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Last Updated: April 26, 2024

Claims for Patent: 8,133,492

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Summary for Patent: 8,133,492

Title:	Pneumococcus polysaccharide-related vaccines
Abstract:	This invention provides novel nitrocellulose-based or Hydrogel-based microarrays and methods of making and using them (1) to detect the presence of one or more agents in a sample, (2) to determine the amount of one or more agents in a sample, (3) to determine whether a subject is afflicted with a disorder, and (4) to determine whether an agent known to specifically bind to a first compound also specifically binds to a second compound. This invention also provides kits which comprise the instant microarrays. This invention further provides antibodies capable of specifically binding to a glycomer present both on the surface of a mammalian macrophage or intestinal epithelial cell, and on a bacterial cell. Finally, this invention provides diagnostic methods using the instant antibodies.
Inventor(s):	Wang; Denong (Middletown City, NY)
Assignee:	The Trustees of Columbia University in the City of New York (New York, NY)
Application Number:	11/472,731
Patent Claims:	1. A cell-free anti-anthrax composition of matter comprising a Pneumococcus type 23 capsular polysaccharide conjugated with Bacillus anthracis protective antigen (PA), wherein the Pneumococcus type 23 capsular polysaccharide cross-reacts with antibodies against Bacillus anthracis spores and comprises L-rhamnose. 2. The composition of matter of claim 1, wherein the Pneumococcus type 23 capsular polysaccharide is the tetrasaccharide unit: ##STR00001## 3. A method for immunizing a subject against Bacillus anthracis infection comprising administering to the subject the composition of matter of claim 1. 4. The method of claim 3, wherein the subject is a mammal. 5. The method of claim 4, wherein the mammal is a human.

Details for Patent 8,133,492

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Emergent Biodefense Operations Lansing Llc	BIOTHRAX	anthrax vaccine adsorbed	Injection	103821	11/12/1998	⤷ Try a Trial	2023-02-14
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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