Claims for Patent: 7,887,832

Summary for Patent: 7,887,832

Title:	Popping oral pharmaceutical compositions
Abstract:	Disclosed are popping pharmaceutical compositions, which comprise OTC or prescription drug, and popping material. The popping material includes pressurized gas trapped within cavities of a pharmaceutically acceptable material in a manner that allows the gas to escape from the pharmaceutical composition upon dissolution, contact with saliva or shattering of the popping material. Such an oral pharmaceutical composition may be popular with children that will prefer it on other ones, which do not pop. Methods for preparation of such oral pharmaceutical compositions are also disclosed.
Inventor(s):	First; Sigal (Petach Tivka, IL), Yamin; Rina (Rehovot, IL)
Assignee:	CTS Chemical Industries, Ltd. (Kiryat Malachi, IL)
Application Number:	10/994,376
Patent Claims:	1. An oral pharmaceutical composition consisting of: one or more active ingredients; a popping material; and an optional flavoring agent; said popping material consisting of a pharmaceutically acceptable material consisting of one or more cavities with thermodynamically stable pressurized gas being trapped in cavities thereof in a manner that allows its escape upon dissolution, contact with saliva or shattering of the popping material, wherein said gas being selected from carbon dioxide, nitrogen, air, helium, argon, and neon, said active ingredient is a prescription drug or a drug sold over the counter and wherein said active ingredient is selected from the group consisting of expectorant, analgesic, antipyretic, anti-inflammatory, anti-hypertensive, anti-anginal, antiepileptic, anxiolytic, antipsychotic, anti-allergic, antidepressant, anti-histamine, hormone, steroid, hypolipidaemic and diuretic agents and said active ingredient is coated by a coating. 2. An oral pharmaceutical composition according to claim 1, wherein said one or more active ingredients is included in the pharmaceutically acceptable material in which gas is entrapped. 3. An oral pharmaceutical composition according to claim 1, wherein said pharmaceutically acceptable material is selected from sugars, corn syrup or mixtures thereof. 4. An oral pharmaceutical composition according to claim 1, wherein said one or more active ingredients are selected from paracetamol, diphenhydramine, dextromethorphan, loratadine, lidocaine, ibuprofen, pseudoephedrine, enalapril, calcium carbonate, isosorbide-mononitrate, enalapril maleate, sodium valporate, aspirin, alprazolam, amitriptyline, benzocaine, celecoxib, dexamethazone, famotidine, simvastatin, lorazepam, testosterone, and verapamil. 5. An oral pharmaceutical composition according to claim 1, suitable for veterinary use. 6. An oral pharmaceutical composition according to claim 5, wherein said one or more active ingredients are selected from nitroscanate, abamectin and ivermectin. 7. An oral pharmaceutical composition according to claim 1, having a form of a tablet, powder, pellet, capsule, syrup, oil, suspension, gel, drops, or losenge. 8. An oral pharmaceutical composition according to claim 1, having a form of a semi-solid, or oil suspension to enhance disintegration or dissolution of the active ingredient. 9. An oral pharmaceutical composition according to claim 1, wherein said coating is a a taste-masking material, a biodegradable polymer, an enteric polymer, a humidity protective material, an oxidation protective material-or a mixture thereof. 10. An oral pharmaceutical composition according to claim 1, wherein said coating is a taste masking coating. 11. A method for preparing an oral pharmaceutical composition according to claim 1 comprising: (i) preparing a mixture consisting of (a) one or more active ingrediences being prescription drugs or drugs sold over the counter, and (b) a pharmaceutically acceptable material trapping pressurized gas within cavities thereof; and (ii) processing said mixture to obtain an oral pharmaceutical composition that permits said gas to escape upon dissolution, contact with saliva or shattering of the popping material.

Details for Patent 7,887,832

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Jubilant Hollisterstier Llc	N/A	positive skin test control-histamine	Injection	103891	03/13/1924		2040-01-28