Claims for Patent: 8,071,565

Summary for Patent: 8,071,565

Title:	Purine derivatives as a2a agonists
Abstract:	Compounds of formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, wherein W, R.sup.1, R.sup.2 and R.sup.3 have the meanings as indicated in the specification, are useful for treating conditions mediated by activation of the adenosine A.sub.2A receptor, especially inflammatory or obstructive airways diseases. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described. ##STR00001##
Inventor(s):	Fairhurst; Robin Alec (Horsham, GB), Taylor; Roger John (Horsham, GB)
Assignee:	Novartis AG (Basel, CH)
Application Number:	12/308,637
Patent Claims:	1. A compound selected from the group consisting of 1-((R)-1-{6-(2,2-Diphenyl-ethylamino)-9-[(2R,3R,4S,5R)-5-(2-ethyl-2H-tetr- azol-5-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-9H-purin-2-yl}-pyrrolidin-- 3-yl)-3-(3-hydroxy-benzyl)-urea; 1-((R)-1-{6-(2,2-Diphenyl-ethylamino)-9-[(2R,3R,4S,5R)-5-(2-ethyl-2H-tetr- azol-5-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-9H-purin-2-yl}-pyrrolidin-- 3-yl)-3-pyridin-3-yl-urea; 4-[3-((R)-1-{6-(2,2-Diphenyl-ethylamino)-9-[(2R,3R,4S,5R)-5-(2-ethyl-2H-t- etrazol-5-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-9H-purin-2-yl}-pyrrolid- in-3-yl)-ureido]-benzenesulfonamide; 3-[3-((R)-1-{6-(2,2-Diphenyl-ethylamino)-9-[(2R,3R,4S,5R)-5-(2-ethyl-2H-t- etrazol-5-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-9H-purin-2-yl}-pyrrolid- in-3-yl)-ureido]-benzenesulfonamide; 1-{(R)-1-[9-[(2R,3R,4S,5R)-5-(2-Ethyl-2H-tetrazol-5-yl)-3,4-dihydroxy-tet- rahydro-furan-2-yl]-6-((S)-1-hydroxymethyl-2-phenyl-ethylamino)-9H-purin-2- -yl]-pyrrolidin-3-yl}-3-(3-hydroxy-benzyl)-urea; 1-{(R)-1-[9-[(2R,3R,4S,5R)-5-(2-Ethyl-2H-tetrazol-5-yl)-3,4-dihydroxy-tet- rahydro-furan-2-yl]-6-((S)-1-hydroxymethyl-2-phenyl-ethylamino)-9H-purin-2- -yl]-pyrrolidin-3-yl}-3-pyridin-3-yl-urea; 4-(3-{(R)-1-[9-[(2R,3R,4S,5R)-5-(2-Ethyl-2H-tetrazol-5-yl)-3,4-dihydroxy-- tetrahydro-furan-2-yl]-6-((S)-1-hydroxymethyl-2-phenyl-ethylamino)-9H-puri- n-2-yl]-pyrrolidin-3-yl}-ureido)-benzenesulfonamide; 3-(3-{(R)-1-[9-[(2R,3R,4S,5R)-5-(2-Ethyl-2H-tetrazol-5-yl)-3,4-dihydroxy-- tetrahydro-furan-2-yl]-6-((S)-1-hydroxymethyl-2-phenyl-ethylamino)-9H-puri- n-2-yl]-pyrrolidin-3-yl}-ureido)-benzenesulfonamide; 1-((R)-1-{6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-[(2R,3R,4S,5R)-5-(2- -ethyl-2H-tetrazol-5-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-9H-purin-2-y- l}-pyrrolidin-3-yl)-3-(3-hydroxy-benzyl)-urea; 1-((R)-1-{6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-[(2R,3R,4S,5R)-5-(2- -ethyl-2H-tetrazol-5-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-9H-purin-2-y- l}-pyrrolidin-3-yl)-3-pyridin-3-yl-urea; 4-[3-((R)-1-{6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-[(2R,3R,4S,5R)-5- -(2-ethyl-2H-tetrazol-5-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-9H-purin-- 2-yl}-pyrrolidin-3-yl)-ureido]-benzenesulfonamide; 3-[3-((R)-1-{6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-[(2R,3R,4S,5R)-5- -(2-ethyl-2H-tetrazol-5-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-9H-purin-- 2-yl}-pyrrolidin-3-yl)-ureido]-benzenesulfonamide; 1-((R)-1-{6-(2,2-Diphenyl-ethylamino)-9-[(2R,3R,4S,5S)-5-(3-ethyl-isoxazo- l-5-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-9H-purin-2-yl}-pyrrolidin-3-y- l)-3-(3-hydroxy-benzyl)-urea; 1-((R)-1-{6-(2,2-Diphenyl-ethylamino)-9-[(2R,3R,4S,5S)-5-(3-ethyl-isoxazo- l-5-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-9H-purin-2-yl}-pyrrolidin-3-y- l)-3-pyridin-3-yl-urea; 4-[3-((R)-1-{6-(2,2-Diphenyl-ethylamino)-9-[(2R,3R,4S,5S)-5-(3-ethyl-isox- azol-5-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-9H-purin-2-yl}-pyrrolidin-- 3-yl)-ureido]-benzenesulfonamide; 3-[3-((R)-1-{6-(2,2-Diphenyl-ethylamino)-9-[(2R,3R,4S,5S)-5-(3-ethyl-isox- azol-5-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-9H-purin-2-yl}-pyrrolidin-- 3-yl)-ureido]-benzenesulfonamide; 1-{(R)-1-[9-[(2R,3R,4S,5S)-5-(3-Ethyl-isoxazol-5-yl)-3,4-dihydroxy-tetrah- ydro-furan-2-yl]-6-((S)-1-hydroxymethyl-2-phenyl-ethylamino)-9H-purin-2-yl- ]-pyrrolidin-3-yl}-3-(3-hydroxy-benzyl)-urea; 1-{(R)-1-[9-[(2R,3R,4S,5S)-5-(3-Ethyl-isoxazol-5-yl)-3,4-dihydroxy-tetrah- ydro-furan-2-yl]-6-((S)-1-hydroxymethyl-2-phenyl-ethylamino)-9H-purin-2-yl- ]-pyrrolidin-3-yl}-3-pyridin-3-yl-urea; 4-(3-{(R)-1-[9-[(2R,3R,4S,5S)-5-(3-Ethyl-isoxazol-5-yl)-3,4-dihydroxy-tet- rahydro-furan-2-yl]-6-((S)-1-hydroxymethyl-2-phenyl-ethylamino)-9H-purin-2- -yl]-pyrrolidin-3-yl}-ureido)-benzenesulfonamide; 3-(3-{(R)-1-[9-[(2R,3R,4S,5S)-5-(3-Ethyl-isoxazol-5-yl)-3,4-dihydroxy-tet- rahydro-furan-2-yl]-6-((S)-1-hydroxymethyl-2-phenyl-ethylamino)-9H-purin-2- -yl]-pyrrolidin-3-yl}-ureido)-benzenesulfonamide; 1-((R)-1-{6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-[(2R,3R,4S,5S)-5-(3- -ethyl-isoxazol-5-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-9H-purin-2-yl}-- pyrrolidin-3-yl)-3-(3-hydroxy-benzyl)-urea; 1-((R)-1-{6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-[(2R,3R,4S,5S)-5-(3- -ethyl-isoxazol-5-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-9H-purin-2-yl}-- pyrrolidin-3-yl)-3-pyridin-3-yl-urea; 4-[3-((R)-1-{6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-[(2R,3R,4S,5S)-5- -(3-ethyl-isoxazol-5-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-9H-purin-2-y- l}-pyrrolidin-3-yl)-ureido]-benzenesulfonamide; 3-[3-((R)-1-{6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-[(2R,3R,4S,5S)-5- -(3-ethyl-isoxazol-5-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-9H-purin-2-y- l}-pyrrolidin-3-yl)-ureido]-benzenesulfonamide; 1-{(R)-1-[9-[(2R,3R,4S,5S)-3,4-Dihydroxy-5-(3-hydroxymethyl-isoxazol-5-yl- )-tetrahydro-furan-2-yl]-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]-pyrrol- idin-3-yl}-3-(3-hydroxy-benzyl)-urea; 1-{(R)-1-[9-[(2R,3R,4S,5S)-3,4-Dihydroxy-5-(3-hydroxymethyl-isoxazol-5-yl- )-tetrahydro-furan-2-yl]-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]-pyrrol- idin-3-yl}-3-pyridin-3-yl-urea; 4-(3-{(R)-1-[9-[(2R,3R,4S,5S)-3,4-Dihydroxy-5-(3-hydroxymethyl-isoxazol-5- -yl)-tetrahydro-furan-2-yl]-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]-pyr- rolidin-3-yl}-ureido)-benzenesulfonamide; 3-(3-{(R)-1-[9-[(2R,3R,4S,5S)-3,4-Dihydroxy-5-(3-hydroxymethyl-isoxazol-5- -yl)-tetrahydro-furan-2-yl]-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]-pyr- rolidin-3-yl}-ureido)-benzenesulfonamide; 1-{(R)-1-[9-[(2R,3R,4S,5S)-3,4-Dihydroxy-5-(3-hydroxymethyl-isoxazol-5-yl- )-tetrahydro-furan-2-yl]-6-((S)-1-hydroxymethyl-2-phenyl-ethylamino)-9H-pu- rin-2-yl]-pyrrolidin-3-yl}-3-(3-hydroxy-benzyl)-urea; 1-{(R)-1-[9-[(2R,3R,4S,5S)-3,4-Dihydroxy-5-(3-hydroxymethyl-isoxazol-5-yl- )-tetrahydro-furan-2-yl]-6-((S)-1-hydroxymethyl-2-phenyl-ethylamino)-9H-pu- rin-2-yl]-pyrrolidin-3-yl}-3-pyridin-3-yl-urea; 4-(3-{(R)-1-[9-[(2R,3R,4S,5S)-3,4-Dihydroxy-5-(3-hydroxymethyl-isoxazol-5- -yl)-tetrahydro-furan-2-yl]-6-((S)-1-hydroxymethyl-2-phenyl-ethylamino)-9H- -purin-2-yl]-pyrrolidin-3-yl}-ureido)-benzenesulfonamide; 3-(3-{(R)-1-[9-[(2R,3R,4S,5S)-3,4-Dihydroxy-5-(3-hydroxymethyl-isoxazol-5- -yl)-tetrahydro-furan-2-yl]-6-((S)-1-hydroxymethyl-2-phenyl-ethylamino)-9H- -purin-2-yl]-pyrrolidin-3-yl}-ureido)-benzenesulfonamide; 1-((R)-1-{6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-[(2R,3R,4S,5S)-3,4-- dihydroxy-5-(3-hydroxymethyl-isoxazol-5-yl)-tetrahydro-furan-2-yl]-9H-puri- n-2-yl}-pyrrolidin-3-yl)-3-(3-hydroxy-benzyl)-urea; 1-((R)-1-{6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-[(2R,3R,4S,5S)-3,4-- dihydroxy-5-(3-hydroxymethyl-isoxazol-5-yl)-tetrahydro-furan-2-yl]-9H-puri- n-2-yl}-pyrrolidin-3-yl)-3-pyridin-3-yl-urea; 4-[3-((R)-1-{6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-[(2R,3R,4S,5S)-3- ,4-dihydroxy-5-(3-hydroxymethyl-isoxazol-5-yl)-tetrahydro-furan-2-yl]-9H-p- urin-2-yl}-pyrrolidin-3-yl)-ureido]-benzenesulfonamide; 3-[3-((R)-1-{6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-[(2R,3R,4S,5S)-3- ,4-dihydroxy-5-(3-hydroxymethyl-isoxazol-5-yl)-tetrahydro-furan-2-yl]-9H-p- urin-2-yl}-pyrrolidin-3-yl)-ureido]-benzenesulfonamide; 1-{(R)-1-[9-{(2R,3R,4S,5R)-3,4-Dihydroxy-5-[2-(2-hydroxy-ethyl)-2H-tetraz- ol-5-yl]-tetrahydro-furan-2-yl}-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]- -pyrrolidin-3-yl}-3-(3-hydroxy-benzyl)-urea; 1-{(R)-1-[9-{(2R,3R,4S,5R)-3,4-Dihydroxy-5-[2-(2-hydroxy-ethyl)-2H-tetraz- ol-5-yl]-tetrahydro-furan-2-yl}-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]- -pyrrolidin-3-yl}-3-pyridin-3-yl-urea; 4-(3-{(R)-1-[9-{(2R,3R,4S,5R)-3,4-Dihydroxy-5-[2-(2-hydroxy-ethyl)-2H-tet- razol-5-yl]-tetrahydro-furan-2-yl}-6-(2,2-diphenyl-ethylamino)-9H-purin-2-- yl]-pyrrolidin-3-yl}-ureido)-benzenesulfonamide; 3-(3-{(R)-1-[9-{(2R,3R,4S,5R)-3,4-Dihydroxy-5-[2-(2-hydroxy-ethyl)-2H-tet- razol-5-yl]-tetrahydro-furan-2-yl}-6-(2,2-diphenyl-ethylamino)-9H-purin-2-- yl]-pyrrolidin-3-yl}-ureido)-benzenesulfonamide; 1-{(R)-1-[9-{(2R,3R,4S,5R)-3,4-Dihydroxy-5-[2-(2-hydroxy-ethyl)-2H-tetraz- ol-5-yl]-tetrahydro-furan-2-yl}-6-((S)-1-hydroxymethyl-2-phenyl-ethylamino- )-9H-purin-2-yl]-pyrrolidin-3-yl}-3-(3-hydroxy-benzyl)-urea; 1-{(R)-1-[9-{(2R,3R,4S,5R)-3,4-Dihydroxy-5-[2-(2-hydroxy-ethyl)-2H-tetraz- ol-5-yl]-tetrahydro-furan-2-yl}-6-((S)-1-hydroxymethyl-2-phenyl-ethylamino- )-9H-purin-2-yl]-pyrrolidin-3-yl}-3-pyridin-3-yl-urea; 4-(3-{(R)-1-[9-{(2R,3R,4S,5R)-3,4-Dihydroxy-5-[2-(2-hydroxy-ethyl)-2H-tet- razol-5-yl]-tetrahydro-furan-2-yl}-6-((S)-1-hydroxymethyl-2-phenyl-ethylam- ino)-9H-purin-2-yl]-pyrrolidin-3-yl}-ureido)-benzenesulfonamide; 3-(3-{(R)-1-[9-{(2R,3R,4S,5R)-3,4-Dihydroxy-5-[2-(2-hydroxy-ethyl)-2H-tet- razol-5-yl]-tetrahydro-furan-2-yl}-6-((S)-1-hydroxymethyl-2-phenyl-ethylam- ino)-9H-purin-2-yl]-pyrrolidin-3-yl}-ureido)-benzenesulfonamide; 1-[(R)-1-(6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-{(2R,3R,4S,5R)-3,4-- dihydroxy-5-[2-(2-hydroxy-ethyl)-2H-tetrazol-5-yl]-tetrahydro-furan-2-yl}-- 9H-purin-2-yl)-pyrrolidin-3-yl]-3-(3-hydroxy-benzyl)-urea; 1-[(R)-1-(6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-{(2R,3R,4S,5R)-3,4-- dihydroxy-5-[2-(2-hydroxy-ethyl)-2H-tetrazol-5-yl]-tetrahydro-furan-2-yl}-- 9H-purin-2-yl)-pyrrolidin-3-yl]-3-pyridin-3-yl-urea; 4-{3-[(R)-1-(6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-{(2R,3R,4S,5R)-3- ,4-dihydroxy-5-[2-(2-hydroxy-ethyl)-2H-tetrazol-5-yl]-tetrahydro-furan-2-y- l-]-9H-purin-2-yl)-pyrrolidin-3-yl]-ureido}-benzenesulfonamide; 3-{3-[(R)-1-(6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-{(2R,3R,4S,5R)-3- ,4-dihydroxy-5-[2-(2-hydroxy-ethyl)-2H-tetrazol-5-yl]-tetrahydro-furan-2-y- l]-9H-purin-2-yl)-pyrrolidin-3-yl]-ureido}-benzenesulfonamide; 1-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-((S)-4-methyl-2,5-dioxo-imidaz- olidin-1-yl)-cyclopentyl]-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]-pyrro- lidin-3-yl}-3-pyridin-3-yl-urea; 1-{(R)-1-[9-[(1R,2S,3R,4S)-4-(2,5-Dioxo-imidazolidin-1-yl)-2,3-dihydroxy-- cyclopentyl]-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]-pyrrolidin-3-yl}-3- -pyridin-3-yl-urea; 1-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-((S)-4-methyl-2,5-dioxo-imidaz- olidin-1-yl)-cyclopentyl]-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]-pyrro- lidin-3-yl}-3-(3-hydroxy-benzyl)-urea; 4-(3-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-((S)-4-methyl-2,5-dioxo-imi- dazolidin-1-yl)-cyclopentyl]-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]-py- rrolidin-3-yl}-ureido)-benzenesulfonamide; 3-(3-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-((S)-4-methyl-2,5-dioxo-imi- dazolidin-1-yl)-cyclopentyl]-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]-py- rrolidin-3-yl}-ureido)-benzenesulfonamide; 1-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-((S)-4-methyl-2,5-dioxo-imidaz- olidin-1-yl)-cyclopentyl]-6-((S)-1-hydroxymethyl-2-phenyl-ethylamino)-9H-p- urin-2-yl]-pyrrolidin-3-yl}-3-pyridin-3-yl-urea; 1-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-((S)-4-methyl-2,5-dioxo-imidaz- olidin-1-yl)-cyclopentyl]-6-((S)-1-hydroxymethyl-2-phenyl-ethylamino)-9H-p- urin-2-yl]-pyrrolidin-3-yl}-3-(3-hydroxy-benzyl)-urea; 4-(3-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-((S)-4-methyl-2,5-dioxo-imi- dazolidin-1-yl)-cyclopentyl]-6-((S)-1-hydroxymethyl-2-phenyl-ethylamino)-9- H-purin-2-yl]-pyrrolidin-3-yl}-ureido)-benzenesulfonamide; 3-(3-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-((S)-4-methyl-2,5-dioxo-imi- dazolidin-1-yl)-cyclopentyl]-6-((S)-1-hydroxymethyl-2-phenyl-ethylamino)-9- H-purin-2-yl]-pyrrolidin-3-yl}-ureido)-benzenesulfonamide; 1-((R)-1-{6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-[(1R,2S,3R,4S)-2,3-- dihydroxy-4-((S)-4-methyl-2,5-dioxo-imidazolidin-1-yl)-cyclopentyl]-9H-pur- in-2-yl}-pyrrolidin-3-yl)-3-pyridin-3-yl-urea; 1-((R)-1-{6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-[(1R,2S,3R,4S)-2,3-- dihydroxy-4-((S)-4-methyl-2,5-dioxo-imidazolidin-1-yl)-cyclopentyl]-9H-pur- in-2-yl}-pyrrolidin-3-yl)-3-(3-hydroxy-benzyl)-urea; 4-[3-((R)-1-{6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-[(1R,2S,3R,4S)-2- ,3-dihydroxy-4-((S)-4-methyl-2,5-dioxo-imidazolidin-1-yl)-cyclopentyl]-9H-- purin-2-yl}-pyrrolidin-3-yl)-ureido]-benzenesulfonamide; 3-[3-((R)-1-{6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-[(1R,2S,3R,4S)-2- ,3-dihydroxy-4-((S)-4-methyl-2,5-dioxo-imidazolidin-1-yl)-cyclopentyl]-9H-- purin-2-yl}-pyrrolidin-3-yl)-ureido]-benzenesulfonamide; 1-{(R)-1-[9-[(1R,2S,3R,4S)-4-(2,5-Dioxo-imidazolidin-1-yl)-2,3-dihydroxy-- cyclopentyl]-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]-pyrrolidin-3-yl}-3- -(3-hydroxy-benzyl)-urea; 4-(3-{(R)-1-[9-[(1R,2S,3R,4S)-4-(2,5-Dioxo-imidazolidin-1-yl)-2,3-dihydro- xy-cyclopentyl]-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]-pyrrolidin-3-yl- }-ureido)-benzenesulfonamide; 3-(3-{(R)-1-[9-[(1R,2S,3R,4S)-4-(2,5-Dioxo-imidazolidin-1-yl)-2,3-dihydro- xy-cyclopentyl]-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]-pyrrolidin-3-yl- }-ureido)-benzenesulfonamide; 1-{(R)-1-[9-[(1R,2S,3R,4S)-4-(2,5-Dioxo-imidazolidin-1-yl)-2,3-dihydroxy-- cyclopentyl]-6-((S)-1-hydroxymethyl-2-phenyl-ethylamino)-9H-purin-2-yl]-py- rrolidin-3-yl}-3-pyridin-3-yl-urea; 1-{(R)-1-[9-[(1R,2S,3R,4S)-4-(2,5-Dioxo-imidazolidin-1-yl)-2,3-dihydroxy-- cyclopentyl]-6-((S)-1-hydroxymethyl-2-phenyl-ethylamino)-9H-purin-2-yl]-py- rrolidin-3-yl}-3-(3-hydroxy-benzyl)-urea; 4-(3-{(R)-1-[9-[(1R,2S,3R,4S)-4-(2,5-Dioxo-imidazolidin-1-yl)-2,3-dihydro- xy-cyclopentyl]-6-((S)-1-hydroxymethyl-2-phenyl-ethylamino)-9H-purin-2-yl]- -pyrrolidin-3-yl}-ureido)-benzenesulfonamide; 3-(3-{(R)-1-[9-[(1R,2S,3R,4S)-4-(2,5-Dioxo-imidazolidin-1-yl)-2,3-dihydro- xy-cyclopentyl]-6-((S)-1-hydroxymethyl-2-phenyl-ethylamino)-9H-purin-2-yl]- -pyrrolidin-3-yl}-ureido)-benzenesulfonamide; 1-((R)-1-{6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-[(1R,2S,3R,4S)-4-(2- ,5-dioxo-imidazolidin-1-yl)-2,3-dihydroxy-cyclopentyl]-9H-purin-2-yl}-pyrr- olidin-3-yl)-3-pyridin-3-yl-urea; 1-((R)-1-{6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-[(1R,2S,3R,4S)-4-(2- ,5-dioxo-imidazolidin-1-yl)-2,3-dihydroxy-cyclopentyl]-9H-purin-2-yl}-pyrr- olidin-3-yl)-3-(3-hydroxy-benzyl)-urea; 4-[3-((R)-1-{6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-[(1R,2S,3R,4S)-4- -(2,5-dioxo-imidazolidin-1-yl)-2,3-dihydroxy-cyclopentyl]-9H-purin-2-yl}-p- yrrolidin-3-yl)-ureido]-benzenesulfonamide; 3-[3-((R)-1-{6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-[(1R,2S,3R,4S)-4- -(2,5-dioxo-imidazolidin-1-yl)-2,3-dihydroxy-cyclopentyl]-9H-purin-2-yl}-p- yrrolidin-3-yl)-ureido]-benzenesulfonamide; 1-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-(3-methyl-2,5-dioxo-imidazolid- in-1-yl)-cyclopentyl]-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]-pyrrolidi- n-3-yl}-3-pyridin-3-yl-urea; 1-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-(3-methyl-2,5-dioxo-imidazolid- in-1-yl)-cyclopentyl]-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]-pyrrolidi- n-3-yl}-3-(3-hydroxy-benzyl)-urea; 4-(3-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-(3-methyl-2,5-dioxo-imidazo- lidin-1-yl)-cyclopentyl]-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]-pyrrol- idin-3-yl}-ureido)-benzenesulfonamide; 3-(3-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-(3-methyl-2,5-dioxo-imidazo- lidin-1-yl)-cyclopentyl]-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]-pyrrol- idin-3-yl}-ureido)-benzenesulfonamide; 1-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-(3-methyl-2,5-dioxo-imidazolid- in-1-yl)-cyclopentyl]-6-((S)-1-hydroxymethyl-2-phenyl-ethylamino)-9H-purin- -2-yl]-pyrrolidin-3-yl}-3-pyridin-3-yl-urea; 1-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-(3-methyl-2,5-dioxo-imidazolid- in-1-yl)-cyclopentyl]-6-((S)-1-hydroxymethyl-2-phenyl-ethylamino)-9H-purin- -2-yl]-pyrrolidin-3-yl}-3-(3-hydroxy-benzyl)-urea; 4-(3-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-(3-methyl-2,5-dioxo-imidazo- lidin-1-yl)-cyclopentyl]-6-((S)-1-hydroxymethyl-2-phenyl-ethylamino)-9H-pu- rin-2-yl]-pyrrolidin-3-yl}-ureido)-benzenesulfonamide; 3-(3-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-(3-methyl-2,5-dioxo-imidazo- lidin-1-yl)-cyclopentyl]-6-((S)-1-hydroxymethyl-2-phenyl-ethylamino)-9H-pu- rin-2-yl]-pyrrolidin-3-yl}-ureido)-benzenesulfonamide; 1-((R)-1-{6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-[(1R,2S,3R,4S)-2,3-- dihydroxy-4-(3-methyl-2,5-dioxo-imidazolidin-1-yl)-cyclopentyl]-9H-purin-2- -yl}-pyrrolidin-3-yl)-3-pyridin-3-yl-urea; 1-((R)-1-{6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-[(1R,2S,3R,4S)-2,3-- dihydroxy-4-(3-methyl-2,5-dioxo-imidazolidin-1-yl)-cyclopentyl]-9H-purin-2- -yl}-pyrrolidin-3-yl)-3-(3-hydroxy-benzyl)-urea; 4-[3-((R)-1-{6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-[(1R,2S,3R,4S)-2- ,3-dihydroxy-4-(3-methyl-2,5-dioxo-imidazolidin-1-yl)-cyclopentyl]-9H-puri- n-2-yl}-pyrrolidin-3-yl)-ureido]-benzenesulfonamide; 3-[3-((R)-1-{6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-[(1R,2S,3R,4S)-2- ,3-dihydroxy-4-(3-methyl-2,5-dioxo-imidazolidin-1-yl)-cyclopentyl]-9H-puri- n-2-yl}-pyrrolidin-3-yl)-ureido]-benzenesulfonamide; 1-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-(4-hydroxymethyl-2,5-dioxo-imi- dazolidin-1-yl)-cyclopentyl]-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]-py- rrolidin-3-yl}-3-pyridin-3-yl-urea; 1-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-(4-hydroxymethyl-2,5-dioxo-imi- dazolidin-1-yl)-cyclopentyl]-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]-py- rrolidin-3-yl}-3-(3-hydroxy-benzyl)-urea; 4-(3-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-(4-hydroxymethyl-2,5-dioxo-- imidazolidin-1-yl)-cyclopentyl]-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]- -pyrrolidin-3-yl}-ureido)-benzenesulfonamide; 3-(3-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-(4-hydroxymethyl-2,5-dioxo-- imidazolidin-1-yl)-cyclopentyl]-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]- -pyrrolidin-3-yl}-ureido)-benzenesulfonamide; 1-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-(4-hydroxymethyl-2,5-dioxo-imi- dazolidin-1-yl)-cyclopentyl]-6-((S)-1-hydroxymethyl-2-phenyl-ethylamino)-9- H-purin-2-yl]-pyrrolidin-3-yl}-3-pyridin-3-yl-urea; 1-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-(4-hydroxymethyl-2,5-dioxo-imi- dazolidin-1-yl)-cyclopentyl]-6-((S)-1-hydroxymethyl-2-phenyl-ethylamino)-9- H-purin-2-yl]-pyrrolidin-3-yl}-3-(3-hydroxy-benzyl)-urea; 4-(3-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-(4-hydroxymethyl-2,5-dioxo-- imidazolidin-1-yl)-cyclopentyl]-6-((S)-1-hydroxymethyl-2-phenyl-ethylamino- )-9H-purin-2-yl]-pyrrolidin-3-yl}-ureido)-benzenesulfonamide; 3-(3-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-(4-hydroxymethyl-2,5-dioxo-- imidazolidin-1-yl)-cyclopentyl]-6-((S)-1-hydroxymethyl-2-phenyl-ethylamino- )-9H-purin-2-yl]-pyrrolidin-3-yl}-ureido)-benzenesulfonamide; 1-((R)-1-{6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-[(1R,2S,3R,4S)-2,3-- dihydroxy-4-(4-hydroxymethyl-2,5-dioxo-imidazolidin-1-yl)-cyclopentyl]-9H-- purin-2-yl}-pyrrolidin-3-yl)-3-pyridin-3-yl-urea; 1-((R)-1-{6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-[(1R,2S,3R,4S)-2,3-- dihydroxy-4-(4-hydroxymethyl-2,5-dioxo-imidazolidin-1-yl)-cyclopentyl]-9H-- purin-2-yl}-pyrrolidin-3-yl)-3-(3-hydroxy-benzyl)-urea; 4-[3-((R)-1-{6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-[(1R,2S,3R,4S)-2- ,3-dihydroxy-4-(4-hydroxymethyl-2,5-dioxo-imidazolidin-1-yl)-cyclopentyl]-- 9H-purin-2-yl}-pyrrolidin-3-yl)-ureido]-benzenesulfonamide; 3-[3-((R)-1-{6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-[(1R,2S,3R,4S)-2- ,3-dihydroxy-4-(4-hydroxymethyl-2,5-dioxo-imidazolidin-1-yl)-cyclopentyl]-- 9H-purin-2-yl}-pyrrolidin-3-yl)-ureido]-benzenesulfonamide; 1-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-(4-hydroxymethyl-pyrazol-1-yl)- -cyclopentyl]-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]-pyrrolidin-3-yl}-- 3-pyridin-3-yl-urea; 1-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-(4-hydroxymethyl-pyrazol-1-yl)- -cyclopentyl]-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]-pyrrolidin-3-yl}-- 3-(3-hydroxy-benzyl)-urea; 4-(3-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-(4-hydroxymethyl-pyrazol-1-- yl)-cyclopentyl]-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]-pyrrolidin-3-y- l}-ureido)-benzenesulfonamide; 3-(3-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-(4-hydroxymethyl-pyrazol-1-- yl)-cyclopentyl]-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]-pyrrolidin-3-y- l}-ureido)-benzenesulfonamide; 1-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-(4-hydroxymethyl-pyrazol-1-yl)- -cyclopentyl]-6-((S)-1-hydroxymethyl-2-phenyl-ethylamino)-9H-purin-2-yl]-p- yrrolidin-3-yl}-3-pyridin-3-yl-urea; 1-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-(4-hydroxymethyl-pyrazol-1-yl)- -cyclopentyl]-6-((S)-1-hydroxymethyl-2-phenyl-ethylamino)-9H-purin-2-yl]-p- yrrolidin-3-yl}-3-(3-hydroxy-benzyl)-urea; 4-(3-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-(4-hydroxymethyl-pyrazol-1-- yl)-cyclopentyl]-6-((S)-1-hydroxymethyl-2-phenyl-ethylamino)-9H-purin-2-yl- ]-pyrrolidin-3-yl}-ureido)-benzenesulfonamide; 3-(3-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-(4-hydroxymethyl-pyrazol-1-- yl)-cyclopentyl]-6-((S)-1-hydroxymethyl-2-phenyl-ethylamino)-9H-purin-2-yl- ]-pyrrolidin-3-yl}-ureido)-benzenesulfonamide; 1-((R)-1-{6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-[(1R,2S,3R,4S)-2,3-- dihydroxy-4-(4-hydroxymethyl-pyrazol-1-yl)-cyclopentyl]-9H-purin-2-yl}-pyr- rolidin-3-yl)-3-pyridin-3-yl-urea; 1-((R)-1-{6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-[(1R,2S,3R,4S)-2,3-- dihydroxy-4-(4-hydroxymethyl-pyrazol-1-yl)-cyclopentyl]-9H-purin-2-yl}-pyr- rolidin-3-yl)-3-(3-hydroxy-benzyl)-urea; 4-[3-((R)-1-{6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-[(1R,2S,3R,4S)-2- ,3-dihydroxy-4-(4-hydroxymethyl-pyrazol-1-yl)-cyclopentyl]-9H-purin-2-yl}-- pyrrolidin-3-yl)-ureido]-benzenesulfonamide; 3-[3-((R)-1-{6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-[(1R,2S,3R,4S)-2- ,3-dihydroxy-4-(4-hydroxymethyl-pyrazol-1-yl)-cyclopentyl]-9H-purin-2-yl}-- pyrrolidin-3-yl)-ureido]-benzenesulfonamide; 1-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-(4-hydroxymethyl-[1,2,3]triazo- l-2-yl)-cyclopentyl]-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]-pyrrolidin- -3-yl}-3-pyridin-3-yl-urea; 1-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-(4-hydroxymethyl-[1,2,3]triazo- l-2-yl)-cyclopentyl]-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]-pyrrolidin- -3-yl}-3-(3-hydroxy-benzyl)-urea; 4-(3-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-(4-hydroxymethyl-[1,2,3]tri- azol-2-yl)-cyclopentyl]-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]-pyrroli- din-3-yl}-ureido)-benzenesulfonamide; 3-(3-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-(4-hydroxymethyl-[1,2,3]tri- azol-2-yl)-cyclopentyl]-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]-pyrroli- din-3-yl}-ureido)-benzenesulfonamide; 1-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-(4-hydroxymethyl-[1,2,3]triazo- l-2-yl)-cyclopentyl]-6-((S)-1-hydroxymethyl-2-phenyl-ethylamino)-9H-purin-- 2-yl]-pyrrolidin-3-yl}-3-pyridin-3-yl-urea; 1-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-(4-hydroxymethyl-[1,2,3]triazo- l-2-yl)-cyclopentyl]-6-((S)-1-hydroxymethyl-2-phenyl-ethylamino)-9H-purin-- 2-yl]-pyrrolidin-3-yl}-3-(3-hydroxy-benzyl)-urea; 4-(3-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-(4-hydroxymethyl-[1,2,3]tri- azol-2-yl)-cyclopentyl]-6-((S)-1-hydroxymethyl-2-phenyl-ethylamino)-9H-pur- in-2-yl]-pyrrolidin-3-yl}-ureido)-benzenesulfonamide; 3-(3-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-(4-hydroxymethyl-[1,2,3]tri- azol-2-yl)-cyclopentyl]-6-((S)-1-hydroxymethyl-2-phenyl-ethylamino)-9H-pur- in-2-yl]-pyrrolidin-3-yl}-ureido)-benzenesulfonamide; 1-((R)-1-{6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-[(1R,2S,3R,4S)-2,3-- dihydroxy-4-(4-hydroxymethyl-[1,2,3]triazol-2-yl)-cyclopentyl]-9H-purin-2-- yl}-pyrrolidin-3-yl)-3-pyridin-3-yl-urea; 1-((R)-1-{6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-[(1R,2S,3R,4S)-2,3-- dihydroxy-4-(4-hydroxymethyl-[1,2,3]triazol-2-yl)-cyclopentyl]-9H-purin-2-- yl}-pyrrolidin-3-yl)-3-(3-hydroxy-benzyl)-urea; 4-[3-((R)-1-{6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-[(1R,2S,3R,4S)-2- ,3-dihydroxy-4-(4-hydroxymethyl-[1,2,3]triazol-2-yl)-cyclopentyl]-9H-purin- -2-yl}-pyrrolidin-3-yl)-ureido]-benzenesulfonamide; 3-[3-((R)-1-{6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-[(1R,2S,3R,4S)-2- ,3-dihydroxy-4-(4-hydroxymethyl-[1,2,3]triazol-2-yl)-cyclopentyl]-9H-purin- -2-yl}-pyrrolidin-3-yl)-ureido]-benzenesulfonamide; 1-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-(5-hydroxymethyl-tetrazol-2-yl- )-cyclopentyl]-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]-pyrrolidin-3-yl}- -3-pyridin-3-yl-urea; 1-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-(5-hydroxymethyl-tetrazol-2-yl- )-cyclopentyl]-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]-pyrrolidin-3-yl}- -3-(3-hydroxy-benzyl)-urea; 4-(3-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-(5-hydroxymethyl-tetrazol-2- -yl)-cyclopentyl]-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]-pyrrolidin-3-- yl}-ureido)-benzenesulfonamide; 3-(3-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-(5-hydroxymethyl-tetrazol-2- -yl)-cyclopentyl]-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]-pyrrolidin-3-- yl}-ureido)-benzenesulfonamide; 1-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-(5-hydroxymethyl-tetrazol-2-yl- )-cyclopentyl]-6-((S)-1-hydroxymethyl-2-phenyl-ethylamino)-9H-purin-2-yl]-- pyrrolidin-3-yl}-3-pyridin-3-yl-urea; 1-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-(5-hydroxymethyl-tetrazol-2-yl- )-cyclopentyl]-6-((S)-1-hydroxymethyl-2-phenyl-ethylamino)-9H-purin-2-yl]-- pyrrolidin-3-yl}-3-(3-hydroxy-benzyl)-urea; 4-(3-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-(5-hydroxymethyl-tetrazol-2- -yl)-cyclopentyl]-6-((S)-1-hydroxymethyl-2-phenyl-ethylamino)-9H-purin-2-y- l]-pyrrolidin-3-yl}-ureido)-benzenesulfonamide; 3-(3-{(R)-1-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-(5-hydroxymethyl-tetrazol-2- -yl)-cyclopentyl]-6-((S)-1-hydroxymethyl-2-phenyl-ethylamino)-9H-purin-2-y- l]-pyrrolidin-3-yl}-ureido)-benzenesulfonamide; 1-((R)-1-{6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-[(1R,2S,3R,4S)-2,3-- dihydroxy-4-(5-hydroxymethyl-tetrazol-2-yl)-cyclopentyl]-9H-purin-2-yl}-py- rrolidin-3-yl)-3-pyridin-3-yl-urea; 1-((R)-1-{6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-[(1R,2S,3R,4S)-2,3-- dihydroxy-4-(5-hydroxymethyl-tetrazol-2-yl)-cyclopentyl]-9H-purin-2-yl}-py- rrolidin-3-yl)-3-(3-hydroxy-benzyl)-urea; 4-[3-((R)-1-{6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-[(1R,2S,3R,4S)-2- ,3-dihydroxy-4-(5-hydroxymethyl-tetrazol-2-yl)-cyclopentyl]-9H-purin-2-yl}- -pyrrolidin-3-yl)-ureido]-benzenesulfonamide; 3-[3-((R)-1-{6-[2,2-Bis-(4-hydroxy-phenyl)-ethylamino]-9-[(1R,2S,3R,4S)-2- ,3-dihydroxy-4-(5-hydroxymethyl-tetrazol-2-yl)-cyclopentyl]-9H-purin-2-yl}- -pyrrolidin-3-yl)-ureido]-benzenesulfonamide; and 3-[3-((R)-1-{6-[2,2-Bis-phenyl-ethylamino]-9-[(1R,2S,3R,4S)-2,3-dihydroxy- -4-(5-ethyl-tetrazol-2-yl)-cyclopentyl]-9H-purin-2-yl}-pyrrolidin-3-yl)-ur- eido]-benzenesulfonamide; or stereoisomers or pharmaceutically acceptable salts thereof. 2. The compound according to claim 1, in combination with an anti-inflammatory, bronchodilatory, anti-histamine or anti-tussive drug substance, said compound and said drug substance being in the same or different pharmaceutical composition. 3. A pharmaceutical composition comprising as active ingredient a compound according to claim 1, optionally together with a pharmaceutically acceptable diluent or carrier.

Details for Patent 8,071,565

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Jubilant Hollisterstier Llc	N/A	positive skin test control-histamine	Injection	103891	03/13/1924		2026-07-13