Claims for Patent: 8,435,551

Summary for Patent: 8,435,551

Title:	Cancellous construct with support ring for repair of osteochondral defects
Abstract:	The invention is directed toward an osteochondral repair assembly comprising a shaped allograft construct comprising an unbalanced barbell-shaped cylindrical cancellous bone primary member formed with a mineralized cylindrical base section having a smaller diameter cylindrical stem leading to a second cylindrical section which is demineralized. A mineralized ring-shaped support member is forced over the compressed demineralized second demineralized the aperture of the ring-shaped member to fit around the stem with one ring surface being adjacent the bottom surface to the second cylindrical section and the opposite ring surface being adjacent the upper surface of the mineralized cylindrical base section.
Inventor(s):	Semler; Eric J. (Piscataway, NJ), Shikhanovich; Roman (Edison, NJ), Callahan; Alex B. (Perth Amboy, NJ), Truncale; Katherine Gomes (Hillsborough, NJ), Yannariello-Brown; Judith I. (Somerset, NJ), Huang; Yen-Chen (East Brunswick, NJ)
Assignee:	Musculoskeletal Transplant Foundation (Edison, NJ)
Application Number:	12/508,892
Patent Claims:	1. A construct for repairing an osteochondral defect, comprising: a ring-shaped member having a top surface, a bottom surface, an outer diameter and an inner diameter, said inner diameter being defined by an aperture extending from said top surface to said bottom surface; and a base member derived from bone and having a longitudinal axis, which defines an axial direction, said base member having a first section arranged along said longitudinal axis proximate a first end of said base member, said first section being substantially mineralized and having a first diameter, a stem section arranged along said longitudinal axis, said stem section having one end attached to said first section and a second diameter that is less than said first diameter, and a second section arranged along said longitudinal axis proximate a second end of said base member opposite said first end thereof, said second section having a top surface, a bottom surface, and a thickness that substantially matches the thickness of a patient's surrounding native articular cartilage layer, said second section being attached to another end of said stem section opposite said one end thereof, and said second section being substantially demineralized to thereby provide said second section with an elastic quality that renders said second section deformable from a first condition, in which said second section has a third diameter that is greater than said inner diameter of said ring-shaped member, to a second condition, in which said second section is insertable through said aperture of said ring-shaped member, whereby said ring-shaped member is mountable around said stem section between said first and second sections such that said bottom surface of said second section engages said top surface of said ring-shaped member. 2. The construct as recited in claim 1, wherein each of said first and second sections has a cylindrical shape; and wherein said stem section has a cylindrical shape and said second diameter thereof is smaller than said first diameter of said first section and smaller than said third diameter of said second section, whereby said base member has a barbell-like shape. 3. The construct as recited in claim 1, wherein said ring-shaped member is formed from allograft bone. 4. The construct as recited in claim 1, wherein said second section of said base member is non-osteoinductive. 5. The construct as recited in claim 1, wherein said base member is formed from allograft cancellous bone. 6. The construct as recited in claim 1, wherein said inner diameter of said ring-shaped member is similar to said second diameter of said stem section. 7. The construct as recited in claim 1, wherein said inner diameter of said ring-shaped member is larger than said second diameter of said stem section by about 10% to about 40%. 8. The construct as recited in claim 1, wherein said ring-shaped member is constructed of materials taken from a group consisting of allograft bone, xenograft bone, ceramics and biocompatible plastic polymers. 9. The construct as recited in claim 1, wherein said second section of said base member contains milled allograft cartilage particles. 10. The construct as recited in claim 9, wherein said second section of said base member also contains a biocompatible carrier for said cartilage particles. 11. The construct as recited in claim 9, wherein said cartilage particles contain growth factors. 12. The construct as recited in claim 11, wherein said growth factors are selected from the group consisting of TGF-.beta., FGF-2 and BMP-2. 13. The construct as recited in claim 9, wherein said cartilage particles contain at least one additive taken from a group consisting of growth factors, variants of said growth factors, human chondrocytes, human bone marrow cells, stem cells, insulin, insulin-like growth factor-1, transforming growth factor-B, interleukin-1receptor antagonist, hepatocyte growth factor, platelet-derived growth factor, Indian hedgehog and parathyroid hormone-related peptide, bioactive glue, viral vectors for growth factor or DNA delivery, nanoparticles, and platelet-rich plasma. 14. The construct as recited in claim 13, wherein said growth factors include FGF-2, FGF-5, FGF-7, FGF-9, FGF-11 and FGF-21. 15. The construct as recited in claim 9, wherein said cartilage particles are freeze-milled. 16. The construct as recited in claim 1, wherein at least one of said base member and said ring-shaped member contains at least one additive taken from a group consisting of growth factors, variants of said growth factors, human chondrocytes, human bone marrow cells, stem cells, demineralized bone matrix, cartilage particles, insulin, insulin-like growth factor-1, transforming growth factor-B, interleukin-1 receptor antagonist, hepatocyte growth factor, platelet-derived growth factor, Indian hedgehog and parathyroid hormone-related peptide, bioactive glue, viral vectors for growth factor delivery, viral vectors for DNA delivery, nanoparticles, and platelet-rich plasma. 17. The construct as recited in claim 16, wherein said second section of said base member contains said at least one additive. 18. The construct as recited in claim 1, wherein said second section of said base member contains at least one chondrogenic additive and said first section of said base member contains at least one osteogenic additive. 19. The construct as recited in claim 9, wherein said cartilage particles have a size within a range of from about 10 microns to about 212 microns. 20. The construct as recited in claim 1, whereby said first and second sections of said base member are arranged coaxially relative to said longitudinal axis of said base member. 21. The construct as recited in claim 20, wherein said stem section of said base member is arranged coaxially relative to said first and second sections of said base member.

Details for Patent 8,435,551

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Nps Pharmaceuticals, Inc.	NATPARA	parathyroid hormone	For Injection	125511	01/23/2015		2027-03-06