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Last Updated: April 26, 2024

Claims for Patent: 7,829,082

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Summary for Patent: 7,829,082

Title:	Catheter composition and uses thereof
Abstract:	A composition useful for removal of fibrin-bound blood clots from a catheter comprises water, a fibrinolytically effective amount of a plasminogen activator, and a preservatively effective amount of a bacteriostatic organic alcohol. The composition does not comprise a chelating agent.
Inventor(s):	Semba; Charles P. (Palo Alto, CA)
Assignee:	Genentech, Inc. (South San Francisco, CA)
Application Number:	11/426,263
Patent Claims:	1. A method for removing fibrin-bound blood clots from a catheter that contains such blood clots comprising contacting the catheter for at least about 5 days with a composition comprising water, a fibrinolytically effective amount of a tissue-plasminogen activator in a native form (t-PA) or in a variant form selected from group consisting of reteplase and tenecteplase, and a preservatively effective amount of a bacteriostatic organic alcohol, wherein the composition does not comprise a chelating agent. 2. The method of claim 1 wherein the catheter is contacted with the composition for about 6 to 15 days. 3. The method of claim 1 wherein the tissue-plasminogen activator is in the native form (t-PA). 4. The method of claim 1 wherein the organic alcohol is benzyl alcohol. 5. The method of claim 1 wherein the fibrinolytically effective amount of tissue-plasminogen activator is from about 0.1 to 10 mg/mL and the preservatively effective amount of organic alcohol is from about 0.5 to 1.2% (v/v). 6. The method of claim 5 wherein the fibrinolytically effective amount of tissue-plasminogen activator is from about 0.3 to 4 mg/mL. 7. The method of claim 1 wherein the water in the composition is bacteriostatic water for injection or bacteriostatic normal saline.

Details for Patent 7,829,082

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Chiesi Usa, Inc.	RETAVASE	reteplase	For Injection	103786	10/30/1996	⤷ Try a Trial	2021-11-26
Genentech, Inc.	TNKASE	tenecteplase	For Injection	103909	06/02/2000	⤷ Try a Trial	2021-11-26
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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