Claims for Patent: 8,241,623

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Summary for Patent: 8,241,623

Title:	Protease sensitivity expression system
Abstract:	The present invention uses co-expression of protease inhibitors and protease sensitive therapeutic agents that results in their localized production within the target tissue and inactivation outside of the target tissue, thereby increasing therapeutic activity and reducing the systemic toxicity. Inactivation is also accomplished by engineering protease degradation sites within the therapeutic construct for proteases, preferably those that are under-expressed within the target tissue yet present in non-target tissues within the body, resulting in therapeutic activity within the target tissue and inactivation outside of the target tissue. Novel chimeric proteins secreted by bacteria are also described. The chimeric proteins include chimeric toxins targeted to neoplastic cells and cells of the immune system. Novel combination therapies of these protease inhibitor:chimeric toxin-expressing bacteria together with small-molecule and biologic agents are also described. Non-conjugative bacteria capable of delivering phage/phagemids expression cassettes for DNA and RNA-based therapeutics are also described.
Inventor(s):	David Bermudes
Assignee:	Individual
Application Number:	US12/703,158

Details for Patent 8,241,623

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Alexion Pharmaceuticals, Inc.	SOLIRIS	eculizumab	Injection	125166	March 16, 2007	8,241,623	2030-02-09
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 8,241,623

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Country	Patent Number	Estimated Expiration
United States of America	9657085	⤷ Get Started Free
United States of America	9200289	⤷ Get Started Free
United States of America	8623350	⤷ Get Started Free
United States of America	11485773	⤷ Get Started Free
United States of America	10590185	⤷ Get Started Free
>Country	>Patent Number	>Estimated Expiration

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