Claims for Patent: 7,776,915

Summary for Patent: 7,776,915

Title:	Topical formulations and methods of use
Abstract:	A topical composition comprising a lipoic acid, a carnitine, and a carnosine in a suitable vehicle for topical application and a method for treating skin is provided. The present compositions are useful in improving the appearance of aged skin characterized by wrinkles and loss of elasticity. Preferred components include R-lipoic acid or R-dihydrolipoic acid, acetyl-1-carnitine, and 1-carnosine.
Inventor(s):	Morariu; Marius (Brooklyn, NY)
Assignee:	Tracie Martyn International, LLC (New York, NY)
Application Number:	11/388,908
Patent Claims:	1. A method of treating skin, said method comprising administering a topical composition comprising: (a) 5.0% R-lipoic acid, 2.0% acetyl-1-carnitine, 1.0% carnosine, 1.0% astaxanthin, 0.5% tocotrienol, 0.5% tocopherol, 1.0% sesame oil, 0.5% grape proanthocyanidin, and 0.05% E.D.T.A. (ethylenediamine tetracetic acid); (b) 1.0% R-lipoic acid, 1.0% acetyl-1-carnitine, 1.0% carnosine, 0.2% Benfotiamine, 1.0% bilberry anthocyanin, 0.5% rosmarinic acid, 1.0% shark derived glycosaminoglycan, and 0.5% tocopherol; (c) 1.0% R-dihydrolipoic acid, 2.0% acetyl-1-carnitine, 1.0% carnosine, 0.5% lutein, 3.0% tetrahexyldecylascorbate, 0.5% lycopene, 0.1% coenzyme Q10 (ubiquinone), and 0.5% curcumine; (d) 1.0% R-lipoic acid, 1.0% R-dihydrolipoic acid, 1.0% acetyl-1-carnitine, 3.0% carnosine, and 1.0% NADH; (e) 1.0% R-dihydrolipoic acid, 1.0% acetyl-1-carnitine, 3.0% carnosine, 1.0% dipalmitoyl-hydroxy-proline, and 1.0% wolfberry extract; (f) 2.0% R-lipoic acid, 2.0% 1-carnitine, 2.0% 1-carnosine, 1.0% 1-glutathione, 2.0% bilberry anthocyanin, 1.0% rosemary extract, and 1.0% myristicin; or (g) 1.0% R-lipoic acid, 2.0% 1-carnitine, 2.0% 1-carnosine, 0.5% Huperzine-A, and 1.0% polyenylphosphatidylcholine; and a dermatologically acceptable carrier; wherein amounts are in weight percent and said composition is effective in the treatment of skin. 2. The method of claim 1, wherein the composition comprises: 5.0% R-lipoic acid, 2.0% acetyl-1-carnitine, 1.0% carnosine, 1.0% astaxanthin, 0.5% tocotrienol, 0.5% tocopherol, 1.0% sesame oil, 0.5% grape proanthocyanidin, and 0.05% E.D.T.A. (ethylenediamine tetracetic acid); and a dermatologically acceptable carrier. 3. The method of claim 1, wherein the composition comprises: 1.0% R-lipoic acid, 1.0% acetyl-1-carnitine, 1.0% carnosine, 0.2% benfotiamine, 1.0% bilberry anthocyanin, 0.5% rosmarinic acid, 1.0% shark derived glycosaminoglycan, and 0.5% tocopherol; and a dermatologically acceptable carrier. 4. The method of claim 1, wherein the composition comprises: 1.0% R-dihydrolipoic acid, 2.0% acetyl-1-carnitine, 1.0% carnosine, 0.5% lutein, 3.0% tetrahexyldecylascorbate, 0.5% lycopene, 0.1% coenzyme Q10 (ubiquinone), and 0.5% curcumine; and a dermatologically acceptable carrier. 5. The method of claim 1, wherein the composition comprises: 1.0% R-lipoic acid, 1.0% R-dihydrolipoic acid, 1.0% acetyl-1-carnitine, 3.0% carnosine, and 1.0% NADH; and a dermatologically acceptable carrier. 6. The method of claim 1, wherein the composition comprises: 1.0% R-dihydrolipoic acid, 1.0% acetyl-1-carnitine, 3.0% carnosine, 1.0% dipalmitoyl-hydroxy-proline, and 1.0% wolfberry extract; and a dermatologically acceptable carrier. 7. The method of claim 1, wherein the composition comprises: 2.0% R-lipoic acid, 2.0% 1-carnitine, 2.0% 1-carnosine, 1.0% 1-glutathione, 2.0% bilberry anthocyanin, 1.0% rosemary extract, and 1.0% myristicin; and a dermatologically acceptable carrier. 8. The method of claim 1, wherein the composition comprises: 1.0% R-lipoic acid, 2.0% 1-carnitine, 2.0% 1-carnosine, 0.5% Huperzine-A, and 1.0% polyenylphosphatidylcholine; and a dermatologically acceptable carrier. 9. The method of claim 1, wherein the carnosine is L-carnosine. 10. The method of claim 1, wherein the topical composition further comprises nicotinamide-adenine-dinucleotide. 11. The method of claim 1, wherein the topical composition further comprises an antioxidant. 12. The method of claim 1, wherein the topical composition further comprises an AGE inhibitor. 13. The method of claim 1, wherein the topical composition further comprises a mitochondrial resuscitant. 14. The method of claim 13, wherein the mitochondrial resuscitant is NTBHA, Mn-SOD, COQ10, creatine, D-ribose, pyruvate or stabilized ATP. 15. The method of claim 14 wherein the mitochondrial resuscitant is NTBHA. 16. The method of claim 1, wherein the topical composition further comprises a collagen enhancing agent, a sunscreen agent, an anti-edemic agent, a glutathione or an inducers thereof, a collagenase-inhibitor, an anti-inflammatory agent, a phenylpropanoid glycoside, a depigmenting agent or agent addressing hyperpigmentation, a skin-protective lipids, hyaluronic acid, an alpha hydroxy acid, an agent useful for treating hormonal decline, an anti-acne agent, an agent altering lipolytic activity, an anti-cellulitic agent, an agent altering anti-capillary-fragility, an anti-elastase agent, an anti-erythema agent, or an agent that raises cyclic AMP. 17. The method of claim 1, wherein the composition is encapsulated. 18. The method of claim 17, wherein the composition is encapsulated in a liposome. 19. The method of claim 1, wherein the composition is administered in a makeup. 20. The method of claim 19, wherein the makeup is a foundation, a cover cream, or an eyeshadow. 21. The method of claim 1, further comprising applying electricity to the skin. 22. The method of claim 21, wherein the electricity is applied using an electronic patch or a portanble electronic device. 23. The method of claim 1, further comprising applying light to the skin. 24. The method of claim 21, further comprising applying light to the skin.

Details for Patent 7,776,915

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995	06/04/1965		2025-03-24