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Last Updated: April 26, 2024

Claims for Patent: 8,021,875

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Summary for Patent: 8,021,875

Title:	Methods for expression of transgenes
Abstract:	The present invention relates to compositions and methods for increasing long term expression in vitro and in vivo, comprising sequences and gene expression cassettes that increase expression of genes to which they are operably linked.
Inventor(s):	Wooddell; Christine I. (Madison, WI), Herweijer; Hans (Madison, WI)
Assignee:	Roche Madison Inc. (Madison, WI)
Application Number:	10/229,786
Patent Claims:	1. An expression cassette for long term in vivo expression of a transgene in a mammalian liver cell wherein the expression cassette comprises the coding sequence of said transgene and SEQ ID NO:7 operatively linked to the 3' end of said coding sequence. 2. An in vitro mammalian liver cell transfected with a gene expression cassette wherein said expression cassette comprises a coding sequence of a transgene and SEQ ID NO:7 operatively linked to the 3' end of said coding sequence. 3. A process for increasing long term in vivo expression of a transgene in a mammalian liver cell comprising: a) constructing a gene expression cassette wherein SEQ ID NO:7 is operatively linked to the 3' end of the coding sequence of said transgene: and, b) delivering said gene expression cassette to the liver cell in vivo wherein long term expression of said transgene is increased. 4. The process of claim 3 wherein the liver cell is a hepatocyte. 5. A gene expression cassette comprising: an alpha-fetoprotein (AFP) enhancer, an albumin promoter, a 5' intron, a linker sequence into which a gene coding sequence can be cloned, and SEQ ID NO:7 operatively linked to the 3' end of said linker sequence.

Details for Patent 8,021,875

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132	06/04/1986	⤷ Try a Trial	2021-08-27
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132		⤷ Try a Trial	2021-08-27
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	Injection	103132		⤷ Try a Trial	2021-08-27
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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