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Last Updated: April 26, 2024

Claims for Patent: 8,404,230

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Summary for Patent: 8,404,230

Title:	Therapeutic combination comprising a pulmonary surfactant and antioxidant enzymes
Abstract:	Administration of an exogenous pulmonary surfactant in combination with antioxidant enzymes is effective for the prevention of bronchopulmonary dysplasia (BPD) and decreases the markers of pulmonary oxidative stress.
Inventor(s):	Dani; Carlo (Parma, IT)
Assignee:	Chiesi Farmaceutici S.p.A. (Parma, IT)
Application Number:	13/402,148
Patent Claims:	1. A method for reducing pulmonary oxidative damage, comprising administering an effective amount of a pharmaceutical composition comprising a modified natural pulmonary surfactant selected from the group consisting of poractant alfa, calfactant, bovactant, and beractant in combination with CuZn superoxide dismutase at a unit dose of from 2000 to 10000 U/kg and catalase at a unit dose of from 2000 to 4000 U/kg, to a subject in need thereof. 2. A method according to claim 1, wherein said surfactant is poractant alfa. 3. A method according to claim 2, wherein poractant alfa is present in an amount of from 100 to 200 mg/kg. 4. A method according to claim 1, wherein the unit dose of CuZn superoxide dismutase is from 2500 to 6000 U/kg. 5. A method according to claim 1, wherein the unit dose of catalase is from 2500 to 3500 U/kg. 6. A method for reducing the risk of developing bronchopulmonary dysplasia, comprising administering an effective amount of a pharmaceutical composition comprising a modified natural pulmonary surfactant selected from the group consisting of poractant alfa, calfactant, bovactant, and beractant in combination with CuZn superoxide dismutase at a unit dose of from 2000 to 10000 U/kg and catalase at a unit dose of from 2000 to 4000 U/kg, to a subject in need thereof. 7. A method according to claim 6, wherein said surfactant is poractant alfa. 8. A method according to claim 7, wherein poractant alfa is present in an amount of from 100 to 200 mg/kg. 9. A method according to claim 8, wherein the unit dose of CuZn superoxide dismutase is from 2500 to 6000 U/kg. 10. A method according to claim 6, wherein the unit dose of catalase is from 2500 to 3500 U/kg. 11. A method according to claim 6, wherein said subject is a preterm infant.

Details for Patent 8,404,230

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Abbvie Inc.	SURVANTA	beractant	Suspension	020032	07/01/1991	⤷ Try a Trial	2029-09-08
Ony Biotech Inc.	INFASURF	calfactant	Suspension	020521	07/01/1998	⤷ Try a Trial	2029-09-08
Ony Biotech Inc.	INFASURF	calfactant	Suspension	020521	12/12/2002	⤷ Try a Trial	2029-09-08
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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