Claims for Patent: 7,749,999

Summary for Patent: 7,749,999

Title:	Alpha-ketoamides and derivatives thereof
Abstract:	The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions mediated by cytokines such as arthritis.
Inventor(s):	Boman; Erik (Chula Vista, CA), Ceide; Susana Conde (San Diego, CA), Dahl; Russell (Carlsbad, CA), Delaet; Nancy G. J. (San Diego, CA), Ernst; Justin (San Diego, CA), Montalban; Antonio Garrido (San Diego, CA), Nakanishi; Hiroshi (San Diego, CA), Roberts; Edward (Fallbrook, CA), Saiah; Eddine (La Jolla, CA), Sullivan; Robert (Vista, CA), Wang; Zhinjun (San Diego, CA), Kahl; Jeffrey (San Diego, CA), Larson; Christopher (San Diego, CA)
Assignee:	Itherx Pharmaceuticals, Inc. (San Diego, CA)
Application Number:	10/939,324
Patent Claims:	1. A cytokine inhibitor having Formula IA: ##STR00073## stereoisomers thereof; tautomers thereof, and pharmaceutically acceptable salts thereof, wherein: X is C(O)or C(S); G is a C.sub.3-10 carbocyclyl, a 5-8 membered monocyclic heterocyclyl, or a 8-11 membered bicyclic heterocyclyl containing 1 or more heteroatoms selected from O, N or S; wherein G is substituted by one or more R.sup.1, R.sup.2 or R.sup.3; Ar is --(Y)--(C.sub.0-3 alkyl)-(bicyclic aryl) wherein the bicyclic aryl is naphthyl, tetrahydronaphthyl, dihydronaphthyl, indenyl, or indanyl, or Ar is --(Y)--(C.sub.0-3 alkyl)-(bicyclic heteroaryl), wherein the bicyclic heteroaryl is indazolyl, isoindolyl, quinolinyl, isoquinolinyl, phthalazinyl, dihydroindolyl, benzofuranyl, benzoxazolyl, benzoisoxazolyl, dihydrobenzoisoxoazolyl, dihydroisoindolyl, benzimidazolyl, benzothienyl, benzothiazolyl, benzoisothiazolyl, or benzoisothiazolyl dioxide, and wherein Ar is optionally substituted with one or more R.sup.4 or R.sup.5; provided however, that the bicyclic aryl is not 1,1,4,4-tetramethyl-1,2,3,4-tetrahydro-naphthyl; Y is --C(O)--, --C(NNRC(O)OR)--, --C(NNRR)--, --C(NNHC(O)NRR)-- or --C(NOR)--; L is a covalent bond or a saturated or unsaturated branched or unbranched C.sub.1-10 carbon chain, wherein one or more methylene groups are optionally independently replaced by heteroatoms chosen from O, NR and S(O).sub.m; and wherein L is optionally substituted with 0-2 oxo groups and one or more C.sub.1-4 branched or unbranched alkyl optionally substituted by one or more F, Cl, Br, or I; each m is independently 0, 1 or 2; Q is --NR'R', cycloalkyl, aryl, heterocyclyl, C.sub.1-6 alkoxy, C.sub.1-6 alkyl-S(O).sub.m, or phenyl-S(O).sub.m, wherein the cycloalkyl, aryl, heterocyclyl, C.sub.1-6 alkoxy, C.sub.1-6 alkyl-S(O).sub.m, or phenyl-S(O).sub.m is each optionally substituted with one or more R.sup.27; each R is independently hydrogen or substituted or unsubstituted C.sub.1-6 alkyl; each R' is independently hydrogen, substituted or unsubstituted C.sub.1-8 alkyl, substituted or unsubstituted (C.sub.0-4 alkyl)-(C.sub.6-10 aryl) or substituted or unsubstituted (C.sub.0-4 alkyl)-(5-10 member heterocyclyl); each R.sup.1 is independently F, Cl, Br, I, cyano, --C(O)R, --C(O)NR.sub.2, --C(O)OR, --OR, --NR'R', --SiR.sub.3, --S(O).sub.mR, substituted or unsubstituted straight or branched C.sub.1-10 alkyl, C.sub.2-10 alkenyl, or C.sub.2-10 alkynyl, substituted or unsubstituted C.sub.3-10 cycloalkyl, substituted or unsubstituted C.sub.5-8 cycloalkenyl, substituted or unsubstituted C.sub.7-20 aralkyl, substituted or unsubstituted saturated or unsaturated 3-11 member heterocyclyl or heterocyclylalkyl containing 1, 2, 3, or 4 heteroatoms selected independently from N, O, S(O).sub.m; each R.sup.2, R.sup.4 and R.sup.5 is independently F, Cl, Br, I, cyano, substituted or unsubstituted straight or branched C.sub.1-6 alkyl, substituted or unsubstituted C.sub.6-10 aryl, substituted or unsubstituted 5-10 member heteroaryl, --OR', --OR.sup.6, --C(O)R', --C(O)OR', --C(O)NR'.sub.2, --NR'.sub.2, --NO.sub.2, S(O).sub.mR'', --NR'SO.sub.2R'', --NR'C(O)NR'R', --NR'C(S)NR'R', --NR'C(O)OR' or --SO.sub.2NR'.sub.2; each R'' is independently substituted or unsubstituted C.sub.1-8 alkyl, substituted or unsubstituted C.sub.0-4 alkyl-C.sub.6-10 aryl or substituted or unsubstituted (C.sub.0-4 alkyl)-(5-10 member heterocyclyl); each R.sup.3 is independently substituted or unsubstituted C.sub.6-10 aryl, substituted or unsubstituted saturated or unsaturated 3-11 member heterocyclyl or heterocyclylalkyl containing 1, 2, 3, or 4 heteroatoms selected independently from N, O, S(O).sub.m, substituted or unsubstituted C.sub.3-12 cycloalkyl, substituted or unsubstituted C.sub.5-12 cycloalkenyl, substituted or unsubstituted C.sub.7-20 aralkyl, substituted or unsubstituted straight or branched C.sub.1-8 alkyl, R.sup.20C(O)N(R.sup.21)--, R.sup.22O--, R.sup.23R.sup.24NC(O)--, R.sup.26(CH.sub.2).sub.mC(O)N(R.sup.21)--, R.sup.26C(O)(CH.sub.2).sub.mN(R.sup.21)--, substituted or unsubstituted C.sub.2-8 alkenyl, or substituted or unsubstituted C.sub.2-8 alkynyl, wherein one or more methylene groups of the C.sub.1-8 alkyl, C.sub.2-8 alkenyl, or C.sub.2-8 alkynyl are optionally replaced by O, NH, or S(O).sub.m; each R.sup.6 is a C.sub.1-6 branched or unbranched alkyl optionally partially or fully halogenated and optionally substituted with R.sup.26; each R.sup.26 is independently cyano, morpholino, piperidinyl, piperazinyl, imidazolyl, phenyl, pyridinyl, tetrazolyl, or mono or di-(C.sub.0-4 alkyl)amino optionally partially or fully halogenated; R.sup.20 is substituted or unsubstituted C.sub.1-10 alkyl, substituted or unsubstituted C.sub.0-6 alkyl-phenyl, substituted or unsubstituted C.sub.0-6 alkyl-heterocyclyl, OR' or NR'.sub.2; R.sup.21 is hydrogen or C.sub.1-4 branched or unbranched alkyl optionally partially or fully halogenated; and each R.sup.22, R.sup.23 and R.sup.24 is independently hydrogen, substituted or unsubstituted C.sub.1-10 alkyl, wherein the C.sub.1-10 alkyl is optionally interrupted by one or more O, N or S, substituted or unsubstituted C.sub.0-6 alkyl-phenyl, substituted or unsubstituted C.sub.0-6 alkyl-heterocyclyl; or R.sup.23 and R.sup.24 taken together optionally form a heterocyclic or heteroaryl ring; each R.sup.27 is independently F, Cl, Br, I, cyano, --C(O)R', --C(O)NR'.sub.2, --C(O)OR', --OR', --NR'R', --SiR'.sub.3, --S(O).sub.mR', substituted or unsubstituted straight or branched C.sub.1-10 alkyl, C.sub.2-10 alkenyl, or C.sub.2-10 alkynyl, substituted or unsubstituted C.sub.3-10 cycloalkyl, substituted or unsubstituted C.sub.5-8 cycloalkenyl, substituted or unsubstituted C.sub.7-20 aralkyl, substituted or unsubstituted 3-11 member heterocyclyl or heterocyclylalkyl containing 1, 2, 3, or 4 heteroatoms selected independently from N, O, S(O).sub.m; provided however that when Ar is --(Y)-(bicyclic aryl) and G is N-(substituted or unsubstituted phenyl)-pyrazolyl, the pyrazolyl is additionally substituted with one or more R.sup.1, R.sup.2 or R.sup.3; and IA is not N-(4-chloro-3-methyl-isothiazol-5-yl)-2-[2-(2,2-dimethyl-propyl)-benzooxa- zol-5-yl]-2-oxo-acetamide. 2. The compound of claim 1, wherein G is phenyl, naphthyl, cyclopropyl, benzocyclobutanyl, dihydronaphthyl, tetrahydronaphthyl, benzocycloheptanyl, benzocycloheptenyl, indanyl, indenyl, or benzofuran-3-one. 3. The compound of claim 1, wherein G is pyrazolyl, pyridinyl, pyridonyl, quinolinyl, dihydroquinolinyl, tetrahydroquinoyl, isoquinolinyl, tetrahydroisoquinoyl, pyridazinyl, pyrimidinyl, pyrazinyl, benzimidazolyl, benzthiazolyl, benzoxazolyl, benzofuranyl, benzothiophenyl, benzpyrazolyl, dihydrobenzofuranyl, dihydrobenzothiophenyl, benzoxazolonyl, benzo[1,4]oxazin-3-onyl, benzodioxolyl, benzo[1,3]dioxol-2-onyl, tetrahydrobenzopyranyl, indolyl, indolinyl, indolonyl, indolinonyl, or phthalimidyl. 4. The compound of claim 1, wherein G is phenyl, naphthyl, cyclopropyl, pyrazolyl, pyrrolyl, pyrrolidinyl, imidazolyl, imidazolonyl, thiazolyl, oxazolyl, isoxazolyl, furanyl, thienyl, or pyridinyl. 5. The compound of claim 1, wherein Ar is --(Y)--(C.sub.0-3 alkyl)-(bicyclic aryl), and the bicyclic aryl is naphthyl. 6. The compound of claim 5, wherein Ar is substituted with at least one R.sup.4 or R.sup.5. 7. The compound of claim 5, wherein Y is --C(O)--, --C(NNRC(O)OR)-- or --C(NOR)--. 8. The compound of claim 1, wherein Ar is --(Y)--(C.sub.0-3 alkyl)-(bicyclic heteroaryl). 9. The compound of claim 8, wherein Ar is substituted with at least one R.sup.4 R.sup.5. 10. The compound of claim 8, wherein Y is --C(O)--, --C(NNRC(O)OR)-- or --C(NOR)--. 11. The compound of claim 8, wherein the bicyclic heteroaryl is quinolinyl, isoquinolinyl, phthalazinyl, or quinazolinyl. 12. The compound of claim 1 wherein L is a covalent bond, a C.sub.1-C.sub.9 alkoxy, --C(O)O--, --NH-- or --O--. 13. The compound of claim 1, wherein Q is thiomorpholino sulfoxide, thiomorpholino sulfone, piperazinonyl, oxazepinyl, diazepinonyl, imidazolyl, pyridinyl or morpholino. 14. The compound of claim 1, wherein Q is morpholino, piperazinyl, pyrimidinyl or pyridinyl. 15. The compound of claim 14, wherein R.sup.27 is --C(O)OR, --NR'R', substituted or unsubstituted straight or branched C.sub.1-10 alkyl, substituted or unsubstituted C.sub.7-20 aralkyl, or substituted or unsubstituted saturated or unsaturated 3-11 member heterocyclyl or heterocyclylalkyl containing 1, 2, 3, or 4 heteroatoms selected independently from N, O, S(O).sub.m. 16. The compound of claim 1, wherein each R.sup.1 is independently C.sub.3-10 branched or unbranched alkyl optionally partially or fully halogenated, and optionally substituted with one to three C.sub.3-10 cycloalkyl, hydroxy phenyl, naphthyl, pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, pyrrolyl, imidazolyl, pyrazolyl, thienyl, furyl, isoxazolyl, or isothiazolyl; each of which is optionally substituted with 1 to 5 halogen, C.sub.1-6 branched or unbranched alkyl which is optionally partially or fully halogenated, C.sub.3-8 cycloalkyl, C.sub.5-8 cycloalkenyl, hydroxy, cyano, C.sub.1-3 alkoxy which is optionally partially or fully halogenated and NH.sub.2C(O) or mono- or di-C.sub.1-3 alkyl)aminocarbonyl. 17. The compound of claim 1, wherein each R.sup.1 is independently C.sub.3-10 branched or unbranched alkyl. 18. The compound of claim 1, wherein each R is independently --OR', --OR.sup.6, --C(O)R', --C(O)OR', --C(O)NR'.sub.2, --NR'.sub.2, --NO.sub.2, --S(O).sub.mR'', --NR'SO.sub.2R'', --NR'C(O)NR'R', --NR'C(S)NR'R', --NR'C(O)OR' or --SO.sub.2NR'.sub.2. 19. The compound of claim 1, wherein each R.sup.2 is independently --NR'.sub.2, --NO.sub.2, --C(O)NR'.sub.2, --NR'SO.sub.2R'', --NR'C(O)NR'R', --NR'C(S)NR'R', --NR'C(O)OR' or --SO.sub.2NR'.sub.2. 20. The compound of claim 1, wherein R.sup.3 is phenyl, pyridazinyl or pyridyl, each of which is optionally partially or fully halogenated and optionally substituted with C.sub.1-6 branched or unbranched alkyl which is optionally partially or fully halogenated, hydroxy, oxo, cyano, C.sub.1-3 alkoxy optionally partially or fully halogenated, nitro, amino, or mono- or di-(C.sub.1-3 alkyl)amino; C.sub.1-6 alkyl or C.sub.1-6 alkoxy, each optionally partially or fully halogenated or optionally substituted with R.sup.17, amino, OR.sup.18, C.sub.1-5 mono- or di-alkylamino optionally substituted with R.sup.19; R.sup.20C(O)N(R.sup.21)--, R.sup.22O--, R.sup.23R.sup.24NC(O)--, R.sup.26(CH.sub.2).sub.mC(O)N(R.sup.21)-- or R.sup.26C(O)(CH.sub.2).sub.mN(R.sup.21)--. 21. The compound of claim 1, wherein X is C.dbd.O. 22. The compound of claim 1, wherein Ar is --(Y)-naphthyl-, Y is --C(O)--, or --C(.dbd.NOH)-- and G is phenyl, pyridinyl, pyrazolyl, pyrrolyl, imidazolyl, oxazolyl, isoxazolyl, furanyl or thienyl. 23. The compound of claim 1, wherein Ar is --(Y)-naphthyl-, Y is --C(O)--, or --C(.dbd.NOH)-- and G is phenyl or pyridyl. 24. The compound of claim 23, wherein each R.sup.1 is independently a substituted or unsubstituted straight or branched C.sub.1-10 alkyl. 25. The compound of claim 24, wherein each R.sup.3 is independently R.sup.23R.sup.24N--C(O)--, R.sup.20--C(O)--NR.sup.21--, or OR.sup.22. 26. The compound of claim 25, wherein each R.sup.2 is independently --NR'SO.sub.2R'', --Cl, --Br, --F, --C(O)--NR'.sub.2 substituted or unsubstituted straight or branched C.sub.1-6 alkyl, --NR'.sub.2, or --OR'. 27. The compound of claim 1, wherein Ar is --(Y)-naphthyl-, Y is --C(O)--, or --C(.dbd.NOH)--, and G is pyrazolyl, thienyl or isoxazolyl. 28. The compound of claim 27, wherein each R.sup.1 is independently a substituted or unsubstituted straight or branched C.sub.1-10 alkyl. 29. The compound of claim 28, wherein each R.sup.3 is independently phenyl or pyridinyl, optionally substituted with one, two, or three --F, --Cl, substituted or unsubstituted C.sub.1-6 branched or unbranched alkyl or substituted or unsubstituted C.sub.1-4 alkoxy. 30. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier. 31. A pharmaceutical composition comprising a compound of claim 1 and one or more active ingredients A, wherein A is a non-steroidal anti-inflammatory drug, immunosuppressive drug, immunomodulatory drug, cytostatic drug, angiogenesis inhibitor, biological agent, steroid, vitamin D3 or analog thereof retinoid, or inhibitor of cell adhesion molecule lymphocyte function-associated antigen-1 or intercellular adhesion molecule. 32. The composition according to claim 31, wherein the immunosuppressive drug, immunomodulatory drug, or cytostatic drug is methotrexate, infliximab, leflunomide, or combinations thereof. 33. A compound or a pharmaceutically acceptable salt thereof wherein the compound is selected from the group consisting of N-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-2-[4-(2-morpholin-4-yl-ethoxy)- -naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-2-[4-(2-morpholi- n-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-2-[4-(2-morpholi- n-4-yl-pyrimidin-4-yloxy)-naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-2-hydroxy-3-morpholin-4-ylmethyl-phenyl)-2-[4-(2-morpholi- n-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-2-hydroxy-3-methyl-phenyl)-2-[4-(2-morpholin-4-yl-ethoxy)- -naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-2-methoxy-3-methyl-phenyl)-2-[4-(2-morpholin-4-yl-ethoxy)- -naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl -3-chloro-2-methoxy-phenyl)-2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-y- l]-2-oxo-acetamide; N-(5-tert-Butyl-2-methoxy-3-trifluoromethyl-phenyl)-2-[4-(2-morpholin-4-y- l-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-2-[7-chloro-4-(2-morpholin-4-y- l-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; 5-tert-Butyl-N-cyclopropyl-2-methoxy-3-{2-[4-(2-morpholin-4-yl-ethoxy)-na- phthalen-1-yl]-2-oxo-acetylamino}-benzamide; N-[5-tert-Butyl-2-methoxy-3-(piperidine-1-carbonyl)-phenyl]-2-[4-(2-morph- olin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; 5-tert-Butyl-2-hydroxy-3-{2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]- -2-oxo-acetylamino}-benzoic acid; N-(2-Benzenesulfonyl-5-tert-butyl-2H-pyrazol-3-yl)-2-[4-(2-morpholin-4-yl- -ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-2-[(Z)-hydroxyimino]-2-[4-(2-m- orpholin-4-yl-ethoxy)-naphthalen-1-yl]-acetamide; N-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-2-[(Z)-methoxyimino]-2-[4-(2-m- orpholin-4-yl-ethoxy)-naphthalen-1-yl]-acetamide; N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-2-oxo-2-[4-(2-pi- peridin-1-yl-pyrimidin-4-yloxy)-naphthalen-1-yl]-acetamide; N-[5-tert-Butyl-2-(2,5-difluoro-phenyl)-2H-pyrazol-3-yl]-2-[4-(2-morpholi- n-4-yl-ethoxy)naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-2-methoxy-phenyl)-2[4-(2-morpholin-4-yl-ethoxy)-naphthale- n-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-2-(4-methoxy-nap- hthalen-1-yl)-2-oxo-acetamide; N-[5-tert-Butyl-2-(3-chloro-benzoyl)-2H-pyrazol-3-yl]-2-[4-(2-morpholin-4- -yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-[5-tert-Butyl-2-(3-methanesulfonyl-phenyl)-2H-pyrazol-3-yl]-2-[4-(2-mor- pholin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-[3-(Benzenesulfonyl-carbamoylmethyl-amino)-5-tert-butyl-2-methoxy-pheny- l]-2-naphthalen-1-yl-2-oxo-acetamide; N-(3-tert-Butyl-isoxazol-5-yl)-2[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1- -yl]-2-oxo-acetamide; N-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-2-[4-(2-morpholin-4-yl-pyrimid- in-4-ylamino)-naphthalen-1-yl]-2-oxo-acetamide; N-[5-tert-Butyl-2-(4-sulfamoyl-phenyl)-2H-pyrazol-3-yl]-2-[4-(2-morpholin- -4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; 2-(4-Bromo-naphthalen-1-yl)-N-(5-tert-butyl-2-methyl-2H-pyrazol-3-yl)-2-o- xo-acetamide; 5-tert-Butyl-2-hydroxy-3-{2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]- -2-oxo-acetylamino}-benzamide; N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-2-[4-(6-morpholi- n-4-ylmethyl-pyridin-3-yl)-naphthalen-1-yl]-2-oxo-acetamide; N-(5tert-Butyl-2-methoxy-phenyl)-2-[4-(2-methylamino-pyrimidin-4-ylamino)- -naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-2-methoxy-phenyl)-2-[4-(2-dimethylamino-pyrimidin-4-ylami- no)-naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-2-oxo-2-{4-[2-(1-oxo-1.lamda..- sup.4-thiomorpholin-4-yl)-ethoxy]-naphthalen-1-yl}-acetamide; 5-tert-Butyl-3-{2-[(Z)-hydroxyimino]-2-[4-(2-morpholin-4-yl-ethoxy)-napht- halen-1-yl]-acetylamino}-thiophene-2-carboxylic acid methyl ester; N-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-2-{4-[2-((2R,6R)-2,6-dimethyl-- morpholin-4-yl)-ethoxy]-naphthalen-1-yl}-2-oxo-acetamide; N-(5-tert-Butyl-2-methyl-2H-pyrazol-3-yl)-2-[4-(6-morpholin-4-ylmethyl-py- ridin-3-yl)-naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-2-[7-chloro-4-(2- morpholin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-2-[(Z)-hydroxyim- ino]-2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-acetamide; N-(5-tert-Butyl-2-methoxy-phenyl)-2-[4-(6-morpholin-4-ylmethyl-pyridin-3-- yl)-naphthalen-1-yl]-2-oxo-acetamide; 5-tert-Butyl-N-cyclopropyl-2-methoxy-3-[2-(4-methoxy-naphthalen-1-yl)-2-o- xo-acetylamino]-benzamide; N-(2-Acetyl-5-tert-butyl-2H-pyrazol-3-yl)-2-[4-(2-morpholin-4-yl-ethoxy)-- naphthalen-1-yl]-2-oxo-acetamide; 5-tert-Butyl-N-cyclopropyl-3-{2-hydrazono-2-[4-(2-morpholin-4-yl-ethoxy)-- naphthalen--1-yl]-acetylamino}-2-methoxy-benzamide; N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-2-hydrazono-2-[4- -(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-acetamide; N-(3,4-Dimethyl-phenyl)-2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-2- -oxo-acetamide; N-(5-tert-Butyl-2-cyclohexyl-2H-pyrazol-3-yl)-2-[4-(2-morpholin-4-yl-etho- xy)-naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-2-methoxy-phenyl)-2-oxo-2-(4-pyridin-3-yl-naphthalen-1-yl- )-acetamide; N-(5-tert-Butyl-isoxazol-3-yl)-2-[(Z)-hydroxyimino]-2-[4-(2-morpholin-4-y- l-ethoxy)naphthalen-1-yl]-acetamide; N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-2-[4-(2-diethyla- mino-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-2-oxo-2-{4-[2-(3-oxo-[1,4]diaz- epan-1-yl)-ethyl]-naphthalen-1-yl}-acetamide; 5-tert-Butyl-N-ethyl-2-methoxy-3-[2-(4-methoxy-naphthalen-1-yl)-2-oxo-ace- tylamino]-benzamide; N-(5-tert-Butyl-2-methoxy-phenyl)-2-oxo-2-{4-[6-(tetrahydro-pyran-4-ylami- no)-pyridin-3-yl]-naphthalen-1-yl}-acetamide; N-(2,5Dimethyl-phenyl)-2-[4-(2morpholin-4yl-ethoxy)-naphthalen-1-yl]-2-ox- o-acetamide; Pyrrolidine-1-carboxylic acid (5-tert-butyl-2-methoxy-3-{2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl- ]-2-oxo-acetylamino}-phenyl)-amide; N-(3-Amino-5-tert-butyl-2-methoxy-phenyl)-2-oxo-2-{4-[2-((S)-1-phenyl-eth- ylamino)-pyrimidin-4-ylamino]-naphthalen-1-yl}-acetamide; 5-tert-Butyl-2-methoxy-3-{2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]- -2-oxo-acetylamino}-benzamide; N-(5-tert-Butyl-2-methoxy-3-{2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-- yl]-2-oxo-acetylamino}-phenyl)-benzamide; N-(3,5-Di-tert-butyl-2-methoxy-phenyl)2-[(Z)hydroxyimino]-2-[4-(2-morphol- in-4-yl-ethoxy)-naphthalen-1-yl]-acetamide; N'-[1-(5-tert-Butyl-2-methyl-2H-pyrazol-3-ylcarbamoyl)-1-[4-(2-morpholin-- 4-yl-ethoxy)-naphthalen-1-yl]-meth-(E)-ylidene]-hydrazinecarboxamide; 5-tert-Butyl-3-{2-[(Z)-methoxyimino]-2-[4-(2-morpholin-4-yl-ethoxy)--naph- thalen-1-yl]-acetylamino}-thiophene-2-carboxylic acid amide; 5-tert-Butyl-N-cyclopropylmethyl-2-methoxy-3-{2-[4-(2-morpholin-4-yl-etho- xy)-naphthalen-1-yl]-2-oxo-acetylamino}-benzamide; N-[5-tert-Butyl-2-methoxy-3-(2-methoxy-acetylamino)-phenyl]-2-[4-(2-morph- olin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-2-isopropoxy-3-methanesulfonylamino-phenyl)-2-[4-(2-morph- olin-4-yl -ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-[5-tert-Butyl-2-(3,4-dimethyl-phenyl)-2H-pyrazol-3-yl]-2-[4-(2-morpholi- n-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-2-oxo-2-[4-(2-thiomorpholin-4-- yl-ethoxy)-naphthalen-1-yl]-acetamide; N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-2-[4-(2-dimethyl- amino-pyrimidin-4-ylamino)-naphthalen-1-yl]-2-oxo-acetamide; 1-(2-Amino-4-tert-butyl-6-{2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl- ]-2-oxo-acetylamino}-phenyl)-pyridinium; N-(5-tert-Butyl-2-isopropoxy-phenyl)-2-[4-(2-morpholin-4-yl-ethoxy)-napht- halen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-2-m-tolyl-2H-pyrazol-3-yl)-2-[(Z)-hydroxyimino]-2-[4-(2-m- orpholin-4-yl-ethoxy)-naphthalen-1-yl]-acetamide; 5-tert-Butyl-2-methoxy-3-[2-(4-methoxy-naphthalen-1-yl)-2-oxo-acetylamino- ]benzamide; 5-tert-Butyl-2-methoxy-N-(2-methoxy-ethyl)-3-{2-[4-(2-morpholin-4-yl-etho- xy)-naphthalen-1-yl]-2-oxo-acetylamino}-benzamide; N-(5-tert-Butyl-isoxazol-3-yl)-2-[4-(2-morpholin-4-yl-pyrimidin-4-ylamino- )-naphthalen-1-yl]-2-oxo-acetamide; (5-tert-Butyl-2-methoxy-3-{2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl- ]-2-oxo-acetylamino}-phenyl)-carbamic acid methyl ester; 3-tert-Butyl-5-{2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-ace- tylamino}-pyrazole-1-carboxylic acid adamantan-1-ylamide; 5-tert-Butyl-3-{2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-ace- tylamino}-thiophene-2-carboxylic acid amide; N-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-2-{4-[2-(2,6-dimethyl-morpholi- n-4-yl)-ethyl]-naphthalen-1-yl}-2-oxo-acetamide; N-(5-tert-Butyl-2H-pyrazol-3-yl)-2-[4-(2-morpholin-4-yl-ethoxy)-naphthale- n-1-yl ]-2-oxo-acetamide; 3-tert-Butyl-5-{2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-ace- tylamino}-pyrazole-1-carboxylic acid tert-butylamide; 3-tert-Butyl-5-{2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-ace- tylamino}-pyrazole-1-carboxylic acid amide; N-Allyl-5-tert-butyl-2-methoxy-3-{2-[4-(2-morpholin-4-yl-ethoxy)-naphthal- en-1-yl]-2-oxo-acetylamino}-benzamide; N-(5-tert-Butyl-isoxazol-3-yl)-2-[(Z)-methoxylmino]-2-[4-(2-morpholin-4-y- l-ethoxy)-naphthalen-1-yl]-acetamide; N-(3-Acetylamino-5-tert-butyl-2-methoxy-phenyl)-2-[4-(2morpholin-4-yl-eth- oxy)-naphthalen-1-yl]-2-oxo-acetamide; 5-tert-Butyl-3-{2-[(Z)-hydroxyimino]-2-[4-(2-morpholin-4-yl-pyrimidin-4-y- loxy)-naphthalen-1-yl]-acetylamino}-thiophene-2-carboxylic acid amide; N-[3-(4-Acetyl-piperazine-1-carbonyl)-5-tert-butyl-2-methoxy-phenyl]-2-[4- -(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-4-methyl-2-p-tolyl-2H-pyrazol-3-yl)-2-[(Z)-hydroxyimino]-- 2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-acetamide; 2-[4-(2-Morpholin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-N-(2-phenyl-cyclopr- opyl)-acetamide; N-(5-tert-Butyl-isoxazol-3-yl)-2-[4-(6-morpholin-4-ylmethyl-pyridin-3-yl)- -naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-2,3-dimethoxy-phenyl)-2-[(Z)-hydroxyimino]-2-[4-(2-morpho- lin-4-yl-ethoxy)-naphthalen-1-yl]-acetamide; N-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-2-{4-[2-(4-methyl-piperazin-1-- yl)-ethyl]-naphthalen-1-yl}-2-oxo-acetamide; N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-2-(1H-indol-3-yl- )-2-oxo-acetamide; N-(5-tert-Butyl-2-methoxy-phenyl)-2-[4-(2-morpholin-4-yl-pyridin-4-ylamin- o)naphthalen-1-yl]-2-oxo-acetamide; N-(4-tert-Butyl-6-trifluoromethyl-pyrimidin-2-yl)-2-[4-(2-morpholin-4-yl-- ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; 5-tert-Butyl-3-{2-[(Z)-hydroxyimino]-2[4-(2-morpholin-4-yl-ethoxy)-naphth- alen-1-yl]-acetylamino}-thiophene-2-carboxylic acid methylamide; N-[5-tert-Butyl-2-(3,5-dichloro-phenyl)-2H-pyrazol-3-yl]-2-[4-(2-morpholi- n-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-2-{4-[2-((2R,6S)-2,6-dimethyl-- morpholin-4-yl)-ethoxy]-naphthalen-1-yl}-2-oxo-acetamide; N-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-2-[4-(2-imidazol-1-yl-ethyl)-n- aphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-2-methoxy-3-phenylmethanesulfonylamino-phenyl)-2-[4-(2-mo- rpholin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl-oxo-2-[4-(2-pyridin-4-yl-ethoxy- )naphthalen-1-yl]-acetamide; N-[5-tert-Butyl-2-(3-chloro-phenyl)-2H-pyrazol-3-yl]-2-[4-(2-morpholin-4-- yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-[5-tert-Butyl-2-(6-chloro-pyridazin-3-yl)-2H-Pyrazol-3-yl]-2-[4-(2morph- olin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-2-m-tolyl-2H-pyrazol-3-yl)-2-[4-(2-morpholin-4-yl-ethoxy)- naphthalen-1-yl]-2-oxo-acetamide; 5-tert-Butyl-N-cyclopropyl-2-methoxy-3-{2-[4-(2-morpholin-4-yl-pyrimidin-- 4-ylamino)-naphthalen-1-yl]-2-oxo-acetylamino}-benzamide; [(5-tert-Butyl-2-methoxy-3-{2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-y- l]-2-oxo-acetylamino}-phenyl)-methanesulfonyl-amino]-acetic acid ethyl ester; N-(5-tert-Butyl-4-methyl-2-m-tolyl-2H-pyrazol-3-yl)-2-[(Z)-hydroxy- imino]-2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-acetamide; N-[5-tert-Butyl-2-(2,5-dichloro-phenyl)-2H-pyrazol-3-yl]-2-[4-(2-morpholi- n-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-2-[4-(2-[1,4]oxazepan-4-yl-eth- oxy)-naphthalen-1-yl]-2-oxo-acetamide; N-(2-Bromo-5-trifluoromethyl-phenyl)-2-[4-(2morpholin-4-yl-ethoxy)-naphth- alen-1-yl]-2-oxo-acetamide; 5-tert-Butyl-N-cyclopentyl-2-methoxy-3-{2-[4-(2-morpholin-4-yl-ethoxy)nap- hthalen-1-yl]-2-oxo-acetylamino}-benzamide; N-[5-tert-Butyl-2-(morpholine-4-carbonyl)-thiophen-3-yl]-2-[4-(2-morpholi- n-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-2-methoxy-phenyl)-2-[4-(2-morpholin-4-yl-pyrimidin-4-ylox- y)-naphthalen-1-yl]-2-oxo-acetamide; 5-tert-Butyl-N-cyclopropylmethyl-2-methoxy-3-[2-(4-methoxy-naphthalen-1-y- l)-2-oxo-acetylamino]-benzamide; N- [5-tert-Butyl-3-(3,3-diethyl-ureido)-2-methoxy-phenyl]-2-[4-(2-morpholin-- 4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-[5-tert-Butyl-2-(4-fluoro-phenyl)-2H-pyrazol-3-yl]-2-[4-(2-morpholin-4-- yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-(2-Benzyl-5-tert-butyl-2H-pyrazol-3-yl)-2-[4-(2-morpholin-4-yl-ethoxy)-- naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-2-oxo-2-[4-(2-pi- perazin-1-yl-ethoxy)-naphthalen-1-yl]-acetamide; N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-2-[4-(2-morpholi- n-4-yl-pyridin-4-ylamino)-naphthalen-1-yl]-2-oxo-acetamide; (5-tert-Butyl-2-methoxy-3-{2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl- ]-2-oxo-acetylamino}-phenyl)-carbamic acid isopropyl ester; N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-2-[4-(2-morpholi- n-4-yl-pyrimidin-4-ylamino)-naphthalen-1-yl]-2-oxo-acetamide; N-[3-(3-Allyl-ureido)-5-tert-butyl-2-methoxy-phenyl]-2-[4-(2-morpholin-4-- yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; 5-tert-Butyl-N,N-diethyl-2-methoxy-3-{2-[4-(2-morpholin-4-yl-ethoxy)-naph- thalen-1-yl]-2-oxo-acetylamino}-benzamide; N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-2-[4-(2-[1,4]oxa- zepan-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-(3-tert-Butyl-phenyl)-2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-2- -oxo-acetamide; N-[5-tert-Butyl-2-(6-methyl-pyridin-3-yl)-2H-pyrazol-3-yl]-2-[4-(2-morpho- lin-4-yl-ethoxy)-naphthalen-1-yl ]-2-oxo-acetamide; N-[5-tert-Butyl-2-(4-ureido-phenyl)-2H-pyrazol-3-yl]-2-[4-(2-morpholin-4-- yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-2-m-tolyl-2H-pyrazol-3-yl)-2-[4-(2-dimethylamino-ethoxy)n- aphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-2-methoxy-phenyl)-2-oxo-2-[4-(2-piperidin-1-yl-pyrimidin-- 4-yloxy)-naphthalen-1-yl]-acetamide; N-[5-tert-Butyl-2-(3-fluoro-4-methyl-phenyl)-2H-pyrazol-3-yl]-2-[4-(2-mor- pholin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-[3,5-Bis-(1,1-dimethyl-propyl)-2methoxy-phenyl]-2-[4-(2-morpholin-4-yl-- ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; 4-{2-[4-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylaminooxalyl)- -naphthalen-1-yloxy]-ethyl}-piperazine-1-carboxylic acid ethyl ester; N-(3-Amino-5-tert-butyl-2-methoxy-phenyl)-2-[4-(2-morpholin-4-yl-pyrimidi- n-4-ylamino)-naphthalen-1-yl]-2-oxo-acetamide; N-[5-tert-Butyl-3-(2-dimethylamino-acetylamino)-2-methoxy-phenyl]-2-[4-(2- -morpholin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-2-methyl-2H-pyrazol-3-yl)-2-[4-(2-morpholin-4-yl-ethoxy)-- naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-2-[4(2-dimethyla- mino-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-[1,3,4]thiadiazol-2-yl)-2-[(Z)-hydroxyimino]-2-[4-(2-morp- holin-4-yl-ethoxy)-naphthalen-1-yl]-acetamide; N-(5-tert-Butyl-2-ethoxy-phenyl)-2-[4-(2-morpholin-4-yl-ethoxy)-naphthale- n-1-yl]-2-oxo-acetamide; (5-tert-Butyl-2-methoxy-3-{2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl- ]-2-oxo-acetylamino}-phenyl)-carbamic acid 2-methoxy-ethyl ester; N-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-2-[4-(2-imidazol-1-yl-ethoxy)-- naphthalen-1-yl]-2-oxo-acetamide; N-(4-Bromo-3-trifluoromethyl-phenyl)-2-[4-(2-morpholin-4-yl-ethoxy)-napht- halen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-2-[8-chloro-4-(2- -morpholin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-2-[4-(2-chloro-e- thoxy)-naphthalen-1-yl]-2-oxo-acetamide; 5-tert-Butyl-3-{2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-ace- tylamino}-thiophene-2-carboxylic acid dimethylamide; N-(4-Chloro-3-trifluoromethyl-phenyl)-2-[4-(2-morpholin-4-yl-ethoxy)-naph- thalen-1-yl]-2-oxo-acetamide; N'-[1-(5-tert-Butyl-3-ethylcarbamoyl-2-methoxy-phenylcarbamoyl)-1-[4-(2-m- orpholin-4-yl-ethoxy)-naphthalen-1-yl]-meth-(Z)-ylidene]-hydrazinecarboxyl- ic acid ethyl ester; N-[5-tert-Butyl-2-(3-chloro-benzenesulfonyl)-2H-pyrazol-3-yl]-2-[4-(2-mor- pholin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-2-diethylamino-3-methanesulfonylamino-phenyl)-2-[4-(2-mor- pholin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-[5-tert-Butyl-2-methoxy-3-(propane-1-sulfonylamino)-phenyl]-2-(4-methox- y-naphthalen-1-yl)-2-oxo-acetamide; 2-[4-(2-Morpholin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-N-(3-trifluoromethy- l-phenyl)-acetamide; N-[5-tert-Butyl-2-(4-trifluoromethyl-phenyl)-2H-pyrazol-3-yl]-2-[4-(2-mor- pholin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-[5-tert-Butyl-2-methoxy-3-(propane-1-sulfonylamino)-phenyl]-2-[4-(2-dim- ethylamino-pyrimidin-4-ylamino)-naphthalen-1-yl]-2-oxo-acetamide; N-[5-tert-Butyl-2-methoxy-3-(propane-1-sulfonylamino)-phenyl]-2-[4-(2-mor- pholin-4-yl-pyrimidin-4-yloxy)-naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-2-{4-[2-(2,6-dim- ethyl-morpholin-4-yl)-ethoxy]-naphthalen-1-yl}-2-oxo-acetamide; N-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-2-oxo-2-{4-[2-(3-oxo-piperazin- -1-yl)-ethyl]-naphthalen-1-yl}-acetamide; N-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-2-oxo-2-[4-(3-pyridin-4-yl-pro- poxy)-naphthalen-1-yl]-acetamide; N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-2-[(Z)-hydroxyim- ino]-2-[4-(2-morpholin-4-yl-ethoxy)-5,6,7,8-tetrahydro-naphthalen-1-yl]-ac- etamide; N-[5-tert-Butyl-2-(4-methanesulfonyl-phenyl)-2H-pyrazol-3-yl]-2-[- 4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-2-[4-(2-imidazol- -1-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-[5-tert-Butyl-2-(3,5-dimethyl-phenyl)-2H-pyrazol-3-yl]-2-[4-(2-morpholi- n-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-2-[4-(2-morpholin-4-yl-pyridin- -4-ylamino)-naphthalen-1-yl]-2-oxo-acetamide; N-{5-tert-Butyl-3-[carbamoylmethyl-(propane-1-sulfonyl)-amino]-2-methoxy-- phenyl}-2-naphthalen-1-yl-2-oxo-acetamide; N'-[1-(5-tert-Butyl-2-methyl-2H-pyrazol-3-ylcarbamoyl)-1-[4-(2-morpholin-- 4-yl-ethoxy)-naphthalen-1-yl]-meth-(Z)-ylidene]-hydrazinecarboxylic acid ethyl ester; N-[5-tert-Butyl-2-(3-nitro-phenyl)-2H-pyrazol-3-yl]-2-[4-(2-morpholin-4-y- l-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-2-[3-chloro-4-(2-morpholin-4-y- l-ethoxy)-phenyl]-2-oxo-acetamide; N-(3-Benzenesulfonylamino-5-tert-butyl-2-methoxy-phenyl)-2-[4-(2-morpholi- n-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; 3-tert-Butyl-5-{2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-ace- tylamino}-pyrazole-1-carboxylic acid cyclohexylamide; N-[5-tert-Butyl-2-methoxy-3-(2,2,2-trifluoro-ethanesulfonylamino)-phenyl]- -2-[4-(2-morpholin-4-yl- ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N'-[1-(5-tert-Butyl-3-carbamoyl-2-methoxy-phenylcarbamoyl)-1-[4-(2-morpho- lin-4-yl-ethoxy)-naphthalen-1-yl]-meth-(E)-ylidene]-hydrazinecarboxylic acid ethyl ester; (5-tert-Butyl-2-methoxy-3-{2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl- ]-2-oxo-acetylamino}-phenyl)-carbamic acid 2-dimethylamino-ethyl ester; N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-2-[7-fluoro-4-(2- -morpholin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-isoxazol-3-yl)-2-[4-(2-morpholin-4-yl-pyridin-4-ylamino)-- naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-2-methyl-2H-pyrazol-3-yl)-2-(4-methoxy-naphthalen-1-yl)-2- -oxo-acetamide; N-(5-tert-Butyl-isoxazol-3-yl)-2-(4-methoxy-naphthalen-1-yl)-2-oxo-acetam- ide; N-[5-tert-Butyl-2-(3-methoxy-phenyl)-2H-pyrazol-3-yl]-2-[4-(2-dimethy- lamino-pyrimidin-4-ylamino)-naphthalen-1-yl]-2-oxo-acetamide; N-(2-Chloro-5-trifluoromethyl-phenyl)-2-[4-(2-morpholin-4-yl-ethoxy)-naph- thalen-1-yl]-2-oxo-acetamide; N-(3-Methanesulfonylamino-2-methoxy-5-methyl-phenyl)-2-[4-(2-morpholin-4-- yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; 4-{2-[4-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-ylaminooxalyl)-naphthalen-1-- yl]-ethyl}-piperazine-1-carboxylic acid ethyl ester; N-(3,5-Di-tert-butyl-2-hydroxy-phenyl)-2-[4-(2-morpholin-4-yl-ethoxy)-nap- hthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-2-naphthalen-1-yl-2H-pyrazol-3-yl)-2-[4-(2-morpholin-4-yl- -ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-2-methoxy-phenyl)-2-[4-(2-morpholin-4-yl-pyrimidin-4-ylam- ino)-naphthalen-1-yl]-2-oxo-acetamide; 4-{2-[4-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-ylaminooxalyl)-naphthalen-1-- yloxy]-ethyl}-piperazine-1-carboxylic acid ethyl ester; 5-tert-Butyl-2-methoxy-3-{2-[4-(2-morpholin-4-yl-pyrimidin-4-ylamino)-nap- hthalen-1-yl]-2-oxo-acetylamino}-benzamide; N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-2-(1-methyl-1H-i- ndol-3-yl)-2-oxo-acetamide; N-[2-(4-Acetyl-phenyl)-5-tert-butyl-2H-pyrazol-3-yl]-2-[4-(2-morpholin-4-- yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-[5-tert-Butyl-3-(carbamoylmethyl-methanesulfonyl-amino)-2-methoxy-pheny- l]-2-naphthalen-1-yl-2-oxo-acetamide; N-[2-(4-Amino-phenyl)-5-tert-butyl-2H-pyrazol-3-yl]-2-[4-(2-morpholin-4-y- l-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; (5-tert-Butyl-2-methoxy-3-{2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl- ]-2-oxo-acetylamino}-phenyl)-carbamic acid phenyl ester; N-(5-tert-Butyl-2-isobutoxy-phenyl)-2-[4-(2-morpholin-4-yl-ethoxy)-naphth- alen-1-yl]-2-oxo-acetamide; N-(4-tert-Butyl-phenyl)-2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-2- -oxo-acetamide; N-[5-tert-Butyl-2-(3-methyl-benzoyl)-2H-pyrazol-3-yl]-2-[4-(2-morpholin-4- -yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; 5-tert-Butyl-3-{2-[(Z)-hydroxyimino]-2-[4-(2-morpholin-4-yl-ethoxy)-napht- halen-1-yl]-acetylamino}-thiophene-2-carboxylic acid amide; N-[5-tert-Butyl-2-(2,3-dimethyl-phenyl)-2H-pyrazol-3-yl]-2-[4-(2-morpholi- n-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-[5-tert-Butyl-2-(4-nitro-phenyl)-2H-pyrazol-3-yl]-2-[4-(2-morpholin-4-y- l-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; 2-[(Z)-Hydroxyimino]-N-(3-methanesulfonylamino-2-methoxy-5-methyl-phenyl)- -2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-acetamide; N-[5-tert-Butyl-2-(morpholine-4-carbonyl)-thiophen-3-yl]-2-[(Z)-hydroxyim- ino]-2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-acetamide; N-(5-tert-Butyl-2-phenyl-2H-pyrazol-3-yl)-2-[4-(2-morpholin-4-yl-ethoxy)-- naphthalen-1-yl]-2-oxo-acetamide; N'-[1-(5-tert-Butyl-2-methyl-2H-pyrazol-3-ylcarbamoyl)-1-[4-(2-morpholin-- 4-yl-ethoxy)-naphthalen-1-yl]-meth-(E)-ylidene]-hydrazinecarboxylic acid ethyl ester; N'-[1-(5-tert-Butyl-2-methyl-2H-pyrazol-3-ylcarbamoyl)-1-[4-(2-morpholin-- 4-yl-ethoxy)-naphthalen-1-yl]-meth-(Z)-ylidene]-hydrazinecarboxamide; N-[5-tert-Butyl-2-(3-methoxy-phenyl)-2H-pyrazol-3-yl]-2-[4-(2-morpholin-4- -yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; 5-tert-Butyl-2-methoxy-3-{2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]- -2-oxo-acetylamino}-N-pyridin-2-yl-benzamide; N-[5-tert-Butyl-3-(3,3-dimethyl-ureido)-2-methoxy-phenyl]-2-[4-(2-morphol- in-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; 5-tert-Butyl-3-{2-[7-chloro-4-(2-morpholin-4-yl-ethoxy)-1-yl]-2-oxo-acety- lamino}-2-methoxy-benzamide; 2-[4-(2-Morpholin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-N-quinolin-3-yl-ace- tamide; N-[5-tert-Butyl-2-methoxy-3-morpholine-4-carbonyl)-phenyl]-2-[4-(2- -morpholin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-[5-tert-Butyl-3-(3-isopropyl-ureido)-2-methoxy-phenyl]-2-[4-yl-ethoxy)-- naphthalen-1-yl]-2-oxo-acetamide; N-(3-Amino-5-trifluoromethyl-phenyl)-2-[4-(2-morpholin-4-yl-ethoxy)-napht- halen-1-yl]-2-oxo-acetamide; 5-tert-Butyl-2-methyl-2H-pyrazol-3-yl)2[4-(2-morpholin-4-yl-pyrimidin-4-y- loxy)-naphthalen-1-yl]-2-oxo-acetamide; 2-{4-[2-(4-Acetyl-piperazin-1-yl)-ethoxy]-naphthalen-1-yl}-N-(5-tert-buty- l-3-methanesulfonylamino-2-methoxy-phenyl)-2-oxo-acetamide; N-[5-tert-Butyl-2-(3-fluoro-phenyl)-2H-pyrazol-3-yl]-2-[4-(2-morpholin-4-- yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-[5-tert-Butyl-2-(3,4-dichloro-phenyl)-2H-pyrazol-3-yl]2-[4-(2-morpholin- -4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; 5-tert-Butyl-isoxazol-3-yl)-2-[4-(2-morpholin-4-yl-pyrimidin-4-yloxy)-nap- hthalen-1-yl]-2-oxo-acetamide; N-[5-tert-Butyl-2-(2,5-dimethyl-phenyl)-2H-pyrazol-3-yl]-2-[4-(2-morpholi- n-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-2-[4-(2-morpholi- n-4-yl-ethoxy)-5,6,7,8-tetrahydro-naphthalen-1-yl]-2-oxo-acetamide; N-(4-Chloro-3-trifluoromethyl-phenyl)-2-(4methoxy-naphthalen-1-yl)-2-oxo-- acetamide; N-[5-(1,1-Dimethyl-butyl)-2-p-tolyl-2H-pyrazol-3-yl]-2-[4-(2-mo- rpholin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N'-[1-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-1-[- 4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-meth-(E)-ylidene]-hydrazineca- rboxamide; N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-2-[4(2- -methylamino-pyrimidin-4-ylamino)-naphthalen-1-yl]-2-oxo-acetamide; 5-tert-Butyl-2-m-tolyl-2H-pyrazol-3-yl)-2-[(Z)-methoxyimino]-2-[4-(2-morp- holin-4-yl-ethoxy)-naphthalen-1-yl]-acetamide; 5-tert-Butyl-N-cyclopropyl-3-[2-[(E)-hydroxyimino]-2-(4-methoxy-naphthale- n-1-yl)-acetylamino]-2-methoxy-benzamide; N-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-2-{4-[2-(2,6-dimethyl-morpholi- n-4-yl)-ethoxy]-naphthalen-1-yl}-2-oxo-acetamide; N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-2-[8-fluoro-4-(2- -morpholin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; 5-tert-Butyl-N-furan-2-ylmethyl-2-methoxy-3-{2-[4-(2-morpholin-4-yl-ethox- y)-naphthalen-1-yl]-2-oxo-acetylamino}-benzamide; N-[5-tert-Butyl-2-(3-trifluoromethyl-benzoyl)-2H-pyrazol-3-yl]-2-[4-(2-mo- rpholin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-[5-tert-Butyl-2-methoxy-3-(propane-1-sulfonylamino)-phenyl]-2-[4-(2-mor- pholin-4-yl-pyrimidin-4-ylamino)-naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-2-oxo-2-{4-[2-(3- -oxo-piperazin-1-yl)-ethoxy]-naphthalen-1-yl}-acetamide; 2-{4-[2-(4-Acetyl-piperazin-1-yl)-ethyl]-naphthalen-1-yl}-N-(5-tert-butyl- -2-p-tolyl-2H-pyrazol-3-yl)-2-oxo-acetamide; N-(5-tert-Butyl-2-phenylacetyl-2H-pyrazol-3-yl)-2-[4-(2-morpholin-4-yl-et- hoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-2-oxo-2-{4-[2-(3-oxo-piperazin- -1-yl)-ethoxy]-naphthalen-1-yl}-acetamide; N-[5-tert-Butyl-2-(3-ureido-phenyl)-2H-pyrazol-3-yl]-2-[4-(2-morpholin-4-- yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-2-[(Z)-methoxyim- ino]-2-[4-(2-morpholin-4-yl-pyrimidin-4-yloxy)-naphthalen-1-yl]-acetamide; N-[5-tert-Butyl-2-methoxy-3-(3-oxo-piperazine-1-carbonyl)-phenyl]-2-[4-(2- morpholin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; 3-tert-Butyl-5-{2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-ace- tylamino}-pyrazole-1-carboxylic acid propylamide; 5-tert-4-Butyl-N-cyclopropyl-2-methoxy-3-{2-[4-(2-morpholin-4-yl-pyrimidi- n-4-yloxy)-naphthalen-1-yl]-2-oxo-acetylamino}-benzamide; N-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-2-{4-[2-(4-methyl-piperazin-1-- yl)-ethoxy]-naphthalen-1-yl}-2-oxo-acetamide; N-(3-Amino-5-tert-butyl-2-methoxy-phenyl)-2[4-(2-morpholin-4-yl-pyrmidin-- 4-yloxy)- naphthalen-1-yl]-2-oxo-acetamide; 5-tert-Butyl-2-methoxy-3-{2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]- -2-oxo-acetylamino}-N-propyl-benzamide; N-(5-tert-Butyl-2-methyl-2H-pyrazol-3-yl)-2-[(Z)-hydroxyimino]-2-[4-(2-mo- rpholin-4-yl-ethoxy)-naphthalen-1-yl]-acetamide; N-5-Isopropyl-2-methyl-phenyl)-2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-- 1-yl]-2-oxo-acetamide; (5-tert-Butyl-2-methoxy-3-{2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl- ]-2-oxo-acetylamino}-phenyl)-carbamic acid pyridin-3-ylmethyl ester; N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-2-[4-(2-ethylami- no-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-(3,5-Di-tert-butyl-phenyl)-2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-- yl]-2-oxo-acetamide; N-(3-Amino-5-tert-butyl-2-methoxy-phenyl)-2-[4-(2-methylamino-pyrimidin-4- -ylamino)-naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-2-[4-(2-morpholin-4-yl-pyrimid- in-4-yloxy)-naphthalen-1-yl]-2-oxo-acetamide; N-[5-tert-Butyl-2-(2,3-dichloro-phenyl)-2H-pyrazol-3-yl]-2-[4-(2-morpholi- n-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-[3,5-Bis-(1,1-dimethyl-propyl)-2-hydroxy-phenyl]2[4-(2-morpholin-4-yl-e- thoxy)-naphthalen-1-yl]-2-oxo-acetamide; 4-{2-[4-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylaminooxalyl)- -naphthalen-1-yloxy]-ethyl}-piperazine-1-carboxylic acid tert-butyl ester; 5-tert-Butyl-N-isopropyl-2-methoxy-3-{2-[4-(2-morpholin-4-yl-ethoxy)-naph- thalen-1-yl]-2-oxo-acetylamino}-benzamide; N-(5-tert-Butyl-3-diethylaminomethyl-2-hydroxy-phenyl)-2-[4-(2-morpholin-- 4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-2-m-tolyl-2H-pyrazol-3-yl)-2-[4-(2-morpholin-4-yl-pyrimid- in-4-ylamino)-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-2-methyl-2H-pyrazol-3-yl)-2-[4-(2-morpholin-4-yl-pyrimidi- n-4-ylamino)-naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-2-[4-(4-morpholi- n-4-yl-pyrimidin-2-ylamino)-naphthalen-1-yl]-2-oxo-acetamide; N-(3-Amino-5-tert-butyl-2-methoxy-phenyl)-2-[4-(2-morpholin-4-yl-ethoxy)-- naphthalen -1-yl]-2-oxo-acetamide; 5-tert-Butyl-3-{2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-ace- tylamino}-thiophene-2-carboxylic acid methylamide; N-[5-tert-Butyl-2-(3-methoxy-phenyl)-2H-pyrazol-3-yl]-2-[4-(2-morpholin-4- -yl-pyrimidin-4-ylamino)-naphthalen-1-yl]-2-oxo-acetamide; N'-[1-(5-tert-Butyl-3-carbamoyl-2-methoxy-phenylcarbamoyl)-1-[4-(2-morpho- lin-4-yl-ethoxy)-naphthalen-1-yl]-meth-(Z)-ylidene]-hydrazinecarboxylic acid ethyl ester; N-(4-Fluoro-3-trifluoromethyl-phenyl)-2-[4-(2-morpholin-4-yl-ethoxy)-naph- thalen-1-yl]-2 -oxo-acetamide; N-(2,5-Di-tert-butyl-phenyl)-2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-- yl]-2-oxo-acetamide; 2-[4-(2-Morpholin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-N-((1S,2R)-2-phenyl- -cyclopropyl)-acetamide; N-(2-Methoxy-5-trifluoromethyl-phenyl)-2-[4-(2-morpholin-4-yl-ethoxy)-nap- hthalen-1-yl]-2-oxo-acetamide; N-[2-(4-Bromo-phenyl)-5-tert-butyl-2H-pyrazol-3-yl]-2-[4-(2-morpholin-4-y- l-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; 5-tert-Butyl-2-methoxy-N-methyl-3-{2-[4-(2-morpholin-4-yl-ethoxy)-naphtha- len-1-yl]-2-oxo-acetylamino}-benzamide; N-(5-tert-Butyl-2-methoxy-3-piperidin-1-ylmethyl-phenyl)-2-[4-(2-morpholi- n-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-2-methoxy-phenyl)-2-naphthalen-1-yl-2-oxo-acetamide; N-(2,5-Di-tert-butyl-2H-pyrazol-3-yl)-2-[4-(2-morpholin-4-yl-ethoxy)-naph- thalen-1-yl]-2-oxo-acetamide; N-(3-Amino-5-tert-butyl-2-methoxy-phenyl)-2naphthalen-1-yl-2-oxo-acetamid- e; 5-tert-Butyl-N-ethyl-3-{2-[(Z)-hydroxyimino]-2-[4-(2-morpholin-4-yl-eth- oxy)-naphthalen-1-yl]-acetylamino}-2-methoxy-benzamide; 4-{2-[4-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-ylaminooxalyl)-naphthalen-1-- yl]-ethyl}-piperazine-1-carboxylic acid tert-butyl ester; 5-tert-Butyl-N-ethyl-2-hydroxy-3-{2-[4-(2-morpholin-4-yl-ethoxy)-naphthal- en-1-yl]-2-oxo-acetylamino}-benzamide; N-(5-tert-Butyl-2-ethoxy-3-methanesulfonylamino-phenyl)-2[4-(2-morpholin-- 4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N'-[1-(5-tert-Butyl-3-ethylcarbamoyl-2-methoxy-phenylcarbamoyl)-1-[4-(2-m- orpholin-4-yl-ethoxy) -naphthalen-1-yl]-meth-(E)-ylidene]-hydrazinecarboxamide; 2-{4-[2-(4-Acetyl-piperazin-1-yl)-ethoxy]-naphthalen-1-yl}-N-(5-tert-buty- l-2-p-tolyl-2H-pyrazol-3-yl)-2-oxo-acetamide; 5-tert-Butyl-N-ethyl-2-methoxy-3-{2-[4-(2-morpholin-4-yl-ethoxy)-naphthal- en-1-yl]-2-oxo-acetylamino}-benzamide; 5-tert-Butyl-2-methoxy-3-{2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]- -2-oxo-acetylamino}-benzoic acid; N-(5-tert-Butyl-isoxazol-3-yl)-2-[4-(2-dimethylamino-pyrimidin-4-ylamino)- -naphthalen-1-yl]-2-oxo-acetamide; 5-tert-Butyl-3-{2-[4-(2-morpholin-4-yl-pyridin-4-ylamino)-naphthalen-1-yl- ]-2-oxo-acetylamino}-thiophene-2-carboxylic acid amide; 2-[4-(2-Morpholin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-N-m-tolyl-acetamide- ; 5-tert-Butyl-3-{2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-ac- etylamino}-thiophene-2-carboxylic acid methyl ester; N'-[1-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyly-1-[- 4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-meth-(Z)-ylidene]-hydrazineca- rboxamide; N-[5-tert-Butyl-2-(3-methoxy-phenyl)-2H-pyrazol-3-yl]-2-[4-(2-m- orpholin-4-yl-pyridin-4-ylamino)-naphthalen-1-yl]-2-oxo-acetamide; N-(5-Isopropyl-2-p-tolyl-2H-pyrazol-3-yl)-2-[4-(2-morpholin-4-yl-ethoxy)-- naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-isoxazol-3-yl)-2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-- 1-yl]-2-oxo-acetamide; N-(2-Benzoyl-5-tert-butyl-2H-pyrazol-3-yl)-2-[4-(2-morpholin-4-yl-ethoxy)- -naphthalen-1-yl]-2-oxo-acetamide; 5-tert-Butyl-N-ethyl-3-{2-hydrazono-2-[4-(2-morpholin-4-yl-ethoxy)-naphth- alen-1-yl]-acetylamino)}-2-methoxy-benzamide; N-(5-tert-Butyl-3-ethanesulfonylamino-2-methoxy-phenyl)-2-[(Z)-hydroxyimi- no]-2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-acetamide; N-(3-Amino-5-tert-butyl-2-methoxy-phenyl)-2-[4-(2-dimethylamino-pyrimidin- -4-ylamino)-naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-thiophen-3-yl)-2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-- 1-yl]-2-oxo-acetamide; N-[5-tert-Butyl-2-(4-chloro-phenyl)-2H-pyrazol-3-yl]-2-[4-(2-morpholin-4-- yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N'-[1-(5-tert-Butyl-3-carbamoyl-2-methoxy-phenylcarbamoyl)-1-[4-(2-morpho- lin-4-yl-ethoxy)-naphthalen-1-yl]-meth-(E)-ylidene]-hydrazinecarboxamide; N-[5-tert-Butyl-2-(4-methoxy-phenyl)-2H-pyrazol-3-yl]-2-[4-(2-morpholin-4- -yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; 5-tert-Butyl-3-{2-[7-chloro-4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-- 2-oxo-acetylamino}-N-cyclopropyl-2-methoxy-benzamide; N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-2-{4-[2-(4-methy- l-piperazin-1-yl)-ethoxy]-naphthalen-1-yl}-2-oxo-acetamide; N-(5-tert-Butyl-thiophen-3-yl)-2-[(Z)-hydroxyimino]-2-[4-(2-morpholin-4-y- l-ethoxy)-naphthalen-1-yl]-acetamide; 5-tert-Butyl-N-cyclopropyl-3-[2-[(Z)-hydroxyimino]-2-(4-methoxy-naphthale- n-1-yl)-acetylamino]-2-methoxy-benzamide; N-(5-tert-Butyl-2-methyl-2H-pyrazol-3-yl)-2-[4-(4-morpholin-4-yl-pyrimidi- n-2-ylamino)-naphthalen-1-yl]-2-oxo-acetamide; N-[5-tert-Butyl-2-(3-methoxy-phenyl)-2H-pyrazol-3-yl]-2-[(Z)-hydroxyimino- ]-2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-acetamide; N-[2-Methoxy-5-(1-methyl-1-phenyl-ethyl)-phenyl]-2-[4-(2-morpholin-4-yl-e- thoxy)-naphthalen-1-yl]-2-oxo-acetamide; 5-tert-Butyl-3-{2-[4-(2-morpholin-4-yl-pyrimidin-4-ylamino)-naphthalen-1-- yl]-2-oxo-acetylamino}-thiophene-2-carboxylic acid amide; 5-tert-Butyl-N-isobutyl-2-methoxy-3-{2-[4-(2-morpholin-4-yl-ethoxy)-napht- halen-1-yl]-2-oxo-acetylamino}-benzamide; N-(3,5-Di-tert-butyl-2-methoxy-phenyl)-2-[4-(2-morpholin-4-yl-ethoxy)-nap- hthalen-1-yl]-2-oxo-acetamide; 5-tert-Butyl-3-{2-[(Z)-hydroxyimino]-2-[4-(2-morpholin-4-yl-ethoxy)-napht- halen-1-yl]-acetylamino}-thiophene-2-carboxylic acid dimethylamide; N-(5-tert-Butyl-2-methoxy-3-methyl-phenyl)-2-[(Z)-hydroxyimino]-2-[4-(2-m- orpholin-4-yl-ethoxy)-naphthalen-1-yl]-acetamide; N'-[1-(5-tert-Butyl-3-cyclopropylcarbamoyl-2-methoxy-phenylcarbamoyl)-1-[- 4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-meth-(E)-ylidene]-hydrazineca- rboxylic acid ethyl ester; N-Indan-5-yl-2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetam- ide; N-[5-tert-Butyl-2-(3-chloro-4-fluoro-phenyl)-2H-pyrazol-3-yl]-2-[4-(2- -morpholin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-[5-tert-Butyl-3-(imidazole-1-carbonyl)-2-methoxy-phenyl]-2-[4-(2-morpho- lin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-[5-tert-Butyl-2-(2,4-difluoro-phenyl)-2H-pyrazol-3-yl]-2-[4-(2-morpholi- n-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-2-oxo-2-{4-[2-(5-oxo-[1,4]diaze- pan-1-yl)-ethoxy]-naphthalen-1-yl}-acetamide; N-(5-tert-Butyl-3-ethanesulfonylamino-2-methoxy-phenyl)-2-[4-(2-morpholin- -4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; 3-tert-Butyl-5-{2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-ace- tylamino}-pyrazole-1-carboxylic acid isopropylamide; N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-2-[(Z)-hydroxyim- ino]-2-[4-(2-morpholin-4-yl-pyrimidin-4-yloxy)-naphthalen-1-yl]-acetamide; N-[2-(3-Amino-phenyl)-5-tert-butyl-2H-pyrazol-3-yl]-2-[4-(2-morpholin-4-y- l-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; 3-tert-Butyl-5-{2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-ace- tylamino}-pyrazole-1-carboxylic acid phenylamide; N-(5-tert-Butyl-2-o-tolyl-2H-pyrazol-3-yl)-2-[4-(2-morpholin-4-yl-ethoxy)- -naphthalen-1-yl]-2-oxo-acetamide; 5-tert-Butyl-3-{2-[4-(2-morpholin-4-yl-pyrimidin-4-yloxy)-naphthalen-1-yl- ]-2-oxo-acetylamino}-thiophene-2-carboxylic acid amide; N-[5-tert-Butyl-2-(2-(2,4-dichloro-phenyl)-2H-pyrazol-3-yl]-2-[4-(2-morph- olin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-isoxazol-3-yl)-2-[4-(3-hydroxy-propoxy)-naphthalen-1-yl]-- 2-oxo-acetamide; N-(3-tert-Butyl-isoxazol-5-yl)-2[(Z)-hydroxyimino]-2[-4-(2-morpholin-4-yl- -ethoxy)-naphthalen-1-yl]-acetamide; N-[5-tert-Butyl-2-methoxy-3-(propane-1-sulfonylamino)-phenyl]-2-[4-(2-mor- pholin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-2-oxo-2-{4-[2-(5- -oxo-[1,4]diazepan-1-yl)-ethoxy]-naphthalen-1-yl}-acetamide; N-[5-tert-Butyl-2-(3-cyano-phenyl)-2H-pyrazol-3-yl]-2-[4-(2-morpholin-4-y- l-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-2-methoxy-3-phenylacetylamino-phenyl)-2-[4-(2-morpholin-4- -yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; 5-tert-Butyl-3-{2-[4-(2-dimethylamino-pyrimidin-4-ylamino)-naphthalen-1-y- l]-2-oxo-acetylamino}-thiophene-2-carboxylic acid amide; N'-[1-(5-tert-Butyl-3-ethylcarbamoyl-2-methoxy-phenylcarbamoyl)-1-[4-(2-m- orpholin-4-yl-ethoxy)-naphthalen-1-yl]-meth-(E)-ylidene]-hydrazinecarboxyl- ic acid ethyl ester; N-(3-Methanesulfonylamino-5-trifluoromethyl-phenyl)-2-[4(2morpholin-4-yl-- ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-2-hydroxy-3-piperidin-1-ylmethyl-phenyl)-2-[4-(2-morpholi- n-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-2-methoxy-phenyl)-2-oxo-2-{4-[2-((S)-1-phenyl-ethylamino)- -pyrimidin-4-ylamino]-naphthalen-1-yl}-acetamide; N-[5-tert-Butyl-2-(4-cyano-phenyl)-2H-pyrazol-3-yl]-2-[4-(2-morpholin-4-y- l-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N'-[1-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-1-[- 4-(2-morpholin-4-yl -ethoxy)-naphthalen-1-yl]-meth-(E)-ylidene]-hydrazinecarboxylic acid ethyl ester; N-(5-tert-Butyl-2-methoxy-3-{2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-- yl]-2-oxo-acetylamino}-phenyl)-isobutyramide; N-[5-tert-Butyl-2-(4-methyl-benzoyl)-2H-pyrazol-3-yl]-2-[4-(2-morpholin-4- -yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-[5-tert-Butyl-2-(2-chloro-phenyl)-2H-pyrazol-3-yl]-2-[4-(2-morpholin-4-- yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-[5-tert-Butyl-2-(3-chloro-4-methyl-phenyl)-2H-pyrazol-3-yl]-2-[4-(2-mor- pholin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide; N-[5-tert-Butyl-2-methoxy-3-(propane-1-sulfonylamino)-phenyl]-2-[4-(2-mor- pholin-4-yl-pyridin-4-ylamino)-naphthalen-1-yl]-2-oxo-acetamide; 5-tert-Butyl-N-cyclopropyl-2-methoxy-3-{2-[4-(2-morpholin-4-yl-pyridin-4-- ylamino)-naphthalen-1-yl]-2-oxo-acetylamino}-benzamide; N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-2-oxo-2-{4-[6-(t- etrahydro-pyran-4-ylamino)-pyridin-3-yl]-naphthalen-1-yl}-acetamide; 3-[2-(4-Bromo-naphthalen-1-yl)-2-oxo-acetylamino]-5-tert-butyl-N-cyclopro- pyl-2-methoxy-benzamide; N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-2-[4-(6-morpholi- n-4-yl-pyridin-3-yl)-naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-2-[4-(6-morpholin-4-ylmethyl-p- yridin-3-yl)-naphthalen-1-yl]-2-oxo-acetamide; N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-2-oxo-2-(4-pyrid- in-3-yl-naphthalen-1-yl)-acetamide; or N-(5-tert-Butyl-2-methyl-2H-pyrazol-3-yl)-2-oxo-2-(4-pyridin-3-yl-naphtha- len-1-yl)-acetamide. 34. The compound or pharmaceutical salt thereof of claim 33 wherein the compound is N-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-2-[4-(2-morpholi- n-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetamide. 35. The compound or pharmaceutical salt thereof of claim 33 wherein the compound is N-(5-tert-Butyl-2-methoxy-phenyl)-2-[4-(2-morpholin-4-yl-ethoxy)-naphthal- en-1-yl]-2-oxo-acetamide.

Details for Patent 7,749,999

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Janssen Biotech, Inc.	REMICADE	infliximab	For Injection	103772	08/24/1998		2023-09-11