the group consisting of cyanato, thiocyanato, selenocyanato, trifluoromethoxy, azido, cyano, nitro, hydroxyl, formyl, mercapto, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclyl, optionally substituted heteroaryl, optionally substituted heteroaralkyl, optionally substituted heterocyclylalkyl, --R.sup.12--OR.sup.13, --R.sup.12--N(R.sup.14)R.sup.15, --R.sup.12--C(O)R.sup.13, --R.sup.12--C(O)OR.sup.15, --R.sup.12--N(R.sup.14)C(O)R.sup.15, --R.sup.12--N(R.sup.14)C(O)OR.sup.15, --R.sup.12--S(O).sub.tR.sup.15 and --R.sup.12--S(O).sub.tN(R.sup.14)R.sup.15; each R.sup.5 independently selected from the group consisting of halo, cyanato, thiocyanato, selenocyanato, trifluoromethoxy, azido, cyano, hydroxyl, formyl, mercapto, hydroxycarbonyl, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, --OR.sup.20, --S(O).sub.tR.sup.20, --N(R.sup.7)R.sup.20, --N(R.sup.9)S(O).sub.tR.sup.20, --C(O)R.sup.20, and --C(O)OR.sup.20; R.sup.7 represents H or optionally substituted alkyl; each R.sup.9 is independently H or optionally substituted alkyl; R.sup.12 represents a C.sub.1-C.sub.6 alkylene, C.sub.2-C.sub.6 alkenylene, C.sub.2-C.sub.6 alkynylene or C.sub.1-C.sub.6 alkyleneoxy; R.sup.13 represents optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl or optionally substituted heterocyclyl; R.sup.14 represents H or optionally substituted alkyl; R.sup.15 represents optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl or optionally substituted heterocyclyl; R.sup.20 is represents optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl or optionally substituted heterocyclyl, and where each t is independently 0 to 2. 5. The pharmaceutical composition of claim 2 wherein n is 0 to 2; p is 0 to 2; X is O, or S(O).sub.r where r is 0 to 2; R.sup.1 is each independently selected from the group consisting of halo, cyanato, thiocyanato, selenocyanato, trifluoromethoxy, azido, cyano, nitro, hydroxyl, formyl, mercapto, hydroxycarbonyl, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, alkoxy, aminoalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted cycloalkyl, and optionally substituted heterocyclyl; R.sup.3 is independently selected from the group consisting of hydrogen, halo, cyanato, thiocyanato, selenocyanato, trifluoromethoxy, azido, nitro, hydroxyl, formyl, mercapto, alkyl, optionally substituted alkenyl, optionally substituted alkynyl, alkoxy, aminoalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted cycloalkyl, and optionally substituted heterocyclyl; and R.sup.4 selected from the group consisting of cyanato, thiocyanato, selenocyanato, trifluoromethoxy, azido, cyano, nitro, hydroxyl, formyl, mercapto, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, optionally substituted heteroaralkyl, --R.sup.12--OR.sup.13, --R.sup.12--N(R.sup.14)R.sup.15, --R.sup.12--C(O)R.sup.13--R.sup.12--C(O)OR.sup.15, --R.sup.12--N(R.sup.14)C(O)R.sup.15, and --R.sup.12--S(O).sub.tR.sup.15; each R.sup.5 independently selected from the group consisting of halo, cyanato, thiocyanato, selenocyanato, trifluoromethoxy, azido, cyano, hydroxyl, formyl, mercapto, hydroxycarbonyl, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, --OR.sup.20, --S(O).sub.tR.sup.20, --N(R.sup.7)R.sup.20, --N(R.sup.9)S(O).sub.tR.sup.20, --C(O)R.sup.20, and --C(O)OR.sup.20; R.sup.7 represents H or optionally substituted alkyl; each R.sup.9 is independently H or optionally substituted alkyl; R.sup.12 represents a C.sub.1-C.sub.6 alkylene, C.sub.2-C.sub.6 alkenylene, C.sub.2-C.sub.6 alkynylene or C.sub.1-C.sub.6 alkyleneoxy; R.sup.13 represents optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl or optionally substituted heterocyclyl; R.sup.14 represents H or optionally substituted alkyl; R.sup.15 represents optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl or optionally substituted heterocyclyl; R.sup.20 represents optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl or optionally substituted heterocyclyl, and where each t is independently 0 to 2. 6. The pharmaceutical composition of claim 2 wherein n is 0 to 2; p is 0 to 2; X is O, or S(O).sub.r where r is 0 to 2; R.sup.1 is each independently selected from the group consisting of halo, cyanato, thiocyanato, selenocyanato, trifluoromethoxy, azido, cyano, nitro, hydroxyl, formyl, mercapto, hydroxycarbonyl, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, alkoxy, aminoalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted cycloalkyl, and optionally substituted heterocyclyl; R.sup.3 is independently selected from the group consisting of hydrogen, halo, cyanato, thiocyanato, selenocyanato, trifluoromethoxy, azido, nitro, hydroxyl, formyl, mercapto, alkyl, optionally substituted alkenyl, optionally substituted alkynyl, alkoxy, aminoalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted cycloalkyl, and optionally substituted heterocyclyl; R.sup.4 selected from the group consisting of cyanato, thiocyanato, selenocyanato, trifluoromethoxy, azido, cyano, nitro, hydroxyl, formyl, mercapto, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclyl, optionally substituted heteroaryl, optionally substituted heteroaralkyl, optionally substituted heterocyclylalkyl, --R.sup.12--OR.sup.13, --R.sup.12--N(R.sup.14)R.sup.15, --R.sup.12--C(O)R.sup.13, --R.sup.12--C(O)OR.sup.15, --R.sup.12--N(R.sup.14)C(O)R.sup.15, --R.sup.12--N(R.sup.14)C(O)OR.sup.15, --R.sup.12--S(O).sub.tR.sup.15 and --R.sup.12--S(O).sub.tN(R.sup.14)R.sup.15; each R.sup.5 independently selected from the group consisting of halo, cyano, hydroxyl, formyl, hydroxycarbonyl, optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, --OR.sup.20, --S(O).sub.tR.sup.20, --N(R.sup.7)R.sup.20, --C(O)R.sup.20, and --C(O)OR.sup.20; R.sup.7 represents H or optionally substituted alkyl; each R.sup.9 is independently H or optionally substituted alkyl; R.sup.12 represents a C.sub.1-C.sub.6 alkylene, C.sub.2-C.sub.6 alkenylene, C.sub.2-C.sub.6 alkynylene, or C.sub.1-C.sub.6 alkyleneoxy; R.sup.13 represents optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl or optionally substituted heterocyclyl; R.sup.14 represents H or optionally substituted alkyl; R.sup.15 represents optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl or optionally substituted heterocyclyl and R.sup.20 represents optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl or optionally substituted heterocyclyl, and where each t is independently 0 to 2. 7. The pharmaceutical composition of claim 2 wherein n is 0 or 1; p is 1 to 2; X is S(O).sub.r, where r is 0; R.sup.1 is each independently selected from the group consisting of halo, cyanato, thiocyanato, selenocyanato, trifluoromethoxy, azido, cyano, nitro, hydroxyl, hydroxycarbonyl, optionally substituted alkyl, alkoxy, and aminoalkyl; R.sup.3 is independently selected from the group consisting of hydrogen, halo, cyanato, thiocyanato, selenocyanato, trifluoromethoxy, azido, nitro, hydroxyl, formyl, mercapto, lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, lower alkoxy, lower aminoalkyl; R.sup.4 selected from the group consisting of cyanato, thiocyanato, selenocyanato, trifluoromethoxy, azido, cyano, nitro, hydroxyl, formyl, mercapto, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, optionally substituted heteroaralkyl, --R.sup.12--OR.sup.13, --R.sup.12--N(R.sup.14)R.sup.15, --R.sup.12--C(O)R.sup.13, --R.sup.12--C(O)OR.sup.15, --R.sup.12--N(R.sup.14)C(O)R.sup.15, --R.sup.12--S(O).sub.tR.sup.15; each R.sup.5 independently selected from the group consisting of halo, cyano, nitro, hydroxyl, formyl, hydroxycarbonyl, optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, --OR.sup.20, --S(O).sub.tR.sup.20, --N(R.sup.7)R.sup.20, --C(O)R.sup.20, and --C(O)OR.sup.20; R.sup.7 represents H or optionally substituted alkyl; each R.sup.9 is independently H or optionally substituted alkyl; R.sup.12 represents a C.sub.1-C.sub.6 alkylene, C.sub.2-C.sub.6 alkenylene, C.sub.2-C.sub.6 alkynylene, or C.sub.1-C.sub.6 alkyleneoxy; R.sup.13 represents optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl or optionally substituted heterocyclyl; R.sup.14 represents H or optionally substituted alkyl; R.sup.15 represents optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl or optionally substituted heterocyclyl; R.sup.20 represents optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl or optionally substituted heterocyclyl, and where each t is independently 0 to 2. 8. The pharmaceutical composition of claim 2 wherein n is 0 or 1; p is 1 to 2; X is O; R.sup.1 is each independently selected from the group consisting of halo, cyanato, thiocyanato, selenocyanato, trifluoromethoxy, azido, cyano, nitro, hydroxyl, hydroxycarbonyl, optionally substituted alkyl, alkoxy, and aminoalkyl; R.sup.3 is independently selected from the group consisting of hydrogen, halo, cyanato, thiocyanato, selenocyanato, trifluoromethoxy, azido, nitro, hydroxyl, formyl, mercapto, lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, alkoxy, and lower aminoalkyl; R.sup.4 selected from the group consisting of cyanato, thiocyanato, selenocyanato, trifluoromethoxy, azido, cyano, nitro, hydroxyl, formyl, mercapto, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, optionally substituted heteroaralkyl, --R.sup.12--OR.sup.13, --R.sup.12--N(R.sup.14)R.sup.15, --R.sup.12--C(O)R.sup.13, --R.sup.12--C(O)OR.sup.15, --R.sup.12--N(R.sup.14)C(O)R.sup.15, and --R.sup.12--S(O).sub.tR.sup.15; each R.sup.5 independently selected from the group consisting of halo, cyano, hydroxyl, formyl, hydroxycarbonyl, optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, --OR.sup.20, --S(O).sub.tR.sup.20, --N(R.sup.7)R.sup.20, --C(O)R.sup.20, and --C(O)OR.sup.20; R.sup.7 represents H or optionally substituted alkyl; each R.sup.9 is independently H or optionally substituted alkyl; R.sup.12 represents a C.sub.1-C.sub.6 alkylene, C.sub.2-C.sub.6 alkenylene, C.sub.2-C.sub.6 alkynylene, or C.sub.1-C.sub.6 alkyleneoxy; R.sup.13 represents optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl or optionally substituted heterocyclyl; R.sup.14 represents H or optionally substituted alkyl; R.sup.15 represents optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl or optionally substituted heterocyclyl and R.sup.20 represents optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl or optionally substituted heterocyclyl, and where each t is independently 0 to 2. 9. The pharmaceutical composition of claim 2 wherein n is 0 or 1; p is 1 to 2; X is S(O).sub.r where r is 2; R.sup.1 is each independently selected from the group consisting of halo, cyanato, thiocyanato, selenocyanato, trifluoromethoxy, azido, cyano, nitro, hydroxyl, hydroxycarbonyl, optionally substituted alkyl, alkoxy, and aminoalkyl; R.sup.3 is independently selected from the group consisting of hydrogen, halo, cyanato, thiocyanato, selenocyanato, trifluoromethoxy, azido, nitro, hydroxyl, formyl, mercapto, lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, lower alkoxy, and lower aminoalkyl; R.sup.4 selected from the group consisting of cyanato, thiocyanato, selenocyanato, trifluoromethoxy, azido, cyano, nitro, hydroxyl, formyl, mercapto, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, optionally substituted heteroaralkyl, --R.sup.12--OR.sup.13, --R.sup.12--N(R.sup.14)R.sup.15, --R.sup.12--C(O)R.sup.13, --R.sup.12--C(O)OR.sup.15, --R.sup.12--N(R.sup.14)C(O)R.sup.15, and --R.sup.12--S(O).sub.tR.sup.15; each R.sup.5 independently selected from the group consisting of halo, cyano, hydroxyl, formyl, hydroxycarbonyl, optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, --OR.sup.20, --S(O).sub.tR.sup.20, --N(R.sup.7)R.sup.20, --C(O)R.sup.20, and --C(O)OR.sup.20; R.sup.7 represents H or optionally substituted alkyl; each R.sup.9 is independently H or optionally substituted alkyl; R.sup.12 represents a C.sub.1-C.sub.6 alkylene, C.sub.2-C.sub.6 alkenylene, C.sub.2-C.sub.6 alkynylene, or C.sub.1-C.sub.6 alkyleneoxy; R.sup.13 represents optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl or optionally substituted heterocyclyl; R.sup.14 represents H or optionally substituted alkyl; R.sup.15 represents optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl or optionally substituted heterocyclyl; R.sup.20 represents optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl or optionally substituted heterocyclyl, and where each t is independently 0 to 2. 10. The pharmaceutical composition of claim 1 wherein each t is independently 0 or 2. 11. The pharmaceutical composition of claim 1 wherein the optional substituents are independently Q.sup.1, wherein Q.sup.1 represents alkyl, alkoxy, aminoalkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, heterocyclylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, cyano, halo, hydroxyl, hydroxycarbonyl cyanato, thiocyanato, selenocyanato, trifluoromethoxy or azido. 12. A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound selected from the group consisting of: 4-(4-nitrophenoxy)-2,6-diphenylpyrimidine; 2-(4-bromophenyl)-4-phenoxy-6-phenylpyrimidine; 2,4-diphenyl-6-(4-propylphenoxy)pyrimidine; 4-(2,6-diphenylpyrimidin-4-yloxy)benzaldehyde; 4-(2,6-diphenylpyrimidin-4-yloxy)benzonitrile; 4-phenoxy-2,6-diphenylpyrimidine; 4-(2-(4-bromophenyl)-6-phenylpyrimidin-4-yloxy)benzonitrile; 2-(4-bromophenyl)-4-methyl-6-phenoxypyrimidine; 4-(biphenyl-4-yloxy)-2-(4-bromophenyl)-6-phenylpyrimidine; 4-(4-butylphenoxy)-2,6-diphenylpyrimidine; 4-(biphenyl-4-yloxy)-2-(4-bromophenyl)-6-methylpyrimidine; 1-(4-(2-(4-bromophenyl)-6-methylpyrimidin-4-yloxy)phenyl)ethanone; 2-(4-(biphenyl-4-yloxy)-6-methylpyrimidin-2-yl)phenol; 2-(4-bromophenyl)-4-methyl-6-(4-nitrophenoxy)pyrimidine; 2-(4-bromophenyl)-4-methyl-6-(4-propylphenoxy)pyrimidine; 4-((4-chlorophenylthio)methyl)-2-phenyl-6-(phenylthio)pyrimidine; 4-(4-chlorophenylthio)-6-((4-chlorophenylthio)methyl)-2-phenylpyrimidine; 2-phenyl-4-(phenylsulfonylmethyl)-6-(phenylthio)pyrimidine; 4-phenoxy-2-phenyl-6-(phenylsulfonylmethyl)pyrimidine; 4-(4-chlorophenylthio)-2-phenyl-6-(phenylsulfonylmethyl)pyrimidine; 4-((4-chlorophenylsulfinyl)methyl)-6-phenoxy-2-phenylpyrimidine; 4-((4-chlorophenylsulfinyl)methyl)-6-(4-chlorophenylthio)-2-phenylpyrimid- ine; 2-phenyl-4-(phenylsulfinylmethyl)-6-(phenylthio)pyrimidine; 4-phenoxy-2-phenyl-6-(phenylsulfonylmethyl)pyrimidine; 4-phenoxy-2-phenyl-6-(phenylsulfinylmethyl)pyrimidine; 4-(methylthiomethyl)-2-phenyl-6-(phenylthio)pyrimidine; 4-(methylthiomethyl)-2-phenyl-6-(3-(trifluoromethyl)phenylthio)pyrimidine- ; 4-(methylthiomethyl)-6-phenoxy-2-phenylpyrimidine; 4-(4-chlorophenylthio)-6-(methylsulfonylmethyl)-2-phenylpyrimidine; methyl 2-(6-(methylsulfonylmethyl)-2-phenylpyrimidin-4-ylthio)benzoate; 4-(2,3-dichlorophenylthio)-6-(methoxymethyl)-2-phenylpyrimidine; 4-(2,6-dichlorophenylthio)-6-(methoxymethyl)-2-phenylpyrimidine; 4-(2,4-dichlorophenylthio)-6-(methoxymethyl)-2-phenylpyrimidine; 4-(4-bromophenylthio)-6-(methoxymethyl)-2-phenylpyrimidine; 4-(methoxymethyl)-6-(4-methoxyphenylthio)-2-phenylpyrimidine; 4-(4-bromophenylthio)-2-phenyl-6-(phenylthiomethyl)pyrimidine; 4-(4-chlorophenylthio)-6-(methoxymethyl)-2-phenylpyrimidine; 4-((4-chlorophenylthio)methyl)-2-phenyl-6-(p-tolylthio)pyrimidine; 4-((4-chlorophenylthio)methyl)-6-(2,6-dichlorophenylthio)-2-phenylpyrimid- ine; 4-(3-chlorophenylthio)-6-((4-chlorophenylthio)methyl)-2-phenylpyrimid- ine; 4-((4-chlorophenylthio)methyl)-6-(2,4-dichlorophenylthio)-2-phenylpyr- imidine; 4-((4-chlorophenylthio)methyl)-6-(4-methoxyphenylthio)-2-phenylpy- rimidine; 4-(4-chlorophenylthio)-6-((4-chlorophenylthio)methyl)-2-phenylpy- rimidine; 4-((4-chlorophenylthio)methyl)-6-(4-fluorophenylthio)-2-phenylpy- rimidine; 4-(4-bromophenylthio)-6-(methylsulfonylmethyl)-2-phenylpyrimidin- e; methyl 4-(2,6-diphenylpyrimidin-4-yloxy)benzoate; methyl 4-(2-(4-bromophenyl)-6-methylpyrimidin-4-yloxy)benzoate; 4-(2-(2-hydroxyphenyl)-6-methylpyrimidin-4-yloxy)benzoic acid; and 4-(biphenyl-4-yloxy)-6-methyl-2-phenylpyrimidine. 13. A pharmaceutical composition comprising the composition of claim 1 and an additional therapeutically active compound. 14. The pharmaceutical composition of claim 13, wherein said additional therapeutically active compound is selected from levodopa (L-dihydroxyphenylalanine), L-aromatic amino acid decarboxylase (AADC) inhibitors and catechol O-methyl transferase (COMT) inhibitors. 15. The pharmaceutical composition of claim 13, wherein said additional therapeutically active compound is selected from an anti-inflammatory compound. 16. The pharmaceutical composition of claim 15, wherein said anti-inflammatory compound is selected from a matrix metalloproteinase inhibitor, an inhibitor of pro-inflammatory cytokines , non-steroidal anti-inflammatory drugs (NSAIDs), prostaglandin synthase inhibitors, cyclooxygenase-1 (COX-1) or cyclooxygenase-2 (COX-2) inhibitors, or corticosteroids. 17. The pharmaceutical composition of claim 13, wherein said additional therapeutically active compound is selected from an antihyperlipidemic agent; a plasma high-density lipoprotein (HDL)-raising agent; an antihypercholesterolemic agent; an acyl-coenzyme A cholesterol acyltransferase (ACAT) inhibitor; probucol; nicotinic acid and the salts thereof and niacinamide; a cholesterol absorption inhibitor; a bile acid sequestrant anion exchange resin; an LDL (low density lipoprotein) receptor inducer; ciofibrate; bezafibrate; fenofibrate; gemfibrizo; vitamin B.sub.6 (pyridoxine) and the pharmaceutically acceptable salts thereof; vitamin B.sub.12 (cyanocobalamin); vitamin B.sub.3 ; anti-oxidant vitamins; a beta-blocker; liver X receptor (LXR) .alpha. or .beta. agonists, antagonists, or partial agonists, farnesoid X receptor (FXR) agonists, antagonists, or partial agonists, an angiotensin II antagonist; an angiotensin converting enzyme inhibitor; and a platelet aggregation inhibitor and aspirin. 18. The pharmaceutical composition of claim 13, wherein said additional therapeutically active compound comprises parathyroid hormone (PTH) or human parathyroid hormone fragment (hPTHF) 1-34. 19. A pharmaceutical composition comprising a compound selected from the group consisting of: 4-(6-methyl-2-phenylpyrimidin-4-ylamino)benzoic acid; 4-(5-allyl-6-methyl-2-phenylpyrimidin-4-ylamino)benzoic acid; and 3-(6-methyl-2-phenylpyrimidin-4-ylamino)benzoic acid; and a pharmaceutically acceptable excipient. 20. A pharmaceutical composition comprising a compound of formula (I) ##STR00011## or a pharmaceutical acceptable salt thereof, wherein n is 0 to 5; R.sup.1 is each independently selected from the group consisting of halo, cyanato, thiocyanato, selenocyanato, trifluoromethoxy, azido, cyano, nitro, hydroxyl, formyl, mercapto, hydroxycarbonyl, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, alkoxy, aminoalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted cycloalkyl, and optionally substituted heterocyclyl; R.sup.2 is selected from the group consisting of optionally substituted cycloalkyl, optionally substituted aralkyl, --OR.sup.6, --S(O)R.sup.6, --S(O).sub.2R.sup.6, --N(R.sup.9)S(O).sub.tR.sup.10, --C(O)R.sup.6, --C(O)OR.sup.6, and --C(O)N(R.sup.7)R.sup.8; R.sup.3 is independently selected from the group consisting of hydrogen, halo, cyanato, thiocyanato, selenocyanato, trifluoromethoxy, azido, nitro, hydroxyl, mercapto, alkyl, optionally substituted alkenyl, optionally substituted alkynyl, alkoxy, aminoalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted cycloalkyl, and optionally substituted heterocyclyl; and R.sup.4 selected from the group consisting of cyanato, thiocyanato, selenocyanato, trifluoromethoxy, azido, cyano, nitro, hydroxyl, formyl, mercapto, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclyl, optionally substituted heteroaryl, optionally substituted heteroaralkyl, optionally substituted heterocyclylalkyl, --R.sup.12--OR.sup.13, --R.sup.12--N(R.sup.14)R.sup.15, --R.sup.12--C(O)R.sup.13, --R.sup.12--C(O)OR.sup.15, R.sup.12--N(R.sup.14)C(O)R.sup.15, --R.sup.12--N(R.sup.14)C(O)OR.sup.15, --R.sup.12--S(O).sub.tR.sup.15 and --R.sup.12--S(O).sub.tN(R.sup.14)R.sup.15; R.sup.6 represents substituted alkyl, optionally substituted aryl, optionally substituted aralkyl or optionally substituted heterocyclyl; R.sup.7 represents H or optionally substituted alkyl; R.sup.8 represents optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl or optionally substituted heterocyclyl; R.sup.9 represents H or optionally substituted alkyl; R.sup.10 represents optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl or optionally substituted heterocyclyl; R.sup.12 represents a C.sub.1-C.sub.6 alkylene, C.sub.2-C.sub.6 alkenylene, C.sub.2-C.sub.6 alkynylene or C.sub.1-C.sub.6 alkyleneoxy; R.sup.13 represents optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl or optionally substituted heterocyclyl; R.sup.14 represents H or optionally substituted alkyl; R.sup.15 represents optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl or optionally substituted heterocyclyl, and where each t is independently 0 to 2, wherein the optional substituents are independently Q.sup.1, where Q.sup.1 represents alkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, heterocyclylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, cyano, halo, hydroxyl, hydroxycarbonyl, cyanato, thiocyanato, selenocyanato, trifluoromethoxy, azido, --R.sup.30--OR.sup.31, --R.sup.30--SR.sup.16, --R.sup.30--N(R.sup.32)(R.sup.33), --R.sup.30--C(J)R.sup.34, --R.sup.30--C(J)OR.sup.31, --R.sup.30--C(J)N(R.sup.31)N(R.sup.32)(R.sup.33), --R.sup.30--N(R.sup.31)C(J)R.sup.34, --R.sup.30--N(R.sup.31)C(J)OR.sup.31, --R.sup.30--N(R.sup.31)C(J)N(R.sup.32)(R.sup.33), --R.sup.30--OC(J)R.sup.34, --R.sup.30--OC(J)OR.sup.31, --R.sup.30--OC(J)N(R.sup.32)(R.sup.33), --Si(R.sup.35).sub.3, --N(R.sup.31)S(O).sub.yR.sup.36 or --R.sup.30--S(O).sub.yR.sup.36; where each R.sup.30 is independently a direct bond or a straight or branched alkylene chain; R.sup.31 and R.sup.34 are each independently hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, cycloalkylalkyl, heterocyclylalkyl, aryl, aralkyl, heteroaryl or heteroaralkyl; R.sup.32 and R.sup.33 are each independently hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, aryl, aralkyl, heteroaryl or heteroaralkyl; or R.sup.32 and R.sup.33 together with the nitrogen atom to which they are attached, from a heterocyclylalkenyl, or heteroaryl; R.sup.35 R.sup.36 and R.sup.16 are each independently alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, aralkyl, heteroaryl or heteroaralkyl; each J is independently O or S; and each y is independently 0 to 2; and a pharmaceutically acceptable excipient.

Details for Patent 8,455,489

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Nps Pharmaceuticals, Inc.	NATPARA	parathyroid hormone	For Injection	125511	01/23/2015		2023-11-10