Claims for Patent: 8,084,466

Summary for Patent: 8,084,466

Title:	Bicyclic heteroaryl-substituted imidazoles as modulators of the histamine H.sub.4 receptor
Abstract:	Bicyclic heteroaryl-substituted imidazole compounds are described, which are useful as H.sub.4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the modulation of histamine H.sub.4 receptor activity and for the treatment of disease states, disorders, and conditions mediated by H.sub.4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.
Inventor(s):	Kindrachuk; David E. (Cardiff by the Sea, CA), Venable; Jennifer D. (Solana Beach, CA)
Assignee:	Janssen Pharmaceutica NV (Beerse, BE)
Application Number:	12/316,835
Patent Claims:	1. A chemical entity selected from the group consisting of compounds of Formula (I), and pharmaceutically acceptable salts of compounds of Formula (I): ##STR00152## wherein R.sup.1 is: a) an imidazol-2-yl ring, substituted with one or two R.sup.a substituents; where each R.sup.a substitutent is independently C.sub.1-4a1kyl, CF.sub.3, or a phenyl ring unsubstituted or substituted with one or two substituents independently selected from methyl, halo, and CF.sub.3; b) a benzimidazol-2-yl ring, unsubstituted or substituted with one or two R.sup.b substituents; where each R.sup.b substituent is independently C.sub.1-4alkyl, C.sub.2-4alkenyl, C.sub.2-4alkynyl, phenyl, --CF.sub.3, --OCF.sub.3, --CN, halo, --NO.sub.2, --OC.sub.1-4alkyl, --SC.sub.1-4alkyl, --S(O)C.sub.1-4alkyl, --SO.sub.2C.sub.1-4alkyl, --C(O)C.sub.1-4alkyl, --C(O)phenyl, --C(O)NR.sup.cR.sup.d, --CO.sub.2C.sub.1-4alkyl, --CO.sub.2H, --C(O)NR.sup.cR.sup.d, or --NR.sup.cR.sup.d; where R.sup.c and R.sup.d are each independently H or C.sub.1-4alkyl; or two R.sup.b substituents on adjacent carbon atoms taken together form --O(CH.sub.2).sub.1-2O--; or c) a ring system selected from the group consisting of: ##STR00153## each ring system unsubstituted or substituted with C.sub.1-4alkyl, CF.sub.3, or halo; A is N or CR.sup.e; where R.sup.3 is H, methyl, or halo; each R.sup.2 substituent is independently H, methyl, or halo; X is --(CH.sub.2).sub.2--, --C(R.sup.f).dbd.C(R.sup.g)--, or --N.dbd.CH--, where R.sup.f is H, methyl, halo, or --CH.sub.2N(CH.sub.3).sub.2; and R.sup.g is H or methyl; m is 1 or 2; n is 1 or 2; Z is N or CH; and R.sup.3 is H or C.sub.1-4alkyl. 2. A chemical entity as in claim 1, wherein R.sup.1 is an imidazol-2-yl ring, substituted with one or two R.sup.a substituents. 3. A chemical entity as in claim 2, wherein each R.sup.a substituent is independently methyl, propyl, CF.sub.3, phenyl, 4-methylphenyl, 3-trifluoromethylphenyl, 4-chlorophenyl, 4-trifluoromethylphenyl, or 3,5-dichlorophenyl. 4. A chemical entity as in claim 1, wherein R.sup.1 is a benzimidazol-2-yl ring, unsubstituted or substituted with one or two R.sup.b substituents. 5. A chemical entity as in claim 4, wherein each R.sup.b substituent is independently methyl, tert-butyl, fluoro, chloro, CF.sub.3, --CO.sub.2CH.sub.3, or benzoyl. 6. A chemical entity as in claim 1, wherein A is N. 7. A chemical entity as in claim 1, wherein A is CR.sup.e, and R.sup.e is H, methyl, or chloro. 8. A chemical entity as in claim 1, wherein each R.sup.2 substituent is independently H, methyl, fluoro, or chloro. 9. A chemical entity as in claim 1, wherein X is --C(R.sup.f).dbd.C(R.sup.g)--or --N.dbd.CH--. 10. A chemical entity as in claim 9, wherein R.sup.f is H, methyl, or chloro. 11. A chemical entity as in claim 9, wherein R.sup.g is H or methyl. 12. A chemical entity as in claim 1, wherein n is 1. 13. A chemical entity as in claim 1, wherein Z is CH. 14. A chemical entity as in claim 1, wherein R.sup.3 is H or methyl. 15. An chemical entity selected from the group consisting of: 5-Fluoro-4-methyl-2-{4-methyl-1-[3-(1-methyl-piperidin-4-yl)-propyl]-2,3-- dihydro-1H-indol-5-yl}-1H-benzoimidazole; 4,5-Dimethyl-2-{4-methyl-1-[3-(1-methyl-piperidin-4-yl)-propyl]-2,3-dihyd- ro-1H-indol-5-yl}-1H-benzoimidazole; 2-{4-Chloro-1-[3-(1-methyl-piperidin-4-yl)-propyl]-2,3-dihydro-1H-indol-5- -yl}-4,6-dimethyl-1H-benzoimidazole; 2-{4-Chloro-1-[3-(1-methyl-piperidin-4-yl)-propyl]-2,3-dihydro-1H-indol-5- -yl}-5-fluoro-4-methyl-1 H-benzoimidazole; 2-{4-Chloro-1-[3-(1-methyl-piperidin-4-yl)-propyl]-2,3-dihydro-1H-indol-5- -yl}-1H-benzoimidazole-5-carboxylic acid methyl ester; 5-Fluoro-2-{4-fluoro-1-[3-(1-methyl-piperidin-4-yl)-propyl]-2,3-dihydro-1- H-indol-5-yl}-4-methyl-1H-benzoimidazole; 5-Fluoro-4-methyl-2-{4-methyl-1-[3-(1-methyl-piperidin-4-yl)-propyl]-1H-i- ndol-5-yl}-1H-benzoimidazole; 2-{4-Chloro-1-[3-(1-methyl-piperidin-4-yl)-propyl]-1H-indol-5-yl}-5-fluor- o-4-methyl-1H-benzoimidazole; 2-{4-Chloro-1-[3-(1-methyl-piperidin-4-yl)-propyl]-1H-indol-5-yl}-4,6-dim- ethyl-1H-benzoimidazole; 5-Chloro-2-{4-methyl-1-[3-(1-methyl-piperidin-4-yl)-propyl]-1H-indol-5-yl- }-1H-benzoimidazole; 5-Fluoro-4-methyl-2-{1-[3-(1-methyl-piperidin-4-yl)-propyl]-1H-indol-5-yl- }-1H-benzoimidazole; 4-Methyl-2-{1-[3-(1-methyl-piperidin-4-yl)-propyl]-1H-indol-5-yl}-1H-benz- oimidazole; 5-Fluoro-4-methyl-2-{1-[3-(4-methyl-piperazin-1-yl)-propyl]-1H-indol-5-yl- }-1H-benzoimidazole; 2-{2,3-Dimethyl-1-[3-(1-methyl-piperidin-4-yl)-propyl]-1H-indol-5-yl}-4,6- -dimethyl-1H-benzoimidazole; 2-{2,3-Dimethyl-1-[3-(1-methyl-piperidin-4-yl)-propyl]-1H-indol-5-yl}-5-f- luoro-4-methyl-1H-benzoimidazole; 5-Fluoro-4-methyl-2-{1-[4-(1-methyl-piperidin-4-yl)-butyl]-1H-indol-4-yl}- -1H-benzoimidazole; 4-Chloro-2-{1-[4-(1-methyl-piperidin-4-yl)-butyl]-1H-indol-4-yl}-1H-benzo- imidazole; 2-{1-[4-(1-Methyl-piperidin-4-yl)-butyl]-1H-indol-4-yl}-5-trifl- uoromethyl-1H-benzoimidazole; 6-{1-[4-(1-Methyl-piperidin-4-yl)-butyl]-1H-indol-4-yl}-5H-[1,3]dioxolo[4- ',5':4,5]benzo[1,2-d]imidazole; (2-{1-[4-(1-Methyl-piperidin-4-yl)-butyl]-1H-indol-4-yl}-1H-benzoimidazol- -5-yl)-phenyl-methanone; 2-{1-[4-(1-Methyl-piperidin-4-yl)-butyl]-1H-indol-4-yl}-1H-naphtho[2,3-d]- imidazole; 6-Chloro-4-methyl-2-{1-[4-(1-methyl-piperidin-4-yl)-butyl]-1H-i- ndol-4-yl}-1H-benzoimidazole; 4-Methyl-2-{1-[4-(1-methyl-piperidin-4-yl)-butyl]-1H-indol-4-yl}-1H-benzo- imidazole; 5-tert-Butyl-2-{1-[4-(1-methyl-piperidin-4-yl)-butyl]-1H-indol-- 4-yl}-1H-benzoimidazole; 4,6-Dimethyl-2-{1-[4-(1-methyl-piperidin-4-yl)-butyl]-1H-indol-6-yl}-1H-b- enzoimidazole; 5-Fluoro-4-methyl-2-{1-[4-(1-methyl-piperidin-4-yl)-butyl]-1H-indol-6-yl}- -1H-benzoimidazole; 4-Methyl-2-{1-[4-(1-methyl-piperidin-4-yl)-butyl]-1H-indol-6-yl}-1H-benzo- imidazole; 5-tert-Butyl-2-{3-chloro-1-[3-(1-methyl-piperidin-4-yl)-propyl]- -1H-indol-5-yl}-1H-benzoimidazole; 6-Chloro-2-{3-chloro-1-[3-(1-methyl-piperidin-4-yl)-propyl]-1H-indol-5-yl- }-4-methyl-1H-benzoimidazole; 2-{3-Chloro-1-[4-(1-methyl-piperidin-4-yl)-butyl]-1H-indol-4-yl}-5-triflu- oromethyl-1H-benzoimidazole; 2-{3-Chloro-1-[4-(1-methyl-piperidin-4-yl)-butyl]-1H-indol-4-yl}-5-fluoro- -4-methyl-1H-benzoimidazole; 2-{3-Chloro-1-[4-(1-methyl-piperidin-4-yl)-butyl]-1H-indol-4-yl}-5,6-difl- uoro-1H-benzoimidazole; 5-Fluoro-4-methyl-2-[1-(3-piperazin-1-yl-propyl)-1H-indol-5-yl]-1H-benzoi- midazole; 5-tert-Butyl-2-[3-chloro-1-(3-piperidin-4-yl-propyl)-1H-indol-5-- yl]-1H-benzoimidazole; 5-Fluoro-4-methyl-2-[1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-1H-benzoim- idazole; 4-Chloro-2-[1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-1H-benzoimi- dazole; 4,6-Dimethyl-2-[1-(4-piperidin-4-yl-butyl)-1H-indol-6-yl]-1H-benzo- imidazole; 5-Fluoro-4-methyl-2-[1-(4-piperidin-4-yl-butyl)-1H-indol-6-yl]-- 1H-benzoimidazole; [5-(5-tert-Butyl-1H-benzoimidazol-2-yl)-1-(4-piperidin-4-yl-butyl)-1H-ind- ol-3-ylmethyl]-dimethyl-amine; 5-Fluoro-4-methyl-1'-[3-(1-methyl-piperidin-4-yl)-propyl]-1H,1'H-[2,5']bi- benzoimidazolyl; 5-Fluoro-4-methyl-3'-[3-(1-methyl-piperidin-4-yl)-propyl]-1H,3'H-[2,5']bi- benzoimidazolyl; 4-Methyl-1'[4-(1-methyl-piperidin-4-yl)-butyl]-1H,1'H-[2,5']bibenzoimidaz- olyl; 4-Methyl-3'[4-(1-methyl-piperidin-4-yl)-butyl]-1H,3'H-[2,5']bibenzoi- midazolyl; 5-Fluoro-4-methyl-1'-[4-(1-methyl-piperidin-4-yl)-butyl]-1H,1'H- -[2,5']bibenzoimidazolyl; 5-Fluoro-4-methyl-3'-[4-(1-methyl-piperidin-4-yl)-butyl]-1H,3'H-[2,5']bib- enzoimidazolyl; 5-Fluoro-4-methyl-2-{1-[3-(1-methyl-piperidin-4-yl)-propyl]-1H-pyrrolo[2,- 3-b]pyridin-5-yl}-1H-benzoimidazole; 4,5-Dimethyl-2-{1-[3-(1-methyl-pipendin-4-yl)-propyl]-1H-pyrrolo[2,3-b]py- ridin-5-yl}-1H-benzoimidazole; 2-{6-Chloro-1-[3-(1-methyl-pipendin-4-yl)-propyl]-1H-indol-5-yl}-4,6-difl- uoro-1H-benzoimidazole; 2-[6-Chloro-1-(3-pipendin-4-yl-propyl)-1H-indol-5-yl]-5-fluoro-4-methyl-1- H-benzoimidazole; 2-{6-Chloro-1-[3-(1-methyl-pipendin-4-yl)-propyl]-1H-indol-5-yl}-5-fluoro- -4-methyl-1H-benzoimidazole; 5-Fluoro-4,4'-dimethyl-1'-[3-(1-methyl-pipendin-4-yl)-propyl]-1H,1'H-[2,5- ']bibenzoimidazolyl; 5,4'-Trimethyl-1'-[3-(1-methyl-pipendin-4-yl)-propyl]-1H,1'H-[2,5']bibenz- oimidazolyl; 4,4'-Dimethyl-1'-[3-(1-methyl-pipendin-4-yl)-propyl]-1H,1'H-[2,5']bibenzo- imidazolyl; 5-Chloro-4,4'-dimethyl-1'-[3-(1-methyl-pipendin-4-yl)-propyl]-1H,1'H-[2,5- ']bibenzoimidazolyl; 6-Fluoro-4,4'-dimethyl-1'-[3-(1-methyl-pipendin-4-yl)-propyl]-1H,1'H-[2,5- ']bibenzoimidazolyl; 4,5-Dimethyl-2-[1-(3-pipendin-4-yl-propyl)-2,3-dihydro-1H-indol-5-yl]-1H-- benzoimidazole; 4,6-Dimethyl-2-{4-methyl-1-[3-(1-methyl-pipendin-4-yl)-propyl]-2,3-dihydr- o-1H-indol-5-yl}-1H-benzoimidazole; 5-Chloro-2-{4-methyl-1-[3-(1-methyl-pipendin-4-yl)-propyl]-2,3-dihydro-1H- -indol-5-yl}-1H-benzoimidazole; 6-Fluoro-4-methyl-2-{4-methyl-1-[3-(1-methyl-pipendin-4-yl)-propyl]-2,3-d- ihydro-1H-indol-5-y}1H-benzoimidazole; 2-Methyl-7-{4-methyl-1-[3-(1-methyl-pipendin-4-yl)-propyl]-2,3-dihydro-1H- -indol-5-yl}-6H-imidazo[4',5':3,4]benzo[2,1-d]thiazole; 4,6-Dimethyl-2-{4-methyl-1-[3-(1-methyl-pipendin-4-yl)-propyl]-1H-indol-5- -yl}-1H-benzoimidazole; 4,5-Dimethyl-2-[1-(3-piperazin-1-yl-propyl)-1H-indol-5-yl]-1H-benzoimidaz- ole; 5-tert-Butyl-2-[1-(3-piperazin-1-yl-propyl)-1H-indol-5-yl]-1H-benzoim- idazole; 5-Chloro-2-[1-(3-piperazin-1-yl-propyl)-1H-indol-5-yl]-1H-benzoim- idazole; 5-Chloro-2-{1-[3-(4-methyl-piperazin-1-yl)-propyl]-1H-indol-5-yl}- -1H-benzoimidazole; 4-Methyl-2-[1-(4-pipendin-4-yl-butyl)-1H-indol-4-yl]-1H-benzoimidazole; 5,6-Difluoro-2-{1-[4-(1-methyl-pipendin-4-yl)-butyl]-1H-indol-4-yl}-1H-be- nzoimidazole; 5-Chloro-2-{1-[4-(1-methyl-pipendin-4-yl)-butyl]-1H-indol-4-yl}-1H-benzoi- midazole; 5-Fluoro-2-{1-[4-(1-methyl-pipendin-4-yl)-butyl]-1H-indol-4-yl}-- 1H-benzoimidazole; 4,6-Difluoro-2-{1-[4-(1-methyl-pipendin-4-yl)-butyl]-1H-indol-4-yl}-1H-be- nzoimidazole; 2-{1-[4-(1-Methyl-pipendin-4-yl)-butyl]-1H-indol-4-yl}-1H-naphtho[1,2-d]i- midazole; (2-{3-Chloro-1-[4-(1-methyl-pipendin-4-yl)-butyl]-1H-indol-4-yl}- -3H-benzoimidazol-4-yl)-phenyl-methanone; 2-[3-Chloro-1-(4-pipendin-4-yl-butyl)-1H-indol-4-yl]-4,5-dimethyl-1H-benz- oimidazole; 2-{3-Chloro-1-[4-(1-methyl-piperidin-4-yl)-butyl]-1H-indol-4-yl}-4,5-dime- thyl-1H-benzoimidazole; 2-{3-Chloro-1-[4-(1-methyl-piperidin-4-yl)-butyl]-1H-indol-4-yl}-4,5-difl- uoro-1H-benzoimidazole; 6-[1-(4-Piperidin-4-yl-butyl)-1H-indol-4-yl]-5H-[1,3]dioxolo[4',5':4,5]-b- enzo[1,2-d]imidazole; Phenyl-{2-[1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-1H-benzoimidazol-5-y- l}-methanone; 4,5-Dimethyl-2-{1-[4-(1-methyl-piperidin-4-yl)-butyl]-1H-indol-4-yl}-1H-b- enzoimidazole; 1-[3-(4-Methyl-piperazin-1-yl)-propyl]-5-[5-methyl-4-(3-trifluoromethyl-p- henyl)-1H-imidazol-2-yl]-1H-indole; 5-[4-(4-Chloro-phenyl)-5-methyl-1H-imidazol-2-yl]-1-[3-(4-methyl-piperazi- n-1-yl)-propyl]-1H-indole; 4-Methyl-1-[3-(1-methyl-piperidin-4-yl)-propyl]-5-(4-methyl-5-propyl-1H-i- midazol-2-yl)-1H-benzoimidazole; 4-Methyl-1-[3-(1-methyl-piperidin-4-yl)-propyl]-5-[4-methyl-5-(4-trifluor- omethyl-phenyl)-1H-imidazol-2-yl]-1H-benzoimidazole; 5-[5-(3,5-Dichloro-phenyl)-4-methyl-1H-imidazol-2-yl]-4-methyl-1-[3-(1-me- thyl-piperidin-4-yl)-propyl]-1H-benzoimidazole; 4-Methyl-1-[3-(1-methyl-piperidin-4-yl)-propyl]-5-(5-phenyl-4-trifluorome- thyl-1H-imidazol-2-yl)-1H-benzoimidazole; 5-[5-(4-Chloro-phenyl)-4-p-tolyl-1H-imidazol-2-yl]-4-methyl-1-[3-(1-methy- l-piperidin-4-yl)-propyl]-1H-benzoimidazole; {5-(5-Fluoro-4-methyl-1H-benzoimidazol-2-yl)-1-[3-(1-methyl-piperidin-4-y- l)-propyl]-1H-indol-3-ylmethyl}-dimethyl-amine; 2-[3-Chloro-1-(3-piperidin-4-yl-propyl)-1H-indol-5-yl]-5-fluoro-4-methyl-- 1H-benzoimidazole; 2-{3-Chloro-1-[3-(1-methyl-piperidin-4-yl)-propyl]-1H-indol-5-yl}-5-fluor- o-4-methyl-1H-benzoimidazole; 2-[2,3-Dimethyl-1-(3-piperidin-4-yl-propyl)-1H-indol-5-yl]-4,6-dimethyl-1- H-benzoimidazole; 2-[2,3-Dimethyl-1-(3-piperidin-4-yl-propyl)-1H-indol-5-yl]-5-fluoro-4-met- hyl-1H-benzoimidazole; 5-Fluoro-4-methyl-2-[1-(3-piperidin-4-yl-propyl)-1H-pyrrolo[2,3-b]pyridin- -5-yl]-1H-benzoimidazole; 5-tert-Butyl-2-{1-[3-(1-methyl-piperidin-4-yl)-propyl]-1H-pyrrolo[2,3-b]p- yridin-5-yl}-1H-benzoimidazole; 5-Fluoro-4-methyl-2-[1-(3-piperidin-4-yl-propyl)-2,3-dihydro-1H-indol-5-y- l]-1H-benzoimidazole; 5-Chloro-2-[1-(3-piperidin-4-yl-propyl)-2,3-dihydro-1H-indol-5-yl]-1H-ben- zoimidazole; 4-Methyl-2-[1-(3-piperidin-4-yl-propyl)-2,3-dihydro-1H-indol-5-yl]-1H-ben- zoimidazole; 5-Fluoro-4-methyl-2-{1-[3-(1-methyl-piperidin-4-yl)-propyl]-2,3-dihydro-1- H-indol-5-yl}-1H-benzoimidazole; 5-Chloro-2-{1-[3-(1-methyl-piperidin-4-yl)-propyl]-2,3-dihydro-1H-indol-5- -yl}-1H-benzoimidazole; 4-Methyl-2-{1-[3-(1-methyl-piperidin-4-yl)-propyl]-2,3-dihydro-1H-indol-5- -yl}-1H-benzoimidazole; 2-[6-Chloro-1-(3-piperidin-4-yl-propyl)-1H-indol-5-yl]-4,6-difluoro-1H-be- nzoimidazole; 2-[6-Chloro-1-(3-piperidin-4-yl-propyl)-1H-indol-5-yl]-4,5-dimethyl-1H-be- nzoimidazole; 5-Chloro-2-[6-chloro-1-(3-piperidin-4-yl-propyl)-1H-indol-5-yl]-1H-benzoi- midazole; 5-Chloro-2-{6-chloro-1-[3-(1-methyl-piperidin-4-yl)-propyl]-1H-i- ndol-5-yl}-1H-benzoimidazole; 2-{6-Chloro-1-[3-(1-methyl-piperidin-4-yl)-propyl]-1H-indol-5-yl}-4,5-dim- ethyl-1H-benzoimidazole; 6-Chloro-4-methyl-2-[1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-1H-benzoim- idazole; 5-tert-Butyl-2-[1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-1H-benz- oimidazole; 6,7-Dimethyl-2-[1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-1H-benzoimidazo- le; 4-Methyl-2-[1-(4-piperidin-4-yl-butyl)-1H-indol-6-yl]-1H-benzoimidazol- e; 6-Chloro-4-methyl-2-[1-(4-piperidin-4-yl-butyl)-1H-indol-6-yl]-1H-benzo- imidazole; 5-tert-Butyl-2-[1-(4-piperidin-4-yl-butyl)-1H-indol-6-yl]-1H-be- nzoimidazole; 4,5-Difluoro-2-[1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-1H-benzoimidazo- le; 4,4'-Dimethyl-1'-(3-piperidin-4-yl-propyl)-1H,1'H-[2,5']bibenzoimidazo- lyl; 6-Fluoro-4,4'-dimethyl-1'-(3-piperidin-4-yl-propyl)-1H,1'H-[2,5']bibe- nzoimidazolyl; 5-Chloro-4,4'-dimethyl-1'-(3-piperidin-4-yl-propyl)-1H,1'H-[2,5']bibenzoi- midazolyl; 5-Fluoro-4,4'-dimethyl-1'-(3-piperidin-4-yl-propyl)-1H,1'H-[2,5- ']bibenzoimidazolyl; 5-Fluoro-2-[1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-1H-benzoimidazole; 4,6-Difluoro-2-[1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-1H-benzoimidazo- le; 4-Methyl-1'-(4-piperidin-4-yl-butyl)-1H,1'H-[2,5']bibenzoimidazolyl; 4,5-Dimethyl-1'-(4-piperidin-4-yl-butyl)-1H,1'H-[2,5']bibenzoimidazolyl; 5-Fluoro-1'-(4-piperidin-4-yl-butyl)-1H,1'H-[2,4']bibenzoimidazolyl; 5-Fluoro-1'[4-(1-methyl-piperidin-4-yl)-butyl]-1H,1'H-[2,5']bibenzoimidaz- olyl; 4,5-Dimethyl-1'[4-(1-methyl-piperidin-4-yl)-butyl]-1H,1'H-[2,5']bibe- nzoimidazolyl; 4-Methyl-3'-(4-piperidin-4-yl-butyl)-1H,3'H-[2,5']bibenzoimidazolyl; 4,5-Dimethyl-3'-(4-piperidin-4-yl-butyl)-1H,3'H-[2,5']bibenzoimidazolyl; 5-Fluoro-3'-(4-piperidin-4-yl-butyl)-1H,3'H-[2,5']bibenzoimidazolyl; 4,5-Dimethyl-3'[4-(1-methyl-piperidin-4-yl)-butyl]-1H,3'H-[2,5']bibenzoim- idazolyl; 5-Fluoro-3'[4-(1-methyl-piperidin-4-yl)-butyl]-1H,3'H [2,5']bibenzoimidazolyl; 2-[1-(4-Piperidin-4-yl-butyl)-1H-indol-4-yl]-1H-naphtho[2,3-d]imidazole; 2-[1-(4-Piperidin-4-yl-butyl)-1H-indol-4-yl]-1H-naphtho[1,2-d]imidazole; {2-[3-Chloro-1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-1H-benzoimidazol-5- -yl}-phenyl-methanone; 2-[3-Chloro-1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-5-trifluoromethyl-1- H-benzoimidazole; 2-[3-Chloro-1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-5,6-difluoro-1H-ben- zoimidazole; 2-[3-Chloro-1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-4,5-difluoro-1H-ben- zoimidazole; 2-[3-Chloro-1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-5-fluoro-4-methyl-1- H-benzoimidazole; 7-[3-Chloro-1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-2-methyl-8H-imidazo- [4',5':3,4]benzo[1,2-d]thiazole; 2-[3-Chloro-1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-3H-benzoimidazole-5- -carboxylic acid methyl ester; 7-{3-Chloro-1-[4-(1-methyl-piperidin-4-yl)-butyl]-1H-indol-4-yl}-2-methyl- -8H-imidazo[4',5':3,4]benzo[1,2-d]thiazole; 2-{3-Chloro-1-[4-(1-methyl-piperidin-4-yl)-butyl]-1H-indol-4-yl}-3H-benzo- imidazole-5-carboxylic acid methyl ester; 4,5,4'-Trimethyl-1'-(3-piperidin-4-yl-propyl)-1H,1'H-[2,5']bibenzoimidazo- lyl; 4,6-Dimethyl-2-[1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-1H-benzoimi- dazole; 6-Chloro-2-[1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-1H-benzoimid- azole; 2-[1-(4-Piperidin-4-yl-butyl)-1H-indol-4-yl]-6-trifluoromethyl-1H-b- enzoimidazole; 4-Methyl-1-[3-(1-methyl-piperidin-4-yl)-propyl]-5-[4-methyl-5-(4-trifluor- omethyl-phenyl)-1H-imidazol-2-yl]-1H-benzoimidazole; 5-[5-(4-Methoxy-phenyl)-4-methyl-1H-imidazol-2-yl]-4-methyl-1-[3-(1-methy- l-piperidin-4-yl)-propyl]-1H-benzoimidazole; and pharmaceutically acceptable salts, thereof. 16. A pharmaceutical composition comprising an effective amount of at least one chemical entity selected from compounds of Formula (I), and pharmaceutically acceptable salts of compounds of Formula (I). 17. A pharmaceutical composition as in claim 16, wherein said at least one chemical entity is selected from the group consisting of: 5-Fluoro-4-methyl-2-{4-methyl-1-[3-(1-methyl-piperidin-4-yl)-propyl]-2,3-- dihydro-1H-indol-5-yl}-1H-benzoimidazole; 4,5-Dimethyl-2-{4-methyl-1-[3-(1-methyl-piperidin-4-yl)-propyl]-2,3-dihyd- ro-1H-indol-5-yl}-1H-benzoimidazole; 2-{4-Chloro-1-[3-(1-methyl-piperidin-4-yl)-propyl]-2,3-dihydro-1H-indol-5- -yl}-4,6-dimethyl-1H-benzoimidazole; 2-{4-Chloro-1-[3-(1-methyl-piperidin-4-yl)-propyl]-2,3-dihydro-1H-indol-5- yl}-5-flouro-4methyl-1H-benzoimidazole; 2-{4-Chloro-1-[3-(1-methyl-piperidin-4-yl)-propyl]-2,3-dihydro-1H-indol-5- -yl}-1H-benzoimidazole-5-carboxylic acid methyl ester; 5-Fluoro-2-{4-fluoro-1-[3-(1-methyl-piperidin-4-yl)-propyl]-2,3-dihydro-1- H-indol-5-yl}-4methyl-1H-benzoimidazole; 5-Fluoro-4-methyl-2-{4-methyl-1-[3-(1-methyl-piperidin-4-yl)-propyl]-1H-i- ndol-5-yl}-1H-benzoimidazole; 2-{4-Chloro-1-[3-(1-methyl-piperidin-4-yl)-propyl]-1H-indol-5-yl}-5-fluor- o-4-methyl-1H-benzoimidazole; 2-{4-Chloro-1-[3-(1-methyl-piperidin-4-yl)-propyl]-1H-indol-5-yl}-benzoim- idazole; 5-Chloro-2-{4-methyl-1-[3-(1-methyl-piperidin-4-yl)-propyl]-1H-in- dol-5-yl}-1H-benzoimidazole; 5-Fluoro-4-methyl-2-{1-[3-(1-methyl-piperidin-4-yl)-propyl]-1H-indol-5-yl- }-1H-benzoimidazole; 4-Methyl-2-{1-[3-(1-methyl-piperidin-4-yl)-propyl]-1H-indol-5-yl}-1H-benz- oimidazole; 5-Fluoro-4-methyl-2-{1-[3-(4-methyl-piperazin-1-yl)-propyl]-1H-indol-5-yl- }-1H-benzoimidazole; 2-{2,3-Dimethyl-1-[3-(1-methyl-piperidin-4-yl)-propyl]-1H-indol-5-yl}-4,6- -dimethyl-1H-benzoimidazole; 2-{2,3-Dimethyl-1-[3-(1-methyl-piperidin-4-yl)-propyl]-1H-indol-5-yl}-5-f- luoro-4-methyl-1H-benzoimidazole; 5-Fluoro-4-methyl-2-{1-[4-(1-methyl-piperidin-4-yl)-butyl]-1H-indol-4-yl}- -1H-benzoimidazole; 4-Chloro-2-{1-[4-(1-methyl-piperidin-4-yl)-butyl]-1H-indol-4-yl}-1H-benzo- imidazole; 2-{1-[4-(1-Methyl-piperidin-4-yl)-butyl]-1H-indol-4-yl}-5-trifl- uoromethyl-1H-benzoimidazole; 6-{1-[4-(1-Methyl-piperidin-4-yl)-butyl]-1H-indol-4-yl}-5H-[1 ,3]dioxolo[4',5':4,5]benzo[1,2-d]imidazole; (2-{1-[4-(1-Methyl-piperidin-4-yl)-butyl]-1H-indol-4-yl}-1H-benzoimidazol- -5-yl)-phenyl-methanone; 2-{1-[4-(1-Methyl-piperidin-4-yl)-butyl]-1H-indol-4-yl}-1H-naphtho[2,3-d]- imidazole; 6-Chloro-4-methyl-2-{1-[4-(1-methyl-piperidin-4-yl)-butyl]-1H-i- ndol-4-yl}-1H-benzoimidazole; 4-Methyl-2-{1-[4-(1-methyl-piperidin-4-yl)-butyl]-1H-indol-4-yl}-1H-benzo- imidazole; 5-tert-Butyl-2-{1-[4-(1-methyl-piperidin-4-yl)-butyl]-1H-indol-- 4-yl}-1H-benzoimidazole; 4,6-Dimethyl-2-{1-[4-(1-methyl-piperidin-4-yl)-butyl]-1H-indol-6-yl}-1H-b- enzoimidazole; 5-Fluoro-4-methyl-2-{1-[4-(1-methyl-piperidin-4-yl)-butyl]-1H-indol-6-yl}- -1H-benzoimidazole; 4-Methyl-2-{1-[4-(1-methyl-piperidin-4-yl)-butyl]-1H-indol-6-yl}-1H-benzo- imidazole; 5-tert-Butyl-2-{3-chloro-1-[3-(1-methyl-piperidin-4-yl)-propyl]- -1H-indol-5-yl}-1H-benzoimidazole; 6-Chloro-2-{3-chloro-1-[3-(1-methyl-piperidin-4-yl)-propyl]-1H-indol-5-yl- }-4-methyl-1H-benzoimidazole; 2-{3-Chloro-1-[4-(1-methyl-piperidin-4-yl)-butyl]-1H-indol-4-yl}-5-triflu- oromethyl-1H-benzoimidazole; 2-{3-Chloro-1-[4-(1-methyl-piperidin-4-yl)-butyl]-1H-indol-4-yl}-5-fluoro- -4-methyl-1H-benzoimidazole; 2-{3-Chloro-1-[4-(1-methyl-piperidin-4-yl)-butyl]-1H-indol-4-yl}-5,6-difl- uoro-1H-benzoimidazole; 5-Fluoro-4-methyl-2-[1-(3-piperazin-1-yl-propyl)-1H-indol-5-yl]-1H-benzoi- midazole; 5-tert-Butyl-2-[3-chloro-1-(3-piperidin-4-yl-propyl)-1H-indol-5-- yl]-1H-benzoimidazole; 5-Fluoro-4-methyl-2-[1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-1H-benzoim- idazole; 4-Chloro-2-[1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-1H-benzoimi- dazole; 4,6-Dimethyl-2-[1-(4-piperidin-4-yl-butyl)-1H-indol-6-yl]-1H-benzo- imidazole; 5-Fluoro-4-methyl-2-[1-(4-piperidin-4-yl-butyl)-1H-indol-6-yl]-- 1H-benzoimidazole; [5-(5-tert-Butyl-1H-benzoimidazol-2-yl)-1-(4-piperidin-4-yl-butyl)-1H-ind- ol-3-ylmethyl]-dimethyl-amine; 5-Fluoro-4-methyl-1'-[3-(1-methyl-piperidin-4-yl)-propyl]-1H,1'H-[2,5']bi- benzoimidazolyl; 5-Fluoro-4-methyl-3'-[3-(1-methyl-piperidin-4-yl)-propyl]-1H,3'H-[2,5']bi- benzoimidazolyl; 4-Methyl-1'[4-(1-methyl-piperidin-4-yl)-butyl]-1H,1'H-[2,5']bibenzoimidaz- olyl; 4-Methyl-3'[4-(1-methyl-piperidin-4-yl)-butyl]-1H,3'H-[2,5']bibenzoi- midazolyl; 5-Fluoro-4-methyl-1'-[4-(1-methyl-piperidin-4-yl)-butyl]-1H,1'H- -[2,5']bibenzoimidazolyl; 5-Fluoro-4-methyl-3'-[4-(1-methyl-piperidin-4-yl)-butyl]-1H,3'H-[2,5']bib- enzoimidazolyl; 5-Fluoro-4-methyl-2-{1-[3-(1-methyl-piperidin-4-yl)-propyl]-1H-pyrrolo[2,- 3-b]pyridin-5-yl}-1H-benzoimidazole; 4,5-Dimethyl-2-{1-[3-(1-methyl-piperidin-4-yl)-propyl]-1H-pyrrolo[2,3-b]p- yridin-5-yl}-1H-benzoimidazole; 2-{6-Chloro-1-[3-(1-methyl-piperidin-4-yl)-propyl]-1H-indol-5-yl}-4,6-dif- luoro-1H-benzoimidazole; 2-[6-Chloro-1-(3-piperidin-4-yl-propyl)-1H-indol-5-yl]-5-fluoro-4-methyl-- 1H-benzoimidazole; 2-{6-Chloro-1-[3-(1-methyl-piperidin-4-yl)-propyl]-1H-indol-5-yl}-5-fluor- o-4-methyl-1H-benzoimidazole; 5-Fluoro-4,4'-dimethyl-1'-[3-(1-methyl-pipendin-4-yl)-propyl]-1H,1'H-[2,5- ']bibenzoimidazolyl; 5,4'-Trimethyl-1'-[3-(1-methyl-pipendin-4-yl)-propyl]-1H,1'H-[2,5']bibenz- oimidazolyl; 4,4'-Dimethyl-1'-[3-(1-methyl-pipendin-4-yl)-propyl]-1H,1'H-[2,5']bibenzo- imidazolyl; 5-Chloro-4,4'-dimethyl-1'-[3-(1-methyl-pipendin-4-yl)-propyl]-1H,1'H-[2,5- ']bibenzoimidazolyl; 6-Fluoro-4,4'-dimethyl-1'-[3-(1-methyl-pipendin-4-yl)-propyl]-1H,1'H-[2,5- ']bibenzoimidazolyl; 4,5-Dimethyl-2-[1-(3-pipendin-4-yl-propyl)-2,3-dihydro-1H-indol-5-yl]-1H-- benzoimidazole; 4,6-Dimethyl-2-{4-methyl-1-[3-(1-methyl-pipendin-4-yl)-propyl]-2,3-dihydr- o-1H-indol-5-yl}-1H-benzoimidazole; 5-Chloro-2-{4-methyl-1-[3-(1-methyl-pipendin-4-yl)-propyl]-2,3-dihydro-1H- -indol-5-yl}-1H-benzoimidazole; 6-Fluoro-4-methyl-2-{4-methyl-1-[3-(1-methyl-pipendin-4-yl)-propyl]-2,3-d- ihydro-1H-indol-5-yl}-1H-benzoimidazole; 2-Methyl-7-{4-methyl-1-[3-(1-methyl-pipendin-4-yl)-propyl]-2,3-dihydro-1H- -indol-5-yl}-6H-imidazo[4',5':3,4]benzo[2,1-d]thiazole; 4,6-Dimethyl-2-{4-methyl-1-[3-(1-methyl-pipendin-4-yl)-propyl]-1H-indol-5- -yl}-1H-benzoimidazole; 4,5-Dimethyl-2-[1-(3-piperazin-1-yl-propyl)-1H-indol-5-yl]-1H-benzoimidaz- ole; 5-tert-Butyl-2-[1-(3-piperazin-1-yl-propyl)-1H-indol-5-yl]-1H-benzoim- idazole; 5-Chloro-2-[1-(3-piperazin-1-yl-propyl)-1H-indol-5-yl]-1H-benzoim- idazole; 5-Chloro-2-{1-[3-(4-methyl-piperazin-1-yl)-propyl]-1H-indol-5-yl}- -1H-benzoimidazole; 4-Methyl-2-[1-(4-pipendin-4-yl-butyl)-1H-indol-4-yl]-1H-benzoimidazole; 5,6-Difluoro-2-{1-[4-(1-methyl-pipendin-4-yl)-butyl]-1H-indol-4-yl}-1H-be- nzoimidazole; 5-Chloro-2-{1-[4-(1-methyl-pipendin-4-yl)-butyl]-1H-indol-4-yl}-1H-benzoi- midazole; 5-Fluoro-2-{1-[4-(1-methyl-pipendin-4-yl)-butyl]-1H-indol-4-yl}-- 1H-benzoimidazole; 4,6-Difluoro-2-{1-[4-(1-methyl-pipendin-4-yl)-butyl]-1H-indol-4-yl}-1H-be- nzoimidazole; 2-{1-[4-(1-Methyl-pipendin-4-yl)-butyl]-1H-indol-4-yl}-1H-naphtho[1,2-d]i- midazole; (2-{3-Chloro-1-[4-(1-methyl-pipendin-4-yl)-butyl]-1H-indol-4-yl}- -3H-benzoimidazol-4-yl) -phenyl-methanone; 2-[3-Chloro-1-(4-pipendin-4-yl-butyl)-1H-indol-4-yl]-4,5-dimethyl-1H-benz- oimidazole; 2-{3-Chloro-1-[4-(1-methyl-pipendin-4-yl)-butyl]-1H-indol-4-yl}-4,5-dimet- hyl-1H-benzoimidazole; 2-{3-Chloro-1-[4-(1-methyl-pipendin-4-yl)-butyl]-1H-indol-4-yl}-4,5-diflu- oro-1H-benzoimidazole; 6-[1-(4-Pipendin-4-yl-butyl)-1H-indol-4-yl]-5H-[1,3]dioxolo[4',5':4,5]-be- nzo[1,2-d]imidazole; Phenyl-{2-[1-(4-pipendin-4-yl-butyl)-1H-indol-4-yl]-1H-benzoimidazol-5-yl- }-methanone; 4,5-Dimethyl-2-{1-[4-(1-methyl-pipendin-4-yl)-butyl]-1H-indol-4-yl}-1H-be- nzoimidazole; 1-[3-(4-Methyl-piperazin-1-yl)-propyl]-5-[5-methyl-4-(3-trifluoromethyl-p- henyl)-1H-imidazol-2-yl]-1H-indole; 5-[4-(4-Chloro-phenyl)-5-methyl-1H-imidazol-2-yl]-1-[3-(4-methyl-piperazi- n-1-yl)-propyl]-1H-indole; 4-Methyl-1-[3-(1-methyl-piperidin-4-yl)-propyl]-5-(4-methyl-5-propyl-1H-i- midazol-2-yl)-1H-benzoimidazole; 4-Methyl-1-[3-(1-methyl-piperidin-4-yl)-propyl]-5-[4-methyl-5-(4-trifluor- omethyl-phenyl)-1H-imidazol-2-yl]-1H-benzoimidazole; 5-[5-(3,5-Dichloro-phenyl)-4-methyl-1H-imidazol-2-yl]-4-methyl-1-[3-(1-me- thyl-piperidin-4-yl)-propyl]-1H-benzoimidazole; 4-Methyl-1-[3-(1-methyl-piperidin-4-yl)-propyl]-5-(5-phenyl-4-trifluorome- thyl-1H-imidazol-2-yl)-1H-benzoimidazole; 5-[5-(4-Chloro-phenyl)-4-p-tolyl-1H-imidazol-2-yl]-4-methyl-1-[3-(1-methy- l-piperidin-4-yl)-propyl]-1H-benzoimidazole; {5-(5-Fluoro-4-methyl-1H-benzoimidazol-2-yl)-1-[3-(1-methyl-piperidin-4-y- l)-propyl]-1H-indol-3-ylmethyl}-dimethyl-amine; 2-[3-Chloro-1-(3-piperidin-4-yl-propyl)-1H-indol-5-yl]-5-fluoro-4-methyl-- 1H-benzoimidazole; 2-{3-Chloro-1-[3-(1-methyl-piperidin-4-yl)-propyl]-1H-indol-5-yl}-5-fluor- o-4-methyl-1H-benzoimidazole; 2-[2,3-Dimethyl-1-(3-piperidin-4-yl-propyl)-1H-indol-5-yl]-4,6-dimethyl-1- H-benzoimidazole; 2-[2,3-Dimethyl-1-(3-piperidin-4-yl-propyl)-1H-indol-5-yl]-5-fluoro-4-met- hyl-1H-benzoimidazole; 5-Fluoro-4-methyl-2-[1-(3-piperidin-4-yl-propyl)-1H-pyrrolo[2,3-b]pyridin- -5-yl]-1H-benzoimidazole; 5-tert-Butyl-2-{1-[3-(1-methyl-piperidin-4-yl)-propyl]-1H-pyrrolo[2,3-b]p- yridin-5-yl}-1H-benzoimidazole; 5-Fluoro-4-methyl-2-[1-(3-piperidin-4-yl-propyl)-2,3-dihydro-1H-indol-5-y- l]-1H-benzoimidazole; 5-Chloro-2-[1-(3-piperidin-4-yl-propyl)-2,3-dihydro-1H-indol-5-yl]-1H-ben- zoimidazole; 4-Methyl-2-[1-(3-piperidin-4-yl-propyl)-2,3-dihydro-1H-indol-5-yl]-1H-ben- zoimidazole; 5-Fluoro-4-methyl-2-{1-[3-(1-methyl-piperidin-4-yl)-propyl]-2,3-dihydro-1- H-indol-5-yl}-1H-benzoimidazole; 5-Chloro-2-{1-[3-(1-methyl-piperidin-4-yl)-propyl]-2,3-dihydro-1H-indol-5- -yl}-1H-benzoimidazole; 4-Methyl-2-{1-[3-(1-methyl-piperidin-4-yl)-propyl]-2,3-dihydro-1H-indol-5- -yl}-1H-benzoimidazole; 2-[6-Chloro-1-(3-piperidin-4-yl-propyl)-1H-indol-5-yl]-4,6-difluoro-1H-be- nzoimidazole; 2-[6-Chloro-1-(3-piperidin-4-yl-propyl)-1H-indol-5-yl]-4,5-dimethyl-1H-be- nzoimidazole; 5-Chloro-2-[6-chloro-1-(3-piperidin-4-yl-propyl)-1H-indol-5-yl]-1H-benzoi- midazole; 5-Chloro-2-{6-chloro-1-[3-(1-methyl-piperidin-4-yl)-propyl]-1H-i- ndol-5-yl}-1H-benzoimidazole; 2-{6-Chloro-1-[3-(1-methyl-piperidin-4-yl)-propyl]-1H-indol-5-yl}-4,5-dim- ethyl-1H-benzoimidazole; 6-Chloro-4-methyl-2-[1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-1H-benzoim- idazole; 5-tert-Butyl-2-[1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-1H-benz- oimidazole; 6,7-Dimethyl-2-[1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-1H-benzoimidazo- le; 4-Methyl-2-[1-(4-piperidin-4-yl-butyl)-1H-indol-6-yl]-1H-benzoimidazol- e; 6-Chloro-4-methyl-2-[1-(4-piperidin-4-yl-butyl)-1H-indol-6-yl]-1H-benzo- imidazole; 5-tert-Butyl-2-[1-(4-piperidin-4-yl-butyl)-1H-indol-6-yl]-1H-be- nzoimidazole; 4,5-Difluoro-2-[1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-1H-benzoimidazo- le; 4,4'-Dimethyl-1'-(3-piperidin-4-yl-propyl)-1H,1'H-[2,5']bibenzoimidazo- lyl; 6-Fluoro-4,4'-dimethyl-1'-(3-piperidin-4-yl-propyl)-1H,1'H-[2,5']bibe- nzoimidazolyl; 5-Chloro-4,4'-dimethyl-1'-(3-piperidin-4-yl-propyl)-1H,1'H-[2,5']bibenzoi- midazolyl; 5-Fluoro-4,4'-dimethyl-1'-(3-piperidin-4-yl-propyl)-1H,1'H-[2,5- ']bibenzoimidazolyl; 5-Fluoro-2-[1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-1H-benzoimidazole; 4,6-Difluoro-2-[1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-1H-benzoimidazo- le; 4-Methyl-1'-(4-piperidin-4-yl-butyl)-1H,1'H-[2,5']bibenzoimidazolyl; 4,5-Dimethyl-1'-(4-piperidin-4-yl-butyl)-1H,1'H-[2,5']bibenzoimidazolyl; 5-Fluoro-1'-(4-piperidin-4-yl-butyl)-1H,1'H-[2,4']bibenzoimidazolyl; 5-Fluoro-1'[4-(1-methyl-piperidin-4-yl)-butyl]-1H,1'H-[2,5']bibenzoimidaz- olyl; 4,5-Dimethyl-1'-[4-(1-methyl-piperidin-4-yl)-butyl]-1H,1'H-[2,5']bib- enzoimidazolyl; 4-Methyl-3'-(4-piperidin-4-yl-butyl)-1H,3'H-[2,5']bibenzoimidazolyl; 4,5-Dimethyl-3'-(4-piperidin-4-yl-butyl)-1H,3'H-[2,5']bibenzoimidazolyl; 5-Fluoro-3'-(4-piperidin-4-yl-butyl)-1H,3'H-[2,5']bibenzoimidazolyl; 4,5-Dimethyl-3'[4-(1-methyl-piperidin-4-yl)-butyl]-1H,3'H-[2,5']bibenzoim- idazolyl; 5-Fluoro-3'-[4-(1-methyl-piperidin-4-yl)-butyl]-1H,3'H [2,5']bibenzoimidazolyl; 2-[1-(4-Piperidin-4-yl-butyl)-1H-indol-4-yl]-1H-naphtho[2,3-d]imidazole; 2-[1-(4-Piperidin-4-yl-butyl)-1H-indol-4-yl]-1H-naphtho[1,2-d]imidazole; {2-[3-Chloro-1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-1H-benzoimidazol-5- -yl}-phenyl-methanone; 2-[3-Chloro-1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-5-trifluoromethyl-1- H-benzoimidazole; 2-[3-Chloro-1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-5,6-difluoro-1H-ben- zoimidazole; 2-[3-Chloro-1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-4,5-difluoro-1H-ben- zoimidazole; 2-[3-Chloro-1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-5-fluoro-4-methyl-1- H-benzoimidazole; 7-[3-Chloro-1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-2-methyl-8H-imidazo- [4',5':3,4]benzo[1,2-d]thiazole; 2-[3-Chloro-1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-3H-benzoimidazole-5- -carboxylic acid methyl ester; 7-{3-Chloro-1-[4-(1-methyl-piperidin-4-yl)-butyl]-1H-indol-4-yl}-2-methyl- -8H-imidazo[4',5':3,4]benzo[1,2-d]thiazole; 2-{3-Chloro-1-[4-(1-methyl-piperidin-4-yl)-butyl]-1H-indol-4-yl}-3H-benzo- imidazole-5-carboxylic acid methyl ester; 4,5,4'-Trimethyl-1'-(3-piperidin-4-yl-propyl)-1H,1'H-[2,5']bibenzoimidazo- lyl; 4,6-Dimethyl-2-[1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-1H-benzoimi- dazole; 6-Chloro-2-[1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-1H-benzoimid- azole; 2-[1-(4-Piperidin-4-yl-butyl)-1H-indol-4-yl]-6-trifluoromethyl-1H-b- enzoimidazole; 4-Methyl-1-[3-(1-methyl-piperidin-4-yl)-propyl]-5-[4-methyl-5-(4-trifluor- omethyl-phenyl)-1H-imidazol-2-yl]-1H-benzoimidazole; 5-[5-(4-Methoxy-phenyl)-4-methyl-1H-imidazol-2-yl]-4-methyl-1-[3-(1-methy- l-piperidin-4-yl)-propyl]-1H-benzoimidazole; and pharmaceutically acceptable salts thereof. 18. A method for modulating histamine H.sub.4 receptor activity, comprising exposing histamine H.sub.4 receptor to an effective amount of at least one chemical entity selected from compounds of Formula (I), and pharmaceutically acceptable salts of compounds of Formula (I). 19. A method as in claim 18, wherein the histamine H.sub.4 receptor is in a subiect with a disease, disorder, or medical condition mediated by histamine H.sub.4 receptor activity, and wherein said disease, disorder, or medical condition is inflammation. 20. A method as in claim 19, wherein said at least one chemical entity is at least one of: 5-Fluoro-4-methyl-2-{4-methyl-1-[3-(1-methyl-piperidin-4-yl)-propyl]-2,3-- dihydro-1H-indol-5-yl}-1H-benzoimidazole; 4,5-Dimethyl-2-{4-methyl-1-[3-(1-methyl-piperidin-4-yl)-propyl]-2,3-dihyd- ro-1H-indol-5-yl}-1H-benzoimidazole; 2-{4-Chloro-1-[3-(1-methyl-piperidin-4-yl)-propyl]-2,3-dihydro-1H-indol-5- -yl}-4,6-dimethyl-1H-benzoimidazole; 2-{4-Chloro-1-[3-(1-methyl-piperidin-4-yl)-propyl]-2,3-dihydro-1H-indol-5- -yl}-5-fluoro-4-methyl-1H-benzoimidazole; 2-{4-Chloro-1-[3-(1-methyl-piperidin-4-yl)-propyl]-2,3-dihydro-1H-indol-5- -yl}1H-benzoimidazole-5-carboxylic acid methyl ester; 5-Fluoro-2-{4-fluoro-1-[3-(1-methyl-piperidin-4-yl)-propyl]-2,3-dihydro-1- H-indol-5-yl}-4-methyl-1H-benzoimidazole; 5-Fluoro-4-methyl-2-{4-methyl-1-[3-(1-methyl-piperidin-4-yl)-propyl]-1H-i- ndol-5-yl}-1H -benzoimidazole; 2-{4-Chloro-1-[3-(1-methyl-piperidin-4-yl)-propyl]-1H-indol-5-yl}-5-fluor- o-4-methyl-1H-benzoimidazole; 2-{4-Chloro-1-[3-(1-methyl-piperidin-4-yl)-propyl]-1H-indol-5-yl}-4,6-dim- ethyl-1H-benzoimidazole; 5-Chloro-2-{4-methyl-1-[3-(1-methyl-piperidin-4-yl)-propyl]-1H-indol-5-yl- }-1H-benzoimidazole; 5-Fluoro-4-methyl-2-{1-[3-(1-methyl-piperidin-4-yl)-propyl]-1H-indol-5-yl- }-1H-benzoimidazole; 4-Methyl-2-{1-[3-(1-methyl-piperidin-4-yl)-propyl]-1H-indol-5-yl}-1H-benz- oimidazole; 5-Fluoro-4-methyl-2-{1-[3-(4-methyl-piperazin-1-yl)-propyl]-1H-indol-5-yl- }-1H-benzoimidazole; 2-{2,3-Dimethyl-1-[3-(1-methyl-piperidin-4-yl)-propyl]-1H-indol-5-yl}-4,6- -dimethyl-1H-benzoimidazole; 2-{2,3-Dimethyl-1-[3-(1-methyl-piperidin-4-yl)-propyl]-1H-indol-5-yl}-5-f- luoro-4-methyl-1H-benzoimidazole; 5-Fluoro-4-methyl-2-{1-[4-(1-methyl-piperidin-4-yl)-butyl]-1H-indol-4-yl}- -1H-benzoimidazole; 4-Chloro-2-{1-[4-(1-methyl-piperidin-4-yl)-butyl]-1H-indol-4-yl}-1H-benzo- imidazole; 2-{1-[4-(1-Methyl-piperidin-4-yl)-butyl]-1H-indol-4-yl}-5-trifl- uoromethyl-1H-benzoimidazole; 6-{1-[4-(1-Methyl-piperidin-4-yl)-butyl]-1H-indol-4-yl}-5H-[1,3]dioxolo[4- ',5':4,5]benzo[1,2-d]imidazole; (2-{1-[4-(1-Methyl-piperidin-4-yl)-butyl]-1H-indol-4-yl}-1H-benzoimidazol- -5-yl)-phenyl-methanone; 2-{1-[4-(1-Methyl-pipendin-4-yl)-butyl]-1H-indol-4-yl}-1H-naphtho[2,3-d]i- midazole; 6-Chloro-4-methyl-2-{1-[4-(1-methyl-pipendin-4-yl)-butyl]-1H-ind- ol-4-yl}-1H-benzoimidazole; 4-Methyl-2-{1-[4-(1-methyl-pipendin-4-yl)-butyl]-1H-indol-4-yl}-1H-benzoi- midazole; 5-tert-Butyl-2-{1-[4-(1-methyl-pipendin-4-yl)-butyl]-1H-indol-4-- yl}-1H-benzoimidazole; 4,6-Dimethyl-2-{1-[4-(1-methyl-pipendin-4-yl)-butyl]-1H-indol-6-yl}-1H-be- nzoimidazole; 5-Fluoro-4-methyl-2-{1-[4-(1-methyl-pipendin-4-yl)-butyl]-1H-indol-6-yl}-- 1H-benzoimidazole; 4-Methyl-2-{1-[4-(1-methyl-pipendin-4-yl)-butyl]-1H-indol-6-yl}-1H-benzoi- midazole; 5-tert-Butyl-2-{3-chloro-1-[3-(1-methyl-pipendin-4-yl)-propyl]-1- H-indol-5-yl}-1H-benzoimidazole; 6-Chloro-2-{3-chloro-1-[3-(1-methyl-pipendin-4-yl)-propyl]-1H-indol-5-yl}- -4-methyl-1H-benzoimidazole; 2-{3-Chloro-1-[4-(1-methyl-pipendin-4-yl)-butyl]-1H-indol-4-yl}-5-trifluo- romethyl-1H-benzoimidazole; 2-{3-Chloro-1-[4-(1-methyl-pipendin-4-yl)-butyl]-1H-indol-4-yl}-5-fluoro-- 4-methyl-1H-benzoimidazole; 2-{3-Chloro-1-[4-(1-methyl-pipendin-4-yl)-butyl]-1H-indol-4-yl}-5,6-diflu- oro-1H-benzoimidazole; 5-Fluoro-4-methyl-2-[1-(3-piperazin-1-yl-propyl)-1H-indol-5-yl]-1H-benzoi- midazole; 5-tert-Butyl-2-[3-chloro-1-(3-pipendin-4-yl-propyl)-1H-indol-5-y- l]-1H-benzoimidazole; 5-Fluoro-4-methyl-2-[1-(4-pipendin-4-yl-butyl)-1H-indol-4-yl]-1H-benzoimi- dazole; 4-Chloro-2-[1-(4-pipendin-4-yl-butyl)-1H-indol-4-yl]-1H-benzoimida- zole; 4,6-Dimethyl-2-[1-(4-pipendin-4-yl-butyl)-1H-indol-6-yl]-1H-benzoimi- dazole; 5-Fluoro-4-methyl-2-[1-(4-pipendin-4-yl-butyl)-1H-indol-6-yl]-1H-b- enzoimidazole; [5-(5-tert-Butyl-1H-benzoimidazol-2-yl)-1-(4-pipendin-4-yl-butyl)-1H-indo- l-3-ylmethyl]-dimethyl-amine; 5-Fluoro-4-methyl-1'-[3-(1-methyl-pipendin-4-yl)-propyl]-1H,1'H-[2,5']bib- enzoimidazolyl; 5-Fluoro-4-methyl-3'-[3-(1-methyl-pipendin-4-yl)-propyl]-1H,3'H-[2,5']bib- enzoimidazolyl; 4-Methyl-1'-[4-(1-methyl-pipendin-4-yl)-butyl]-1H,1'H-[2,5']bibenzoimidaz- olyl; 4-Methyl-3'-[4-(1-methyl-pipendin-4-yl)-butyl]-1H,3'H-[2,5']bibenzoi- midazolyl; 5-Fluoro-4-methyl-1'-[4-(1-methyl-pipendin-4-yl)-butyl]-1H,1'H-- [2,5']bibenzoimidazolyl; 5-Fluoro-4-methyl-3'-[4-(1-methyl-pipendin-4-yl)-butyl]-1H,3'H-[2,5']bibe- nzoimidazolyl; 5-Fluoro-4-methyl-2-{1-[3-(1-methyl-pipendin-4-yl)-propyl]-1H-pyrrolo[2,3- -b]pyridin-5-yl}-1H-benzoimidazole; 4,5-Dimethyl-2-{1-[3-(1-methyl-pipendin-4-yl)-propyl]-1H-pyrrolo[2,3-b]py- ridin-5-yl}-1H-benzoimidazole; 2-{6-Chloro-1-[3-(1-methyl-pipendin-4-yl)-propyl]-1H-indol-5-yl}-4,6-difl- uoro-1H-benzoimidazole; 2-[6-Chloro-1-(3-pipendin-4-yl-propyl)-1H-indol-5-yl]-5-fluoro-4-methyl-1- H-benzoimidazole; 2-{6-Chloro-1-[3-(1-methyl-pipendin-4-yl)-propyl]-1H-indol-5-yl}-5-fluoro- -4-methyl-1H-benzoimidazole; 5-Fluoro-4,4'-dimethyl-1'-[3-(1-methyl-pipendin-4-yl)-propyl]-1H,1'H-[2,5- ']bibenzoimidazolyl; 5,4'-Trimethyl-1'-[3-(1-methyl-pipendin-4-yl)-propyl]-1H,1'H-[2,5']bibenz- oimidazolyl; 4,4'-Dimethyl-1'-[3-(1-methyl-pipendin-4-yl)-propyl]-1H,1'H-[2,5']bibenzo- imidazolyl; 5-Chloro-4,4'-dimethyl-1'-[3-(1-methyl-pipendin-4-yl)-propyl]-1H,1'H-[2,5- ']bibenzoimidazolyl; 6-Fluoro-4,4'-dimethyl-1'-[3-(1-methyl-pipendin-4-yl)-propyl]-1H,1'H-[2,5- ']bibenzoimidazolyl; 4,5-Dimethyl-2-[1-(3-pipendin-4-yl-propyl)-2,3-dihydro-1H-indol-5-yl]-1H-- benzoimidazole; 4,6-Dimethyl-2-{4-methyl-1-[3-(1-methyl-pipendin-4-yl)-propyl]-2,3-dihydr- o-1H-indol-5-yl}-1H-benzoimidazole; 5-Chloro-2-{4-methyl-1-[3-(1-methyl-pipendin-4-yl)-propyl]-2,3-dihydro-1H- -indol-5-yl}-1H-benzoimidazole; 6-Fluoro-4-methyl-2-{4-methyl-1-[3-(1-methyl-pipendin-4-yl)-propyl]-2,3-d- ihydro-1H-indol-5-yl}H-benzoimidazole; 2-Methyl-7-{4-methyl-1-[3-(1-methyl-pipendin-4-yl)-propyl]-2,3-dihydro-1H- -indol-5-yl}-6H-imidazo[4',5':3,4]benzo[2,1-d]thiazole; 4,6-Dimethyl-2-{4-methyl-1-[3-(1-methyl-pipendin-4-yl)-propyl]-1H-indol-5- -yl}-1H-benzoimidazole; 4,5-Dimethyl-2-[1-(3-piperazin-1-yl-propyl)-1H-indol-5-yl]-1H-benzoimidaz- ole; 5-tert-Butyl-2-[1-(3-piperazin-1-yl-propyl)-1H-indol-5-yl]-1H-benzoim- idazole; 5-Chloro-2-[1-(3-piperazin-1-yl-propyl)-1H-indol-5-yl]-1H-benzoim- idazole; 5-Chloro-2-{1-[3-(4-methyl-piperazin-1-yl)-propyl]-1H-indol-5-yl}- -1H-benzoimidazole; 4-Methyl-2-[1-(4-pipendin-4-yl-butyl)-1H-indol-4-yl]-1H-benzoimidazole; 5,6-Difluoro-2-{1-[4-(1-methyl-pipendin-4-yl)-butyl]-1H-indol-4-yl}-1H-be- nzoimidazole; 5-Chloro-2-{1-[4-(1-methyl-pipendin-4-yl)-butyl]-1H-indol-4-yl}-1H-benzoi- midazole; 5-Fluoro-2-{1-[4-(1-methyl-pipendin-4-yl)-butyl]-1H-indol-4-yl}-- 1H-benzoimidazole; 4,6-Difluoro-2-{1-[4-(1-methyl-pipendin-4-yl)-butyl]-1H-indol-4-yl}-1H-be- nzoimidazole; 2-{1-[4-(1-Methyl-pipendin-4-yl)-butyl]-1H-indol-4-yl}-1H-naphtho[1,2-d]i- midazole; (2-{3-Chloro-1-[4-(1-methyl-pipendin-4-yl)-butyl]-1H-indol-4-yl}- -3H-benzoimidazol-4-yl) -phenyl-methanone; 2-[3-Chloro-1-(4-pipendin-4-yl-butyl)-1H-indol-4-yl]-4,5-dimethyl-1H-benz- oimidazole; 2-{3-Chloro-1-[4-(1-methyl-pipendin-4-yl)-butyl]-1H-indol-4-yl}-4,5-dimet- hyl-1H-benzoimidazole; 2-{3-Chloro-1-[4-(1-methyl-piperidin-4-yl)-butyl]-1H-indol-4-yl}-4,5-difl- uoro-1H-benzoimidazole; 6-[1-(4-Piperidin-4-yl-butyl)-1H-indol-4-yl]-5H-[1,3]dioxolo[4',5':4,5]-b- enzo[1,2-d]imidazole; Phenyl-{2-[1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-1H-benzoimidazol-5-y- l}-methanone; 4,5-Dimethyl-2-{1-[4-(1-methyl-piperidin-4-yl)-butyl]-1H-indol-4-yl}-1H-b- enzoimidazole; 1-[3-(4-Methyl-piperazin-1-yl)-propyl]-5-[5-methyl-4-(3-trifluoromethyl-p- henyl)-1H-imidazol-2-yl]-1H-indole; 5-[4-(4-Chloro-phenyl)-5-methyl-1H-imidazol-2-yl]-1-[3-(4-methyl-piperazi- n-1-yl)-propyl]-1H-indole; 4-Methyl-1-[3-(1-methyl-piperidin-4-yl)-propyl]-5-(4-methyl-5-propyl-1H-i- midazol-2-yl)-1H-benzoimidazole; 4-Methyl-1-[3-(1-methyl-piperidin-4-yl)-propyl]-5-[4-methyl-5-(4-trifluor- omethyl-phenyl)-1H-imidazol-2-yl]-1H-benzoimidazole; 5-[5-(3,5-Dichloro-phenyl)-4-methyl-1H-imidazol-2-yl]-4-methyl-1-[3-(1-me- thyl-piperidin-4-yl)-propyl]-1H-benzoimidazole; 4-Methyl-1-[3-(1-methyl-piperidin-4-yl)-propyl]-5-(5-phenyl-4-trifluorome- thyl-1H-imidazol-2-yl)-1H-benzoimidazole; 5-[5-(4-Chloro-phenyl)-4-p-tolyl-1H-imidazol-2-yl]-4-methyl-1-[3-(1-methy- l-piperidin-4-yl)-propyl]-1H-benzoimidazole; {5-(5-Fluoro-4-methyl-1H-benzoimidazol-2-yl)-1-[3-(1-methyl-piperidin-4-y- l)-propyl]-1H-indol-3-ylmethyl}-dimethyl-amine; 2-[3-Chloro-1-(3-piperidin-4-yl-propyl)-1H-indol-5-yl]-5-fluoro-4-methyl-- 1H-benzoimidazole; 2-{3-Chloro-1-[3-(1-methyl-piperidin-4-yl)-propyl]-1H-indol-5-yl}-5-fluor- o-4-methyl-1H-benzoimidazole; 2-[2,3-Dimethyl-1-(3-piperidin-4-yl-propyl)-1H-indol-5-yl]-4,6-dimethyl-1- H-benzoimidazole; 2-[2,3-Dimethyl-1-(3-piperidin-4-yl-propyl)-1H-indol-5-yl]-5-fluoro-4-met- hyl-1H-benzoimidazole; 5-Fluoro-4-methyl-2-[1-(3-piperidin-4-yl-propyl)-1H-pyrrolo[2,3-b]pyridin- -5-yl]-1H-benzoimidazole; 5-tert-Butyl-2-{1-[3-(1-methyl-piperidin-4-yl)-propyl]-1H-pyrrolo[2,3-b]p- yridin-5-yl}-1H-benzoimidazole; 5-Fluoro-4-methyl-2-[1-(3-piperidin-4-yl-propyl)-2,3-dihydro-1H-indol-5-y- l]-1H-benzoimidazole; 5-Chloro-2-[1-(3-piperidin-4-yl-propyl)-2,3-dihydro-1H-indol-5-yl]-1H-ben- zoimidazole; 4-Methyl-2-[1-(3-piperidin-4-yl-propyl)-2,3-dihydro-1H-indol-5-yl]-1H-ben- zoimidazole; 5-Fluoro-4-methyl-2-{1-[3-(1-methyl-piperidin-4-yl)-propyl]-2,3-dihydro-1- H-indol-5-yl}-1H-benzoimidazole; 5-Chloro-2-{1-[3-(1-methyl-piperidin-4-yl)-propyl]-2,3-dihydro-1H-indol-5- -yl}-1H-benzoimidazole; 4-Methyl-2-{1-[3-(1-methyl-piperidin-4-yl)-propyl]-2,3-dihydro-1H-indol-5- -yl}-1H-benzoimidazole; 2-[6-Chloro-1-(3-piperidin-4-yl-propyl)-1H-indol-5-yl]-4,6-difluoro-1H-be- nzoimidazole; 2-[6-Chloro-1-(3-piperidin-4-yl-propyl)-1H-indol-5-yl]-4,5-dimethyl-1H-be- nzoimidazole; 5-Chloro-2-[6-chloro-1-(3-piperidin-4-yl-propyl)-1H-indol-5-yl]-1H-benzoi- midazole; 5-Chloro-2-{6-chloro-1-[3-(1-methyl-piperidin-4-yl)-propyl]-1H-i- ndol-5-yl}-1H-benzoimidazole; 2-{6-Chloro-1-[3-(1-methyl-piperidin-4-yl)-propyl]-1H-indol-5-yl}-4,5-dim- ethyl-1H-benzoimidazole; 6-Chloro-4-methyl-2-[1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-1H-benzoim- idazole; 5-tert-Butyl-2-[1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-1H-benz- oimidazole; 6,7-Dimethyl-2-[1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-1H-benzoimidazo- le; 4-Methyl-2-[1-(4-piperidin-4-yl-butyl)-1H-indol-6-yl]-1H-benzoimidazol- e; 6-Chloro-4-methyl-2-[1-(4-piperidin-4-yl-butyl)-1H-indol-6-yl]-1H-benzo- imidazole; 5-tert-Butyl-2-[1-(4-piperidin-4-yl-butyl)-1H-indol-6-yl]-1H-be- nzoimidazole; 4,5-Difluoro-2-[1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-1H-benzoimidazo- le; 4,4'-Dimethyl-1'-(3-piperidin-4-yl-propyl)-1H,1'H-[2,5']bibenzoimidazo- lyl; 6-Fluoro-4,4'-dimethyl-1'-(3-piperidin-4-yl-propyl)-1H,1'H-[2,5']bibe- nzoimidazolyl; 5-Chloro-4,4'-dimethyl-1'-(3-piperidin-4-yl-propyl)-1H,1'H-[2,5']bibenzoi- midazolyl; 5-Fluoro-4,4'-dimethyl-1'-(3-piperidin-4-yl-propyl)-1H,1'H-[2,5- ']bibenzoimidazolyl; 5-Fluoro-2-[1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-1H-benzoimidazole; 4,6-Difluoro-2-[1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-1H-benzoimidazo- le; 4-Methyl-1'-(4-piperidin-4-yl-butyl)-1H,1'H-[2,5']bibenzoimidazolyl; 4,5-Dimethyl-1'-(4-piperidin-4-yl-butyl)-1H,1'H-[2,5']bibenzoimidazolyl; 5-Fluoro-1'-(4-piperidin-4-yl-butyl)-1H,1'H-[2,4']bibenzoimidazolyl; 5-Fluoro-1'-[4-(1-methyl-piperidin-4-yl)-butyl]-1H,1'H-[2,5']bibenzoimida- zolyl; 4,5-Dimethyl-1'-[4-(1-methyl-piperidin-4-yl)-butyl]-1H,1'H-[2,5']bi- benzoimidazolyl; 4-Methyl-3'-(4-piperidin-4-yl-butyl)-1H,3'H-[2,5']bibenzoimidazolyl; 4,5-Dimethyl-3'-(4-piperidin-4-yl-butyl)-1H,3'H-[2,5']bibenzoimidazolyl; 5-Fluoro-3'-(4-piperidin-4-yl-butyl)-1H,3'H-[2,5']bibenzoimidazolyl; 4,5-Dimethyl-3'[4-(1-methyl-piperidin-4-yl)-butyl]-1H,3'H-[2,5']bibenzoim- idazolyl; 5-Fluoro-3'-[4-(1-methyl-piperidin-4-yl)-butyl]-1H,3'H [2,5']bibenzoimidazolyl; 2-[1-(4-Piperidin-4-yl-butyl)-1H-indol-4-yl]-1H-naphtho[2,3-d]imidazole; 2-[1-(4-Piperidin-4-yl-butyl)-1H-indol-4-yl]-1H-naphtho[1,2-d]imidazole; {2-[3-Chloro-1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-1H-benzoimidazol-5- -yl}-phenyl-methanone; 2-[3-Chloro-1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-5-trifluoromethyl-1- H-benzoimidazole; 2-[3-Chloro-1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-5,6-difluoro-1H-ben- zoimidazole; 2-[3-Chloro-1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-4,5-difluoro-1H-ben- zoimidazole; 2-[3-Chloro-1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-5-fluoro-4-methyl-1- H-benzoimidazole; 7-[3-Chloro-1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-2-methyl-8H-imidazo- [4',5':3,4]benzo[1,2-d]thiazole; 2-[3-Chloro-1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-3H-benzoimidazole-5- -carboxylic acid methyl ester; 7-{3-Chloro-1-[4-(1-methyl-piperidin-4-yl)butyl]-1H-indol-4-yl}-2-methyl-- 8H-imidazo[4',5':3,4]benzo[1 ,2-d]thiazole; 2-{3-Chloro-1-[4-(1-methyl-piperidin-4-yl)-butyl]-1H-indol-4-yl}-3H-benzo- imidazole-5-carboxylic acid methyl ester; 4,5,4'-Trimethyl-1'-(3-piperidin-4-yl-propyl)-1H,1'H-[2,5']bibenzoimidazo- lyl; 4,6-Dimethyl-2-[1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-1H-benzoimi- dazole; 6-Chloro-2-[1-(4-piperidin-4-yl-butyl)-1H-indol-4-yl]-1H-benzoimid- azole; 2-[1-(4-Piperidin-4-yl-butyl)-1H-indol-4-yl]-6-trifluoromethyl-1H-b- enzoimidazole; 4-Methyl-1-[3-(1-methyl-piperidin-4-yl)-propyl]-5-[4-methyl-5-(4-trifluor- omethyl-phenyl)-1H-imidazol-2-yl]-1H-benzoimidazole; 5-[5-(4-Methoxy-phenyl)-4-methyl-1H-imidazol-2-yl]-4-methyl-1-[3-(1-methy- l-piperidin-4-yl)-propyl]-1H-benzoimidazole; and pharmaceutically acceptable salts thereof.

Details for Patent 8,084,466

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Jubilant Hollisterstier Llc	N/A	positive skin test control-histamine	Injection	103891	03/13/1924		2027-12-18